LOCUS       NM_013734               3485 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase, Na+/K+ transporting, alpha 4 polypeptide
            (Atp1a4), mRNA.
ACCESSION   NM_013734
VERSION     NM_013734.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3485)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3485)
  AUTHORS   Numata,S., McDermott,J.P., Sanchez,G., Mitra,A. and Blanco,G.
  TITLE     The sodium-glucose cotransporter isoform 1 (SGLT-1) is important
            for sperm energetics, motility, and fertilitydagger
  JOURNAL   Biol Reprod 106 (6), 1206-1217 (2022)
   PUBMED   35420639
REFERENCE   3  (bases 1 to 3485)
  AUTHORS   Numata,S., McDermott,J.P. and Blanco,G.
  TITLE     Genetic Ablation of Na,K-ATPase alpha4 Results in Sperm Energetic
            Defects
  JOURNAL   Front Cell Dev Biol 10, 911056 (2022)
   PUBMED   35693932
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3485)
  AUTHORS   McDermott,J.P., Numata,S. and Blanco,G.
  TITLE     Na,K-ATPase Atp1a4 isoform is important for maintaining sperm
            flagellar shape
  JOURNAL   J Assist Reprod Genet 38 (6), 1493-1505 (2021)
   PUBMED   33977467
  REMARK    GeneRIF: Na,K-ATPase Atp1a4 isoform is important for maintaining
            sperm flagellar shape.
REFERENCE   5  (bases 1 to 3485)
  AUTHORS   Takagishi,M., Sawada,M., Ohata,S., Asai,N., Enomoto,A.,
            Takahashi,K., Weng,L., Ushida,K., Ara,H., Matsui,S., Kaibuchi,K.,
            Sawamoto,K. and Takahashi,M.
  TITLE     Daple Coordinates Planar Polarized Microtubule Dynamics in
            Ependymal Cells and Contributes to Hydrocephalus
  JOURNAL   Cell Rep 20 (4), 960-972 (2017)
   PUBMED   28746879
REFERENCE   6  (bases 1 to 3485)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   7  (bases 1 to 3485)
  AUTHORS   Underhill,D.A., Vogan,K.J., Kibar,Z., Morrison,J., Rommens,J. and
            Gros,P.
  TITLE     Transcription mapping and expression analysis of candidate genes in
            the vicinity of the mouse Loop-tail mutation
  JOURNAL   Mamm Genome 11 (8), 633-638 (2000)
   PUBMED   10920231
REFERENCE   8  (bases 1 to 3485)
  AUTHORS   MacPhee,D.J., Jones,D.H., Barr,K.J., Betts,D.H., Watson,A.J. and
            Kidder,G.M.
  TITLE     Differential involvement of Na(+),K(+)-ATPase isozymes in
            preimplantation development of the mouse
  JOURNAL   Dev Biol 222 (2), 486-498 (2000)
   PUBMED   10837135
REFERENCE   9  (bases 1 to 3485)
  AUTHORS   Underhill,D.A., Canfield,V.A., Dahl,J.P., Gros,P. and Levenson,R.
  TITLE     The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant
            alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on
            mouse chromosome 1
  JOURNAL   Biochemistry 38 (45), 14746-14751 (1999)
   PUBMED   10555956
REFERENCE   10 (bases 1 to 3485)
  AUTHORS   Smit,J.W., Huisman,M.T., van Tellingen,O., Wiltshire,H.R. and
            Schinkel,A.H.
  TITLE     Absence or pharmacological blocking of placental P-glycoprotein
            profoundly increases fetal drug exposure
  JOURNAL   J Clin Invest 104 (10), 1441-1447 (1999)
   PUBMED   10562306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074311.28, AC087061.22 and AC074310.29.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC074311.28        21752-21821         c
            71-246              AC074311.28        21282-21457         c
            247-306             AC074311.28        21040-21099         c
            307-513             AC074311.28        18254-18460         c
            514-627             AC074311.28        17450-17563         c
            628-762             AC074311.28        14681-14815         c
            763-880             AC074311.28        14283-14400         c
            881-1149            AC074311.28        10029-10297         c
            1150-1351           AC074311.28        8228-8429           c
            1352-1461           AC074311.28        7735-7844           c
            1462-1596           AC074311.28        7424-7558           c
            1597-1786           AC074311.28        3402-3591           c
            1787-1959           AC074311.28        3098-3270           c
            1960-2096           AC087061.22        95736-95872
            2097-2247           AC087061.22        96255-96405
            2248-2416           AC087061.22        96690-96858
            2417-2571           AC087061.22        98471-98625
            2572-2695           AC087061.22        98763-98886
