LOCUS       NM_144900               3720 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus ATPase, Na+/K+ transporting, alpha 1 polypeptide
            (Atp1a1), mRNA.
ACCESSION   NM_144900
VERSION     NM_144900.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3720)
  AUTHORS   Huang,M., Wang,X., Chen,Y., Pessoa,M.T., Terrell,K.C., Zhang,J.,
            Tian,J., Xie,Z., Pierre,S.V. and Cai,L.
  TITLE     Role of Na/K-ATPase alpha1 caveolin-binding motif in adipogenesis
  JOURNAL   Am J Physiol Cell Physiol 327 (1), C48-C64 (2024)
   PUBMED   38708522
  REMARK    GeneRIF: Role of Na/K-ATPase alpha1 caveolin-binding motif in
            adipogenesis.
REFERENCE   3  (bases 1 to 3720)
  AUTHORS   Lu,D., Zhi,Y., Su,H., Lin,X., Lin,J., Shi,Y., Yi,W., Hong,C.,
            Zhang,T., Fu,Z., Chen,L.Y., Zhao,Z., Li,R., Xu,Z., Chen,W., Wang,N.
            and Xu,D.
  TITLE     ESCRT-I protein UBAP1 controls ventricular expansion and cortical
            neurogenesis via modulating adherens junctions of radial glial
            cells
  JOURNAL   Cell Rep 43 (3), 113818 (2024)
   PUBMED   38402586
REFERENCE   4  (bases 1 to 3720)
  AUTHORS   Huang,S., Dong,W., Lin,X., Xu,K., Li,K., Xiong,S., Wang,Z., Nie,X.
            and Bian,J.S.
  TITLE     Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in
            microglia promotes stress-induced anxiety
  JOURNAL   Immunity 57 (3), 495-512 (2024)
   PUBMED   38395698
REFERENCE   5  (bases 1 to 3720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3720)
  AUTHORS   Yasue,M., Serikawa,T., Kuramoto,T., Mori,M., Higashiguchi,T.,
            Ishizaki,K. and Yamada,J.
  TITLE     Chromosomal assignments of 17 structural genes and 11 related DNA
            fragments in rats (Rattus norvegicus) by Southern blot analysis of
            rat x mouse somatic cell hybrid clones
  JOURNAL   Genomics 12 (4), 659-664 (1992)
   PUBMED   1572638
REFERENCE   7  (bases 1 to 3720)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   8  (bases 1 to 3720)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   9  (bases 1 to 3720)
  AUTHORS   Boyle,A.L., Ballard,S.G. and Ward,D.C.
  TITLE     Differential distribution of long and short interspersed element
            sequences in the mouse genome: chromosome karyotyping by
            fluorescence in situ hybridization
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7757-7761 (1990)
   PUBMED   2170987
REFERENCE   10 (bases 1 to 3720)
  AUTHORS   Kingsmore,S.F., Moseley,W.S., Watson,M.L., Sabina,R.L., Holmes,E.W.
            and Seldin,M.F.
  TITLE     Long-range restriction site mapping of a syntenic segment conserved
            between human chromosome 1 and mouse chromosome 3
  JOURNAL   Genomics 7 (1), 75-83 (1990)
   PUBMED   1970802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131658.3, BB863666.1, AK159306.1, AC127357.5 and BE994800.1.
