LOCUS       NM_001164612            4114 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase type 13A4 (Atp13a4), transcript variant 1,
            mRNA.
ACCESSION   NM_001164612
VERSION     NM_001164612.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Sorensen,D.M., Holemans,T., van Veen,S., Martin,S., Arslan,T.,
            Haagendahl,I.W., Holen,H.W., Hamouda,N.N., Eggermont,J.,
            Palmgren,M. and Vangheluwe,P.
  TITLE     Parkinson disease related ATP13A2 evolved early in animal evolution
  JOURNAL   PLoS One 13 (3), e0193228 (2018)
   PUBMED   29505581
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   Vallipuram,J., Grenville,J. and Crawford,D.A.
  TITLE     The E646D-ATP13A4 mutation associated with autism reveals a defect
            in calcium regulation
  JOURNAL   Cell Mol Neurobiol 30 (2), 233-246 (2010)
   PUBMED   19731010
  REMARK    GeneRIF: Data suggest that ATP13A4 may play a vital role in the
            developing nervous system and its impairment can contribute to the
            symptoms seen in autism spectrum disorder.
REFERENCE   5  (bases 1 to 4114)
  AUTHORS   Schultheis,P.J., Hagen,T.T., O'Toole,K.K., Tachibana,A.,
            Burke,C.R., McGill,D.L., Okunade,G.W. and Shull,G.E.
  TITLE     Characterization of the P5 subfamily of P-type transport ATPases in
            mice
  JOURNAL   Biochem Biophys Res Commun 323 (3), 731-738 (2004)
   PUBMED   15381061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC175464.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005557.1, SRR1660817.174057.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC175464.1         29609-29848
            241-414             AC175464.1         80909-81082
            415-561             AC175464.1         91190-91336
            562-632             AC175464.1         95464-95534
            633-713             AC175464.1         95624-95704
            714-783             AC175464.1         97589-97658
            784-918             AC175464.1         99069-99203
            919-988             AC175464.1         101782-101851
            989-1123            AC175464.1         111525-111659
            1124-1294           AC175464.1         114374-114544
            1295-1452           AC175464.1         115568-115725
            1453-1641           AC175464.1         116212-116400
            1642-1703           AC175464.1         118460-118521
            1704-1854           AC175464.1         121027-121177
            1855-1941           AC175464.1         129454-129540
            1942-2095           AC175464.1         129784-129937
            2096-2207           AC175464.1         130961-131072
            2208-2332           AC175464.1         136996-137120
            2333-2496           AC175464.1         148342-148505
            2497-2619           AC175464.1         149310-149432
            2620-2699           AC175464.1         150633-150712
            2700-2742           AC175464.1         152508-152550
            2743-2852           AC175464.1         153218-153327
            2853-2949           AC175464.1         155213-155309
            2950-3022           AC175464.1         157291-157363
            3023-3194           AC175464.1         161220-161391
            3195-3388           AC175464.1         162015-162208
            3389-3477           AC175464.1         163463-163551
            3478-3558           AC175464.1         167231-167311
            3559-4114           AC175464.1         174499-175054
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 20.24 cM"
     gene            1..4114
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /note="ATPase type 13A4"
                     /db_xref="GeneID:224079"
                     /db_xref="MGI:MGI:1924456"
     exon            1..240
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..3759
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /EC_number="3.6.3.-"
                     /note="isoform 1 is encoded by transcript variant 1; type
                     V P-type ATPase; probable cation-transporting ATPase 13A4;
                     P5-ATPase"
                     /codon_start=1
                     /product="probable cation-transporting ATPase 13A4 isoform
                     1"
                     /protein_id="NP_001158084.1"
                     /db_xref="CCDS:CCDS49816.1"
                     /db_xref="GeneID:224079"
