LOCUS       NM_001037863            6096 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ATPase, class VI, type 11C (Atp11c), transcript
            variant 1, mRNA.
ACCESSION   NM_001037863
VERSION     NM_001037863.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6096)
  AUTHORS   Dearden,L., Furigo,I.C., Pantaleao,L.C., Wong,L.W.P.,
            Fernandez-Twinn,D.S., de Almeida-Faria,J., Kentistou,K.A.,
            Carreira,M.V., Bidault,G., Vidal-Puig,A., Ong,K.K., Perry,J.R.B.,
            Donato,J. Jr. and Ozanne,S.E.
  TITLE     Maternal obesity increases hypothalamic miR-505-5p expression in
            mouse offspring leading to altered fatty acid sensing and increased
            intake of high-fat food
  JOURNAL   PLoS Biol 22 (6), e3002641 (2024)
   PUBMED   38833481
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6096)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6096)
  AUTHORS   Yabas,M., Bostanci,A. and Aral,S.
  TITLE     ATP11C promotes the differentiation of pre-B cells into immature B
            cells but does not affect their IL-7-dependent proliferation
  JOURNAL   Immunol Res 71 (4), 609-616 (2023)
   PUBMED   36753036
  REMARK    GeneRIF: ATP11C promotes the differentiation of pre-B cells into
            immature B cells but does not affect their IL-7-dependent
            proliferation.
REFERENCE   4  (bases 1 to 6096)
  AUTHORS   Miyata,Y., Yamada,K., Nagata,S. and Segawa,K.
  TITLE     Two types of type IV P-type ATPases independently re-establish the
            asymmetrical distribution of phosphatidylserine in plasma membranes
  JOURNAL   J Biol Chem 298 (11), 102527 (2022)
   PUBMED   36162506
REFERENCE   5  (bases 1 to 6096)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6096)
  AUTHORS   Yabas,M., Teh,C.E., Frankenreiter,S., Lal,D., Roots,C.M.,
            Whittle,B., Andrews,D.T., Zhang,Y., Teoh,N.C., Sprent,J., Tze,L.E.,
            Kucharska,E.M., Kofler,J., Farell,G.C., Broer,S., Goodnow,C.C. and
            Enders,A.
  TITLE     ATP11C is critical for the internalization of phosphatidylserine
            and differentiation of B lymphocytes
  JOURNAL   Nat Immunol 12 (5), 441-449 (2011)
   PUBMED   21423173
  REMARK    GeneRIF: A defect is ATP11C results inlower B-cell
            phosphatidylserine flippase activity and disrupts B-cell
            development and antibody production and also causes hepatocellular
            carcinoma.
REFERENCE   7  (bases 1 to 6096)
  AUTHORS   Siggs,O.M., Arnold,C.N., Huber,C., Pirie,E., Xia,Y., Lin,P.,
            Nemazee,D. and Beutler,B.
  TITLE     The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult
            bone marrow
  JOURNAL   Nat Immunol 12 (5), 434-440 (2011)
   PUBMED   21423172
  REMARK    GeneRIF: ATP11C is redundant during B cell development in the fetal
            liver but essential in the context of adult bone marrow where it is
            required for optiml responses to IL-7 and sustained expression of
            Ebf1.
REFERENCE   8  (bases 1 to 6096)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   9  (bases 1 to 6096)
  AUTHORS   Nelms,K.A. and Goodnow,C.C.
  TITLE     Genome-wide ENU mutagenesis to reveal immune regulators
  JOURNAL   Immunity 15 (3), 409-418 (2001)
   PUBMED   11567631
  REMARK    Review article
REFERENCE   10 (bases 1 to 6096)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU682339.17, BY017646.1, BC106087.1 and CO042050.1.
