LOCUS       NM_146091               6387 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus atlastin GTPase 3 (Atl3), transcript variant 2, mRNA.
ACCESSION   NM_146091 NM_027566
VERSION     NM_146091.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6387)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6387)
  AUTHORS   Behrendt,L., Hoischen,C. and Kaether,C.
  TITLE     Disease-causing mutated ATLASTIN 3 is excluded from distal axons
            and reduces axonal autophagy
  JOURNAL   Neurobiol Dis 155, 105400 (2021)
   PUBMED   34019998
  REMARK    GeneRIF: Disease-causing mutated ATLASTIN 3 is excluded from distal
            axons and reduces axonal autophagy.
REFERENCE   3  (bases 1 to 6387)
  AUTHORS   Lee,S.H., Hadipour-Lakmehsari,S., Murthy,H.R., Gibb,N., Miyake,T.,
            Teng,A.C.T., Cosme,J., Yu,J.C., Moon,M., Lim,S., Wong,V., Liu,P.,
            Billia,F., Fernandez-Gonzalez,R., Stagljar,I., Sharma,P.,
            Kislinger,T., Scott,I.C. and Gramolini,A.O.
  TITLE     REEP5 depletion causes sarco-endoplasmic reticulum vacuolization
            and cardiac functional defects
  JOURNAL   Nat Commun 11 (1), 965 (2020)
   PUBMED   32075961
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6387)
  AUTHORS   Zhao,G., Zhu,P.P., Renvoise,B., Maldonado-Baez,L., Park,S.H. and
            Blackstone,C.
  TITLE     Mammalian knock out cells reveal prominent roles for atlastin
            GTPases in ER network morphology
  JOURNAL   Exp Cell Res 349 (1), 32-44 (2016)
   PUBMED   27669642
  REMARK    GeneRIF: Endoplasmic reticulum morphology is markedly disrupted in
            ATL1, ATL2, and ATL3 knockout cells.
REFERENCE   5  (bases 1 to 6387)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   6  (bases 1 to 6387)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA318221.1, BY108453.1, AK077752.1, AK147720.1, AK085735.1,
            AC163276.4 and BP759756.1.
            
            On Jul 29, 2009 this sequence version replaced NM_146091.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147720.1, AK028842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               CA318221.1         1-135
            136-138             BY108453.1         134-136
            139-2001            AK077752.1         2-1864
            2002-4368           AK147720.1         1960-4326
            4369-5416           AK085735.1         1899-2946
            5417-5885           AC163276.4         4432-4900           c
            5886-6387           BP759756.1         33-534              c
FEATURES             Location/Qualifiers
     source          1..6387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.32 cM"
     gene            1..6387
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /note="atlastin GTPase 3"
                     /db_xref="GeneID:109168"
                     /db_xref="MGI:MGI:1924270"
     exon            1..224
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1804
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     atlastin-3"
                     /codon_start=1
                     /product="atlastin-3 isoform 2"
                     /protein_id="NP_666203.3"
                     /db_xref="CCDS:CCDS29527.1"
                     /db_xref="GeneID:109168"
                     /db_xref="MGI:MGI:1924270"
                     /translation="MLSPQRTAAVASRGAGDAMENGKPGPVQVVLVHKEQHSFELEER
                     ALASVLLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYSQKEGGHSDWLGDPEEP
                     LTGFSWRGGSDPETTGIQIWSEVFTVKKPCGKKVAVVLMDTQGAFDSQSTVKDCATIF
                     ALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEIFQKPFQTLMFLIRDWSFP
                     YEYNYGLQGGMAFLDKRLHVKEHQHEEIQNVRNHIHSCFSDVTCFLLPHPGLQVATSP
                     NFDGKLKDIASEFKEQLQALIPYVLNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQG
                     EDLPHPKSMLQATAEANNLAAAASAKDIYYNNMEEICGGEKPYLSPDILEEKHLEFKQ
                     LALDHFKKIKKMGGKDFSFRYQQELEEEIKELYENFCKHNGSKNVFSTFRTPAVLFTG
