LOCUS       NP_001121568            1249 aa            linear   ROD 27-APR-2025
DEFINITION  polyamine-transporting ATPase 13A3 isoform 1 [Mus musculus].
ACCESSION   NP_001121568
VERSION     NP_001121568.1
DBSOURCE    REFSEQ: accession NM_001128096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1249)
  AUTHORS   Liu,B., Azfar,M., Legchenko,E., West,J.A., Martin,S., Van den
            Haute,C., Baekelandt,V., Wharton,J., Howard,L., Wilkins,M.R.,
            Vangheluwe,P., Morrell,N.W. and Upton,P.D.
  TITLE     ATP13A3 variants promote pulmonary arterial hypertension by
            disrupting polyamine transport
  JOURNAL   Cardiovasc Res 120 (7), 756-768 (2024)
   PUBMED   38626311
  REMARK    GeneRIF: ATP13A3 variants promote pulmonary arterial hypertension
            by disrupting polyamine transport.
REFERENCE   2  (residues 1 to 1249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1249)
  AUTHORS   Schultheis,P.J., Hagen,T.T., O'Toole,K.K., Tachibana,A.,
            Burke,C.R., McGill,D.L., Okunade,G.W. and Shull,G.E.
  TITLE     Characterization of the P5 subfamily of P-type transport ATPases in
            mice
  JOURNAL   Biochem Biophys Res Commun 323 (3), 731-738 (2004)
   PUBMED   15381061
REFERENCE   4  (residues 1 to 1249)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154608.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.26 cM"
     Protein         1..1249
                     /product="polyamine-transporting ATPase 13A3 isoform 1"
                     /EC_number="7.6.2.16"
                     /note="probable cation-transporting ATPase 13A3; type V
                     P-type ATPase; putrescine transporting ATPase;
                     polyamine-transporting ATPase 13A3"
                     /calculated_mol_wt=140896
     Region          14..1142
                     /region_name="P-ATPase-V"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     TIGR01657"
                     /db_xref="CDD:273738"
     CDS             1..1249
                     /gene="Atp13a3"
                     /gene_synonym="Gm1745; Gm541; Gm542"
                     /coded_by="NM_001128096.1:280..4029"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49821.1"
                     /db_xref="GeneID:224088"
                     /db_xref="MGI:MGI:2685387"
ORIGIN      
        1 mdkeerktin kgqedemeih gynlcrwkla mvfvgvictg gflllllywl pewrvkatcv
       61 raavkdcevv llrttdefrv wfcakihflp venqpnlnak clvnevsngh avhlteenrc
      121 emnkysqsqs qqmryfthhs iryfwndaih nfdflkglde gvscaslyek hsagltqgmh
      181 ayrkliygvn eiavkvpsvf kllikevlnp fyifqlfsvi lwsvdeyyyy alaivimsvv
      241 siisslysir kqyvmlhdmv athstvrvsv creneeieei fstdlvpgdv miiplngtvm
      301 pcdavlingt civnesmltg esvpvtktnl pnpsvdvkgm geeqyspeth krhtlfcgtt
      361 viqtrfytge lvkaivvrtg fstskgqlvr silypkptdf klyrdaylfl lclvvvagig
      421 fiytiinsil nekevqeiii ksldiititv ppalpaamta givyaqrrlk kvgifcispq
      481 rinicgqlnl vcfdktgtlt edgldlwgiq rventrfllp ednvcsemlv ksqfvacmat
      541 chsltkiegv lsgdpldlkm feaigwilee ateeetalhn rimptvvrps kqllpeptta
      601 gnqemelfel paiyeigivr qfpfssalqr msvvartlge krmdaymkga pevvaslckp
      661 etvpvdfekv ledytkqgfr vialahrkle skltwhkvqh isrdaiennm dfmgliimqn
      721 klkqetpavl edlhkanirt vmvtgdnmlt avsvardcgm ilpqdkviia ealppkdgkv
      781 akinwhytds lsqcsessai dseaipikla hdsledlevt ryhfamngks fsvilehfqd
      841 lvpklmlhgt vfarmapdqk tqlvealqnv dyfvgmcgdg andcgalkra hggislsele
      901 asvaspftsk tpsiscvpnl iregraalmt sfcvfkfmal ysiiqyfsvt llysilsnlg
      961 dfqflfidla iilvvvftms lnpawkelva qrppsglisg allfsvlsqi visvgfqslg
     1021 ffwvkqykvc dpnsdvcntt rsacwnsshl yngteldsck iqnyenttvf fissfqyltv
     1081 avafskgkpf rqpcyknyff visviilyvf ilfimlhpva svdqvleimc vpyqwriyml
     1141 iivlinafvs itvesffldt vlwkvvfnrd kqgecrfstt qppqesvdrw gkcclswals
     1201 crkktpkaky mylaqelrfd pewppkpqtt teakavvken gscqiitia
//
