LOCUS       NM_007502               1867 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus ATPase, Na+/K+ transporting, beta 3 polypeptide
            (Atp1b3), transcript variant 1, mRNA.
ACCESSION   NM_007502
VERSION     NM_007502.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1867)
  AUTHORS   Honda,K., Kim,S.H., Kelly,M.C., Burns,J.C., Constance,L., Li,X.,
            Zhou,F., Hoa,M., Kelley,M.W., Wangemann,P., Morell,R.J. and
            Griffith,A.J.
  TITLE     Molecular architecture underlying fluid absorption by the
            developing inner ear
  JOURNAL   Elife 6, e26851 (2017)
   PUBMED   28994389
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1867)
  AUTHORS   Chang,I., Bramall,A.N., Baynash,A.G., Rattner,A., Rakheja,D.,
            Post,M., Joza,S., McKerlie,C., Stewart,D.J., McInnes,R.R. and
            Yanagisawa,M.
  TITLE     Endothelin-2 deficiency causes growth retardation, hypothermia, and
            emphysema in mice
  JOURNAL   J Clin Invest 123 (6), 2643-2653 (2013)
   PUBMED   23676500
REFERENCE   5  (bases 1 to 1867)
  AUTHORS   Yu,Z., Liu,N., Wang,Y., Li,X. and Wang,X.
  TITLE     Identification of neuroglobin-interacting proteins using yeast
            two-hybrid screening
  JOURNAL   Neuroscience 200, 99-105 (2012)
   PUBMED   22079573
REFERENCE   6  (bases 1 to 1867)
  AUTHORS   MacPhee,D.J., Jones,D.H., Barr,K.J., Betts,D.H., Watson,A.J. and
            Kidder,G.M.
  TITLE     Differential involvement of Na(+),K(+)-ATPase isozymes in
            preimplantation development of the mouse
  JOURNAL   Dev Biol 222 (2), 486-498 (2000)
   PUBMED   10837135
REFERENCE   7  (bases 1 to 1867)
  AUTHORS   Besirli,C.G., Gong,T.W. and Lomax,M.I.
  TITLE     The Atp1b3 gene for Na,K-ATPase beta 3 subunit maps to mouse
            chromosome 9, and a related gene, Atp1b3-rs, maps to mouse
            chromosome 3
  JOURNAL   Mamm Genome 9 (2), 171-172 (1998)
   PUBMED   9457684
REFERENCE   8  (bases 1 to 1867)
  AUTHORS   Malik,N., Canfield,V., Sanchez-Watts,G., Watts,A.G., Scherer,S.,
            Beatty,B.G., Gros,P. and Levenson,R.
  TITLE     Structural organization and chromosomal localization of the human
            Na,K-ATPase beta 3 subunit gene and pseudogene
  JOURNAL   Mamm Genome 9 (2), 136-143 (1998)
   PUBMED   9457675
REFERENCE   9  (bases 1 to 1867)
  AUTHORS   Besirli,C.G., Gong,T.W. and Lomax,M.I.
  TITLE     Novel beta 3 isoform of the Na,K-ATPase beta subunit from mouse
            retina
  JOURNAL   Biochim Biophys Acta 1350 (1), 21-26 (1997)
   PUBMED   9003452
REFERENCE   10 (bases 1 to 1867)
  AUTHORS   Malik,N., Canfield,V.A., Beckers,M.C., Gros,P. and Levenson,R.
  TITLE     Identification of the mammalian Na,K-ATPase 3 subunit
  JOURNAL   J Biol Chem 271 (37), 22754-22758 (1996)
   PUBMED   8798450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117248.3.
