LOCUS       NM_177700               4900 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ATM interactor (Atmin), mRNA.
ACCESSION   NM_177700 XM_915513
VERSION     NM_177700.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4900)
  AUTHORS   Foster,H., Ruiz,E.J., Moore,C., Stamp,G.W.H., Nye,E.L., Li,N.,
            Pan,Y., He,Y., Downward,J. and Behrens,A.
  TITLE     ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma
  JOURNAL   Cancer Res 79 (20), 5159-5166 (2019)
   PUBMED   31481498
  REMARK    GeneRIF: Heterozygous Atmin deletion significantly increased tumor
            cell proliferation, tumor burden, and tumor grade in the
            LSL-KRasG12D; Trp53 F/F (KP) mouse model of lung adenocarcinoma,
            identifying ATMIN as a haploinsufficient tumor suppressor.
            ATMIN-deficient KP lung tumor cells showed increased survival in
            response to replication stress and consequently accumulated DNA
            damage.
REFERENCE   2  (bases 1 to 4900)
  AUTHORS   Richards,T., Modarage,K., Dean,C., McCarthy-Boxer,A., Hilton,H.,
            Esapa,C., Norman,J., Wilson,P. and Goggolidou,P.
  TITLE     Atmin modulates Pkhd1 expression and may mediate Autosomal
            Recessive Polycystic Kidney Disease (ARPKD) through altered
            non-canonical Wnt/Planar Cell Polarity (PCP) signalling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (2), 378-390 (2019)
   PUBMED   30414501
  REMARK    GeneRIF: This work indicates a novel role for non-canonical
            Wnt/planar cell polarity signalling in Autosomal Recessive
            Polycystic Kidney Disease and suggests ATMIN as a modulator of
            PKHD1.
REFERENCE   3  (bases 1 to 4900)
  AUTHORS   King,A., Li,L., Wong,D.M., Liu,R., Bamford,R., Strasser,A.,
            Tarlinton,D.M. and Heierhorst,J.
  TITLE     Dynein light chain regulates adaptive and innate B cell development
            by distinctive genetic mechanisms
  JOURNAL   PLoS Genet 13 (9), e1007010 (2017)
   PUBMED   28922373
  REMARK    GeneRIF: oncogenic MYC expression, which is synthetic lethal with
            Dynll1 deletion in B-2 cells, did not further reduce B-1a cell
            numbers in Dynll1-defcient mice. we found that the ASCIZ-DYNLL1
            axis was also required for the early-juvenile development of
            aggressive MYC-driven and p53-deficient B cell lymphomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4900)
  AUTHORS   Liu,R., King,A., Hoch,N.C., Chang,C., Kelly,G.L., Deans,A.J. and
            Heierhorst,J.
  TITLE     ASCIZ/ATMIN is dispensable for ATM signaling in response to
            replication stress
  JOURNAL   DNA Repair (Amst) 57, 29-34 (2017)
   PUBMED   28648892
  REMARK    GeneRIF: ASCIZ/ATMIN is dispensable for ATM activation, and
            contradict the previously reported dependence of ATM on
            ASCIZ/ATMIN.
REFERENCE   5  (bases 1 to 4900)
  AUTHORS   Anjos-Afonso,F., Loizou,J.I., Bradburn,A., Kanu,N., Purewal,S., Da
            Costa,C., Bonnet,D. and Behrens,A.
  TITLE     Perturbed hematopoiesis in mice lacking ATMIN
  JOURNAL   Blood 128 (16), 2017-2021 (2016)
   PUBMED   27581360
  REMARK    GeneRIF: ATMIN, therefore, has multiple roles in different cell
            types, and its absence results in perturbed hematopoiesis,
            especially during stress conditions and aging.
REFERENCE   6  (bases 1 to 4900)
  AUTHORS   Kanu,N., Penicud,K., Hristova,M., Wong,B., Irvine,E., Plattner,F.,
            Raivich,G. and Behrens,A.
