LOCUS       NM_001374627            3615 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ATPase, Na+/K+ transporting, alpha 3 polypeptide
            (Atp1a3), transcript variant 1, mRNA.
ACCESSION   NM_001374627 XM_011250520
VERSION     NM_001374627.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3615)
  AUTHORS   Liu,Y.B., Arystarkhova,E., Sacino,A.N., Szabari,M.V., Lutz,C.M.,
            Terrey,M., Morsci,N.S., Jakobs,T.C., Lykke-Hartmann,K.,
            Brashear,A., Napoli,E. and Sweadner,K.J.
  TITLE     Phenotype Distinctions in Mice Deficient in the Neuron-Specific
            alpha3 Subunit of Na,K-ATPase: Atp1a3tm1Ling/+ and Atp1a3+/D801Y
  JOURNAL   eNeuro 11 (8) (2024)
   PUBMED   39111836
  REMARK    GeneRIF: Phenotype Distinctions in Mice Deficient in the
            Neuron-Specific alpha3 Subunit of Na,K-ATPase: Atp1a3[tm1Ling/+]
            and Atp1a3 [+/D801Y].
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3615)
  AUTHORS   Fujii,F., Kanemasa,H., Okuzono,S., Setoyama,D., Taira,R.,
            Yonemoto,K., Motomura,Y., Kato,H., Masuda,K., Kato,T.A., Ohga,S.
            and Sakai,Y.
  TITLE     ATP1A3 regulates protein synthesis for mitochondrial stability
            under heat stress
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38804677
  REMARK    GeneRIF: ATP1A3 regulates protein synthesis for mitochondrial
            stability under heat stress.
REFERENCE   3  (bases 1 to 3615)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3615)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   5  (bases 1 to 3615)
  AUTHORS   Bornstein,B., Heinemann-Yerushalmi,L., Krief,S., Adler,R.,
            Dassa,B., Leshkowitz,D., Kim,M., Bewick,G., Banks,R.W. and
            Zelzer,E.
  TITLE     Molecular characterization of the intact mouse muscle spindle using
            a multi-omics approach
  JOURNAL   Elife 12, e81843 (2023)
   PUBMED   36744866
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3615)
  AUTHORS   Yasue,M., Serikawa,T., Kuramoto,T., Mori,M., Higashiguchi,T.,
            Ishizaki,K. and Yamada,J.
  TITLE     Chromosomal assignments of 17 structural genes and 11 related DNA
            fragments in rats (Rattus norvegicus) by Southern blot analysis of
            rat x mouse somatic cell hybrid clones
  JOURNAL   Genomics 12 (4), 659-664 (1992)
   PUBMED   1572638
REFERENCE   7  (bases 1 to 3615)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   8  (bases 1 to 3615)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 3615)
  AUTHORS   Cavanna,J.S., Greenfield,A.J., Johnson,K.J., Marks,A.R.,
            Nadal-Ginard,B. and Brown,S.D.
  TITLE     Establishment of the mouse chromosome 7 region with homology to the
            myotonic dystrophy region of human chromosome 19q
  JOURNAL   Genomics 7 (1), 12-18 (1990)
   PUBMED   1970795
REFERENCE   10 (bases 1 to 3615)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125468.5.
