LOCUS       NP_001361556            1026 aa            linear   ROD 19-NOV-2024
DEFINITION  sodium/potassium-transporting ATPase subunit alpha-3 isoform 1 [Mus
            musculus].
ACCESSION   NP_001361556 XP_011248822
VERSION     NP_001361556.1
DBSOURCE    REFSEQ: accession NM_001374627.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1026)
  AUTHORS   Liu,Y.B., Arystarkhova,E., Sacino,A.N., Szabari,M.V., Lutz,C.M.,
            Terrey,M., Morsci,N.S., Jakobs,T.C., Lykke-Hartmann,K.,
            Brashear,A., Napoli,E. and Sweadner,K.J.
  TITLE     Phenotype Distinctions in Mice Deficient in the Neuron-Specific
            alpha3 Subunit of Na,K-ATPase: Atp1a3tm1Ling/+ and Atp1a3+/D801Y
  JOURNAL   eNeuro 11 (8) (2024)
   PUBMED   39111836
  REMARK    GeneRIF: Phenotype Distinctions in Mice Deficient in the
            Neuron-Specific alpha3 Subunit of Na,K-ATPase: Atp1a3[tm1Ling/+]
            and Atp1a3 [+/D801Y].
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1026)
  AUTHORS   Fujii,F., Kanemasa,H., Okuzono,S., Setoyama,D., Taira,R.,
            Yonemoto,K., Motomura,Y., Kato,H., Masuda,K., Kato,T.A., Ohga,S.
            and Sakai,Y.
  TITLE     ATP1A3 regulates protein synthesis for mitochondrial stability
            under heat stress
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38804677
  REMARK    GeneRIF: ATP1A3 regulates protein synthesis for mitochondrial
            stability under heat stress.
REFERENCE   3  (residues 1 to 1026)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1026)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   5  (residues 1 to 1026)
  AUTHORS   Bornstein,B., Heinemann-Yerushalmi,L., Krief,S., Adler,R.,
            Dassa,B., Leshkowitz,D., Kim,M., Bewick,G., Banks,R.W. and
            Zelzer,E.
  TITLE     Molecular characterization of the intact mouse muscle spindle using
            a multi-omics approach
  JOURNAL   Elife 12, e81843 (2023)
   PUBMED   36744866
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1026)
  AUTHORS   Yasue,M., Serikawa,T., Kuramoto,T., Mori,M., Higashiguchi,T.,
            Ishizaki,K. and Yamada,J.
  TITLE     Chromosomal assignments of 17 structural genes and 11 related DNA
            fragments in rats (Rattus norvegicus) by Southern blot analysis of
            rat x mouse somatic cell hybrid clones
  JOURNAL   Genomics 12 (4), 659-664 (1992)
   PUBMED   1572638
REFERENCE   7  (residues 1 to 1026)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   8  (residues 1 to 1026)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (residues 1 to 1026)
  AUTHORS   Cavanna,J.S., Greenfield,A.J., Johnson,K.J., Marks,A.R.,
            Nadal-Ginard,B. and Brown,S.D.
  TITLE     Establishment of the mouse chromosome 7 region with homology to the
            myotonic dystrophy region of human chromosome 19q
  JOURNAL   Genomics 7 (1), 12-18 (1990)
   PUBMED   1970795
REFERENCE   10 (residues 1 to 1026)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125468.5.
            
            On Oct 7, 2019 this sequence version replaced XP_011248822.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.78235.1,
                                           ERR3363658.2722111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     Protein         1..1026
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-3 isoform 1"
                     /EC_number="7.2.2.13"
                     /note="sodium/potassium-transporting ATPase subunit
                     alpha-3; sodium pump subunit alpha-3; Na(+)/K(+) ATPase
                     alpha-3 subunit; Na(+)/K(+) ATPase alpha(III) subunit"
                     /calculated_mol_wt=112857
     Region          31..1026
                     /region_name="ATPase-IIC_X-K"
                     /note="sodium or proton efflux -- potassium uptake
                     antiporter, P-type ATPase, alpha subunit; TIGR01106"
                     /db_xref="CDD:273445"
     CDS             1..1026
                     /gene="Atp1a3"
                     /gene_synonym="Atpa-2"
                     /coded_by="NM_001374627.1:154..3234"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS90184.1"
                     /db_xref="GeneID:232975"
                     /db_xref="MGI:MGI:88107"
ORIGIN      
        1 mgsggsdsyr vatsqdkkdd ksspkkskak errdlddlkk evamtehkms veevcrkynt
       61 dcvqglthsk aqeilardgp naltpppttp ewvkfcrqlf ggfsillwig ailcflaygi
      121 qagteddpsg dnlylgivla avviitgcfs yyqeaksski mesfknmvpq qalviregek
      181 mqvnaeevvv gdlveikggd rvpadlriis ahgckvdnss ltgesepqtr spdcthdnpl
      241 etrnitffst ncvegtargv vvatgdrtvm griatlasgl evgktpiaie iehfiqlitg
      301 vavflgvsff ilslilgytw leavifligi ivanvpegll atvtvcltlt akrmarkncl
      361 vknleavetl gststicsdk tgtltqnrmt vahmwfdnqi headttedqs gtsfdkssht
      421 wvalshiagl cnravfkggq dnipvlkrdv agdasesall kcielssgsv klmrernkkv
      481 aeipfnstnk yqlsiheted pndnryllvm kgaperildr catillqgke qpldeemkea
      541 fqnaylelgg lgervlgfch yylpeeqfpk gfafdcddvn fttdnlcfvg lmsmidppra
      601 avpdavgkcr sagikvimvt gdhpitakai akgvgiiseg netvediaar lnipvsqvnp
      661 rdakacvihg tdlkdftseq ideilqnhte ivfartspqq kliivegcqr qgaivavtgd
      721 gvndspalkk adigvamgia gsdvskqaad millddnfas ivtgveegrl ifdnlkksia
      781 ytltsnipei tpfllfiman iplplgtiti lcidlgtdmv paislayeaa esdimkrqpr
      841 nprtdklvne rlismaygqi gmiqalggff syfvilaeng flpgnlvgir lnwddrtvnd
      901 ledsygqqwt yeqrkvveft chtaffvsiv vvqwadliic ktrrnsvfqq gmknkilifg
      961 lfeetalaaf lsycpgmdva lrmyplkpsw wfcafpysfl ifvydeirkl ilrrnpggwv
     1021 eketyy
//