            
            On Dec 16, 2017 this sequence version replaced NM_001037863.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106087.1, SRR17253014.3017353.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CU682339.17        49193-49216         c
            25-338              BY017646.1         3-316
            339-6071            BC106087.1         294-6026
            6072-6096           CO042050.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..6096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 33.5 cM"
     gene            1..6096
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /note="ATPase, class VI, type 11C"
                     /db_xref="GeneID:320940"
                     /db_xref="MGI:MGI:1859661"
     exon            1..201
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3564
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /EC_number="7.6.2.1"
                     /note="isoform a is encoded by transcript variant 1;
                     probable phospholipid-transporting ATPase 11C; Atpase 11c,
                     p type; P4-ATPase flippase complex alpha subunit ATP11C"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase 11C isoform a"
                     /protein_id="NP_001032952.1"
                     /db_xref="CCDS:CCDS40988.1"
                     /db_xref="GeneID:320940"
                     /db_xref="MGI:MGI:1859661"
                     /translation="MFRRTLNRLCAGEEKRVGTRTVFVGNHPISGTEPYIAQRFCDNR
                     IVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTSPVTSGLPLFFVITVT
                     AIKQGYEDWLRHRADNEVNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLI
                     LLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAESIDNLRATIECEQPQPDL
                     YRFVGRISIYSNSIEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQG
                     KSQKCSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSSPYNDEPWYNQKTQKERET
                     FQVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVN
                     TSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEVDGLSQTDGPLAY
                     FDKADKNREALFLRALCLCHTVEMKTNDDVDGPVEGAGFTYISSSPDEIALVKGAKRF
                     GFTFLGNQNGYIRVENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGAD
                     SSIFPRVHSHQIELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQD
                     REEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAK
                     STCYACRLFQTNTELLELTTKTIEESERKEDRLHELLIEYRKKLLHEFPKSTRSLKKA
                     WTEHQEYGLIIDGSTLSLILNSSQDCSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQI
                     VRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLK
                     KLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNIC
                     FTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFF
                     GTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSL
                     AFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIVVK
                     NVRRRSARRNLSCRRASDSLSARPSVRPLLLRTFSDESNIL"
     exon            202..321
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            322..411
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            412..492
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            493..600
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            601..729
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            730..833
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            834..884
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            885..949
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1031
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1182
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1380
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1542
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1694
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1766
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1840
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1944
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2126
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2390
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2565
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2668