            2696-2841           AC087061.22        99534-99679
            2842-2871           AC087061.22        103381-103410
            2872-2972           AC074310.29        1-101
            2973-3074           AC074310.29        217-318
            3075-3166           AC074310.29        3213-3304
            3167-3485           AC074310.29        3575-3893
FEATURES             Location/Qualifiers
     source          1..3485
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..3485
                     /gene="Atp1a4"
                     /note="ATPase, Na+/K+ transporting, alpha 4 polypeptide"
                     /db_xref="GeneID:27222"
                     /db_xref="MGI:MGI:1351335"
     exon            1..70
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            71..246
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3195
                     /gene="Atp1a4"
                     /EC_number="7.2.2.13"
                     /note="sodium/potassium-transporting ATPase alpha-4 chain;
                     Na+/K+ ATPase alpha 4 subunit; sodium pump subunit
                     alpha-4; Na(+)/K(+) ATPase alpha-4 subunit"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-4"
                     /protein_id="NP_038762.1"
                     /db_xref="CCDS:CCDS48446.1"
                     /db_xref="GeneID:27222"
                     /db_xref="MGI:MGI:1351335"
                     /translation="MEPGKEKEVEAPGELNQKPRPSTRSSTTNRQPKMKRRKKDLEEL
                     KKEVVMDDHKLTLDELSAKYSVDLTKGLSILEAQDILFQNGPNVLTPPPTTPEWVKFC
                     RQLFGGFSLLLWTGACLCFLAYGIHVNYYKENANKDNLYLGIVLSAVVIITGCFSYYQ
                     EAKSSKIMESFKNMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQIPADIRVISA
                     QGCKVDNSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGIVIATGDYTV
                     MGRIASLTSGLQMGKTPIATEIEHFIHLITAVAVFLGVSFFWLSIILGYTWLDAVIFL
                     IGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLT
                     QNRMTVAHLWFDKTVYEADTSEEQTTGKTFPKSSDTWFYLARIAGLCNRADFKPHQES
                     VPIAKRATTGDASESALLKFIEQSYNPVSEMRQKNPKVAEIPFNSTNKYQMSIHLLED
                     NSEAHVLLMKGAPERIFDFCSSFLLNGQEYPMDEEMKMDFQNAYIELGGLGERVLGFC
                     FLNLPSNFSKGFQFNTDELNFPMENLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIM
                     VTGDHPITAKAIAKSVGIISEGNDTAEDIAARLNIPISQVNNKSVKAIVVHGSELKDM
                     ESQQLDDILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIG
                     IAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITP
                     FLLFIILSIPLPLGTITILCIDLGTDMVPAISLAYESPESDIMKRLPRNPKTDNLVNN
                     RLIGMAYGQIGMIQALAGFFTYFVILAENGFKPLDLLGIRLYWDDTQLNDLEDSYGQQ
                     WTYEQRKVVEFTCQTAFFISIVIVQWADLIICKTRRNSLFKQGMKNKILIFGLLEETV
                     LAAFLSYVPGMDVSLRMYPLKINWWFCALPYSVLIFVYDEIRKLIIRRRPGGWLEKET
                     YY"
     exon            247..306
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            307..513
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..627
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            628..762
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            763..880
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1149
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1351
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1461
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1596
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1786
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1959
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2096
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2247
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2416
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2571
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2695
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2841
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2972
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3074
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3166
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3485
                     /gene="Atp1a4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3457..3462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1a4"
                     /note="hexamer: GATAAA"
     polyA_site      3480
                     /gene="Atp1a4"
