LOCUS       NM_007881               4426 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus atrophin 1 (Atn1), mRNA.
ACCESSION   NM_007881 XM_981322
VERSION     NM_007881.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4426)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4426)
  AUTHORS   D,D., Hung,K.Y. and Tarn,W.Y.
  TITLE     RBM4 Modulates Radial Migration via Alternative Splicing of Dab1
            during Cortex Development
  JOURNAL   Mol Cell Biol 38 (12), e00007-18 (2018)
   PUBMED   29581187
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4426)
  AUTHORS   Zhang,M., Chen,D., Xia,J., Han,W., Cui,X., Neuenkirchen,N.,
            Hermes,G., Sestan,N. and Lin,H.
  TITLE     Post-transcriptional regulation of mouse neurogenesis by Pumilio
            proteins
  JOURNAL   Genes Dev 31 (13), 1354-1369 (2017)
   PUBMED   28794184
REFERENCE   4  (bases 1 to 4426)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4426)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4426)
  AUTHORS   Schilling,G., Wood,J.D., Duan,K., Slunt,H.H., Gonzales,V.,
            Yamada,M., Cooper,J.K., Margolis,R.L., Jenkins,N.A., Copeland,N.G.,
            Takahashi,H., Tsuji,S., Price,D.L., Borchelt,D.R. and Ross,C.A.
  TITLE     Nuclear accumulation of truncated atrophin-1 fragments in a
            transgenic mouse model of DRPLA
  JOURNAL   Neuron 24 (1), 275-286 (1999)
   PUBMED   10677044
REFERENCE   7  (bases 1 to 4426)
  AUTHORS   Sato,T., Oyake,M., Nakamura,K., Nakao,K., Fukusima,Y., Onodera,O.,
            Igarashi,S., Takano,H., Kikugawa,K., Ishida,Y., Shimohata,T.,
            Koide,R., Ikeuchi,T., Tanaka,H., Futamura,N., Matsumura,R.,
            Takayanagi,T., Tanaka,F., Sobue,G., Komure,O., Takahashi,M.,
            Sano,A., Ichikawa,Y., Goto,J., Kanazawa,I. et al.
  TITLE     Transgenic mice harboring a full-length human mutant DRPLA gene
            exhibit age-dependent intergenerational and somatic instabilities
            of CAG repeats comparable with those in DRPLA patients
  JOURNAL   Hum Mol Genet 8 (1), 99-106 (1999)
   PUBMED   9887337
REFERENCE   8  (bases 1 to 4426)
  AUTHORS   Ansari-Lari,M.A., Oeltjen,J.C., Schwartz,S., Zhang,Z., Muzny,D.M.,
            Lu,J., Gorrell,J.H., Chinault,A.C., Belmont,J.W., Miller,W. and
            Gibbs,R.A.
  TITLE     Comparative sequence analysis of a gene-rich cluster at human
            chromosome 12p13 and its syntenic region in mouse chromosome 6
  JOURNAL   Genome Res 8 (1), 29-40 (1998)
   PUBMED   9445485
REFERENCE   9  (bases 1 to 4426)
  AUTHORS   Oyake,M., Onodera,O., Shiroishi,T., Takano,H., Takahashi,Y.,
            Kominami,R., Moriwaki,K., Ikeuchi,T., Igarashi,S., Tanaka,H. and
            Tsuji,S.
  TITLE     Molecular cloning of murine homologue dentatorubral-pallidoluysian
            atrophy (DRPLA) cDNA: strong conservation of a polymorphic CAG
            repeat in the murine gene
  JOURNAL   Genomics 40 (1), 205-207 (1997)
   PUBMED   9070948
REFERENCE   10 (bases 1 to 4426)
  AUTHORS   Onodera,O., Oyake,M., Takano,H., Ikeuchi,T., Igarashi,S. and
            Tsuji,S.
