LOCUS       NP_033851                304 aa            linear   ROD 06-JUN-2024
DEFINITION  sodium/potassium-transporting ATPase subunit beta-1 [Mus musculus].
ACCESSION   NP_033851
VERSION     NP_033851.1
DBSOURCE    REFSEQ: accession NM_009721.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 304)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   2  (residues 1 to 304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 304)
  AUTHORS   Kryvenko,V., Wessendorf,M., Tello,K., Herold,S., Morty,R.E.,
            Seeger,W. and Vadasz,I.
  TITLE     Hypercapnia Induces Inositol-Requiring Enzyme 1alpha-Driven
            Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase
            beta-Subunit
  JOURNAL   Am J Respir Cell Mol Biol 65 (6), 615-629 (2021)
   PUBMED   34192507
  REMARK    GeneRIF: Hypercapnia Induces Inositol-Requiring Enzyme
            1alpha-Driven Endoplasmic Reticulum-associated Degradation of the
            Na,K-ATPase beta-Subunit.
REFERENCE   4  (residues 1 to 304)
  AUTHORS   Cao,L., Liu,J., Pu,J., Milne,G., Chen,M., Xu,H., Shipley,A.,
            Forrester,J.V., McCaig,C.D. and Lois,N.
  TITLE     Polarized retinal pigment epithelium generates electrical signals
            that diminish with age and regulate retinal pathology
  JOURNAL   J Cell Mol Med 22 (11), 5552-5564 (2018)
   PUBMED   30160348
  REMARK    GeneRIF: the transepithelial potential difference (TEP) across the
            retinal pigment epithelial (RPE) depends on the expression of
            ATP1B1 and this regulates the secretion of PEDF by RPE cells and so
            may regulate the onset of retinal disease. Increasing the
            expression of PEDF using an applied EF to replenish a disease or
            age-reduced TEP may offer a new way of preventing or reversing
            retinal dysfunction.
REFERENCE   5  (residues 1 to 304)
  AUTHORS   Ding,B., Walton,J.P., Zhu,X. and Frisina,R.D.
  TITLE     Age-related changes in Na, K-ATPase expression, subunit isoform
            selection and assembly in the stria vascularis lateral wall of
            mouse cochlea
  JOURNAL   Hear Res 367, 59-73 (2018)
   PUBMED   30029086
  REMARK    GeneRIF: Functional selection and assembly of NKA subunit isoforms
            occurs in the cochlear stria vascularis lateral wall, which is
            disrupted and dysregulated with age.
REFERENCE   6  (residues 1 to 304)
  AUTHORS   Barisoni,L., Trudel,M., Chretien,N., Ward,L., van Adelsberg,J. and
            D'Agati,V.
  TITLE     Analysis of the role of membrane polarity in polycystic kidney
            disease of transgenic SBM mice
  JOURNAL   Am J Pathol 147 (6), 1728-1735 (1995)
   PUBMED   7495297
REFERENCE   7  (residues 1 to 304)
  AUTHORS   Crump,R.G., Askew,G.R., Wert,S.E., Lingrel,J.B. and Joiner,C.H.
  TITLE     In situ localization of sodium-potassium ATPase mRNA in developing
            mouse lung epithelium
  JOURNAL   Am J Physiol 269 (3 Pt 1), L299-L308 (1995)
   PUBMED   7573462
REFERENCE   8  (residues 1 to 304)
  AUTHORS   Gloor,S.
  TITLE     Cloning and nucleotide sequence of the mouse Na,K-ATPase
            beta-subunit
  JOURNAL   Nucleic Acids Res 17 (23), 10117 (1989)
   PUBMED   2557580
REFERENCE   9  (residues 1 to 304)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
REFERENCE   10 (residues 1 to 304)
  AUTHORS   Kent,R.B., Fallows,D.A., Geissler,E., Glaser,T., Emanuel,J.R.,
            Lalley,P.A., Levenson,R. and Housman,D.E.
  TITLE     Genes encoding alpha and beta subunits of Na,K-ATPase are located
            on three different chromosomes in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 84 (15), 5369-5373 (1987)
   PUBMED   2885848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK010677.1, AK005071.1 and
            AK160405.1.
            
            Summary: This gene encodes an integral membrane protein that
            comprises a subunit of an ATP-metabolizing enzyme responsible for
            transporting sodium and potassium ions across the plasma membrane.
            This enzyme regulates the electrochemical gradient of these ions in
            cells, and plays a central role in osmoregulation and signal
            transmission in nerves and muscles, among other biological
            processes. The encoded protein is the non-catalytic beta subunit;
            it works together with a catalytic alpha subunit and a gamma
            subunit. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160405.1, AK010677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.75 cM"
     Protein         1..304
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1"
                     /EC_number="3.6.1.3"
                     /note="sodium/potassium-dependent ATPase subunit beta-1;
                     sodium/potassium ATPase beta subunit"
                     /calculated_mol_wt=35064
     Region          1..304
                     /region_name="Na_K_ATPase_bet"
                     /note="Sodium Potassium ATPase beta subunit; TIGR01107"
                     /db_xref="CDD:273446"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P07340; propagated from
                     UniProtKB/Swiss-Prot (P14094.1)"
     Site            35..62
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14094.1)"
     Site            101
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:18034455; propagated from
                     UniProtKB/Swiss-Prot (P14094.1)"
     Site            158
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P14094.1)"
     Region          191..304
                     /region_name="immunoglobulin-like. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P14094.1)"
     Site            193
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P14094.1)"
     Site            266
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P14094.1)"
     CDS             1..304
                     /gene="Atp1b1"
                     /gene_synonym="Atp4b; Atpb; Atpb-1; NKbeta1"
                     /coded_by="NM_009721.6:499..1413"
                     /db_xref="CCDS:CCDS35755.1"
                     /db_xref="GeneID:11931"
                     /db_xref="MGI:MGI:88108"
ORIGIN      
        1 margkakeeg swkkfiwnse kkeflgrtgg swfkillfyv ifygclagif igtiqvmllt
       61 iselkptyqd rvappgltqi pqiqkteisf rpndpksyea yvlniirfle kykdsaqkdd
      121 mifedcgnvp sepkergdin hergerkvcr fkldwlgncs glnddsygyr egkpciiikl
      181 nrvlgfkpkp pknesletyp lmmkynpnvl pvqctgkrde dkdkvgniey fgmggyygfp
      241 lqyypyygkl lqpkylqpll avqftnltvd teirveckay genigysekd rfqgrfdvki
      301 eiks
//
