LOCUS       NM_007500               2121 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus atonal bHLH transcription factor 1 (Atoh1), mRNA.
ACCESSION   NM_007500
VERSION     NM_007500.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2121)
  AUTHORS   Wu,M., Jia,G., Liu,Y., Lou,Y., Li,Y., Xia,M., Li,H. and Li,W.
  TITLE     PKM2 controls cochlear development through lactate-dependent
            transcriptional regulation
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2410829122 (2025)
   PUBMED   39773029
REFERENCE   2  (bases 1 to 2121)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   3  (bases 1 to 2121)
  AUTHORS   Wang,T., Yang,T., Kedaigle,A., Pregernig,G., McCarthy,R.,
            Holmes,B., Wu,X., Becker,L., Pan,N., So,K., Chen,L., He,J.,
            Mahmoudi,A., Negi,S., Kowalczyk,M., Gibson,T., Druckenbrod,N.,
            Cheng,A.G. and Burns,J.
  TITLE     Precise genetic control of ATOH1 enhances maturation of regenerated
            hair cells in the mature mouse utricle
  JOURNAL   Nat Commun 15 (1), 9166 (2024)
   PUBMED   39448563
  REMARK    GeneRIF: Precise genetic control of ATOH1 enhances maturation of
            regenerated hair cells in the mature mouse utricle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2121)
  AUTHORS   Cai,X.Y., Ma,S.Y., Tang,M.H., Hu,L., Wu,K.D., Zhang,Z., Zhang,Y.Q.,
            Lin,Y., Patel,N., Yang,Z.C. and Mo,X.M.
  TITLE     Atoh1 mediated disturbance of neuronal maturation by perinatal
            hypoxia induces cognitive deficits
  JOURNAL   Commun Biol 7 (1), 1121 (2024)
   PUBMED   39261625
  REMARK    GeneRIF: Atoh1 mediated disturbance of neuronal maturation by
            perinatal hypoxia induces cognitive deficits.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2121)
  AUTHORS   Imada,S., Khawaled,S., Shin,H., Meckelmann,S.W., Whittaker,C.A.,
            Correa,R.O., Alquati,C., Lu,Y., Tie,G., Pradhan,D.,
            Calibasi-Kocal,G., Nascentes Melo,L.M., Allies,G., Rosler,J.,
            Wittenhofer,P., Krystkiewicz,J., Schmitz,O.J., Roper,J.,
            Vinolo,M.A.R., Ricciardiello,L., Lien,E.C., Vander Heiden,M.G.,
            Shivdasani,R.A., Cheng,C.W., Tasdogan,A. and Yilmaz,O.H.
  TITLE     Short-term post-fast refeeding enhances intestinal stemness via
            polyamines
  JOURNAL   Nature 633 (8031), 895-904 (2024)
   PUBMED   39169180
REFERENCE   6  (bases 1 to 2121)
  AUTHORS   Isaka,F., Shimizu,C., Nakanishi,S. and Kageyama,R.
  TITLE     Genetic mapping of four mouse bHLH genes related to Drosophila
            proneural gene atonal
  JOURNAL   Genomics 37 (3), 400-402 (1996)
   PUBMED   8938455
REFERENCE   7  (bases 1 to 2121)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   8  (bases 1 to 2121)
  AUTHORS   Ishibashi,M., Ang,S.L., Shiota,K., Nakanishi,S., Kageyama,R. and
            Guillemot,F.
  TITLE     Targeted disruption of mammalian hairy and Enhancer of split
            homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix
            factors, premature neurogenesis, and severe neural tube defects
  JOURNAL   Genes Dev 9 (24), 3136-3148 (1995)
   PUBMED   8543157
REFERENCE   9  (bases 1 to 2121)
  AUTHORS   Akazawa,C., Ishibashi,M., Shimizu,C., Nakanishi,S. and Kageyama,R.
  TITLE     A mammalian helix-loop-helix factor structurally related to the
            product of Drosophila proneural gene atonal is a positive
            transcriptional regulator expressed in the developing nervous
            system
  JOURNAL   J Biol Chem 270 (15), 8730-8738 (1995)
   PUBMED   7721778
REFERENCE   10 (bases 1 to 2121)
  AUTHORS   Shimizu,C., Akazawa,C., Nakanishi,S. and Kageyama,R.
  TITLE     MATH-2, a mammalian helix-loop-helix factor structurally related to
            the product of Drosophila proneural gene atonal, is specifically
            expressed in the nervous system
  JOURNAL   Eur J Biochem 229 (1), 239-248 (1995)
   PUBMED   7744035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082354.1 and AC162924.5.