  TITLE     The ATM cofactor ATMIN protects against oxidative stress and
            accumulation of DNA damage in the aging brain
  JOURNAL   J Biol Chem 285 (49), 38534-38542 (2010)
   PUBMED   20889973
  REMARK    GeneRIF: ATMIN mediates ATM activation by oxidative stress, and
            thereby ATMIN protects the aging brain by preventing accumulation
            of DNA damage.
REFERENCE   7  (bases 1 to 4900)
  AUTHORS   Jurado,S., Smyth,I., van Denderen,B., Tenis,N., Hammet,A.,
            Hewitt,K., Ng,J.L., McNees,C.J., Kozlov,S.V., Oka,H., Kobayashi,M.,
            Conlan,L.A., Cole,T.J., Yamamoto,K., Taniguchi,Y., Takeda,S.,
            Lavin,M.F. and Heierhorst,J.
  TITLE     Dual functions of ASCIZ in the DNA base damage response and
            pulmonary organogenesis
  JOURNAL   PLoS Genet 6 (10), e1001170 (2010)
   PUBMED   20975950
  REMARK    GeneRIF: Data indicate that, in addition to its role in the DNA
            base damage response, ASCIZ has separate developmental functions as
            an essential regulator of respiratory organogenesis.
            GeneRIF: Asciz is essential for mouse embryonic development and
            lung organogenesis likely as a transcription factor
            GeneRIF: Absence of Asciz (Atmin) leads to increased oxidative and
            methylating DNA base damage sensitivity in primary fibroblasts
            GeneRIF: Asciz (Atmin) deletion or knock-down does not affect ATM
            levels and activation in mouse, chicken, or human cells
            Erratum:[PLoS Genet. 2010;6(11). doi:
            10.1371/annotation/bce92e15-60b4-493b-89de-28529386f4ac]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4900)
  AUTHORS   Ermakov,A., Stevens,J.L., Whitehill,E., Robson,J.E., Pieles,G.,
            Brooker,D., Goggolidou,P., Powles-Glover,N., Hacker,T., Young,S.R.,
            Dear,N., Hirst,E., Tymowska-Lalanne,Z., Briscoe,J., Bhattacharya,S.
            and Norris,D.P.
  TITLE     Mouse mutagenesis identifies novel roles for left-right patterning
            genes in pulmonary, craniofacial, ocular, and limb development
  JOURNAL   Dev Dyn 238 (3), 581-594 (2009)
   PUBMED   19235720
REFERENCE   9  (bases 1 to 4900)
  AUTHORS   Quwailid,M.M., Hugill,A., Dear,N., Vizor,L., Wells,S., Horner,E.,
            Fuller,S., Weedon,J., McMath,H., Woodman,P., Edwards,D.,
            Campbell,D., Rodger,S., Carey,J., Roberts,A., Glenister,P.,
            Lalanne,Z., Parkinson,N., Coghill,E.L., McKeone,R., Cox,S.,
            Willan,J., Greenfield,A., Keays,D., Brady,S., Spurr,N., Gray,I.,
            Hunter,J., Brown,S.D. and Cox,R.D.
  TITLE     A gene-driven ENU-based approach to generating an allelic series in
            any gene
  JOURNAL   Mamm Genome 15 (8), 585-591 (2004)
   PUBMED   15457338
REFERENCE   10 (bases 1 to 4900)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045227.1, CJ089804.1 and BC060631.1.
