LOCUS       NP_038762               1032 aa            linear   ROD 30-APR-2024
DEFINITION  sodium/potassium-transporting ATPase subunit alpha-4 [Mus
            musculus].
ACCESSION   NP_038762
VERSION     NP_038762.1
DBSOURCE    REFSEQ: accession NM_013734.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1032)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1032)
  AUTHORS   Numata,S., McDermott,J.P., Sanchez,G., Mitra,A. and Blanco,G.
  TITLE     The sodium-glucose cotransporter isoform 1 (SGLT-1) is important
            for sperm energetics, motility, and fertilitydagger
  JOURNAL   Biol Reprod 106 (6), 1206-1217 (2022)
   PUBMED   35420639
REFERENCE   3  (residues 1 to 1032)
  AUTHORS   Numata,S., McDermott,J.P. and Blanco,G.
  TITLE     Genetic Ablation of Na,K-ATPase alpha4 Results in Sperm Energetic
            Defects
  JOURNAL   Front Cell Dev Biol 10, 911056 (2022)
   PUBMED   35693932
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1032)
  AUTHORS   McDermott,J.P., Numata,S. and Blanco,G.
  TITLE     Na,K-ATPase Atp1a4 isoform is important for maintaining sperm
            flagellar shape
  JOURNAL   J Assist Reprod Genet 38 (6), 1493-1505 (2021)
   PUBMED   33977467
  REMARK    GeneRIF: Na,K-ATPase Atp1a4 isoform is important for maintaining
            sperm flagellar shape.
REFERENCE   5  (residues 1 to 1032)
  AUTHORS   Takagishi,M., Sawada,M., Ohata,S., Asai,N., Enomoto,A.,
            Takahashi,K., Weng,L., Ushida,K., Ara,H., Matsui,S., Kaibuchi,K.,
            Sawamoto,K. and Takahashi,M.
  TITLE     Daple Coordinates Planar Polarized Microtubule Dynamics in
            Ependymal Cells and Contributes to Hydrocephalus
  JOURNAL   Cell Rep 20 (4), 960-972 (2017)
   PUBMED   28746879
REFERENCE   6  (residues 1 to 1032)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   7  (residues 1 to 1032)
  AUTHORS   Underhill,D.A., Vogan,K.J., Kibar,Z., Morrison,J., Rommens,J. and
            Gros,P.
  TITLE     Transcription mapping and expression analysis of candidate genes in
            the vicinity of the mouse Loop-tail mutation
  JOURNAL   Mamm Genome 11 (8), 633-638 (2000)
   PUBMED   10920231
REFERENCE   8  (residues 1 to 1032)
  AUTHORS   MacPhee,D.J., Jones,D.H., Barr,K.J., Betts,D.H., Watson,A.J. and
            Kidder,G.M.
  TITLE     Differential involvement of Na(+),K(+)-ATPase isozymes in
            preimplantation development of the mouse
  JOURNAL   Dev Biol 222 (2), 486-498 (2000)
   PUBMED   10837135
REFERENCE   9  (residues 1 to 1032)
  AUTHORS   Underhill,D.A., Canfield,V.A., Dahl,J.P., Gros,P. and Levenson,R.
  TITLE     The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant
            alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on
            mouse chromosome 1
  JOURNAL   Biochemistry 38 (45), 14746-14751 (1999)
   PUBMED   10555956
REFERENCE   10 (residues 1 to 1032)
  AUTHORS   Smit,J.W., Huisman,M.T., van Tellingen,O., Wiltshire,H.R. and
            Schinkel,A.H.
  TITLE     Absence or pharmacological blocking of placental P-glycoprotein
            profoundly increases fetal drug exposure
  JOURNAL   J Clin Invest 104 (10), 1441-1447 (1999)
   PUBMED   10562306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074311.28, AC087061.22 and AC074310.29.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     Protein         1..1032
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-4"
                     /EC_number="7.2.2.13"
                     /note="sodium/potassium-transporting ATPase alpha-4 chain;
                     Na+/K+ ATPase alpha 4 subunit; sodium pump subunit
                     alpha-4; Na(+)/K(+) ATPase alpha-4 subunit"
                     /calculated_mol_wt=114756
     Region          1..42
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Region          36..1032
                     /region_name="ATPase-IIC_X-K"
                     /note="sodium or proton efflux -- potassium uptake
                     antiporter, P-type ATPase, alpha subunit; TIGR01106"
                     /db_xref="CDD:273445"
     Region          91..93
                     /region_name="Interaction with phosphoinositide-3 kinase.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            97..117
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            142..162
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            299..318
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            331..348
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            782..801
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            812..832
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            853..875
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            928..947
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            952
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            961..979
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     Site            995..1015
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV27.3)"
     CDS             1..1032
                     /gene="Atp1a4"
                     /coded_by="NM_013734.1:97..3195"
                     /db_xref="CCDS:CCDS48446.1"
                     /db_xref="GeneID:27222"
                     /db_xref="MGI:MGI:1351335"
ORIGIN      
        1 mepgkekeve apgelnqkpr pstrssttnr qpkmkrrkkd leelkkevvm ddhkltldel
       61 sakysvdltk glsileaqdi lfqngpnvlt pppttpewvk fcrqlfggfs lllwtgaclc
      121 flaygihvny ykenankdnl ylgivlsavv iitgcfsyyq eaksskimes fknmvpqqal
      181 virdgekmqi nvrdvvlgdl vevkggdqip adirvisaqg ckvdnssltg esepqsrcpd
      241 cthenpletr niiffstncv egtargivia tgdytvmgri asltsglqmg ktpiateieh
      301 fihlitavav flgvsffwls iilgytwlda vifligiiva nvpegllatv tvcltltakr
      361 marknclvkn leavetlgst sticsdktgt ltqnrmtvah lwfdktvyea dtseeqttgk
      421 tfpkssdtwf ylariaglcn radfkphqes vpiakrattg dasesallkf ieqsynpvse
      481 mrqknpkvae ipfnstnkyq msihlledns eahvllmkga perifdfcss fllngqeypm
      541 deemkmdfqn ayielgglge rvlgfcflnl psnfskgfqf ntdelnfpme nlcfaglism
      601 idpprtavpd avskcrsagi kvimvtgdhp itakaiaksv giisegndta ediaarlnip
      661 isqvnnksvk aivvhgselk dmesqqlddi lksykeivfa rtspqqklii vegcqrlgai
      721 vavtgdgvnd spalkkadig iamgitgsdv skqaadmill ddnfasivtg veegrlifdn
      781 lkksiaytlt snipeitpfl lfiilsiplp lgtitilcid lgtdmvpais layespesdi
      841 mkrlprnpkt dnlvnnrlig maygqigmiq alagfftyfv ilaengfkpl dllgirlywd
      901 dtqlndleds ygqqwtyeqr kvveftcqta ffisivivqw adliicktrr nslfkqgmkn
      961 kilifgllee tvlaaflsyv pgmdvslrmy plkinwwfca lpysvlifvy deirkliirr
     1021 rpggwleket yy
//
