LOCUS       NM_009721               2590 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ATPase, Na+/K+ transporting, beta 1 polypeptide
            (Atp1b1), mRNA.
ACCESSION   NM_009721
VERSION     NM_009721.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2590)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   2  (bases 1 to 2590)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2590)
  AUTHORS   Kryvenko,V., Wessendorf,M., Tello,K., Herold,S., Morty,R.E.,
            Seeger,W. and Vadasz,I.
  TITLE     Hypercapnia Induces Inositol-Requiring Enzyme 1alpha-Driven
            Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase
            beta-Subunit
  JOURNAL   Am J Respir Cell Mol Biol 65 (6), 615-629 (2021)
   PUBMED   34192507
  REMARK    GeneRIF: Hypercapnia Induces Inositol-Requiring Enzyme
            1alpha-Driven Endoplasmic Reticulum-associated Degradation of the
            Na,K-ATPase beta-Subunit.
REFERENCE   4  (bases 1 to 2590)
  AUTHORS   Cao,L., Liu,J., Pu,J., Milne,G., Chen,M., Xu,H., Shipley,A.,
            Forrester,J.V., McCaig,C.D. and Lois,N.
  TITLE     Polarized retinal pigment epithelium generates electrical signals
            that diminish with age and regulate retinal pathology
  JOURNAL   J Cell Mol Med 22 (11), 5552-5564 (2018)
   PUBMED   30160348
  REMARK    GeneRIF: the transepithelial potential difference (TEP) across the
            retinal pigment epithelial (RPE) depends on the expression of
            ATP1B1 and this regulates the secretion of PEDF by RPE cells and so
            may regulate the onset of retinal disease. Increasing the
            expression of PEDF using an applied EF to replenish a disease or
            age-reduced TEP may offer a new way of preventing or reversing
            retinal dysfunction.
REFERENCE   5  (bases 1 to 2590)
  AUTHORS   Ding,B., Walton,J.P., Zhu,X. and Frisina,R.D.
  TITLE     Age-related changes in Na, K-ATPase expression, subunit isoform
            selection and assembly in the stria vascularis lateral wall of
            mouse cochlea
  JOURNAL   Hear Res 367, 59-73 (2018)
   PUBMED   30029086
  REMARK    GeneRIF: Functional selection and assembly of NKA subunit isoforms
            occurs in the cochlear stria vascularis lateral wall, which is
            disrupted and dysregulated with age.
REFERENCE   6  (bases 1 to 2590)
  AUTHORS   Barisoni,L., Trudel,M., Chretien,N., Ward,L., van Adelsberg,J. and
            D'Agati,V.
  TITLE     Analysis of the role of membrane polarity in polycystic kidney
            disease of transgenic SBM mice
  JOURNAL   Am J Pathol 147 (6), 1728-1735 (1995)
   PUBMED   7495297
REFERENCE   7  (bases 1 to 2590)
  AUTHORS   Crump,R.G., Askew,G.R., Wert,S.E., Lingrel,J.B. and Joiner,C.H.
  TITLE     In situ localization of sodium-potassium ATPase mRNA in developing
            mouse lung epithelium
  JOURNAL   Am J Physiol 269 (3 Pt 1), L299-L308 (1995)
   PUBMED   7573462
REFERENCE   8  (bases 1 to 2590)
  AUTHORS   Gloor,S.
  TITLE     Cloning and nucleotide sequence of the mouse Na,K-ATPase
            beta-subunit
  JOURNAL   Nucleic Acids Res 17 (23), 10117 (1989)
   PUBMED   2557580
REFERENCE   9  (bases 1 to 2590)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
REFERENCE   10 (bases 1 to 2590)
  AUTHORS   Kent,R.B., Fallows,D.A., Geissler,E., Glaser,T., Emanuel,J.R.,
            Lalley,P.A., Levenson,R. and Housman,D.E.
  TITLE     Genes encoding alpha and beta subunits of Na,K-ATPase are located
            on three different chromosomes in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 84 (15), 5369-5373 (1987)
   PUBMED   2885848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK010677.1, AK005071.1 and
            AK160405.1.
            
            On Mar 19, 2013 this sequence version replaced NM_009721.5.
            
            Summary: This gene encodes an integral membrane protein that
            comprises a subunit of an ATP-metabolizing enzyme responsible for
            transporting sodium and potassium ions across the plasma membrane.