                     /db_xref="MGI:MGI:1924456"
                     /translation="MGDHLEKSQHALLNEGDENEMEIFGYRTQGCRKALCLIGSIFSL
                     GMLPLVFYWRPAWRVWANCVPCSLQEADVVLLKTTDEFKIYSWKKVIWISLSALSSTS
                     GLTPDHPLITDEGYIINRAIRKPDLKVRYIKVQKIRYVWNNLEGQFQKIGSLEDWLSS
                     AKIHQKFGLGLTSEEQEIRRLICGPNAIDVEITPIWKLLIKEVLNPFYIFQLFSVCLW
                     FSEDYKEYALAIILMSVISIALTVYDLRQQSVKLHHLVESHNSITVSVYERKAGAQDL
                     ESRLLVPGDLLILTGSRVQMPCDAILIDGSCVVDEGMLTGESIPVTKTPLSQTASSVP
                     WKMQSEADPRRHVLFCGTEVIQAKAAGSGAVRAVVLQTGFNTAKGDLVRSILYPKPMN
                     FKLYRDAIRFLLCLVGTATIGMVYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAA
                     LTTGIIYAQRRLKKKGIFCISPQRINVCGQLNLVCFDKTGTLTRGGLDPWGVVPCDQN
                     GFQAVHSFASGKALPQGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATKWEMTASGD
                     DFHIKEMLAHTIVVKPTDMVAQVPAEGLAIVHQFPFSSALQRMTVIVQEMGGGRLAFM
                     KGAPERVASFCQPDTVPTSFISELQIYTTQGFRVIALAYKKLEMDCPTTALMREKVES
                     DLVFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVARKSGMVSEGQK
                     VILVEANEATGSSSASISWKLVEEKKPGPFGSQDTYINIREEVPENGRDGSYHFALSG
                     KSFHVISQYFSSLLPKILINGTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGA
                     LKMAHVGISLSEQEASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMI
                     QYVGVLLLYWKTNSLSNYQFLFQDLAITTLIGVTMNLNGANPKLVPFRPAGRLISPPL
                     LLSVVLNILLSLAMHIVGFILVQKQPWYIMDYHSVCPVRNESASALAASPSVPEKTRS
                     NSTFASFENTTIWFLGTINCIFVALVFSKGKPFRQPTYTNYIFVLVLILQMGVCLFIL
                     FADIPEMHRRLDLLCTPVLWRVYILIMISSNFVVSLAVEKAIIENRALWIAVKRCFGY
                     QSKSQYRIWQRNLANDSSWPPLNQTSYSDMQGVSYSNPVFESNEEQL"
     exon            241..414
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            415..561
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            562..632
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..713
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            714..783
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..918
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            919..988
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1123
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1294
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1452
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1641
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1703
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1854
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1941
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2095
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2207
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2332
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2496
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2619
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2699
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2742
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2852
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2949
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3022
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3194
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3388
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3477
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3558
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..4114
                     /gene="Atp13a4"
                     /gene_synonym="4631413J11Rik; 4832416L12; 9330174J19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggaggag tccacttcgc taaatattgt catttgctga aagaaggtgt gtgctcaagg
       61 agtttttaac ctggaagatc attaactctt tcatccagcg gtccggaggc gtctctggag
      121 tgggtcctga aagcggctgc acacaagggt cagggagcag gagtggagcg tgtttccatg
      181 ggtgaccacc ttgagaagag ccagcatgct ttactcaatg aaggggacga gaatgagatg
      241 gaaatatttg gctatcggac tcaaggctgt cggaaggctc tttgtctcat tggatccatc
      301 ttctctcttg gaatgctccc attggtattt tattggagac cagcttggcg tgtatgggca
      361 aactgtgtcc catgttccct gcaagaagca gatgttgtgt tgctgaagac aacagatgaa
      421 ttcaaaattt attcttggaa aaaagtaata tggatctccc tgtcagcact gagcagcaca
      481 tctggtctca cgcctgacca ccctctcatt acagacgagg gatacatcat aaacagagcc
      541 atccgaaagc cagatctaaa ggtgagatac ataaaagtgc agaaaatacg atatgtttgg