            
            On Jul 15, 2011 this sequence version replaced NM_144900.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032187.2, AK159279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC131658.3         107774-107778       c
            6-44                BB863666.1         8-46
            45-687              AK159306.1         2-644
            688-689             AC127357.5         212431-212432       c
            690-3695            AK159306.1         645-3650
            3696-3720           BE994800.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 44.3 cM"
     gene            1..3720
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /note="ATPase, Na+/K+ transporting, alpha 1 polypeptide"
                     /db_xref="GeneID:11928"
                     /db_xref="MGI:MGI:88105"
     exon            1..305
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..3365
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /EC_number="7.2.2.13"
                     /note="sodium pump subunit alpha-1; Na(+)/K(+) ATPase
                     alpha-1 subunit"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-1"
                     /protein_id="NP_659149.1"
                     /db_xref="CCDS:CCDS17683.1"
                     /db_xref="GeneID:11928"
                     /db_xref="MGI:MGI:88105"
                     /translation="MGKGVGRDKYEPAAVSEHGDKKGKKAKKERDMDELKKEVSMDDH
                     KLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSM
                     LLWIGAILCFLAYGIRSATEEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMES
                     FKNMVPQQALVIRNGEKMSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSL
                     TGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASG
                     LEGGQTPIAEEIEHFIHLITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPE
                     GLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW
                     FDNQIHEADTTENQSGVSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGD
                     ASESALLKCIEVCCGSVMEMREKYSKIVEIPFNSTNKYQLSIHKNPNASEPKHLLVMK
                     GAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFP
                     EGFQFDTDDVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITA
                     KAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEELDDIL
                     RYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSD
                     VSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANI
                     PLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQ
                     IGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWVNDVEDSYGQQWTYEQRKIV
                     EFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCP
                     GMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY"
     exon            306..416
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..476
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..680
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..794
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..929
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1047
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1316
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1515
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1625
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1760
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1953
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2129
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2266
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2417
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2586
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2741
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2865
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3011
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3142
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3244
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3336
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3702
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /note="hexamer: AATAAA"
     polyA_site      3698
                     /gene="Atp1a1"
                     /gene_synonym="Atpa-1"
                     /note="major polyA site"
ORIGIN      
        1 acgcaggttg catattttag gaagtgagga ggaggcacgg gctcgagctg cggctgggtc
       61 tggggcgcgg agcctcggcg ggaggaggcg gacacgtggc agcggcggca gcagcggcgg