                     IAALYIASGFTGFIGLEVVAQLFNCMVGLLLIALLTWGYIRYSGQYRELGGAIDSGAA
                     YVLEQASSHIGNSTQAAVRDAVVGRPPADKKSQ"
     exon            225..439
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            440..583
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            584..688
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..739
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            740..796
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            797..889
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1028
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1156
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1213
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1285
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1717
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..6377
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /note="hexamer: AATGAA"
     polyA_site      1969
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /note="major polyA site"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2730
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
     regulatory      6354..6359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      6377
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /note="major polyA site"
ORIGIN      
        1 cctcgtcacg ccctgcgcca tcggcagggc tgtctcctga gctgtaggct ttctccgcgc
       61 gcccctcctt ctcggtttct ccccaagtcc aggctccgcc tgtttccctc ctccagggca
      121 gcctcaaccc gctcctgtct tctctgcctc tgctacttct gctgaaggag gaggctccat
      181 gttgtcccct cagcgaactg cagcggtggc atcgagagga gcaggtgatg ccatggaaaa
      241 tggaaaacct ggtccagtgc aggttgtttt ggttcataaa gaacaacatt cctttgagct
      301 agaagagaga gccttggcca gcgtcctcct ccaagaccat atccgagatc ttgatgtggt
      361 ggtagtatca gtggctggtg cttttcgaaa gggtaaatcc ttcattctgg actttatgct
      421 gcgatactta tattctcaga aggaaggtgg tcattcagac tggttgggtg acccagaaga
      481 acctctgaca ggattttcat ggcgaggagg ctctgatcca gaaactactg ggattcagat
      541 ttggagtgaa gttttcactg tgaagaagcc atgtggaaaa aaggttgcag ttgttctgat
      601 ggatacccag ggggcctttg acagccagtc aactgtgaag gattgtgcta ccatttttgc
      661 tctaagcact atgactagtt ctgttcagat ttacaatttg tcccagaata ttcaggaaga
      721 tgatcttcag cagctacagc tcttcacaga atatggccgc ctggcaatgg atgaaatttt
      781 ccaaaaacct tttcagacac tgatgttttt gattcgagat tggagtttcc cttatgaata
      841 taactatgga ctgcaaggag gaatggcatt tttggataag cgtttacatg tgaaggaaca
      901 tcaacatgaa gaaattcaga atgtgagaaa tcatattcac tcatgtttct ccgatgtcac
      961 ctgttttctc ttaccacatc cagggctcca ggtggccaca agccccaact ttgatgggaa
     1021 attgaaagat attgctagtg aattcaaaga gcagttacag gctctaatac catatgtact
     1081 aaatccatct aaattaatgg agaaggagat caatggttca aaagtcacct gccggggatt
     1141 gttggaatat tttaaggcat atattaaaat ttaccaagga gaagatctgc ctcacccgaa
     1201 gtccatgctt caggccactg ctgaagccaa taatttggca gctgcagcct ctgccaaaga
     1261 tatttattac aacaacatgg aagagatttg tgggggagag aaaccttatt tgtctccaga
     1321 tattttagaa gagaagcacc tagaattcaa acaacttgct ctggaccact ttaagaagat
     1381 caaaaagatg ggtgggaagg atttcagctt ccgttaccag caggaactgg aggaggaaat
     1441 caaagaactg tatgagaact tctgcaagca caacggcagc aagaatgtct tcagcacctt
     1501 ccgaacccct gcagttctgt tcacaggcat agcagcattg tacatagcct cgggcttcac
     1561 gggcttcatt gggcttgagg ttgtggccca gctgttcaac tgtatggttg gactgctctt
     1621 aatagcactc cttacctggg ggtacatcag atattccggg cagtatcgtg agctgggtgg
     1681 agccattgac tccggtgcag catatgtgtt agagcaggct tcttcgcata ttggtaattc
     1741 tactcaggct gcagtaaggg atgccgttgt tgggagacca cctgctgata aaaaatctca
     1801 atagcatctt aatgggaaga tccaacaaga gcccagtcag cttctggatt tctgccaatg
     1861 ccatcacggg tccaattcca gaggaatggc agatctgaga ccattctgga agatctgaga
     1921 cagggcactg taataaatga actgacttct gctctggttt ccaactccac ttggcttgga
     1981 agcagttctt tttcttgctg ttacagactc aaggctactc ttttctctgt tctctgcttt
     2041 ttgcacttta aggggtgggg gtggggctaa aaggaaaaca gaaatgcagc ttttgagtct