      601 aataatttgg aaggacagtt tcagaaaatt ggctccctgg aagactggct cagttctgca
      661 aagatacatc agaaatttgg attaggtctg acttcagagg aacaagagat caggaggtta
      721 atatgtgggc ctaatgctat tgatgttgaa atcacaccta tttggaaact gctcatcaag
      781 gaggttctga atccatttta catctttcaa ctcttcagcg tctgtttgtg gttcagtgaa
      841 gattacaagg aatatgctct tgccatcatc ctcatgtctg tcatttccat agctttgacc
      901 gtgtatgacc tcagacagca atctgtaaaa ctgcaccatc ttgttgaatc ccataatagc
      961 attacagtct ctgtgtatga gcgaaaagct ggagcccaag acctggaatc ccgcctcctg
     1021 gtgcctggag atttattaat tctgacaggg agcagagtgc aaatgccgtg tgacgccatt
     1081 ctgattgacg gcagctgtgt ggtagatgaa ggcatgctga caggagaaag cattcctgtc
     1141 actaaaactc cactatccca gacagctagt tctgtgccct ggaagatgca gtctgaagca
     1201 gatcccaggc ggcatgttct cttctgtggt acggaggtga tccaggccaa ggcagctggc
     1261 tctggggctg taagagccgt ggtcctgcag acaggattca acactgcaaa gggggacctc
     1321 gtgagatcca tcctgtaccc gaagcccatg aacttcaagc tctacaggga tgccatcagg
     1381 tttctccttt gccttgtagg gacagccacc attggcatgg tctatactct gtgtgtctat
     1441 gtgctcagtg gggaacctcc ggaggaggtg gtaaggaaag ccctggatgt tattaccatt
     1501 gcagtgcctc ccgctctccc tgctgccctg accacaggca tcatctatgc ccagaggagg
     1561 ctgaaaaaga agggcatatt ctgcattagc ccccagagga tcaatgtttg tggacagtta
     1621 aaccttgtct gcttcgacaa gacaggcacc ttaacgaggg gaggcttgga tccttgggga
     1681 gttgtaccct gtgaccagaa tggatttcag gcagtccaca gttttgcctc aggcaaagct
     1741 ttgcctcagg gtccactgtg tgcagccatg gccagctgcc actctctgat tctccttgat
     1801 ggcactattc agggagaccc tctggacctg aagatgtttg aagccaccaa atgggaaatg
     1861 actgcttctg gggatgactt ccatatcaag gaaatgctgg cacacaccat agtagtgaag
     1921 cctacagaca tggtggccca ggtcccagcg gaaggactcg caatcgtcca tcagttccca
     1981 ttctcatcag cactacagag gatgacggtc atcgtccagg agatgggagg tggccgactg
     2041 gcgttcatga aaggtgcacc ggagagagtg gccagctttt gccaacctga cacagtacca
     2101 actagtttta ttagtgaact tcagatttac acaacacagg gtttccgagt catagctctg
     2161 gcctacaaga agctggaaat ggactgcccc acaactgcct tgatgaggga gaaggtggaa
     2221 tcagacctgg tatttctggg attgctgatc ctggagaatc gattgaagga agagaccaag
     2281 cctgtgttag aagagctcat ctctgcccgg atacggactg tcatgatcac aggtgacaat
     2341 cttcagactg caataacagt ggctaggaag tctgggatgg tttccgaagg ccagaaagtc
     2401 attcttgttg aggcaaatga agccactggc tcttcatcgg catctatctc ttggaaatta
     2461 gtggaagaga agaaacctgg tccatttggg agtcaggaca cctatatcaa cattagagag
     2521 gaagtcccag aaaatggcag agacggaagc taccattttg ccctgagtgg aaaatccttt
     2581 catgttataa gccaatattt cagcagctta ttgccaaaga tactgatcaa tgggaccatc
     2641 tttgcaagaa tgtctcctgg gcaaaagtca agcctggtgg aagaattcca gaaactggac
     2701 tactttgtag gtatgtgtgg agatggtgcc aatgactgtg gggccctgaa gatggctcat
     2761 gtcggtatct ctttatcaga gcaggaggca tcggtggcct ctcctttcac ttccaagact
     2821 ccaaacatcg aatgcgtgcc acatctcatc aaggaaggcc gcgctgctct cgttacatcc
     2881 ttttgcatgt ttaagtacat ggccctctac agcatgattc agtatgttgg tgttctgctg
     2941 ctctactgga agacaaacag cctttcaaat taccagtttc tattccagga tctggccatc
     3001 acgactctta ttggtgtaac aatgaatctg aatggtgcca accccaagct cgtgcctttc
     3061 agacccgcag ggcggctgat ctcaccacct cttctgctct cggttgtcct caacatcctg
     3121 ctcagtttgg ccatgcacat cgtgggcttc atcctggtgc agaagcagcc ttggtatatc
     3181 atggactatc acagtgtctg ccctgtgagg aatgagagcg cctcagcctt agctgcatct
     3241 cccagcgttc ctgagaaaac cagaagtaac agcacctttg cgagttttga gaatacgaca
     3301 atatggtttt tgggaacaat caactgtatc tttgtggctc ttgtattctc taaaggaaag
     3361 ccatttaggc agcccaccta tacaaactat atatttgtcc ttgtgctgat cttacagatg
     3421 ggcgtatgtc ttttcattct atttgcggat atcccagaga tgcataggcg tttggacctg
     3481 ctctgcactc ctgtcctgtg gagagtctac attctcatca tgatcagctc caactttgtt
     3541 gtgtcccttg ctgtggagaa ggccattatt gaaaaccgag ctctgtggat agcagtcaaa
     3601 agatgttttg gttatcaatc aaaaagtcag tatcggatat ggcagaggaa cttggcaaat
     3661 gattcaagct ggcccccact gaaccaaacc tcctactctg acatgcaggg ggtgtcctac
     3721 agcaacccgg tgtttgagag caatgaggag caactttgaa ggaaagcgat acctaaacag
     3781 ttatcaaaat gaagctaaaa agaacccatt tcagagatgt taaagcaatt tgactcaaca
     3841 ctatcagttg gagttgggga ctatactccc aactcccagg acaagttaaa tttgctcagg
     3901 tggagtctat ggagaacaat gtccccagaa gatggcattc ctcctagctt ctggtgcatt
     3961 ggtgacacct attgaaccaa gaatggagca agtgttgcaa tgggccaaag ggttggcaga
     4021 tatcagaagg aaaacatatc ttcttagaat aagtctttct caaaaataaa ataaaataaa
     4081 ataaaataaa ataaaataaa ataaaataaa atga
//
