LOCUS       NM_133224               3915 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase type 13A1 (Atp13a1), mRNA.
ACCESSION   NM_133224
VERSION     NM_133224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Zhang,R., Hou,X., Wang,C., Li,J., Zhu,J., Jiang,Y. and Hou,F.
  TITLE     The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated
            Antiviral Innate Immunity
  JOURNAL   Adv Sci (Weinh) 9 (33), e2203831 (2022)
   PUBMED   36216581
  REMARK    GeneRIF: The Endoplasmic Reticulum ATP13A1 is Essential for
            MAVS-Mediated Antiviral Innate Immunity.
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Dirr,E.R., Ekhator,O.R., Blackwood,R., Holden,J.G., Masliah,E.,
            Schultheis,P.J. and Fleming,S.M.
  TITLE     Exacerbation of sensorimotor dysfunction in mice deficient in
            Atp13a2 and overexpressing human wildtype alpha-synuclein
  JOURNAL   Behav Brain Res 343, 41-49 (2018)
   PUBMED   29407413
  REMARK    GeneRIF: Double mutant mice with loss of Atp13a2 function combined
            with overexpression of human wildtype aSyn showed an earlier onset
            and accelerated alterations in sensorimotor function that were age,
            sex and test-dependent. Female 13a2-aSyn mice showed early and
            progressive dysfunction on the beam and in locomotor activity. In
            males, 13a2-aSyn mice showed more severe impairments in spontaneous
            activity and adhesive removal.
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Sorensen,D.M., Holemans,T., van Veen,S., Martin,S., Arslan,T.,
            Haagendahl,I.W., Holen,H.W., Hamouda,N.N., Eggermont,J.,
            Palmgren,M. and Vangheluwe,P.
  TITLE     Parkinson disease related ATP13A2 evolved early in animal evolution
  JOURNAL   PLoS One 13 (3), e0193228 (2018)
   PUBMED   29505581
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Qiao,C., Yin,N., Gu,H.Y., Zhu,J.L., Ding,J.H., Lu,M. and Hu,G.
  TITLE     Atp13a2 Deficiency Aggravates Astrocyte-Mediated Neuroinflammation
            via NLRP3 Inflammasome Activation
  JOURNAL   CNS Neurosci Ther 22 (6), 451-460 (2016)
   PUBMED   26848562
  REMARK    GeneRIF: This study revealed a novel role of ATP13A2 in modulating
            astrocyte-mediated neuroinflammation via NLRP3 inflammasome
            activation.
REFERENCE   6  (bases 1 to 3915)
  AUTHORS   Schultheis,P.J., Hagen,T.T., O'Toole,K.K., Tachibana,A.,
            Burke,C.R., McGill,D.L., Okunade,G.W. and Shull,G.E.
  TITLE     Characterization of the P5 subfamily of P-type transport ATPases in
            mice
  JOURNAL   Biochem Biophys Res Commun 323 (3), 731-738 (2004)
   PUBMED   15381061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157564.11 and AK052057.1.
            
            On Jan 6, 2010 this sequence version replaced NM_133224.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138722.1, AB035381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC157564.11        22415-22501         c
            88-3263             AK052057.1         1-3176
            3264-3904           AK052057.1         3178-3818
            3905-3915           AC157564.11        5915-5925           c
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.88 cM"
     gene            1..3915
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /note="ATPase type 13A1"
                     /db_xref="GeneID:170759"
                     /db_xref="MGI:MGI:2180801"
     exon            1..479
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..3695
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /EC_number="7.2.2.10"
                     /note="probable cation-transporting ATPase 13A1;
                     cation-transporting ATPase 2; manganese-transporting
                     ATPase 13A1; endoplasmic reticulum P5A-ATPase"
                     /codon_start=1
                     /product="endoplasmic reticulum transmembrane helix
                     translocase"
                     /protein_id="NP_573487.2"
                     /db_xref="CCDS:CCDS22349.1"
                     /db_xref="GeneID:170759"
                     /db_xref="MGI:MGI:2180801"
                     /translation="MAVVGNAVPCGARPGGARDNGSPQPGSRLRPGLAAGPALIANGD