            
            On Feb 13, 2018 this sequence version replaced NM_007500.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK082354.1, BC010820.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AK082354.1         2-210
            210-1137            AC162924.5         73074-74001
            1138-2108           AK082354.1         1144-2114
            2109-2121           AC162924.5         74973-74985
FEATURES             Location/Qualifiers
     source          1..2121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.03 cM"
     gene            1..2121
                     /gene="Atoh1"
                     /gene_synonym="bHLHa14; Hath1; MATH-1; Math1"
                     /note="atonal bHLH transcription factor 1"
                     /db_xref="GeneID:11921"
                     /db_xref="MGI:MGI:104654"
     exon            1..2121
                     /gene="Atoh1"
                     /gene_synonym="bHLHa14; Hath1; MATH-1; Math1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1254
                     /gene="Atoh1"
                     /gene_synonym="bHLHa14; Hath1; MATH-1; Math1"
                     /note="protein atonal homolog 1; helix-loop-helix protein
                     mATH-1"
                     /codon_start=1
                     /product="transcription factor Atoh1"
                     /protein_id="NP_031526.1"
                     /db_xref="CCDS:CCDS20203.1"
                     /db_xref="GeneID:11921"
                     /db_xref="MGI:MGI:104654"
                     /translation="MSRLLHAEEWAEVKELGDHHRHPQPHHVPPLTPQPPATLQARDL
                     PVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSPELGASEAAAPRDEADSQGE
                     LVRRSGCGGLSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLA
                     ANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPNVG
                     EQPPPPTASCKNDHHHLRTASSYEGGAGASAVAGAQPAPGGGPRPTPPGPCRTRFSGP
                     ASSGGYSVQLDALHFPAFEDRALTAMMAQKDLSPSLPGGILQPVQEDNSKTSPRSHRS
                     DGEFSPHSHYSDSDEAS"
ORIGIN      
        1 ggagaagctt cgttgcacgc gacctggtgt gcgatctccg agtgagaggg ggagggtcag
       61 aggaggaagg aaaaaaaatc agaccttgca gaagagacta ggaaggtttt tgttgttgtt
      121 gttcggggct tatccccttc gttgaactgg gttgccagca cctcctctaa cacggcacct
      181 ccgagccatt gcagtgcgat gtcccgcctg ctgcatgcag aagagtgggc tgaggtaaaa
      241 gagttggggg accaccatcg ccatccccag ccgcaccacg tcccgccgct gacgccacag
      301 ccacctgcta ccctgcaggc gagagacctt cccgtctacc cggcagaact gtccctcctg
      361 gatagcaccg acccacgcgc ctggctgact cccactttgc agggcctctg cacggcacgc
      421 gccgcccagt atctgctgca ttctcccgag ctgggtgcct ccgaggccgc ggcgccccgg
      481 gacgaggctg acagccaggg tgagctggta aggagaagcg gctgtggcgg cctcagcaag
      541 agccccgggc ccgtcaaagt acgggaacag ctgtgcaagc tgaagggtgg ggttgtagtg
      601 gacgagcttg gctgcagccg ccagcgagcc ccttccagca aacaggtgaa tggggtacag
      661 aagcaaagga ggctggcagc aaacgcaagg gaacggcgca ggatgcacgg gctgaaccac
      721 gccttcgacc agctgcgcaa cgttatcccg tccttcaaca acgacaagaa gctgtccaaa
      781 tatgagaccc tacagatggc ccagatctac atcaacgctc tgtcggagtt gctgcagact
      841 cccaatgtcg gagagcaacc gccgccgccc acagcttcct gcaaaaatga ccaccatcac
      901 cttcgcaccg cctcctccta tgaaggaggt gcgggcgcct ctgcggtagc tggggctcag
      961 ccagccccgg gagggggccc gagacctacc ccgcccgggc cttgccggac tcgcttctca
     1021 ggcccagctt cctctggggg ttactcggtg cagctggacg ctttgcactt cccagccttc
     1081 gaggacaggg ccctaacagc gatgatggca cagaaggacc tgtcgccttc gctgcccggg
     1141 ggcatcctgc agcctgtaca ggaggacaac agcaaaacat ctcccagatc ccacagaagt
     1201 gacggagagt tttcccccca ctctcattac agtgactctg atgaggccag ttaggaaggc
     1261 aacagctccc tgaaaactga gacaaccaaa tgcccttcct agcgcgcggg aagccccgtg
     1321 acaaatatcc ctgcaccctt taatttttgg tctgtggtga tcgttgttag caacgacttg
     1381 acttcggacg gctgcagctc ttccaatccc cttcctccta ccttctcctt cctctgtatg
     1441 tagatactgt atcattatat gtacctttac gtggcatcgt ttcatggtcc atgctgccaa
     1501 tatgctgcta aaatgtcgta tctctgcctc tggtctgggt ttcacttatt ttataccttg
     1561 ggagttcatc cttgcgtgtt gcgctcactc acaaataagg gagttagtca atgaagttgt
     1621 ttccccaact gcttgagacc cgcattgggt actttactga acacggacta ttgtgttgtt
     1681 aaaatgcagg ggcagataag agtatctgta gagcttagac accaagtgtg tccagcagtg
     1741 tgtctagcgg acccagaata cacgcacttc atcactggcc gctgcgccgc cttgaagaaa
     1801 ctcaactgcc aatgcagagc aacttttgat tttaaaaaca gccactcata atcattaaac
     1861 tctttgcaaa tgtttgtttt tgcaaatgaa aattaaaaaa aaacatgtag tgtcaaaggc
     1921 atttggtcaa ttttattttg ctttgttaac attagaaaag ttatttatta ttgcgtattt
     1981 ggacccattt ctacttaatt gccttttttt tacattttct actcgagatc gttttatttt
     2041 gatttagcaa atccagttgc cattgcttta tgtatgtatg ctcttttaca aatgataaaa
     2101 taaactcgga aaaaaaaaac c
//