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2814
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2874
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3002
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3138
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3204
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3308
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3462
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3567
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..6078
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3720..3725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /note="hexamer: AATAAA"
     polyA_site      3744
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
     regulatory      6053..6058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /note="hexamer: AATAAA"
     polyA_site      6074
                     /gene="Atp11c"
                     /gene_synonym="A330005H02Rik; Ig"
                     /note="major polyA site"
ORIGIN      
        1 gcagaggcga ggagggcagg cggcaggagg gcaggcggca gcgggctggc gacagggcag
       61 gcgagctagc tgtccgcttt gcgccgcggg cccacgccgc agtgtgtttt gtggacggcg
      121 ccttcccaga cagcccagcg gagcccagcc tggcaccccg cagcctcgga cgcgatgttc
      181 cgccggaccc tcaaccgttt gtgtgctgga gaagagaaac gagttggtac acgcacagtg
      241 tttgttggca atcatcccat ttctggaaca gaaccttata ttgcgcaaag attttgtgat
      301 aatagaatag tctcatctaa gtatacactt tggaatttcc tccctaagaa tttgtttgaa
      361 cagtttagaa gaattgcgaa tttttatttc ctcatcattt tccttgtaca ggtcacagta
      421 gacacaccaa ccagcccagt taccagtgga cttccacttt ttttcgttat aactgttaca
      481 gcaatcaagc aggggtatga agattggctt agacacagag ctgataatga agttaacaaa
      541 agtgctgttt atattattga aaatgcaaag cgagtgagga aagaaagtga aaaaatcaag
      601 gttggtgatg tagtagaagt acaggcaaat gaaacctttc cctgtgatct tatacttctg
      661 tcatcctgca caactgatgg aacctgttat gtcactacag ccagtcttga tggtgaatct
      721 aattgcaaga cacattatgc agtacgagat accattgcac tgtgtacagc cgaatccatt
      781 gataatctcc gagcaacaat tgaatgtgag cagcctcaac ctgatctcta caggtttgtt
      841 gggcgaatca gtatctatag taatagtatt gaggctgttg ccaggtcttt gggacctgaa
      901 aatcttttgc tgaaaggagc cacacttaaa aataccaaga agatatatgg agttgctgtt
      961 tacactggga tggaaaccaa aatggctttg aactaccaag ggaaatctca gaaatgttct
     1021 gctgttgaaa aatctattaa tgccttcttg attgtttatt tatttatctt actgaccaaa
     1081 gctgcagtat gcacaactct taagtatgtt tggcaaagtt ccccatacaa tgatgaacca
     1141 tggtataacc aaaagactca aaaggaacgg gaaacttttc aggttttgaa aatgttcact
     1201 gactttttat cattcatggt tcttttcaac ttcattatac ctgtctccat gtatgtcaca
     1261 gtagaaatgc agaaattttt agggtcattc tttatttcat gggataaaga cttttttgat
     1321 gaagaaatta atgaaggagc cttggttaat acatcagacc ttaatgaaga acttggtcag
     1381 gtggactatg tatttacaga taagactggg acactcactg aaaatagcat ggaattcatt
     1441 gaatgctgca tagatgggca caaatataaa ggcacaactc aggaagttga tggattatct
     1501 cagactgatg ggcccttagc ctattttgat aaagcagata agaaccgaga ggcactcttt
     1561 ctccgtgccc tatgcttatg tcacactgta gaaatgaaaa caaatgatga tgttgatgga
     1621 cctgtagaag gagccggatt cacatatatc tcctcctcac cagatgaaat agctttggtg
     1681 aaaggagcta aaaggtttgg gttcacattt ttgggaaatc agaatggata tatcagagta
     1741 gagaaccaaa gaaaagaaat agaagagtat gaacttctcc acaccttaaa ttttgattct
     1801 gtccgccgac gtatgagtgt aattgtaagg acccaaaaag gagatattct acttttctgt
     1861 aaaggagcag attcatcaat ttttcccagg gtacatagcc atcaaattga gttaaccaaa
     1921 gaccatgtgg aacgtaatgc aatggatggg tatcggactc tttgtgtagc cttcaaagaa
     1981 attcctccag atgattttga aagaatcaat gcacaactag tagaggcaaa aatggcccta
     2041 caagatagag aagaaaaact ggaaaaggtt tttgatgaga ttgagactaa catgaattta
     2101 attggagcca ctgctgtgga agacaagctg caagatcagg ctgcagagac cattgaagct
     2161 ctccatgcag ctggcttaaa agtctgggtg cttactgggg acaagatgga aacagccaaa
     2221 tctacttgct atgcctgccg ccttttccaa accaatactg agctcttgga actgaccaca
     2281 aaaaccattg aagagagtga aaggaaagaa gatcgattac atgaactgct aatagaatat
     2341 cgtaagaagt tgctgcatga atttcctaaa agcactagaa gccttaaaaa agcatggaca
     2401 gaacatcagg aatatggatt aatcattgat ggctccacat tgtcactcat actaaattct
     2461 agtcaagatt gtagttcaaa caactataaa agtatttttc tacaaatctg tatgaaatgc
     2521 actgcagtgc tctgctgccg gatggcacca ttacaaaaag cccagattgt cagaatggtg
     2581 aagaacttga aaggcagccc cataacactg tcaataggtg atggtgccaa tgatgtcagt
