LOCUS       NP_619593               1035 aa            linear   ROD 27-APR-2025
DEFINITION  potassium-transporting ATPase alpha chain 2 [Mus musculus].
ACCESSION   NP_619593
VERSION     NP_619593.2
DBSOURCE    REFSEQ: accession NM_138652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1035)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1035)
  AUTHORS   Ayasse,N., Berg,P., Andersen,J.F., Svendsen,S.L., Sorensen,M.V.,
            Fedosova,N.U., Lynch,I.J., Wingo,C.S. and Leipziger,J.
  TITLE     Benzamil-mediated urine alkalization is caused by the inhibition of
            H+-K+-ATPases
  JOURNAL   Am J Physiol Renal Physiol 320 (4), F596-F607 (2021)
   PUBMED   33554781
REFERENCE   3  (residues 1 to 1035)
  AUTHORS   Walter,C., Rafael,C., Genna,A., Baron,S. and Crambert,G.
  TITLE     Increased colonic K+ excretion through inhibition of the H,K-ATPase
            type 2 helps reduce plasma K+ level in a murine model of nephronic
            reduction
  JOURNAL   Sci Rep 11 (1), 1833 (2021)
   PUBMED   33469051
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1035)
  AUTHORS   Walter,C., Rafael,C., Lasaad,S., Baron,S., Salhi,A. and Crambert,G.
  TITLE     H,K-ATPase type 2 regulates gestational extracellular compartment
            expansion and blood pressure in mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 318 (2), R320-R328 (2020)
   PUBMED   31913688
  REMARK    GeneRIF: H,K-ATPase type 2 regulates renal salt and potassium
            metabolism during gestation, controlling plasma volume expansion
            and blood pressure.
REFERENCE   5  (residues 1 to 1035)
  AUTHORS   Cheval,L., Bakouh,N., Walter,C., Tembely,D., Morla,L., Escher,G.,
            Vogt,B., Crambert,G., Planelles,G. and Doucet,A.
  TITLE     ANP-stimulated Na+ secretion in the collecting duct prevents Na+
            retention in the renal adaptation to acid load
  JOURNAL   Am J Physiol Renal Physiol 317 (2), F435-F443 (2019)
   PUBMED   31188029
REFERENCE   6  (residues 1 to 1035)
  AUTHORS   Zhang,W., Kuncewicz,T., Higham,S.C. and Kone,B.C.
  TITLE     Structure, promoter analysis, and chromosomal localization of the
            murine H(+)/K(+)-ATPase alpha 2 subunit gene
  JOURNAL   J Am Soc Nephrol 12 (12), 2554-2564 (2001)
   PUBMED   11729223
REFERENCE   7  (residues 1 to 1035)
  AUTHORS   Spicer,Z., Clarke,L.L., Gawenis,L.R. and Shull,G.E.
  TITLE     Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic
            Na(+) absorption during Na(+) restriction
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (6), G1369-G1377 (2001)
   PUBMED   11705741
REFERENCE   8  (residues 1 to 1035)
  AUTHORS   Pestov,N.B., Romanova,L.G., Korneenko,T.V., Egorov,M.V.,
            Kostina,M.B., Sverdlov,V.E., Askari,A., Shakhparonov,M.I. and
            Modyanov,N.N.
  TITLE     Ouabain-sensitive H,K-ATPase: tissue-specific expression of the
            mammalian genes encoding the catalytic alpha subunit
  JOURNAL   FEBS Lett 440 (3), 320-324 (1998)
   PUBMED   9872395
REFERENCE   9  (residues 1 to 1035)
  AUTHORS   Meneton,P., Schultheis,P.J., Greeb,J., Nieman,M.L., Liu,L.H.,
            Clarke,L.L., Duffy,J.J., Doetschman,T., Lorenz,J.N. and Shull,G.E.