                     ELVAAVWPYRRLALLRRLTVLPFAGLLYPAWLGAAASGCWGWGSSWTQIPEAALLALA
                     TICLAHALTVLSGHWSVHAHCALTCTPEYDPNKVTFVKVVPTPNNGSTELVALHRDKG
                     EDGLEVLSFEFQKIKYSYDALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKK
                     FGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEAS
                     LVQQQMRNMSEIRKMGNKPHMIQVYRSRKWRPVASDDIVPGDIVSIGRSPQENLVPCD
                     VLLLRGRCIVDEAMLTGESVPQMKEPIEDLSPDRVLDLQADARLHVIFGGTKVVQHIP
                     PQKATSGLKPVDNGCVAFVLRTGFNTSQGRLLRTILFGVKRVTANNLETFIFILFLLV
                     FAIAAAAYVWVEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKL
                     YMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVTPVSSIPIETHR
                     ALASCHSLMQLDDGTLVGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGLKIHQRFHFA
                     SALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMFSQCPPDYHHIHTEISREGARV
                     LALGYKELGHLTHQQAREIKREALECSLKFVGFIVVSCPLKADSKAVIREIQNASHRV
                     VMITGDNPLTACHVAQELHFIDKAHTLILHPPSEKGQPCEWRSIDSSIVLPLTLGSPK
                     ALALEHALCLTGDGLAHLQAVDPQQLLCLIPHVQVFARVAPKQKEFVITSLKELGYVT
                     LMCGDGTNDVGALKHADVGVALLANAPERVVERRRRPRDSPVLSNSGPRVSRSTKQKS
                     ALLSPEEPPASHRDRLSQVLRDLEEESTPIVKLGDASIAAPFTSKLSSIQCICHVIKQ
                     GRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLFISRS
                     KPLKTLSRERPLPNIFNLYTILTVMLQFSVHFLSLVYLYREAQARSPEKQEQFVDLYK
                     EFEPSLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPLVWSLAVSLLAIIGLLL
                     GSSPDFNSQFGLVDIPVEFKLVIGQVLALDFCLALLADRVLQFFLGTPKLRVPS"
     exon            480..569
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            570..760
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            761..833
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            834..989
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1059
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1166
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1296
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1352
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1479
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1617
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1738
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1896
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2072
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2183
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2309
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2418
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2618
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2715
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2873
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2988
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3185
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3328
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3440
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3584
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3915
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3888..3893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /note="hexamer: AATAAA"
     polyA_site      3911
                     /gene="Atp13a1"
                     /gene_synonym="Atp13a; catp; Cgi152"
                     /note="major polyA site"
ORIGIN      
        1 cctattccaa ggtggcgctc agaccttacc ggaagtaata gaccggaagt ggggcggtgc
       61 ctctgccgga agccagcgca gcgctgggaa agatggcggt ggtgggcaac gcggttcctt
      121 gcggagcccg gcctggcggg gcccgggaca acgggtctcc tcagcctggg tcgcgattgc
      181 ggccgggcct agctgccggg ccagcactca tagcgaacgg cgacgaactg gtggccgccg
      241 tgtggccgta ccggcggctg gcgcttctgc ggcgcctcac cgtgctgccg tttgccgggc
      301 tgctgtaccc agcctggctg ggcgccgccg ccagcggttg ctggggatgg ggcagcagct
      361 ggacccagat acccgaggcc gcgctgctgg cgctcgccac catctgcctc gcgcacgcac
      421 tcactgtcct gtcggggcat tggtctgtgc acgcgcactg cgcgctcacc tgcaccccgg
      481 agtatgatcc caacaaagta acctttgtga aggtggtgcc aacccccaac aatggctcca
      541 ctgagcttgt ggccctgcac cgtgacaagg gtgaagatgg gctggaggtg ctgtcatttg