      121 cagcagcggc ggcctcggtc cggggcgccg gccgtcctcc ctctttcctc ccgcggcagc
      181 cctagttccc gcctctcggc tcccccggct ccgctctccc ggccgggagc tgctctcttc
      241 tctttctagt ctccagcaac aggacccggc gcggggcccg cagcgccgcc accatgggga
      301 agggggttgg acgagacaag tatgagcctg ccgctgtatc ggagcatggt gacaaaaagg
      361 gcaaaaaggc caagaaggaa agggatatgg atgagctcaa gaaggaagtg tctatggacg
      421 accataaact cagcctggat gaactccatc gtaaatacgg aacagatttg agccgaggat
      481 taacacctgc aagggccgct gagatcctgg cccgggatgg ccccaacgcc ctcacacccc
      541 ctcccactac tcccgaatgg gtgaaattct gccggcagct ctttggaggc ttttccatgt
      601 tactgtggat cggggccatt ctttgtttcc tggcttatgg catccgaagt gctacagaag
      661 aggaaccgcc aaacgatgat ctgtacctcg gggtggtgct ctctgctgta gtcatcataa
      721 ctggctgttt ctcctattat caagaagcaa aaagctccaa gatcatggaa tccttcaaga
      781 acatggtccc tcagcaagcc cttgtgattc gaaatggaga gaaaatgagc atcaatgcgg
      841 aggatgtcgt cgtcggggat ctggtggagg tgaaaggggg agaccggatc cctgctgatc
      901 ttagaatcat atctgcaaac ggctgcaagg tggataactc ctcactcact ggtgaatcag
      961 aaccccagac tcggtccccg gatttcacaa acgagaaccc cttggagaca aggaacattg
     1021 ccttcttctc aaccaactgt gtggaaggaa ccgcacgtgg catcgtcgtg tacactgggg
     1081 accgcaccgt gatgggcagg attgccacgc ttgcctctgg gctagaaggt ggccagaccc
     1141 ccattgctga agagattgag catttcatcc acctcatcac cggggtggcc gtgttcctgg
     1201 gggtgtcttt cttcatcctt tctctgatcc ttgagtacac ctggctcgag gctgtcatct
     1261 tcctcattgg tatcatcgta gccaacgtgc cagaaggtct gctggccact gtcacggtct
     1321 gtctgacact cactgccaag cgcatggcga ggaagaactg cctggtgaag aacttggaag
     1381 ctgtggagac cttggggtcc acatctacca tctgctcaga caagacggga actctgactc
     1441 agaaccggat gacagtggcc cacatgtggt ttgacaatca gatccatgaa gctgacacca
     1501 cggagaatca gagtggtgtc tcctttgaca agacgtcagc cacctggttc gctctgtcca
     1561 gaattgctgg tctctgtaac agggcagtgt ttcaggctaa ccaagaaaac ctgcctattc
     1621 ttaagcgggc agtagcggga gatgcctctg agtcggcgct cttaaagtgc attgaagtct
     1681 gctgcggctc cgtgatggag atgagggaga aatacagcaa gatagtggag attcccttca
     1741 actccaccaa caagtaccag ttgtccattc acaagaaccc aaatgcatct gagcccaaac
     1801 acctgctagt gatgaagggc gccccagaaa ggatcctgga ccgctgcagc tccatccttc
     1861 tccacggcaa ggagcagcca ctggatgaag agctgaagga cgcttttcag aacgcctacc
     1921 tagagctggg gggccttgga gaacgtgtgc taggtttctg ccacctcctc ctgcctgacg
     1981 aacagtttcc cgaaggcttc cagtttgaca ctgacgatgt caatttcccc gtggataacc
     2041 tctgcttcgt gggtcttatc tccatgattg accctccccg agctgctgtc cccgatgctg
     2101 tgggcaaatg ccgcagcgct gggattaagg tcatcatggt tacaggagac catccaatca
     2161 cagcgaaagc cattgccaag ggggtaggca ttatctcaga aggcaatgag actgtggaag
     2221 acattgctgc ccgcctcaac attccagtga accaggtgaa ccccagagat gccaaggcct
     2281 gtgtggtcca cggcagtgac ctgaaggaca tgacctccga ggagctggat gacatcttgc
     2341 ggtaccacac agagatcgtc tttgccagga cctctcctca gcagaagctc atcattgtgg
     2401 agggctgcca gcggcagggc gccatcgtgg ccgtcacagg ggatggtgtc aatgactctc
     2461 cagctttgaa aaaggcagat attggggttg ccatggggat tgttggctct gatgtgtcca
     2521 agcaagctgc tgacatgatc cttctggatg acaactttgc ctccattgtg actggagtag
     2581 aggaaggtcg tctgattttt gataacttga agaaatccat cgcttacacc ctaaccagta
     2641 acattccgga aatcaccccc ttcttgatat ttattattgc aaacattcca ctgcccctgg
     2701 ggactgtgac catcctctgc attgacttgg gcactgacat ggttcctgcc atctccctgg
     2761 cctacgagca agctgagagc gacatcatga agaggcagcc cagaaacccc aaaacggaca
     2821 aacttgtgaa cgagcgtctg atcagcatgg cctatggaca gatcggtatg atccaggccc
     2881 tgggaggctt cttcacttac tttgtgattc tggctgagaa cggtttcctg ccctttcacc
     2941 tgttgggcat ccgagagacc tgggatgacc gctgggtcaa cgatgtggag gacagctacg
     3001 ggcagcagtg gacctacgag cagaggaaga tcgtggagtt cacctgccat acagcgttct
     3061 ttgtcagtat tgtggtagtg cagtgggccg acttggtcat ctgcaagacc agaaggaatt
     3121 ctgtcttcca gcagggaatg aagaacaaga tcttgatatt tggcctcttt gaagagacag
     3181 cccttgctgc tttcttatcc tactgccccg ggatgggggc agcccttagg atgtatcccc
     3241 tcaaacctac atggtggttc tgtgccttcc cctactccct tctcatcttt gtgtatgacg
     3301 aggtgcggaa gctcattatc aggcggcgcc ctggcggctg ggtggagaag gaaacctact
     3361 actagcccac tgccctgcac gccgtggaac attgtgccac acactgcacc cacccctacc
     3421 ccctctttgt gtacttcaag tcttggagct cggaactcta ccctggtagg aaagcaccaa
     3481 agcatgtggg gatgcagacg tcctggaatg aagcatgtag ctgtaacggg gggcggggcg
     3541 ggggggaggg ctgcctgaga aacaccgtgt acggggacga cagcgggcaa ggtttatacg
     3601 tgcctttttg tttttgtaaa aaaggaaaac ctggaaagac tgaaagatta cgttttatat
     3661 ctggattttt acaaataaag atggctatta taacggaatt tgaaaaaaaa aaaaaaaaaa
//