  TITLE     Molecular cloning of a full-length cDNA for
            dentatorubral-pallidoluysian atrophy and regional expressions of
            the expanded alleles in the CNS
  JOURNAL   Am J Hum Genet 57 (5), 1050-1060 (1995)
   PUBMED   7485154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050920.1 and BC053051.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_981322.1, NM_007881.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050920.1, SRR17784647.382743.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4421              BC050920.1         1-4421
            4422-4426           BC053051.1         4250-4254
FEATURES             Location/Qualifiers
     source          1..4426
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..4426
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /note="atrophin 1"
                     /db_xref="GeneID:13498"
                     /db_xref="MGI:MGI:104725"
     exon            1..192
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            193..367
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..3868
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /note="dentatorubral-pallidoluysian atrophy protein
                     homolog; dentatorubral pallidoluysian atrophy"
                     /codon_start=1
                     /product="atrophin-1"
                     /protein_id="NP_031907.2"
                     /db_xref="CCDS:CCDS20526.1"
                     /db_xref="GeneID:13498"
                     /db_xref="MGI:MGI:104725"
                     /translation="MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSD
                     GKAEKSRQTAKKARIEEPSAPKASKQGRSEEISESESEETSAPKKTKTEQELPRPQSP
                     SDLDSLDGRSINDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYH
                     PPPLFPPSPPPPDSTPRQPESGFEPHPSVPPTGYHAPMEPPTSRLFQGPPPGAPPTHP
                     QLYPGNASGGVLSGPPMGPKGGAAASSVGAPSGGKQHPPPTTPIPISSSGASGAPPAK
                     PPSAPVGGGSLPSAPPPASFPHVTPNLPPPPALRPLNNASASPPGMGAQPIPGHLPSP
                     HAMGQGMSGLPPGPEKGPTLAPSPHPLPPASSSAPGPPMRYPYSSSSSSAAASSSSSS
                     SSASQYPASQALPSYPHSFPPPTSMSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRL
                     LANNNTHPGPFPPTGGQSTAHPAAPTHHHHQQQPQQQHHHGNSGPPPPGAYPHPLESS
                     NSHHAHPYNMSPSLGSLRPYPPGPAHLPPPHGQVSYNQAGPNGPPVSSSNSSGSSSQA
                     SYSCSHPSSSQGPQGASYPFPPVPPVTTSSATLSTVIATVASSPAGYKTASPPGPPQY
                     SKRAPSPGSYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPL
                     PPAGPSSLSSLPPPPAAPTTGPPLTATQIKQEPAEEYEPPESPVPPARSPSPPPKVVD
                     VPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRARE
                     EKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVAT
                     VPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPA
                     AREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLH
                     PFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQML
                     NVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPL
                     LPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWL
                     HAHHPLHSVPLPAQEDYYSHLKKESDKPL"
     exon            368..505
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            506..619
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            620..2589
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2812
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..3509
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3653
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3834
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..4396
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4367..4372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /note="hexamer: AACAAA"
     polyA_site      4396
                     /gene="Atn1"
                     /gene_synonym="Atr1; atrophin-1; Drpla"
                     /note="major polyA site"
ORIGIN      
        1 gccgatcggg gctgcgcggg gagccgggca tgggggccgc cctccggggg ggccggggcc
       61 gccgccgccg ccgccgcggc agcgactgaa gccgcgctgt aaggaggggc ggggagtggc
      121 cgccgccgtc cccgggaggc gccggagccc gaccgcactc gcagccagcc agccgtcccg
      181 agctgctcgc agattcactg aaaacaccct gcaagtacca cgtgcctaca actgctgcca
      241 gcttcccagg ccacagctgt ggggagcttg gggtacagca gactcgtttc tgtattcagc
      301 tgcccaggca gaggagaatg gggtctccac agcctgaaga atgaagacac gacagaataa
      361 agactcgatg tcaatgagga gtggacggaa gaaagaggcc cccgggcccc gggaagagct
      421 gagatcaagg ggccgggcct cccctggagg ggtcagcaca tccagcagtg atggcaaagc
      481 tgagaagtcc aggcagacag ccaagaaggc ccggatagag gagccctctg ccccaaaggc
      541 cagcaagcag ggccggagcg aggagatctc agagagtgag agcgaggaga ccagtgcgcc
      601 caaaaagacc aaaaccgagc aggagctccc tcgcccgcag tctccctcgg atctggacag