      601 aattccagaa gatcaaatat tcctatgatg ccctggagaa aaagcagttc cttccggtgg
      661 ccttcccagt ggggaatgcc ttctcttact atcaaagcaa cagaggcttc caggaagact
      721 cagagatccg agctgcagag aagaagtttg gaagcaacaa ggctgagatg gtagtgcccg
      781 acttctctga gcttttcaag gagagagcca cagccccttt cttcgtgttt caggtattct
      841 gcgttgggct ctggtgcctg gacgagtatt ggtactacag tgtcttcact ctgtccatgc
      901 tggtggcttt cgaagcttcc ctagtgcagc agcagatgag gaacatgtca gagatccgaa
      961 agatgggcaa caagccccat atgatacagg tctaccgcag ccgaaagtgg aggcctgtcg
     1021 ccagtgatga cattgttcct ggggacatcg tgtctatcgg ccgctcaccc caggagaact
     1081 tggtgccctg tgatgtactg ctgctacggg gccgctgcat tgtagacgag gccatgctca
     1141 ctggggaatc tgtgccacaa atgaaggagc ccattgaaga cctgagccca gaccgtgtcc
     1201 tagacctgca ggccgatgct cggctgcatg tcatctttgg gggcaccaag gtggtacagc
     1261 acattccccc gcagaaggcc acctcgggcc tgaagccggt cgacaatgga tgtgtggcct
     1321 ttgtcctgag aactgggttc aacacatccc agggcagact actgcgtaca attctctttg
     1381 gggtaaagag ggtcactgca aacaacttgg agacctttat cttcatcctc ttcctcctgg
     1441 tcttcgccat tgctgcagct gcgtatgtgt gggttgaagg gaccaaggac cccagccgga
     1501 accgttacaa gctctttctg gagtgcaccc tcatcctcac ctctgttgta ccccctgaac
     1561 tgcccattga actgtctctg gctgtcaaca cctccctcat cgccttggcc aagctctaca
     1621 tgtactgcac agagcctttc cggatcccct tcgctggcaa ggttgaagtg tgttgctttg
     1681 acaagacggg taccttgacc agtgacagcc tggtggtgcg aggcgtggca gggctgagag
     1741 atgggaaaga ggtgacccca gtgtccagca ttcccataga aacacaccgg gccctggcct
     1801 cctgccactc gctcatgcag ctggatgacg gcaccctagt gggtgaccct ctggaaaagg
     1861 ccatgctgac agctgtggac tggacactga ccaaagatga gaaagtattc ccccgaagta
     1921 ttaaaactca ggggctgaaa attcaccagc gctttcattt tgccagtgcc ctaaagcgaa
     1981 tgtctgtgct cgcctcctac gagaagcttg gctccactga cctctgctac atcgcggctg
     2041 tgaagggggc ccccgaaacc ctgcactcta tgttttctca gtgcccacct gactaccacc
     2101 acatccacac tgagatctct cgggaaggag cccgtgtcct ggctctggga tacaaggagc
     2161 taggacatct cacacatcag caggcccggg agatcaagcg ggaggcactg gagtgcagcc
     2221 tcaagtttgt gggcttcatc gtggtctcct gtcccctcaa agctgactcc aaggctgtga
     2281 tccgagagat ccagaatgca tcccacaggg tggtcatgat cacaggagac aaccccctca
     2341 ctgcatgcca tgtagctcag gagctgcact tcattgacaa agcccacacg ctcatcttgc
     2401 atcctccctc ggagaaaggc cagccatgtg agtggcgctc cattgatagc agcatcgttc
     2461 tgcctctcac cctgggctcc cccaaggcac tggccctgga gcacgcgcta tgcctcacag
     2521 gcgatggctt ggctcacctg caggctgtgg acccccagca gctgctctgc ctcatccctc
     2581 atgtgcaggt gtttgcccgt gtagccccta agcagaagga atttgtcatc actagcctga
     2641 aggagctggg ttatgtgacc cttatgtgtg gagatggcac caacgatgtg ggcgcactga
     2701 agcacgctga tgtgggtgta gcactcctgg ccaatgcccc tgagagggtt gtagaacggc
     2761 ggcgacggcc aagggacagc cctgtcctga gcaacagtgg ccccagagtc tccaggtcca
     2821 ccaaacagaa gtcggcactc ctctctcctg aggagccacc agcttcccac agggaccgcc
     2881 tgagccaggt gctgcgggac ctggaggagg agagcacccc catcgtgaag ctgggggatg
     2941 ccagcatcgc agcacccttc acctccaagc tgtcctccat ccagtgcatc tgccacgtga
     3001 tcaagcaggg ccggtgcaca ttggtgacga cgctgcagat gttcaagatc ctggccctca
     3061 atgccctcat cctggcatac agccaaagtg tcctctacct ggagggtgtc aagttcagtg
     3121 acttccaggc cacactgcag gggctgctgc tggccggctg cttcctcttc atctcccgct
     3181 ccaagcctct caagactctt tcccgagagc ggcccctacc caacatcttc aacctgtaca
     3241 ccatccttac ggtgatgctg caattctctg tccacttcct gagcctggtc tacctgtacc
     3301 gtgaggccca ggcacgcagc cctgagaagc aggagcagtt tgtagacctg tacaaggagt
     3361 ttgagccgag cctggtcaac agcactgtgt acatcatggc catggccatg cagatggcca
     3421 ccttcgccat caactacaag ggcccaccct tcatggagag cctgcctgag aacaagcccc
     3481 tggtgtggag tctggcagtg tcactgctgg ccatcattgg cttgctcctt ggttcctcac
     3541 ctgacttcaa cagccagttt ggccttgtgg acatccctgt agagttcaag ctggtcatcg
     3601 gccaggtcct ggccctggac ttctgcctgg cactcctggc tgaccgtgtc ctacagttct
     3661 ttttggggac tccgaagctg agagtgcctt cctgagaaga tggtgctggt atccactgcc
     3721 taccctggct gccactgaac aggaaaaccg ccgctgcccc aggagggagc actgctccca
     3781 tctccacagt gaggcagccc tgccttgctc ttggaagact gagttgggac ccttgtgggc
     3841 atccgctggc cgggctagta gaagagtcct ggctagcacc tttggtaaat aaatcggcgt
     3901 ctgcaatttt ataaa
//