            
            On Jun 6, 2009 this sequence version replaced NM_177700.3.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is well supported by available conservation
            data. The use of an alternative upstream start codon would result
            in a protein that is 98 aa longer at the N-terminal.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060631.1, AK122281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ045227.1         2-6
            6-15                CJ089804.1         7-16
            16-4900             BC060631.1         1-4885
FEATURES             Location/Qualifiers
     source          1..4900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 63.37 cM"
     gene            1..4900
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /note="ATM interactor"
                     /db_xref="GeneID:234776"
                     /db_xref="MGI:MGI:2682328"
     exon            1..358
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2491
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /note="ATM/ATR-substrate CHK2-interacting zinc finger
                     protein; ATM/ATR-substrate CHEK2-interacting zinc finger
                     protein; ASCIZ"
                     /codon_start=1
                     /product="ATM interactor"
                     /protein_id="NP_808368.3"
                     /db_xref="CCDS:CCDS22694.2"
                     /db_xref="GeneID:234776"
                     /db_xref="MGI:MGI:2682328"
                     /translation="MAATEAAAADSAGPAPGVPATPASTRGAAAASSPWRPPESRLQG
                     SRPRPARARAAAPVPPARELIQPTVSELSRAVRTNILCTVRGCGKILPNSPALNMHLV
                     KSHRLQDGIVNPTIRKDLTTAPKFYCCPIKGCPRGPDRPFSQFSLVKQHFMKMHAEKK
                     HKCSKCSNSYGTEWDLKRHEEDCGKTFQCTCGCPYASRTALQSHIYRTGHEIPAEHRD
                     PPSKKRKMESYLQNQKLSSKTTEPLSDQAAPRQDAAEPDAPEVKPAASLEDSCSAHTK
                     KQSVATPPRCPQKLLLPKPKVALVKLPVMQFSPVPVFVPTAESSAQPVVLGVDHSSAA
                     GTVHLVPLSVGALILSLDSEACSLKESLPLSKIISPVVEPMNTGVQVNLGKSLCSPLQ
                     EVGSVCQRTSISSSNVQTDLTYASANLIPSAQWLGPDSSVSSCSQTDLSFDSQVSLPV
                     SVHTQTLVPSSKVTSSIAAQTDAFIDACFQPGGVSRETQTSRMQNRTNDSVPVGHTGL
                     CGDIFESVHASYSVPTDTIMSSSLVAETGTHGLPPQSDPKILGQVMEKSAPVLNFSTQ
                     NGLLPAHTMTDNQTQTIDLLSDLENILSSNLPGQTLDNRSLLSDTNPGPDAQLPAGSA
                     QNSGIDFDIEEFLSASNIQTQTEESELSSMSTEPVLESLDIETQTDVLLSDPSTQPYG
                     FRAGSGFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSMSTDSSDTETQTEGA
                     CPARHLPALESKVQLSSTETQTMSSGFEPLGNLFLTSNETQTAMDDFLLADLAWNTME
                     SQFSSVETQTCAELHAVSSF"
     exon            359..484
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /inference="alignment:Splign:2.1.0"
     exon            485..684
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /inference="alignment:Splign:2.1.0"
     exon            685..4877
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2654..2659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /note="hexamer: TATAAA"
     polyA_site      2679
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /note="major polyA site"