            This enzyme regulates the electrochemical gradient of these ions in
            cells, and plays a central role in osmoregulation and signal
            transmission in nerves and muscles, among other biological
            processes. The encoded protein is the non-catalytic beta subunit;
            it works together with a catalytic alpha subunit and a gamma
            subunit. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160405.1, AK010677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AK010677.1         2-355
            355-1995            AK005071.1         2-1642
            1996-2590           AK160405.1         1642-2236
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.75 cM"
     gene            1..2590
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /note="ATPase, Na+/K+ transporting, beta 1 polypeptide"
                     /db_xref="GeneID:11931"
                     /db_xref="MGI:MGI:88108"
     exon            1..595
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..1413
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /EC_number="3.6.1.3"
                     /note="sodium/potassium-dependent ATPase subunit beta-1;
                     sodium/potassium ATPase beta subunit"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1"
                     /protein_id="NP_033851.1"
                     /db_xref="CCDS:CCDS35755.1"
                     /db_xref="GeneID:11931"
                     /db_xref="MGI:MGI:88108"
                     /translation="MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYG
                     CLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYV
                     LNIIRFLEKYKDSAQKDDMIFEDCGNVPSEPKERGDINHERGERKVCRFKLDWLGNCS
                     GLNDDSYGYREGKPCIIIKLNRVLGFKPKPPKNESLETYPLMMKYNPNVLPVQCTGKR
                     DEDKDKVGNIEYFGMGGYYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTVDTEIRVE
                     CKAYGENIGYSEKDRFQGRFDVKIEIKS"
     exon            596..724
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..880
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1065
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1149
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..2590
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2560..2565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /note="hexamer: AATAAA"
     polyA_site      2580
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /note="major polyA site"
ORIGIN      
        1 gccaatttct cggctcctgg cctgcgcgcc cgtgtgccga gcccgcgctc cactccgctc
       61 gcccttcccg gtgactttcc ctccttgtcc ctggtccatc tcgccagagg tcacagcaag
      121 cagagtggtg cagctacagc ttgaagcagc agctgcgggg ttcgctgagc cccccggaag
      181 gcgatcggag tgcggggaaa gcccgagagc ggccgcgcgc ccacctctag gtgcggggct
      241 cggagccgcc cagcccgcgc gcgccctcct ccctcgtccc tcctccctcc gcccccgccg
      301 cacctccccc tcctcccgct ctgcctaggc tgctccgcgg cgcgcctcgc actcggagag
      361 ccgcagcggc agcggcgcgt ctcgctttcg gagacagagc cgggccgcgg ggacaccgag
      421 cagccgccgc gaggacgccc agggcgcgcg ccgcactcgc cctccctcgg cctcggccgc
      481 cactgctgag cagacaccat ggcccgcgga aaagccaagg aggaaggcag ctggaagaaa
      541 ttcatctgga actcggagaa gaaggagttt ttgggcagga ccggtggtag ttggtttaag
      601 atccttctgt tctacgtgat attttatggc tgcctggctg gcatcttcat cgggaccatc
      661 caagtaatgc tgctaaccat cagtgaactg aagcccacat accaggaccg agtggccccg
      721 ccaggattga cacagattcc ccagatccag aagactgaga tctccttccg tcctaatgac
      781 cccaagagct acgaggccta cgtgctaaac atcatcaggt tcctggaaaa gtacaaggat
      841 tcagcccaga aggacgacat gattttcgag gactgtggca atgttcccag tgaacccaag
      901 gaacggggcg acatcaatca cgaacgagga gagaggaagg tgtgcaggtt caagcttgac
      961 tggctgggga actgctccgg tctcaatgat gactcttacg gctacagaga ggggaagccc
     1021 tgcatcatta tcaagctcaa ccgagtgttg ggcttcaaac cgaagcctcc caagaatgaa
     1081 tccttggaga cttacccact gatgatgaag tataatccaa atgtcctgcc tgttcagtgc
     1141 actggcaaga gagatgaaga taaggataaa gtcgggaaca tagagtactt tgggatgggc
     1201 ggatactacg gcttccctct gcagtattat ccctactacg gcaaactcct gcagcccaag
     1261 tacctgcagc ccctgctggc cgtgcagttc accaacctca ccgtggacac tgaaatccgc
     1321 gtcgagtgta aggcgtatgg tgagaacatt gggtacagtg agaaagaccg ttttcaggga
     1381 cgctttgatg taaaaattga aattaagagc tgatcacaag cacaaatctt tcccactagc
     1441 catttaataa gttaaaaaaa gatacacaaa cctactagtc ttgaacaaac tgtcatacgt
     1501 atgggaccta cacttaatct ctatgcttta cactagcttc tgcatttaat aggttagaat
     1561 gtaaatttaa agtgtagcaa tagcaacaaa atatttattc tactgtaaat gacaaaagaa
     1621 aaataaaaat tgagccttgg gacgtgccca tttttactgt aaattagatt ccgtaactga
     1681 cttgtagtga gcagtgttct ggcccctaag tattgccgcc ttgtctattt tatttagtgt
     1741 acagtactat aggtgcgcac tctggtcatt tttcaagcca tgttttatca tatctgtttt
     1801 ctactttacg tgagcaaggt ttgctgtcca aggtgtaaat actcaacggg aataaaactg
     1861 gcatggtact ttttcctttc tttcttattt tcttggctct gaaatttcaa aggtaacggc
     1921 ccatcgatga gcatttttaa cacactccat agtctcttcc tgtggtatca ggtctttatt
     1981 attatttttt ttttttcttt atttcctggg gctggggggt gggctgtcat gggggaactg
     2041 ccctttaaat tttaagtgac agtacagaaa aatcaaggtg atgggttgtg ttgtgctccg
     2101 tgctgaatgc tgtctcgcca tctctccccg tgtcctccag tgtgttctgc agctgtgtct
     2161 gagactggga tctgcctgtc actgtggcta gtgatgggct gggtagtttg cttattcgtc
     2221 catttccttt ccttctttcc tttctctgga ggcatcatgc gctggtgctg cgtccttatg
     2281 aatgttttga ccattttcat ggtggaagaa ttttatattt atgcagttgt acaattttat
     2341 ttttttctgc aagaaaaagt gtaatgtatg aaataaaacc aaagtcactt gtttgaaaat
     2401 aaaaatcttt attttgaact ttataaaaag caatgcagta ccccatagac tggtgttaag
     2461 tgttgtctac agtgcaaatc catgttctag catatgtaat aattgccagg agtacagtgc
     2521 tcttgttgat cttgtgtcag tcaggttaac acaacggaca ataaaagaat gaacacattc
     2581 ctcacgtgtg
//
