LOCUS       NM_009720                532 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus antioxidant 1 copper chaperone (Atox1), mRNA.
ACCESSION   NM_009720
VERSION     NM_009720.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 532)
  AUTHORS   Zhao,P., Shi,W., Ye,Y., Xu,K., Hu,J., Chao,H., Tao,Z., Xu,L.,
            Gu,W., Zhang,L., Wang,T., Wang,X. and Ji,J.
  TITLE     Atox1 protects hippocampal neurons after traumatic brain injury via
            DJ-1 mediated anti-oxidative stress and mitophagy
  JOURNAL   Redox Biol 72, 103156 (2024)
   PUBMED   38640584
  REMARK    GeneRIF: Atox1 protects hippocampal neurons after traumatic brain
            injury via DJ-1 mediated anti-oxidative stress and mitophagy.
REFERENCE   2  (bases 1 to 532)
  AUTHORS   Chen,M., Chen,Y., Fu,R., Liu,S., Li,H. and Shen,T.
  TITLE     Atox1 regulates macrophage polarization in intestinal inflammation
            via ROS-NLRP3 inflammasome pathway
  JOURNAL   J Transl Med 22 (1), 497 (2024)
   PUBMED   38796413
  REMARK    GeneRIF: Atox1 regulates macrophage polarization in intestinal
            inflammation via ROS-NLRP3 inflammasome pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 532)
  AUTHORS   Sudhahar,V., Shi,Y., Kaplan,J.H., Ushio-Fukai,M. and Fukai,T.
  TITLE     Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1
            in Endothelial Cells: Role in Inflammation and Atherosclerosis
  JOURNAL   Cells 11 (18), 2919 (2022)
   PUBMED   36139494
  REMARK    GeneRIF: Whole-Transcriptome Sequencing Analyses of Nuclear
            Antixoxidant-1 in Endothelial Cells: Role in Inflammation and
            Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 532)
  AUTHORS   Jin,J., Ma,M., Shi,S., Wang,J., Xiao,P., Yu,H.F., Zhang,C., Guo,Q.,
            Yu,Z., Lou,Z. and Teng,C.B.
  TITLE     Copper enhances genotoxic drug resistance via ATOX1 activated DNA
            damage repair
  JOURNAL   Cancer Lett 536, 215651 (2022)
   PUBMED   35315340
  REMARK    GeneRIF: Copper enhances genotoxic drug resistance via ATOX1
            activated DNA damage repair.
REFERENCE   5  (bases 1 to 532)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 532)
  AUTHORS   Arnesano,F., Banci,L., Bertini,I., Ciofi-Baffoni,S., Molteni,E.,
            Huffman,D.L. and O'Halloran,T.V.
  TITLE     Metallochaperones and metal-transporting ATPases: a comparative
            analysis of sequences and structures
  JOURNAL   Genome Res 12 (2), 255-271 (2002)
   PUBMED   11827945
REFERENCE   7  (bases 1 to 532)
  AUTHORS   Hamza,I., Faisst,A., Prohaska,J., Chen,J., Gruss,P. and Gitlin,J.D.
  TITLE     The metallochaperone Atox1 plays a critical role in perinatal
            copper homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6848-6852 (2001)
   PUBMED   11391006
REFERENCE   8  (bases 1 to 532)
  AUTHORS   Malik,T.H., Shoichet,S.A., Latham,P., Kroll,T.G., Peters,L.L. and
            Shivdasani,R.A.
  TITLE     Transcriptional repression and developmental functions of the
            atypical vertebrate GATA protein TRPS1
  JOURNAL   EMBO J 20 (7), 1715-1725 (2001)
   PUBMED   11285235
REFERENCE   9  (bases 1 to 532)
  AUTHORS   Hamza,I., Klomp,L.W., Gaedigk,R., White,R.A. and Gitlin,J.D.
  TITLE     Structure, expression, and chromosomal localization of the mouse
            Atox1 gene
  JOURNAL   Genomics 63 (2), 294-297 (2000)
   PUBMED   10673341
REFERENCE   10 (bases 1 to 532)
  AUTHORS   Nishihara,E., Furuyama,T., Yamashita,S. and Mori,N.
  TITLE     Expression of copper trafficking genes in the mouse brain
  JOURNAL   Neuroreport 9 (14), 3259-3263 (1998)
   PUBMED   9831461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ747750.1 and BP773958.1.
            
            On Feb 13, 2018 this sequence version replaced NM_009720.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF551157.1, BQ747750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               BQ747750.1         32-541
            511-532             BP773958.1         475-496
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.07 cM"
     gene            1..532
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /note="antioxidant 1 copper chaperone"
                     /db_xref="GeneID:11927"
                     /db_xref="MGI:MGI:1333855"
     exon            1..121
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..322
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /EC_number="6.2.1.2"
                     /note="metal transport protein ATX1; ATX1 (antioxidant
                     protein 1) homolog 1"
                     /codon_start=1
                     /product="copper transport protein ATOX1"
                     /protein_id="NP_033850.1"
                     /db_xref="CCDS:CCDS36158.1"
                     /db_xref="GeneID:11927"
                     /db_xref="MGI:MGI:1333855"
                     /translation="MPKHEFSVDMTCEGCAEAVSRVLNKLGGVEFNIDLPNKKVCIDS
                     EHSSDTLLATLNKTGKAVSYLGPK"
     exon            122..197
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..366
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..514
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      486..491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /note="hexamer: AATAAA"
     polyA_site      514
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /note="major polyA site"
ORIGIN      
        1 gttggcctga gggcggggct ttcaggagcg ctctccggaa gcgcagcttt ggtgtccggg
       61 agaggagttc cagtcgtcgt cgccgctgcc actgcccgtg tgtgccgcgt cagtcatgcc
      121 gaagcacgag ttctccgtgg acatgacctg tgagggctgt gctgaagccg tctccagagt
      181 cctcaacaag ctgggaggag tggagttcaa cattgacctg cccaacaaga aggtctgcat
      241 cgactctgag cacagctcag acaccctgct ggcaaccctc aacaaaacag gaaaggctgt
      301 ttcctacctt ggccccaagt agccaggacc tgggcgagtc cttccggata taaactgaag
      361 aggcaggctg ttgatctggt ctccccggca gatctggaac accaactgct cagtccagtc
      421 cagcccagcc atggagttcc tgcccagaca ggccttcccc gctggctccc tgcaagcttc
      481 catgtaataa agtcaagctg agtttgttga tgaaaaaaaa aaaaaaaaaa aa
//
