LOCUS       NM_013415               2994 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ATPase, Na+/K+ transporting, beta 2 polypeptide
            (Atp1b2), mRNA.
ACCESSION   NM_013415
VERSION     NM_013415.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2994)
  AUTHORS   Litan,A., Li,Z., Tokhtaeva,E., Kelly,P., Vagin,O. and Langhans,S.A.
  TITLE     A Functional Interaction Between Na,K-ATPase beta2-Subunit/AMOG and
            NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule
            Cells
  JOURNAL   Mol Neurobiol 56 (11), 7557-7571 (2019)
   PUBMED   31062247
  REMARK    GeneRIF: a functional link between the Na,K-ATPase beta2-subunit
            and Merlin/NF2 and suggest a role for the beta2-subunit in
            regulating cytoskeletal dynamics and Hippo/YAP signaling during
            neuronal differentiation, is reported.
REFERENCE   3  (bases 1 to 2994)
  AUTHORS   Buenaventura,D.F., Corseri,A. and Emerson,M.M.
  TITLE     Identification of Genes With Enriched Expression in Early
            Developing Mouse Cone Photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 60 (8), 2787-2799 (2019)
   PUBMED   31260032
REFERENCE   4  (bases 1 to 2994)
  AUTHORS   Plossl,K., Straub,K., Schmid,V., Strunz,F., Wild,J., Merkl,R.,
            Weber,B.H.F. and Friedrich,U.
  TITLE     Identification of the retinoschisin-binding site on the retinal
            Na/K-ATPase
  JOURNAL   PLoS One 14 (5), e0216320 (2019)
   PUBMED   31048931
  REMARK    GeneRIF: These and previous results led us to suggest an
            induced-fit binding mechanism for the interaction between
            retinoschisin and the Na/K-ATPase, which is dependent on threonine
            240 in ATP1B2 allowing the accommodation of hyperflexible
            retinoschisin spikes by the associated protein-protein interaction
            patch on ATP1B2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2994)
  AUTHORS   Ding,B., Walton,J.P., Zhu,X. and Frisina,R.D.
  TITLE     Age-related changes in Na, K-ATPase expression, subunit isoform
            selection and assembly in the stria vascularis lateral wall of
            mouse cochlea
  JOURNAL   Hear Res 367, 59-73 (2018)
   PUBMED   30029086
  REMARK    GeneRIF: Functional selection and assembly of NKA subunit isoforms
            occurs in the cochlear stria vascularis lateral wall, which is
            disrupted and dysregulated with age.
REFERENCE   6  (bases 1 to 2994)
  AUTHORS   Shyjan,A.W., Canfield,V.A. and Levenson,R.
  TITLE     Evolution of the Na,K- and H,K-ATPase beta subunit gene family:
            structure of the murine Na,K-ATPase beta 2 subunit gene
  JOURNAL   Genomics 11 (2), 435-442 (1991)
   PUBMED   1663071
REFERENCE   7  (bases 1 to 2994)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   8  (bases 1 to 2994)
  AUTHORS   Magyar,J.P. and Schachner,M.
  TITLE     Genomic structure of the adhesion molecule on glia (AMOG,
            Na/K-ATPase beta 2 subunit)
  JOURNAL   Nucleic Acids Res 18 (22), 6695-6696 (1990)
   PUBMED   1701244
REFERENCE   9  (bases 1 to 2994)
  AUTHORS   Hsieh,C.L., Cheng-Deutsch,A., Gloor,S., Schachner,M. and Francke,U.
  TITLE     Assignment of Amog (adhesion molecule on glia) gene to mouse
            chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17
  JOURNAL   Somat Cell Mol Genet 16 (4), 401-405 (1990)
   PUBMED   1699290
REFERENCE   10 (bases 1 to 2994)
  AUTHORS   Gloor,S., Antonicek,H., Sweadner,K.J., Pagliusi,S., Frank,R.,
            Moos,M. and Schachner,M.
  TITLE     The adhesion molecule on glia (AMOG) is a homologue of the beta
            subunit of the Na,K-ATPase
  JOURNAL   J Cell Biol 110 (1), 165-174 (1990)
   PUBMED   1688561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141786.1, AK158321.1 and CX204070.1.