            
            On Aug 30, 2022 this sequence version replaced NM_007502.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159532.1, AK151700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC117248.3         88538-88807
            271-399             AC117248.3         106960-107088
            400-507             AC117248.3         109478-109585
            508-692             AC117248.3         112467-112651
            693-743             AC117248.3         114144-114194
            744-827             AC117248.3         117391-117474
            828-1867            AC117248.3         119159-120198
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.31 cM"
     gene            1..1867
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /note="ATPase, Na+/K+ transporting, beta 3 polypeptide"
                     /db_xref="GeneID:11933"
                     /db_xref="MGI:MGI:107788"
     exon            1..270
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..998
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /EC_number="7.2.2.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium/potassium-transporting ATPase subunit beta-3; Na
                     K-ATPase beta-3 subunit; sodium/potassium-dependent ATPase
                     subunit beta-3; ATPase, Na+/K+ beta 3 polypeptide"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-3 isoform 1"
                     /protein_id="NP_031528.1"
                     /db_xref="CCDS:CCDS23414.1"
                     /db_xref="GeneID:11933"
                     /db_xref="MGI:MGI:107788"
                     /translation="MTKTEKKSFHQSLAEWKLFIYNPSSGEFLGRTSKSWGLILLFYL
                     VFYGFLAALFTFTMWAMLQTLNDEVPKYRDQIPSPGLMVFPKPQTALEYTFSMSEPQT
                     YKKLVEDLESFLKPYSVEEQKNLTSCPDGAPFIQHGPDYRACQFPVSLLEECSGVTDA
                     NFGYSKGQPCILVKMNRIIDLIPDGYPQISCLPKEENATIATYPEFGVLDLKYFPYYG
                     KKRHVGYRQPLVAVQVKFDSGLNKKEVTVECHIAGTRNLKNKNERDKFLGRVSFKVTA
                     RA"
     exon            271..399
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..507
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            508..692
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            693..743
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..827
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1867
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /note="hexamer: AATAAA"
     polyA_site      1478
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /note="major polyA site"
     regulatory      1828..1833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /note="hexamer: AACAAA"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /note="hexamer: AATACA"
     polyA_site      1849
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
                     /note="major polyA site"
     polyA_site      1867
                     /gene="Atp1b3"
                     /gene_synonym="ATPB-3"
ORIGIN      
        1 agtcggctct agtggtctcg taacgaagag ttgttcccgg ccgtgccgtc ctccgctgtt
       61 gtcgctgggc tgcgccgccg ccgtcgccag gacgcgccgc cgagcccctc gtcgcctcca
      121 gccccgcggc ctccgttcac ctcgacttcc acacgcccat catgacgaag actgagaaga
      181 aatccttcca ccagagcctg gccgagtgga agctgttcat ctacaacccg agcagcggag
      241 agtttctggg gcgcacctcc aagagctggg gtctgatctt gctcttctac ctagtttttt
      301 atgggttctt ggctgcactc ttcacattca caatgtgggc catgctccag actctgaatg
      361 atgaagttcc gaaatatcga gaccagattc ctagtccagg acttatggtt tttcccaaac
      421 cgcagactgc cttggaatat acattcagca tgtctgagcc acagacttac aaaaagttgg
      481 ttgaagacct ggagagtttc ctaaagccat attctgtgga agaacagaag aacctcacaa
      541 gttgtcctga tggagcgcct tttattcagc atggtcctga ctatagggca tgtcagtttc
      601 cagtctcctt gcttgaagaa tgtagtggtg tgactgatgc taattttggc tattccaaag
      661 gacagccttg catccttgtg aaaatgaaca gaataatcga tttaatccca gacggatatc
      721 cacaaatatc gtgtttgcca aaggaagaaa acgcaactat agcaacttat cctgaatttg
      781 gagttttaga cttaaagtat tttccatatt atgggaaaaa acggcatgtt ggatatcgac
      841 agcccctagt tgccgtacag gtcaaatttg actctggtct taacaagaaa gaagtaacag
      901 ttgagtgcca tattgctgga accaggaacc taaaaaacaa gaatgagcgt gacaagttct
      961 tgggacgtgt ttcgttcaaa gtcacagcac gagcctagga ataggatgtc tccacagaat
     1021 tcatgttgtg ttgtcgccat tttgtatcag ctggacctgc cattctagga ttatgaggcc
     1081 accttggagg aggaagtggt gtggtacaca cttgggtgac atcataacat gcttccagat
     1141 catagtgttc agtgtcctct gaagtaactg cctgctgcct ctgctgccct tgaacccatg
     1201 tacggtcgcc agacagggac cagtgagctc ccgaccccaa acatgcagag tgggggccct
     1261 gtcttctttg tgtgtaattg ccaaacgtct aaagcttcat gtgctgggct gtgtacatat
     1321 tttatggatt taacactggt aactgcatat tttgatgcca acaaagtttt agggatacaa
     1381 tggtaccttg ccaacatcga gtgactttag ctggaagaaa tgtctgagaa gctctgtatg
     1441 tgaggaggga aaaggaaaat aaagtggatc tgaaagtaga ctctgcttct gcgcatgtgt
     1501 gagtggtgcc tgtccgtatg ctccagactg tttcttacaa ggtgaactag accatatctg
     1561 attttgctga gaggacaaac tttctgttgt agtacatatt taaaaatact attgggctga
     1621 ctttgagtgt tggaatcaag tcttccacat tcgggtatct tagacacagg gatgaaacag
     1681 catttaaatt aggtgaatgt gcaccgattt ttgttgttgt tgttgttttg ttttttgaat
     1741 gaatgaaatt cccaagatat aaattgtata gtttttcaaa ctgtcttgtt aagtgctttt
     1801 atttagtaga ctgtggaccc taataaaaac aaattgtgaa atacaaaaac ttcaaactga
     1861 tttaaaa
//