     2641 atgattttgg aatcccatgt gggaataggt attaaaggaa aagaaggccg tcaagcagcc
     2701 aggaatagtg attattctgt tccaaagttt aagcatttaa agaaactgct attggttcat
     2761 ggacatctat actatgtgag aatagcacat cttgtacaat atttcttcta caagaacctt
     2821 tgtttcattt tgccacaatt tttgtaccag ttcttctgtg gattctcaca acagccactc
     2881 tatgatgctg cttatcttac aatgtacaat atctgtttca catccctgcc catcctggct
     2941 tatagtctac tggaacagca catcaacatt gatactctga ccgcagaccc tcgattgtat
     3001 atgaaaatta ccggtaatgc tatgttacag ttggggccct tcttacattg gacatttctg
     3061 gctgcatttg aagggacagt attcttcttt gggacttatt tcctttttca gacttcatcc
     3121 ttagaagaca atggaaagat ttatggaaat tggacatttg gaaccattgt ttttacagtc
     3181 ttagtattca ccgtaactct gaagctcgcc ttggataccc ggttctggac atggataaat
     3241 cattttgtga tttggggttc tctagccttt tatgtttttt tctcattctt ctggggagga
     3301 attatttggc cttttctgaa acaacagaga atgtattttg tgtttgctca aatgctctgt
     3361 tctgtatcca catggttggc tataatcctt ttaatattta tcagcctttt ccctgagatt
     3421 ctcctaatag ttgtaaagaa tgttcgaaga agaagtgcca ggagaaatct gagctgtaga
     3481 agggcatctg actcattatc cgccagacct tcagtcagac ctcttctttt acgaacattc
     3541 tcagacgaat ctaatatatt gtaacagaat ccgaatcttg aactgcctat gttattgtcc
     3601 tacaagcata ttgaccgtgg ttgcagctaa agagagaaag catgaaggaa caactacaaa
     3661 agatattaac tcaggatact caatatgaaa caaagaccac tctcatgtgt agggttcaca
     3721 ataaatgttc attaaagtac caaataactc tcttaaccat ttacagttat tgtaagtagc
     3781 cattatggcc caagtgagaa ttagatgaaa gtttaaagta agcatactta gcattctgga
     3841 tttagataga ctaatgtaac tacaaaatgg gtgctctttt aacccgctga ctttgtgaat
     3901 ggatttcaat aatagtataa agtagaaggc atgcaatggg gatgagcagg tttggctaac
     3961 cagtgtttcc ttccgcctgg cagaagtcgt agactgcttg tctcacctct ctcattcctg
     4021 ctcaatgatt atcttttttc ccacacacaa aaggaatact tgaaaataca agactaaatg
     4081 atattactgc atcagacaaa atacatcatc atcttttcag tcataggcta attgtcttgg
     4141 tctaatatcc tttccaaaaa gtaccttgca tacttgtgtg atactgttaa ttctgggtat
     4201 tattgtagaa acaagggtgg aaaggttatt tggtgtgttt tcttctgaat tacacaccac
     4261 ttatgtattt aagactacta aacttgaaaa tacaatattt cagtctcttg gtagtagccc
     4321 ctcaaaacag ttaagtagaa agatttccat ccaatgttag ttttgctggg taacgtggta
     4381 aggtgtgtta aatatttaca taaaaatgaa tgccattctt aacactggca ttttataatt
     4441 ctatgtggca aagatgggaa gaatagccta ttttcaacta ctaacggttt ttatttgaaa
     4501 gagagtgttt ttgtgcatat ttacagcact ttttttttaa aaaaagttac caatttggaa
     4561 agaggagatc tattccaaag ccctgtagag ccacaactct ttggacatga atgttggttc
     4621 ctatagctaa gtgggccaag gaaatggtct atttctaaat tatgtgatgg accttggtaa
     4681 gatcctcaaa ctgctggacc agaaagaggt tttagcccct aatacgttct cttaaaacat
     4741 gaaagaagta tgaaatgtct ttacttgaaa gaaggaccac gtttgacaga taggctaaaa
     4801 tgatatttag aaaatatttt tctatcagtt tccatttttt tgtctgacat gcctgtacta
     4861 tttaatgttt atattgtact ttgatttaag aacatactag actcattgtc ttccagtata
     4921 tttatatgtc catatggcac attttgattc ttccatgtat ttgtgtggat gtttatttgg
     4981 gtgtattttt tcttaaattc taaaaaggcc ataatttcag ttatcagaaa ttattccata
     5041 attacttaat ttaatttgtt ctcatctatc agtattactt ttgagtattt tgttaggtgt
     5101 caatcacagc ttaagtgtgt gctcttgtag cctgtatttg aggaaatctg ctgaaagcaa
     5161 agtctttcta ttctttgcct attccaaaga gctaaaacat ctaacccagg aaagctttgc
     5221 tgctttgtta ttgttgtcat tgttgttgct gctgtattat tattttacat cagaactgta
     5281 aggactgtga ataaatataa gagccaagta gagaggctta gttaatgcag aatgattgag
     5341 gagatgataa aatcaaaata tttaaggtag tagaaataaa actgattatg tatgacttgt
     5401 tgcagcagaa agaaatctag atgaacaaat gagaatttag agtcatgcct cagttaacca
     5461 ttacattgta cactgcactt caaatcagag gaacctgggt ttgctttttg aaaaattttt
     5521 attagtgatc taaaacatgg ctagcatggg cttagcagat gaagttattt gaaatgagcc
     5581 atccgatatt cctagcacta tattttaact attcttattt cagaagaggg caagaaatct
     5641 aacagtaggt ccatattgcc ataattttaa taataatttt tgagctatca aaatgtctat
     5701 gtaattttcc aaattgttgt ctattgtttg aaggtgttgc ctattaaaca aaaaatatcc
     5761 attccatatc tactacatat acaccagcaa cagtataaat gtaagcctaa atttgcaaaa
     5821 gtcataattt agtgatggaa ttttttaata acatgcagta tataaatgtg cagattttat
     5881 gcaagtgttg ataaaaatca tttttcagct tgtaaaatgg gactgcaata ttacattttt
     5941 cacttaagca gttttttaca tctactttgt tgctttctaa aatgacatga atgccatctt
     6001 ttatgaatgc aacttgcctt tttcgttaca gaaactttca tttgatgtaa tcaataaact
     6061 ttggtatgat acaatgggaa aaaaaaaaaa aaaaaa
//
