LOCUS       NP_001280596            1142 aa            linear   ROD 31-JUL-2024
DEFINITION  phospholipid-transporting ATPase IH isoform 2 [Mus musculus].
ACCESSION   NP_001280596 XP_006508898 XP_006508899
VERSION     NP_001280596.1
DBSOURCE    REFSEQ: accession NM_001293667.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1142)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1142)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1142)
  AUTHORS   Chepurwar,S., von Loh,S.M., Wigger,D.C., Neef,J., Frommolt,P.,
            Beutner,D., Lang-Roth,R., Kubisch,C., Strenzke,N. and Volk,A.E.
  TITLE     A mutation in ATP11A causes autosomal-dominant auditory neuropathy
            type 2
  JOURNAL   Hum Mol Genet 32 (7), 1083-1089 (2023)
   PUBMED   36300302
  REMARK    GeneRIF: A mutation in ATP11A causes autosomal-dominant auditory
            neuropathy type 2.
REFERENCE   4  (residues 1 to 1142)
  AUTHORS   Radford,B.N., Zhao,X., Glazer,T., Eaton,M., Blackwell,D.,
            Mohammad,S., Lo Vercio,L.D., Devine,J., Shalom-Barak,T.,
            Hallgrimsson,B., Cross,J.C., Sucov,H.M., Barak,Y., Dean,W. and
            Hemberger,M.
  TITLE     Defects in placental syncytiotrophoblast cells are a common cause
            of developmental heart disease
  JOURNAL   Nat Commun 14 (1), 1174 (2023)
   PUBMED   36859534
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1142)
  AUTHORS   Miyata,Y., Yamada,K., Nagata,S. and Segawa,K.
  TITLE     Two types of type IV P-type ATPases independently re-establish the
            asymmetrical distribution of phosphatidylserine in plasma membranes
  JOURNAL   J Biol Chem 298 (11), 102527 (2022)
   PUBMED   36162506
  REMARK    GeneRIF: Two types of type IV P-type ATPases independently
            re-establish the asymmetrical distribution of phosphatidylserine in
            plasma membranes.
REFERENCE   6  (residues 1 to 1142)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (residues 1 to 1142)
  AUTHORS   Halleck,M.S., Schlegel,R.A. and Williamson,P.L.
  TITLE     Reanalysis of ATP11B, a type IV P-type ATPase
  JOURNAL   J Biol Chem 277 (12), 9736-9740 (2002)
   PUBMED   11790799
REFERENCE   8  (residues 1 to 1142)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (residues 1 to 1142)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 1142)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147497.1 and AC134581.5.
            
            On or before Jun 12, 2014 this sequence version replaced
            XP_006508899.1, XP_006508898.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 3' end compared to variant 1. The resulting isoform (2) has a
            shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     Protein         1..1142
                     /product="phospholipid-transporting ATPase IH isoform 2"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IH;
                     ATPase, class 1, member h; ATPase 11A, p type; ATPase 11A,
                     class VI; P4-ATPase flippase complex alpha subunit ATP11A;
                     9130422H11Rik"
                     /calculated_mol_wt=130554
     Region          47..986
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            62..82
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            89..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            297..318
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            350..372
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            order(414..416,555,578..580,642,689..691,801,804,807,828,
                     831)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     Site            457..458
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:P98196; propagated from
                     UniProtKB/Swiss-Prot (P98197.1)"
     Site            493..494
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:P98196; propagated from
                     UniProtKB/Swiss-Prot (P98197.1)"
     Site            740
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98196; propagated from
                     UniProtKB/Swiss-Prot (P98197.1)"
     Site            885..905
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            918..937
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Region          <955..>1095
                     /region_name="MelB"
                     /note="Na+/melibiose symporter or related transporter
                     [Carbohydrate transport and metabolism]; COG2211"
                     /db_xref="CDD:441813"
     Site            968..989
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            1004..1026
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            1033..1053
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     Site            1072..1096
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98197.1)"
     CDS             1..1142
                     /gene="Atp11a"
                     /gene_synonym="4930558F19Rik; Atpc1h; Ih"
                     /coded_by="NM_001293667.1:299..3727"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS80858.1"
                     /db_xref="GeneID:50770"
                     /db_xref="MGI:MGI:1354735"
ORIGIN      
        1 mdcsllrtlv rrycageenw vdsrtiyvgh kepppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rianfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn radgtchvtt
      181 asldgesshk thyavqdtkg fhteadvdsl hatieceqpq pdlykfvgri nvyndlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmntflivy
      301 lcilvskali ntvlkyvwqs epfrdepwyn ekteserqrn lflraftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeem gegplvntsd lneelgqvey iftdktgtlt
      421 ennmafkecc ieghvyvphv icngqvlpds sgidmidssp gvcgrereel ffraiclcht
      481 vqvkddhcgd dvdgpqkspd akscvyisss pdevalvegv qrlgftylrl kdnymeilnr
      541 endierfell evltfdsvrr rmsvivkstt geiylfckga dssifprvie gkvdqvrsrv
      601 ernaveglrt lcvaykrlep eqyedacrll qsakvalqdr ekklaeayeq iekdlvllga
      661 tavedrlqek aadtiealqk agikvwvltg dkmetasatc yacklfrrst qllelttkkl
      721 eeqslhdvlf dlsktvlrcs gsmtrdsfsg lstdmhdygl iidgaalsli mkpredgsss
      781 gnyrelflei crncsavlcc rmaplqkaqi vklikfskeh pitlaigdga ndvsmileah
      841 vgigvigkeg rqaarnsdya ipkfkhlkkm llvhghfyyi riselvqyff yknvcfifpq
      901 flyqffcgfs qqtlydtayl tlynisftsl pillyslmeq hvgidvlkrd ptlyrdiakn
      961 allrwrvfiy wtflgvfdal vfffgayfif enttvtingq mfgnwtfgtl vftvmvltvt
     1021 lklaldthyw twinhfviwg sllfyiafsl lwggviwpfl syqrmyyvfi smlssgpawl
     1081 giillvtvgl lpdvlkkvlc rqlwptater tqqstrlkal adatsnsarp llkdflpqpr
     1141 hv
//