     regulatory      4855..4860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /note="hexamer: ATTAAA"
     polyA_site      4877
                     /gene="Atmin"
                     /gene_synonym="Asciz; gpg6; mKIAA0431"
                     /note="major polyA site"
ORIGIN      
        1 actgcgagag gggcctggcg gccgtgcggg agccatggcg gccacggagg cggcggcggc
       61 cgattctgcg ggtccggccc cgggtgtccc ggccacgccg gcgagcacgc ggggagccgc
      121 cgccgcctct agcccgtgga ggccgcccga gtcgcgactg caaggcagcc ggccgagacc
      181 ggccagggct cgggccgcgg ccccggtgcc accggcccgg gagctgatcc agccgactgt
      241 gagcgagctg tcccgggctg tgcgcaccaa tattctgtgc accgtgcgcg gctgcggcaa
      301 gatcctgccc aacagccctg cgctcaacat gcacctcgtc aagagccacc gactgcagga
      361 tggcatagta aacccgacaa taaggaaaga cttgacaact gcaccgaaat tctactgttg
      421 tccaatcaaa ggatgtcctc gaggccccga ccgaccgttt tctcagtttt ctctggttaa
      481 acagcacttt atgaaaatgc atgcagagaa gaagcacaaa tgcagtaagt gcagtaattc
      541 ctacggcacc gagtgggacc tgaaaagaca cgaggaggat tgtggcaaga ccttccagtg
      601 tacgtgcggc tgtccctacg ccagcagaac cgcactgcag tctcacatct accgaactgg
      661 ccacgagatc cctgcagagc acagagaccc acctagtaaa aaaaggaaaa tggaaagcta
      721 cctgcaaaac caaaagttgt ccagtaaaac cactgaacca ctgagcgacc aagcagcccc
      781 gcgccaagat gctgctgaac cggatgctcc ggaggtcaag cctgcagcat ccctcgaaga
      841 ctcctgtagc gcccacacca aaaagcagag cgtcgcgacg cctccccggt gtccccagaa
      901 gttgctgtta ccaaagccca aggtggctct ggttaaactc ccagtcatgc agttttcccc
      961 cgtgcctgtc tttgtgccta cagcggagtc ctcggcccag cctgtggtgt taggtgtgga
     1021 tcacagttct gcagccggta ctgtgcactt agtacctctg tcggtaggag ccctgatcct
     1081 cagcctggac tcagaggcct gctctctgaa ggagagccta cctctctcaa aaattatcag
     1141 tcctgttgtt gagccaatga atacaggtgt tcaagtgaac ttgggtaaaa gcctgtgtag
     1201 tcctttacaa gaggtaggga gtgtgtgtca gaggaccagc atttcctcaa gcaacgtgca
     1261 gacagatctg acctatgcct cagccaactt gataccctct gctcagtggc tcggccctga
     1321 ttcctctgtg tcatcgtgtt ctcagactga cctgtcgttt gattctcaag tgtcccttcc
     1381 tgttagtgtc cacacccaga cgttggtgcc cagctctaag gtcacttcat ccatagctgc
     1441 tcagacagat gcatttatag acgcctgttt ccagcctggt ggggtctcca gggaaaccca
     1501 gaccagcagg atgcagaacc gcacaaacga ctcagtgcca gtgggccaca ctggcttgtg
     1561 tggggacatt tttgaaagcg tgcatgcgtc atacagtgtg cctactgaca ccatcatgag
     1621 tagcagctta gttgcagaga cagggactca tggtctgcca cctcagagtg accctaagat
     1681 cttaggccaa gtcatggaaa agtctgcacc cgtgttaaac ttcagcaccc agaacggctt
     1741 gcttcctgca cacaccatga cagataatca gacccaaacc atagatctgc tgagcgactt
     1801 ggaaaacatc ttgtcaagta acctgccagg tcaaacactg gataaccgga gtctcttgtc
     1861 cgacaccaac cccggacctg acgcccagct cccagctggc tcagcgcaga attctgggat
     1921 tgattttgat attgaagagt tcctctcagc ctccaatatc cagactcaga ctgaggagag
     1981 tgagctcagc tccatgagca ctgagccggt cctggagtcc ctggacatcg agacgcagac
     2041 cgacgtcctc ctctcagatc cctccacaca gccctatggc ttcagagcgg ggtcaggctt
     2101 cctgggcctt gagatgttcg acacacagac acaaacagac ttaaacttct tcttagacag
     2161 tagtcctcac ctgcccctgg gcagcatcct gaaacactcc agcttctcca tgagtaccga
     2221 ctcctctgac acagagaccc aaactgaagg agcctgccct gctcggcacc tgcctgctct
     2281 ggagagcaag gtccagttga gcagcacaga aacacaaacc atgagttctg gcttcgagcc