            
            On Feb 13, 2018 this sequence version replaced NM_013415.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.233519.1,
                                           SRR1660815.278250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1676              AK141786.1         2-1677
            1677-1677           AK158321.1         1680-1680
            1678-2951           AK141786.1         1679-2952
            2952-2994           CX204070.1         335-377
FEATURES             Location/Qualifiers
     source          1..2994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..2994
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /note="ATPase, Na+/K+ transporting, beta 2 polypeptide"
                     /db_xref="GeneID:11932"
                     /db_xref="MGI:MGI:88109"
     exon            1..700
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..829
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..934
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1140
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1197
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1296
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..2981
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2936..2941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /note="hexamer: AATAAA"
     polyA_site      2981
                     /gene="Atp1b2"
                     /gene_synonym="Amog; Atpb-2"
                     /note="major polyA site"
ORIGIN      
        1 gcactgctga ggagcggagc ctccgattgg ggggccccta tccttgtctt tcccccacaa
       61 ctgcttgtcc ccgccccagc tcccactggc tgggccaact gtggtgtggc tgtcgccgtt
      121 tgtcggagga gccttaatcg gccacctgcc gcgttctaca gcctctttgc atctcggatt
      181 tcggggcggc tccctccccc atctttccct gcttctttgc accccgcttt ttctgcgttt
      241 cgctcgaatt ttggagccgt ctggttttgc accccttttt gttttgcttc taggcggtgt
      301 gtggggtgaa ggtgcctcgg catccctttc cctggttatc tttccctgtt ttgacagccc
      361 ccctttctat cgcagtcggg gggcctagcc tcggtgcacc ttcgccgcac tgccagcaga
      421 ccacagtgcg tggctgtgca ccccggaatt tgcagcagct gtatatctga ctggagtctc
      481 cctgcctcgc tcccgcgcgc atttggtgcg tggagggctt cagcgcgcga cgccccggct
      541 tctccgcagc ccccagcagc gcgccgggac tcgccccgtg cctccaagat ggtcatccag
      601 aaagagaaga agagctgcgg gcaggtggtt gaggagtgga aggagttcgt gtggaacccg
      661 cggacgcacc agttcatggg gcgcaccggg accagctggg ccttcatcct cctcttctac
      721 ctcgtcttct atggtttcct cacggccatg ttcagcctca ccatgtgggt aatgctgcag
      781 accgtctctg accatacccc caagtaccag gatcgactgg ccacaccagg cttgatgatt
      841 cgacccaaga ctgagaacct tgatgtcatt gtcaacatta gtgacactga aagctggggt
      901 cagcatgttc agaagctcaa caagttcttg gaaccttaca acgactccat ccaagcacag
      961 aagaatgatg tctgccgtcc agggcgatat tatgagcaac ctgataatgg ggttctgaac
     1021 tacccaaaac gtgcctgcca gttcaaccgg acccaactgg gcgattgctc tggcattggg
     1081 gaccctaccc actatggtta cagcaccggg cagccctgtg tcttcatcaa aatgaatcgg
     1141 gtcatcaact tctatgcagg ggcaaaccag agcatgaatg tcacttgtgt tggcaagaga
     1201 gatgaagatg ctgagaacct tggccacttt gtcatgttcc ctgctaatgg cagcattgat
     1261 ctgatgtact ttccctacta tggcaaaaag ttccatgtaa actatactca gcctttggtg
     1321 gctgtaaagt tcctgaatgt gacccccaac gtggaggtga atgttgaatg ccgcatcaac
     1381 gctgccaata ttgccacaga cgatgagcgg gacaagttcg ctggccgtgt ggccttcaaa
     1441 ctccggatca acaaaacctg aggctcccca cccccacccg cccacactct cctgtggatg
     1501 cttctggaat gtccttgacc ctgcctgatc cctccctcac ccaccccaaa ggtatttttt
     1561 ataatagagc tatgacttgt ctgagcctca caccctttcc tcaacttctc tacctagcct
     1621 gatgcccaca caatttccaa catcttccaa ccttagctta gccagagaca gagaggagtc
     1681 gggagttttc tagttcggga accggagttg tcactcagcg acagaggact tgcctagcaa
     1741 gcacgagggc ctcagcattg ttggaggttt tctagtttga gtttatgaat gagatgccct
     1801 tacagctcct gtttcagttt ctactcccat ccccttagag gtacaggaaa tggtctcatc
     1861 cacccagcct ctaccccaca gatccctcga acccgtttca gccacttgct tcccaggggt
     1921 gaacactgtc cttcttcctt ttacaaggtt ctagccactt tcctttcatc tcttcacact
     1981 tctgtcacca tagccagtat cttggtggct ttgacttctg gttcctccag cagttctgcc
     2041 ctctcctctc cctgatccct ctccctctga aaagctgcca tttgtagctc agtacaagtt
     2101 ggttctgtgg ccttttccgt ccttcctgat acatcctgct tctcccccaa ctgtgactcc
     2161 aaaggatgac tggaagagaa gtctttaatt cttctagaaa attctctagt aggcttagac
     2221 ttttaacttc ttcctggtcc ctcctgtcat ccaaacggct cctactcagg cgggcttgac
     2281 ctgctctgaa tatccacttt gttttttaac tgatggctcc cttcccccac tggccttccc
     2341 agaatatctt tcaaattctc cttcccaggg agctctgtgg gggaggggcc gctgtcttgg
     2401 ctctatcccc agcagccacc ttggaaacgt cagctggctg gggggactcc ctaagcccag
     2461 atctacccac ccccatcctc tctctggcta ctccttgcaa gttgctaact ggtcactaag
     2521 gtcttccctt tctgcatgcc agcctgaaag cgtcagacac cctcctccag ctcagctctg
     2581 agtttctttg ctccgcctcc ttcaaactct tttgccttta aaaaacaaac aaacaaacaa
     2641 acaaccctat gacatcccta gaatgttgcg aaagagcccc ctgctccaag ttttcgtcca
     2701 tcagagcagc atattcctct agtctctctg cttctcttta atcctttcca atctcctctt
     2761 caccgcagcc cccacgtccc accctcaagt ggctccttcc ctctttcctc ccgctggatc
     2821 tgtgtctctt ccctttgggt atccaggtct tcctgcccct tcatcttccc agtggtctcc
     2881 ttctgcagtt atttaatgcc tgtgtcagat ctactgtaaa aagagggtaa agtacaataa
     2941 actgagagcg attatatata taaatgtata tcatacacag aaaaaaaaaa aaaa
//