            
            On Oct 7, 2019 this sequence version replaced XM_011250520.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.78235.1,
                                           ERR3363658.2722111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC125468.5         113996-114154       c
            160-285             AC125468.5         109313-109438       c
            286-345             AC125468.5         109161-109220       c
            346-549             AC125468.5         108818-109021       c
            550-663             AC125468.5         107141-107254       c
            664-798             AC125468.5         106915-107049       c
            799-916             AC125468.5         105754-105871       c
            917-1185            AC125468.5         105373-105641       c
            1186-1384           AC125468.5         102777-102975       c
            1385-1494           AC125468.5         102591-102700       c
            1495-1629           AC125468.5         102373-102507       c
            1630-1822           AC125468.5         98604-98796         c
            1823-1998           AC125468.5         98030-98205         c
            1999-2135           AC125468.5         97809-97945         c
            2136-2286           AC125468.5         96219-96369         c
            2287-2455           AC125468.5         95676-95844         c
            2456-2610           AC125468.5         89983-90137         c
            2611-2734           AC125468.5         89760-89883         c
            2735-2880           AC125468.5         88792-88937         c
            2881-3011           AC125468.5         88251-88381         c
            3012-3113           AC125468.5         87536-87637         c
            3114-3205           AC125468.5         87155-87246         c
            3206-3615           AC125468.5         86408-86817         c
FEATURES             Location/Qualifiers
     source          1..3615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..3615
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /note="ATPase, Na+/K+ transporting, alpha 3 polypeptide"
                     /db_xref="GeneID:232975"
                     /db_xref="MGI:MGI:88107"
     exon            1..159
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3234
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /EC_number="7.2.2.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium/potassium-transporting ATPase subunit alpha-3;
                     sodium pump subunit alpha-3; Na(+)/K(+) ATPase alpha-3
                     subunit; Na(+)/K(+) ATPase alpha(III) subunit"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-3 isoform 1"
                     /protein_id="NP_001361556.1"
                     /db_xref="CCDS:CCDS90184.1"
                     /db_xref="GeneID:232975"
                     /db_xref="MGI:MGI:88107"
                     /translation="MGSGGSDSYRVATSQDKKDDKSSPKKSKAKERRDLDDLKKEVAM
                     TEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGG
                     FSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKI
                     MESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDN
                     SSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATL
                     ASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVAN
                     VPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVA
                     HMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDV
                     AGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLL
                     VMKGAPERILDRCATILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEE
                     QFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP
                     ITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQID
                     EILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA
                     GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM
                     ANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMA
                     YGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQR
                     KVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLS
                     YCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY"
     exon            160..285
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..345
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            346..549
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..663
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..798
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..916
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1185
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1384
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1494
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1629
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1822
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1998
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2135
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2286
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2455