     2341 cctggggaac ttgttcctca ccagcaacga aactcagaca gcaatggatg acttccttct
     2401 agccgatctg gcctggaata cgatggagtc ccagttcagc tccgtggaaa cccagacatg
     2461 cgcagagctg cacgctgtct ccagcttctg aaggtgcagc caggcatccc cgctccttgt
     2521 gcgtttagaa catgggctca aggacagcgg caccgactgg ggatgtagtc agtggggcag
     2581 ctgtttagat tctcttcagt tcttggtgtt ttgtactcgt gaccacaaga ttggtgtgca
     2641 aatgtgagtg tattataaag tgtaagtgtt gatctgaaat gtcgcctatg tttgctcctg
     2701 tgtagctatt ctatcttttt ttaaaaaaaa atgcatttga cactgtaaaa cttagaactg
     2761 tttagctaat gccaagctta gcaggtggta gggggcaagc tttgtggctg ctttaactga
     2821 gtatagcaca cttaaatggc atctccacgt aaagggcacc tcaaatgctc agacaatgtt
     2881 tgtgtggccg ctaactcctg agatgccacc accttgcctt gtcatgtccc tctgactcgg
     2941 aagcaccaag ggaagccaca cctgtcttta gcttttatga cagttttgag tctcttctgt
     3001 cccttccctg ctgagctgtg actgccgcca gcttcgtgtg ccatccttct cccaatgtga
     3061 ggttactggc cagtgtgaga acagcaagca ctcggtgtca atggcaggct tagtacgagg
     3121 aaggtatcca gctgtggaga tgcctgcgca ctgtggacac cctcagttct gttcatctca
     3181 ggctcatccc gcttcgtgga cgagctctcc tctgctccct ccagagtgtt gatcaaatct
     3241 gtgggattgc catgtgccag acggcagcca gctgtgagca cacagtagct agagggtagt
     3301 tcctggttga ccccagagct tctagctgtc tgtaaattgg ggttcctatg actccacact
     3361 ctttgtgctc agtgaattta ctagaactca gggatactgt ttctgtgaag ggtaggctgg
     3421 gtgcaaaggg gcagaggact tccacacctt ctctaggcac acctcctacc aagaatctgc
     3481 ctgttagcct cgtaggaacc tccaaactca gtcttgtggg gttaatggct gctttgttgt
     3541 gtgggtagag agttgcttaa accattagca atcaacttaa ccttgagtgt caccctatct
     3601 ggtgggttgg gaggtaggga tgaagctgaa aataccccaa cctttcgatc attaattatt
     3661 ccttggtctc tcctgtgact tgtccccatc ctaatgctac ccagatgcta ccagctacca
     3721 atgacctcat agcaagcaaa agcaaaacat tttttctgaa gactttgggg tgggggcaag
     3781 ttgtgatata cattacatca cctcccccac aaacatcctt cctgctccac agtagaccat
     3841 ggggcctgcc cgactgcttc ccataatgga cttagagacc ctctaagaat taaaaaggaa
     3901 ggcatgggtg ggggaaaggc tttcctgccc agcccccgcc agtatgctgc acttgttatc
     3961 ttgataggag aagcagggcc cacaatgtct ttccttccac ccacccccat ctcctccctg
     4021 aaagaagctc ttaggtctgg caagcatagt atgtgtaccc tgagactagc aactgtagaa
     4081 tagacccatc taaagtacgc tgatctagat tatgttgtga tgcattcttt aaagaggaaa
     4141 aatctggaga gcaattgctt caacggttaa gaatactctc actctgaggg gagagcgagg
     4201 tcaagcctgc ctggggggct ctgtgctaag tagatcatgg attcatagct ggtgcccaac
     4261 tctgaggcaa attcagaatc agcccagcct ggggaccttt ccagtctagc ctggatggaa
     4321 aagccctgtt cttttggcat acgtttgtgc tgccaaaagc tgaaccttca aaatgaaacc
     4381 taagggggct ggtgatgact cattaaataa gttggtattg ctgctgtcct gtcccattca
     4441 cccgatgcag aggactcggg aatgggctaa taacacaccc ggcaggtgaa tgcaacccag
     4501 gagctaaaca gtggttgtgg ccacagtcgc ctgtgaatgt gagtttcaga acagacacaa
     4561 agccttaact tagattttct gttgttttgg actcgtccac tgccttaacg ctcaagcatc
     4621 tatttaagcc ctccggctga aggagaagtg catgtctgct cgtggctctt tgtaaatata
     4681 agtgcagcaa tctatggctt tttaagtttt tgtgtctgtg gcgatgtgtc ttaatagtta
     4741 caagataaag aatggagcat gtaattgtcc ttcatgtgca agaactgtcc ccacaaaaat
     4801 cttaagtcac ctgaactccc ctaaggttgg ttgtttgtga acataaattt ggtgattaaa
     4861 gagaagctag aattctaaaa aaaaaaaaaa aaaaaaaaaa
//