  TITLE     Increased sensitivity to K+ deprivation in colonic
            H,K-ATPase-deficient mice
  JOURNAL   J Clin Invest 101 (3), 536-542 (1998)
   PUBMED   9449685
REFERENCE   10 (residues 1 to 1035)
  AUTHORS   Ono,S., Guntupalli,J. and DuBose,T.D. Jr.
  TITLE     Role of H(+)-K(+)-ATPase in pHi regulation in inner medullary
            collecting duct cells in culture
  JOURNAL   Am J Physiol 270 (5 Pt 2), F852-F861 (1996)
   PUBMED   8928848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC109011.1 and BY663985.1.
            
            On Sep 13, 2007 this sequence version replaced NP_619593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1035
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     Protein         1..1035
                     /product="potassium-transporting ATPase alpha chain 2"
                     /EC_number="7.2.2.19"
                     /EC_number="7.2.2.13"
                     /note="proton pump; non-gastric H(+)/K(+) ATPase subunit
                     alpha; ATPase H+K+-transporting, alpha 2; HK alpha 2;
                     sodium pump; non-gastric Na(+)/K(+) ATPase subunit alpha"
                     /calculated_mol_wt=114596
     Region          22..49
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Region          40..1035
                     /region_name="ATPase-IIC_X-K"
                     /note="sodium or proton efflux -- potassium uptake
                     antiporter, P-type ATPase, alpha subunit; TIGR01106"
                     /db_xref="CDD:273445"
     Site            100..120
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            143..163
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            300..319
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            332..349
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            784..803
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            814..834
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            855..877
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            930..949
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            954
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            964..982
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     Site            998..1018
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W8.3)"
     CDS             1..1035
                     /gene="Atp12a"
                     /gene_synonym="Atp1al1; cHKA; HKalpha2"
                     /coded_by="NM_138652.2:214..3321"
                     /db_xref="CCDS:CCDS27148.1"
                     /db_xref="GeneID:192113"
                     /db_xref="MGI:MGI:1926943"
ORIGIN      
        1 mrrkteiysv elngtkdvel adqkddkkfk ggknkdsepn ksqeeelkke ldlddhrlsn
       61 tdleqkygtn iiqglssira aellardgpn altppkqtpe iikflkqmvg gfsillwiga
      121 alcwiayviq yvsstasldn vylgailvlv viltgifayy qeakstnima sfskmipqqa
      181 lvirdaekki ipaeqlvvgd vveikggdqi padirlvfsq gckvdnsslt gesepqarst
      241 efthenplet knigfysttc legtatgivi ntgdrtiigr iaslasgvgs ektpiaieie
      301 hfvhivaava vsvgviffit avcmkyyvld aiiflisiiv anvpegllat vtvtlsltak
      361 rmakknclvk nleavetlgs tsiicsdktg tltqnrmtva hlwfdnqifv adtsenqtkq
      421 afdqssgtwa slskiitlcn raefrpgqes vpimkrvvvg dasetallkf sevilgdvmd
      481 irkrnhkvae ipfnstnkfq lsihetedpn dkrflmvmkg aperilekcs timingqeqp
      541 ldkssadafh taymelgglg ervlgfchly lpadkfpqsy tfdvdsinfp tsnlcfvgll
      601 smidpprstv pdavskcrsa gikvimvtgd hpitakaiak svgiisanne tvediakrrn
      661 iaveqvnkre akaavvtgme lkdmtpeqld ellinyqeiv fartspqqkl iivegcqrqd
      721 avvavtgdgv ndspalkkad igiamgiags daaknaadmv llddnfasiv tgveegrlif
      781 dnlkktiayt ltkniaelcp fliyivaglp lpigtitilf idlgtdiips ialayekaes
      841 dimnrkprhk kkdrlvnkql aiysylhigl mqalggflvy ftvyaqqgfw ptslinlrvs
      901 wetddindle dsygqewtry qrkylewtgs taffvaimvq qiadliirkt rrnsifqqgl
      961 frnkviwvgi isqiivalvl syglgsvtal sftmlraqyw fvavphaili wvydemrklf
     1021 irlypgswwd knmyy
//
