LOCUS       NM_153778               2355 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus atonal bHLH transcription factor 8 (Atoh8), mRNA.
ACCESSION   NM_153778
VERSION     NM_153778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Divvela,S.S.K., Offei,E.B., Suerland,F., Revuelta Garcia,D.,
            Kwiatkowski,J., Balakrishnan-Renuka,A., Bohne,P., Boing,M.,
            Morosan-Puopolo,G., Mark,M.D. and Brand-Saberi,B.
  TITLE     Atonal homolog 8/Math6 regulates differentiation and maintenance of
            skeletal muscle
  JOURNAL   Front Cell Dev Biol 10, 950414 (2022)
   PUBMED   36060799
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Niu,F., Che,P., Yang,Z., Zhang,J., Yang,L., Zhuang,M., Ou,X. and
            Ji,S.J.
  TITLE     m6A regulation of cortical and retinal neurogenesis is mediated by
            the redundant m6A readers YTHDFs
  JOURNAL   iScience 25 (9), 104908 (2022)
   PUBMED   36039295
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Tang,Q., Xie,M.Y., Zhang,Y.L., Xue,R.Y., Zhu,X.H. and Yang,H.
  TITLE     Targeted deletion of Atoh8 results in severe hearing loss in mice
  JOURNAL   Genesis 59 (9), e23442 (2021)
   PUBMED   34402594
  REMARK    GeneRIF: Targeted deletion of Atoh8 results in severe hearing loss
            in mice.
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Estrada,S.M., Thagard,A.S., Dehart,M.J., Damicis,J.R.,
            Dornisch,E.M., Ippolito,D.L., Burd,I., Napolitano,P.G. and
            Ieronimakis,N.
  TITLE     The orphan nuclear receptor Nr4a1 mediates perinatal
            neuroinflammation in a murine model of preterm labor
  JOURNAL   Cell Death Dis 11 (1), 11 (2020)
   PUBMED   31907354
  REMARK    Erratum:[Cell Death Dis. 2020 Jun 30;11(6):495. doi:
            10.1038/s41419-020-2682-y. PMID: 32606386]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Morikawa,M., Mitani,Y., Holmborn,K., Kato,T., Koinuma,D.,
            Maruyama,J., Vasilaki,E., Sawada,H., Kobayashi,M., Ozawa,T.,
            Morishita,Y., Bessho,Y., Maeda,S., Ledin,J., Aburatani,H.,
            Kageyama,R., Maruyama,K., Heldin,C.H. and Miyazono,K.
  TITLE     The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects
            against the development of pulmonary arterial hypertension
  JOURNAL   Sci Signal 12 (607) (2019)
   PUBMED   31719172
  REMARK    GeneRIF: The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and
            protects against the development of pulmonary arterial
            hypertension.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Stevens,J.D., Roalson,E.H. and Skinner,M.K.
  TITLE     Phylogenetic and expression analysis of the basic helix-loop-helix
            transcription factor gene family: genomic approach to cellular
            differentiation
  JOURNAL   Differentiation 76 (9), 1006-1022 (2008)
   PUBMED   18557763
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Kautz,L., Meynard,D., Monnier,A., Darnaud,V., Bouvet,R., Wang,R.H.,
            Deng,C., Vaulont,S., Mosser,J., Coppin,H. and Roth,M.P.
  TITLE     Iron regulates phosphorylation of Smad1/5/8 and gene expression of
            Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
  JOURNAL   Blood 112 (4), 1503-1509 (2008)
   PUBMED   18539898
  REMARK    GeneRIF: Bmp6, Smad7, Id1, and Atoh8 transcripts are significantly
            modulated by the dietary iron content; activation of Smad7, Id1,
            and Atoh8 transcription by iron requires Smad4.
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Lynn,F.C., Sanchez,L., Gomis,R., German,M.S. and Gasa,R.
  TITLE     Identification of the bHLH factor Math6 as a novel component of the
            embryonic pancreas transcriptional network
  JOURNAL   PLoS One 3 (6), e2430 (2008)
   PUBMED   18560595
  REMARK    GeneRIF: results demonstrate that Math6 is indispensable for early
            embryonic development and indicate a more widespread function for
            this factor in tissue-specific differentiation processes that are
            dependent on class II bHLH genes
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Ross,M.D., Martinka,S., Mukherjee,A., Sedor,J.R., Vinson,C. and
            Bruggeman,L.A.
  TITLE     Math6 expression during kidney development and altered expression
            in a mouse model of glomerulosclerosis
  JOURNAL   Dev Dyn 235 (11), 3102-3109 (2006)
   PUBMED   16937370
  REMARK    GeneRIF: Math6 may participate in kidney development and may be a
            permissive factor for podocyte differentiation.
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Inoue,C., Bae,S.K., Takatsuka,K., Inoue,T., Bessho,Y. and
            Kageyama,R.
  TITLE     Math6, a bHLH gene expressed in the developing nervous system,
            regulates neuronal versus glial differentiation
  JOURNAL   Genes Cells 6 (11), 977-986 (2001)
   PUBMED   11733035
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC122864.3.