                     /note="major polyA site"
ORIGIN      
        1 agaagctcac tctgacctcg gctcccactg cacttcccac ctgctgaacc cctgcatctt
       61 catcatttag agccagctat acctagagat catattatgg agcctggaaa agaaaaggag
      121 gtagaggccc ctggtgagct gaatcagaaa ccaagaccca gcaccaggtc ctcaactaca
      181 aatagacagc cgaaaatgaa aagaaggaag aaagatttag aagagctgaa gaaggaagtg
      241 gttatggatg atcacaagct aacgttggat gagctgagtg ccaagtactc tgtggacttg
      301 accaagggtc ttagcatcct agaagcccag gatattctgt ttcaaaatgg accgaatgta
      361 ctaactcctc ctccaaccac tccagagtgg gtcaaattct gtagacaact gtttggtggc
      421 ttctccctcc tactgtggac tggtgcctgt ctctgcttcc tggcctatgg catacatgta
      481 aattattaca aagaaaacgc caacaaagat aatctgtacc tggggattgt actatctgcc
      541 gtggtcatca ttaccggctg cttctcatat taccaggagg ccaagagctc caagatcatg
      601 gagtctttta agaacatggt gcctcagcaa gctctggtga ttcgagatgg agagaaaatg
      661 caaatcaatg taagagatgt ggttttggga gacctagtag aggtgaaggg aggagaccaa
      721 atccctgctg atatcagggt tatctcggcg caaggatgca aggtagacaa ttcctccttg
      781 actggggagt cagaacccca gtctcgctgc cctgattgca ctcatgagaa ccctctggag
      841 acacggaata tcatcttctt ctccactaac tgtgtagaag gaacagctcg gggtattgtg
      901 attgctacag gagactacac agtaatgggc cggattgctt ccctgacatc aggcttgcaa
      961 atgggcaaga ccccgattgc caccgaaatc gaacacttca tccatttgat cacagctgtc
     1021 gcggtcttcc tcggtgtttc atttttttgg ctctcgatta tcttgggtta cacctggctg
     1081 gatgctgtca ttttccttat tggtatcatt gtggccaatg tgccggaagg gctgctggcc
     1141 actgtcactg tgtgcctgac gctgaccgcc aagcgcatgg ctcgcaagaa ctgcctggtg
     1201 aagaacctgg aggccgtgga gacgctgggc tccacgtcca ccatctgctc agacaagacg
     1261 ggcaccctca cccagaaccg catgacagtg gcgcatttgt ggtttgataa gactgtgtat
     1321 gaggccgaca ccagtgagga gcaaaccacg gggaaaacgt ttcccaagtc ctcagacacc
     1381 tggttttacc tggctcgaat cgctggcctc tgtaaccggg ccgactttaa accccatcag
     1441 gagtctgttc ccatagctaa gcgggcaaca acaggggatg cttccgagtc agctctcctc
     1501 aaattcattg agcagtctta caaccccgtg agcgaaatga ggcagaaaaa ccccaaggtg
     1561 gcggagattc cctttaactc caccaacaag tatcagatgt ccatccacct tctggaagat
     1621 aattccgaag cccacgtgct gctaatgaaa ggtgccccag agaggatctt tgatttttgc
     1681 tccagtttcc tgctgaatgg gcaggagtac cctatggatg aggaaatgaa gatggacttc
     1741 cagaatgcct acatagaact gggaggtctg ggcgaacgtg tgctggggtt ctgcttcttg
     1801 aacttgccta gcaatttctc taaggggttc cagtttaata ccgatgagtt aaattttccc
     1861 atggaaaatc tgtgtttcgc gggcctcatc tccatgattg atcctcctcg gacggccgtg
     1921 cctgacgctg tgagcaaatg tcgaagcgcg gggatcaagg tgatcatggt aacgggggat
     1981 catcccatca cagccaaagc tattgccaaa agtgtgggta tcatttcaga aggtaacgac
     2041 acggcggagg acattgccgc tcggctgaat atccctatca gtcaagtcaa taacaagtct
     2101 gttaaagcca ttgtagtgca cggctcagaa ctgaaagaca tggaatccca acagctggac
     2161 gacatcctca agtcctataa ggagattgtc tttgcccgga cctctcctca gcagaaactc
     2221 atcattgtgg aggggtgtca gcgactggga gccattgtgg cagtgactgg tgacggggtg
     2281 aacgactccc ccgcactgaa gaaggctgac atcggcattg ccatgggcat cacaggctct
     2341 gatgtctcta aacaggcggc tgacatgatc cttcttgacg acaattttgc ctccattgtg
     2401 acaggcgtgg aggagggccg cctcatcttt gacaacctga agaagtccat cgcatacacc
     2461 ctgaccagca acatccctga gatcaccccc ttcctgctgt tcatcatctt aagcataccc
     2521 ttgcctctgg gcaccataac cattctctgc atcgacctgg gcactgacat ggtccctgct
     2581 atctccctgg cttatgaatc acctgaaagt gacatcatga aaaggcttcc acggaacccc
     2641 aaaacggaca atcttgtgaa caaccgtctt attggcatgg cctatgggca gattgggatg
     2701 atacaggctc tggctggatt tttcacctat tttgtgatcc tggcggagaa tggttttaag
     2761 cctcttgatc ttctgggtat ccgtctatac tgggatgata cacaattaaa tgacctagag
     2821 gacagctatg ggcagcagtg gacctatgag cagcggaagg tggtggaatt cacatgccaa
     2881 acggccttct tcatcagtat cgtgattgtg cagtgggctg acctcatcat ctgcaagaca
     2941 cgcagaaatt cactcttcaa gcagggcatg aaaaacaaaa tcctaatatt tggactcctt
     3001 gaggagacag tcctggcagc tttcctgtcc tacgttccag gcatggatgt gtccctgcgg
     3061 atgtacccac tcaagataaa ctggtggttc tgcgcacttc cctacagtgt tctcatcttc
     3121 gtctatgatg aaatcagaaa acttatcatc cggagacggc ctggtggatg gctggagaag
     3181 gagacgtact actaactgcc tcagagaaag atcttcacac gacattggtc tcacgagagc
     3241 caggactgag tataacaatg acacctgaga tagagctgag caggggcccc tgttgtatgg
     3301 gttgaattga ctctggatga gagagacaca ttcctggggc tggaggaaga gtctctggta
     3361 ggagatggaa taggttggga gaaagaaagc ccagcctgtt ctgcctaggg tccagcgagt
     3421 atgtgcagtc ttgttacatc cagcagcctg tctagagata aatgcttgga acaaccctca
     3481 ggtta
//