      661 cttggatggg cgcagcatta acgatgacgg cagcagcgac cctagagata tagaccagga
      721 caaccgaagc acatccccca gcatctacag cccgggcagc gtggaaaatg actcggactc
      781 atcctctggc ctgtcccagg gccccgcccg cccctaccac ccacctccac tcttccctcc
      841 ttcccctcca ccaccagaca gcactccccg acagccagag tctggctttg aacctcatcc
      901 ttctgtgccg cctactggat atcatgctcc gatggagccc cccacatcga gattattcca
      961 gggcccacca cctggagctc ctcccacaca cccacagctc taccctggga atgctagtgg
     1021 aggtgtttta tctggacccc ccatgggtcc caaaggggga gccgctgcct cctcagtggg
     1081 tgcccctagc ggaggcaagc aacacccccc acccactacc ccaattccaa tatcaagttc
     1141 tggggccagt ggtgctcctc cagcaaagcc acccagtgct ccagtgggtg gtgggagctt
     1201 accttctgca ccaccaccag cttctttccc ccatgtgaca ccaaacctgc ctcctccacc
     1261 tgccctgaga cccctcaaca atgcctcagc ctctcctcct ggcatggggg ctcagccaat
     1321 ccctgggcat ctgccctctc cccatgccat ggggcagggc atgagtggac ttcctcctgg
     1381 cccagagaag ggtccaaccc tggccccttc tccccaccct ttgcccccag cttcttcctc
     1441 tgcccctggg cctccaatgc gatatccata ttcatcctcc agtagctctg ccgcagcctc
     1501 ttctagttcc tcctcctcct ctgcctccca gtaccctgct tcccaggccc tgcccagtta
     1561 tcctcattcc ttccccccac caactagtat gtctgtctct aatcagccac ccaagtacac
     1621 ccagccttct ctcccatccc aagctgtgtg gagccagggt ccacctcctc ctcctcccta
     1681 tggccgcctc ttggccaaca acaacaccca tccaggccct ttccctccta ctgggggtca
     1741 atctacagcc cacccagcag cccctacaca tcaccatcac cagcagcagc cacagcaaca
     1801 acatcatcat ggaaactctg ggccccctcc acccggagcg tatcctcacc ctctagagag
     1861 cagtaactcc catcatgcac acccttacaa catgtcaccc tccctggggt ctttaaggcc
     1921 ctacccccca gggccagcac acctgcctcc acctcatggc caggtgtcct ataaccaagc
     1981 aggtcccaat ggtcccccag tttcttcttc caactcttcc gggtcttcct ctcaagcctc
     2041 ctattcatgt tcacacccct cttcatccca gggcccccaa ggagcatcct accccttccc
     2101 accagtccct ccagtcacca cctcctcagc taccctttcc actgtcatcg ccaccgtggc
     2161 ttcctcgcca gcaggctaca aaacagcttc gccacctggg ccccctcagt acagcaagag
     2221 agccccatcc ccagggtcct acaagacagc caccccgcct ggatacaaac cggggtcacc
     2281 accctccttc agaacaggga ccccacccgg ctatcgaggc acctctccgc cagcaggccc
     2341 agggaccttc aaaccaggtt caccgaccgt ggggccgggg cccctgccac ccgcggggcc
     2401 ttcaagtttg tcatctctgc ctccgccacc tgcggccccg actacagggc cgcccctgac
     2461 cgccacgcag atcaaacagg agccggcgga agagtatgaa cctcccgaga gtccggtgcc
     2521 tccggcccgc agcccctcgc cccctcccaa ggtggtggac gtgcccagcc atgccagcca
     2581 gtcagccagg ttcaataagc acttggaccg cggcttcaac tcgtgcgcgc gcagcgacct
     2641 gtacttcgtg ccgctggagg gctccaagct ggccaagaag cgcgcggacc tggtggagaa
     2701 agtgcggcgc gaggccgagc agcgcgcgcg cgaggagaaa gagcgcgagc gcgagcggga
     2761 acgcgaaaag gagcgcgagc gcgagaaaga gcgcgagctg gagcgcagtg tgaaactggc
     2821 ccaggagggc cgtgctccag tggagtgccc atctctgggt ccagtgcccc atcggcctcc
     2881 ctttgagcct ggcagcgctg tggctacagt gcccccttac ctgggtcctg atactccggc
     2941 cttgcgcact ctcagtgaat acgcccgacc tcatgtcatg tctcctggca atcgcaacca
     3001 cccattctat gtgcccttgg gggcagtgga cccggggctt ctgggttaca atgtcccagc
     3061 cctgtacagc agcgacccag ctgcccgaga acgggagcgg gaagcccgtg aacgtgacct
     3121 ccgtgaccgg ctcaagcctg gctttgaggt gaaacctagt gagctggaac ccctacatgg
     3181 ggttcccggg ccaggcctgg atcccttccc ccgacacggg ggcctggctc tacagcccgg
     3241 gccacctggc ctgcatcctt tcccttttca tccgagcctg gggcccctgg aacgagaacg
     3301 gctagcgctg gcagctgggc cagccttgcg tcctgacatg tcttatgctg agcggttggc
     3361 agctgaaagg cagcatgcag aaagggtggc agccctgggc aatgatccac tagcccggct
     3421 gcagatgctc aacgtgactc cccatcacca ccagcactcc cacatccact ctcaccttca
     3481 cctgcaccag caggatgcta tccacgcagc ctctgcctcg gtgcaccctc tcattgaccc
     3541 cctggcctca gggtctcacc ttacccggat cccctaccca gctgggaccc tccccaaccc
     3601 ccttcttcct caccctctgc acgagaacga agttcttcgt caccagcttt ttgctgcccc
     3661 ttaccgggac ctgccggcct ccctttctgc tccaatgtca gcggctcatc agctgcaggc
     3721 catgcacgcg cagtcagctg agctgcagcg cttggcgctg gaacagcagc agtggctaca
     3781 tgctcatcac ccattgcaca gcgtgccact acctgcccag gaagactact acagtcacct
     3841 gaagaaggag agtgacaagc cgctgtagag ctgcgatcca gacagcaccc actgctcctt
     3901 catccagacc ttggaggacc accccaacct tttgacccca ccccaccccc agccgaggag
     3961 agggtgctgc ccgcttgcag agctcctgca gctgggtaga gggagggagg gaagaaggga
     4021 cagacaaggt cagggcccgg ggttgtgtgc agaggtggga agtggcaagg gtgggggcag
     4081 aaagtgcaca gtatcttgga ccaggtccct cctcctatcc cctgcttttc ttctcctcta
     4141 tgccgaatcc ttggtggcca ctgcccctcc cctaacccat tggtgtgatt tttttcatct
     4201 gttagatgtg gctgttttgc gtagcattgt gtgctgcccc gccccatccc tgtgtgtgca
     4261 ccccctccct cggcgatatg tgcccttacc cgtcccacat taataattta tatatataaa
     4321 tatctatatg atgctcttta aaaaacatcc tgaccaaaac caaccaaaca aaaacatcct
     4381 cacagttccc caggaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