            
            On Nov 17, 2006 this sequence version replaced NM_153778.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046527.1, BC023684.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1184              AC122864.3         147826-149009       c
            1185-1376           AC122864.3         137174-137365       c
            1377-2355           AC122864.3         119609-120587       c
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..2355
                     /gene="Atoh8"
                     /gene_synonym="4933425C05Rik; bHLHa21; Hath6; Math6;
                     okadin"
                     /note="atonal bHLH transcription factor 8"
                     /db_xref="GeneID:71093"
                     /db_xref="MGI:MGI:1918343"
     exon            1..1184
                     /gene="Atoh8"
                     /gene_synonym="4933425C05Rik; bHLHa21; Hath6; Math6;
                     okadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1376
                     /gene="Atoh8"
                     /gene_synonym="4933425C05Rik; bHLHa21; Hath6; Math6;
                     okadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..2355
                     /gene="Atoh8"
                     /gene_synonym="4933425C05Rik; bHLHa21; Hath6; Math6;
                     okadin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2334..2339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atoh8"
                     /gene_synonym="4933425C05Rik; bHLHa21; Hath6; Math6;
                     okadin"
                     /note="hexamer: AGTAAA"
     polyA_site      2355
                     /gene="Atoh8"
                     /gene_synonym="4933425C05Rik; bHLHa21; Hath6; Math6;
                     okadin"
                     /note="major polyA site"
ORIGIN      
        1 ggctcgggag gcggcagcgg cggcggcggg agctgcctcc tctccgggcg ggcggcgctg
       61 agtgatcttg cgaactgggc ttctgtgtaa actgaggcta aacaaacaca gatggagcgc
      121 agcgggcgtt ctgcagaaat gctggcaggg cggcagcgac ttcagatgac actctgagct
      181 ctcccgggga accggcagcc tccaaggctt cacggagccg gaggcgcagc tgccccggga
      241 gtgggggtgc gagggaggga cccggggagg gagggtagga ggagagagcg cggcgacaag
      301 gcggcgctca gcgcggcggc cacccggcac agccaggcgc gcggcgtgca gagtgatcgc
      361 tgcgggcgcg cgtcccgggc agtcccacgc cccagcctca cgccgtcctc gccatgaagc
      421 acatcccggt cctcgaggac gggccgtgga agactgtgtg cgttaaagaa ctgaacggcc
      481 tcaagaagct caagcggaaa ggcaaggagc cggtgcggcg cgcgaatggc tataaaactt
      541 tccgattgga cttggaagct cccgagctcg gcgccacagt cagcaccacc gccgccacca
      601 acgggcttcg ggacaggaca caaccgttcc cgatcgcgac cccagtacca gcctcagtgg
      661 cgccggcggt tcctccaggt ggaggcacag acacagccag ggaattccgg ggcatcagag
      721 cgcctgaggt ctctgacgcg cgcaaacgcg gtttcgctct gggcacagtg ggaccgggac
      781 tacccacgcc accgccgcct cccgcatctc agagcttggc acccggggat cccgaggcgc
      841 actccttccg cgagcaggct ctgcgtcccc gcatcttgct gtgcgcccct cccgcgcgtc
      901 ccacacaatc cgcgcctctc gcacccccag cggcgccaca agagtccccc gtgcgccctg
      961 cgccccccac gcgcccgggg gaaagttcct actcgtcaat ttcacacgta atttacaata
     1021 accacccgga ttcttccgcg tcgcctagga aacggccagg cgaagcgacc gccgcctcaa
     1081 cggagatcaa agccctgcag cagacccgga ggcttctggc caacgccagg gagcggacgc
     1141 gggtgcacac catcagcgca gccttcgagg cgctgaggaa gcaggtgccg tgctactcct
     1201 atgggcagaa gctctccaaa ctggccatcc tgaggattgc ctgtaactac atcttgtccc
     1261 tggcacggct ggctgacctg gactacagtg ccgaccacag caacctcagc ttctccgagt
     1321 gtgtgcagcg ctgcacccgc accctgcagg cagaagggcg agccaagaaa cggaaggagt
     1381 gacctgccac aggctagacc acagacacca ctgtgagtct cttcccagtt gggactgagg
     1441 agaaagctgg gaccaccagg agacgaccag cctcattcct tgtcttcctc aagatgctgc
     1501 cagatactca gcccgtgtac catctctcag ggtcacttag aaccagcaca agggccgccg
     1561 gcctccctct ccgtctcctg ccatccaggg ttacttcaga ttttgccttc tgcctggtgg
     1621 ggcgggctat tgccaaagat tctacagaga tcgtccaagg aaattatgga tgaggcccca
     1681 acagcacaaa accacatcat tgctgcccta ccaagtccac ctcaagccaa agatggatta
     1741 gcactactgc taggaaccca tgcagtgggc acctggtgac catcagaagc acttaaccct
     1801 ccaagccagt gctcgctctg tgctgggccc tgagcagctg gttgtcttcg agacaagctt
     1861 cctagagcca cgacaagcag gctgctggtg gaaggtggag cccgagatcc ttggcccttc
     1921 ccattagcta cccagacctc tgactcctgt tcccgatact ctttgggtcc tggctccttc
     1981 ttggacccca agcctcctga gagaggaggg aagggggaga ctaaagaagc aatattgccc
     2041 cataccccac ccgggatgtg ccccaaggaa atctttctga cagtccttgc tcccagcccc
     2101 tgccccagca ggtgcgcctc accagtggtc aggttcaggc taacacttaa attagcactc
     2161 tgctggagag cagctgcctg tggacaggcc aggcaggagg acttagggag gaagggacca
     2221 ggggaatggg ccaggatgtg ggggaagggg cacgttcaaa gccaaggcct gctccttgtg
     2281 ctccagaggc caaagctgtt cacatctgtg tgcaaccatc tgcttcaaat tgaagtaaaa
     2341 gcggcaacat ataaa
//