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2610
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2734
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2880
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3011
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3113
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3205
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3615
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3593..3598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /note="hexamer: AATATA"
     polyA_site      3615
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /note="major polyA site"
ORIGIN      
        1 agcctctgtg cggtgggacc cacggaccga cagacgcacg ctcccaccgc ggcgcgggcg
       61 ctgcagaggc ccccagcccg agcccgcgcc tgagcccatc ctgcggccac cgctcatcag
      121 tctgaacgcc gctcttcccg cggagccgcc aagatggggt ctggtggttc tgacagctac
      181 cgtgtcgcca cctcgcagga caaaaaagat gacaagagct cgcccaagaa gagcaaggcc
      241 aaagagcgcc gggacctgga tgacctcaag aaggaagtgg ctatgacaga gcacaagatg
      301 tcagtagaag aggtctgccg gaaatacaat actgactgcg tgcagggtct gacacacagt
      361 aaagcccagg agatcctagc ccgggatggg cctaacgccc tcacaccacc gcccaccacc
      421 ccagaatggg tcaagttctg ccggcagctg tttggtggct tctctatcct gctgtggatc
      481 ggggcaatcc tttgcttcct ggcctatggc atccaggcag ggacggagga tgacccttcc
      541 ggtgacaatc tgtacctggg catagtgctg gccgcagtcg tgatcatcac cggctgcttc
      601 tcctactacc aagaagccaa gagttctaag atcatggagt ccttcaagaa catggtcccc
      661 cagcaagccc ttgtgatccg ggaaggtgaa aagatgcagg tgaatgcgga ggaggtggtg
      721 gtcggggacc tggtggagat caagggtggt gaccgggtgc cagctgacct gcgcatcatc
      781 tcggcccatg gctgcaaggt ggacaactcc tccctgactg gcgaatctga gcctcagacc
      841 cgctccccgg actgcacaca cgacaacccc ctggagactc ggaacatcac cttcttttcc
      901 accaactgcg tggaaggcac cgctcggggt gtggtggtag ccacaggtga ccgcaccgtc
      961 atgggccgca ttgccaccct ggcctcgggc ttggaggtgg gcaagacgcc catcgccatt
     1021 gagattgagc atttcatcca gctcattacg ggcgtggccg tgttcctggg cgtgtccttc
     1081 ttcatcctct ctctcattct gggttacacc tggctcgagg cagtcatctt cctcatcggc
     1141 atcattgtgg ccaatgtccc agaggggctg ctggctactg tcacggtgtg tctgacgctg
     1201 accgccaagc gcatggctcg caagaactgc ctggtgaaga acctggaggc ggtggagacg
     1261 ctgggctcca cgtccaccat ctgctcggac aagaccggca ctctcaccca gaaccgcatg
     1321 accgtcgccc acatgtggtt tgacaaccag atccacgagg cagacaccac agaggatcag
     1381 tcagggacct ctttcgacaa gagctcacac acctgggtgg ccctgtccca catcgccggg
     1441 ctctgcaacc gggccgtctt caagggcggg caggacaaca tcccagtact caagagggac
     1501 gtggccggtg atgcctccga gtctgccctg cttaagtgca ttgagctgtc ctcgggttcc
     1561 gtaaagctga tgcgagaacg gaacaagaaa gtggctgaga ttccgttcaa ctcgaccaac
     1621 aaataccagc tatccatcca tgagactgag gatcccaatg acaaccggta cctgctagtg
     1681 atgaagggcg cccccgaacg cattctggac cgctgtgcca ccatcctcct gcagggcaag
     1741 gagcagcctc tggatgagga gatgaaggag gccttccaga atgcctacct ggagcttggt
     1801 ggcctgggcg agcgtgtgct gggtttctgc cattactacc tgcctgagga acagttcccc
     1861 aagggctttg cctttgactg tgatgacgtg aacttcacca cagacaacct ttgctttgtg
     1921 ggtctcatgt ccatgattga ccctccccgg gcagccgtcc ctgacgctgt gggcaaatgc
     1981 cgaagcgcag gcatcaaggt catcatggtc accggcgatc accccatcac tgccaaggcc
     2041 attgccaagg gtgtgggtat catctctgag ggtaacgaga ctgtcgaaga catcgctgcc
     2101 cggctcaaca tccctgtcag ccaggtgaac cccagggatg ccaaagcctg tgtgattcac
     2161 ggcaccgacc tcaaggactt cacctcggag cagattgacg agattctgca gaaccacacc
     2221 gagatcgtct ttgcccgaac ctcccctcag cagaagctca tcatcgtgga gggctgtcag
     2281 agacagggag caattgtggc tgtgactggc gatggtgtga atgactcccc tgctctgaag
     2341 aaggctgaca tcggggtggc catgggcatt gctggctctg atgtctctaa gcaggctgcc
     2401 gacatgattc tgctggatga caactttgct tccattgtca ctggtgtgga ggaaggccgc
     2461 ctgatctttg acaacctgaa gaaatccatc gcctacactc tgactagcaa catccctgag
     2521 atcacaccct tcctgctctt catcatggct aacatcccac tgcctcttgg caccatcacc
     2581 atcctctgca ttgacctggg taccgacatg gtccctgcaa tctccctggc ctacgaggct
     2641 gccgagagcg acatcatgaa gaggcagccc aggaacccac gcacagacaa actggtcaac
     2701 gaaaggctca tcagcatggc ctacgggcag attgggatga tccaggccct cggtggtttc
     2761 ttctcctact ttgtcatcct ggcagaaaat ggcttcttgc ccggaaacct ggtgggcatc
     2821 cggctcaact gggatgatcg cactgtcaat gacctagaag acagttatgg gcagcagtgg
     2881 acttatgagc agaggaaggt ggtagagttc acatgccaca cagccttctt tgtgagtatc
     2941 gtggtggtcc agtgggctga cctgatcatc tgcaagacca ggaggaactc cgtcttccag
     3001 cagggcatga agaataagat cttgatcttc ggcttgtttg aggagacggc cctcgctgcc
     3061 ttcctgtcct actgcccagg catggatgtg gcccttcgca tgtaccctct caagcccagc
     3121 tggtggttct gtgccttccc ctacagtttc ctcatcttcg tctatgatga gattcgcaaa
     3181 ctcatcctgc gcaggaaccc cgggggttgg gtggagaaag agacctacta ttgacctcag
     3241 ccaccaccac gtcgcccgtg tcttccctac cccaagccca ggacagccct ctccggtccc
     3301 cccattttgt actctggggg gaggggcctt ctctccccat ggcccccctc tctccttgtg
     3361 gcccagcctc ctctcccaca cctcgattac ctcccacgtt ccctcacttc ttcctctggc
     3421 tggcttctct ccccccacag cccctgcctc tcttctccct ctctcttctg tgtctctccc
     3481 cctctctccc ttgcaactct gcctctcatt tcctccctgg gctctttttt actcccctgg
     3541 gccccgtctc ctggcgtatg ccatctccgg ttctaattct gaacaattat caaatatatc
     3601 agtggggaga gaaaa
//