     2101 ttgatgtgcc acatagtgcc ttttcagacc agtgcatccc tctgcagcca tggaggctaa
     2161 ggaacggagg gcaacctcat gaaatgtggt tttggatcaa tgtggtttta gttcttttgt
     2221 acctttgaag atttgtcttt ttaaaagttt acaccacttg aaaaaggctc agaaagaaag
     2281 gcccactgaa atgatgcttt attatccttc aaaagttttc tcccagtact ggtgattgaa
     2341 cctgttgcct gagtatgcta agcagttgct ctcccctgca gctgccccca gcccacttga
     2401 ctgtgcagac tcagggcttg caattactcg attctccgcg gctgagcttc ccatcgtcct
     2461 ctctccctaa ggtcctgagt agttgaatac agacttgtgg tgccatcctt gcttcaaaag
     2521 ccatatttat atgagttctc tttgctatgc agcatgaaag acgttaagtc acttagtact
     2581 ctgtttcaga ttgtaaggcc ttacaccgag gaggctggca gttttgtcga cattgctttc
     2641 ttatttttat ttctatagct tctttctaga aaagaggcaa actattctta aaaagtcagt
     2701 ggttcataat aaaaggaact agatactcca tggaaattgt agtttgaatg aaccatgaga
     2761 cctctgataa agtcaccttg aatttgtgtc ttggttagat tcactgtaca tttatgtcac
     2821 tgtacattta tgccacaaaa atagtcattt tcaacagaga aaaggcatga ccaaatatta
     2881 ctccttttaa ttaatgttca ctttcatttt gcctagcggt aataccaaat gatctaatct
     2941 aaagtctcta cctaaactct gtgtatgtgt gtgtgtgtat gtgtcgcatg gtgtttccct
     3001 ggcgtgtaga ccaggctagc cttgaactca tagagatatt tgtgcctctg tgtaccattg
     3061 tgcctggccc taaactgctt tttattctat atactatcta atgttcataa tatcaaagct
     3121 agactgttaa ttttatttag taagttttcc cttttttttc ctccatcgaa gaagaaagtg
     3181 tactcagtct agccaaacta tttaaaatat ctcttaagcc aggtggcatt agcacacacc
     3241 tttagtccca acacttcaga ggcagaggca ggtagatcat ctctgtgagt ttgaggccaa
     3301 cctggtctac agagttaaat tccaggatgg ccagggctat ccagagaaac tgtctcaaaa
     3361 aaccagaaaa caaattccct ctcgattctt cttttggtta gtctagcagt ttgaaaataa
     3421 ttggcttagg aaggataatt gctaagactc tcatatttat ttttttacat ttaccttgat
     3481 tatgtgataa agttttatct attgcttttt ttctttgact tgtagtagtg aattattgtg
     3541 gacctaaacc ttctgaaggt atagaagcct tgattttgga gataatgtga gattttgttg
     3601 caggaaggag atacagggtt ttggcaaagc ctagtgtacc ttttatgtac atggagtatg
     3661 agaggaaggt aagagaaaag gaagtcttca tttcatttct ctttaatgca caactttctt
     3721 gttagtaacg gctttccagt caaacattta atgaatcctg aattaatatt aagtatttta
     3781 tatattttca taccatctca tcctgaaaat gttagtagtt tttccttttg ctgtgacatt
     3841 tgggaatggt tccaacttgt tttaaaacta ctcactgctc gtgagtgatg gctgactgta
     3901 aggggcttga aactcactcc tggcgtagtg cagagttttt aggtaatgtc ccctatccga
     3961 acgcttgtat tgagttaagt actcctgata ctgagataag gtcagagagg gttttgggga
     4021 cagggttttg ttatatagtc taggtcagcc tttaacttac tttgtagttt agactggctt
     4081 tgaatttgag gttttgctgc ctcagactcc ccaagtgctg agcttgtagg agtgtgtccc
     4141 catgcccacc tctggttctc ttaatgatga ggaagacgat gtggggaaac tttgccattg
     4201 cttcagtatt acatctgtgt gtgtgtttaa agtgagtgtt ccattaatta gcttactctg
     4261 ctcctgggac atgtatataa agtttctttg agggttggcc tgttttctaa ctttaaattg
     4321 tggattttct attacaattt tcaacacaaa atgccttttt atgactggct ggaaatagtt
     4381 ctgaggagac tcataactgg ttgaaagagt ctcagccttt gctttgtggc tctgggacat
     4441 ggtgaaggag tcagatcagt gtccctatag gtgttctgta caggcaatat tcgtgcactt
     4501 ctgtcactaa gtgtagcaca tttatatgat ataatggaga tttcattaaa aataactcac
     4561 tttaggaaaa gctagttgtt gccaagatgt ccttgttttt gttttgggtg ctgggggtgc
     4621 attcacaggg ctctgtgtat gccaggggct agctctatgc accaggtgta gcgctttagt
     4681 gtgcctctta tcaaatggat aaaattacaa ctttgattct ttcactgaga aatctctcat
     4741 gatttattgc ttactgataa attttgagca tctcttttga agaataccaa aaatctgtct
     4801 catagatgct tgtgacattt ctgtcctctt tccctccctc tacccctttc tctttttctt
     4861 tttctatgca gctccagcca gaggtttgtg tttgatacct gctgtatact gggtcaggcc
     4921 tctgaatgtt tatgcttgat tcactttctc tcactcatta agacagacac gcattgtatt
     4981 ttccatgtag tttctttagt aggtcacaca cagtggttgg tacctggaat atgtgaatga
     5041 gacaaaaatt cagtaggtta atataagccc aagcaaaagg aacccccctc ccatctccca
     5101 agtgccatgg aaatatcaaa aagacctatt ttgtttgtgt aagttttttg gaatatagtt
     5161 gagtatgatt ttatttattt tttttaatca ggtggccaac atctctgtat tttgcaacct
     5221 agcaagtgga accagtgtgt tttttgtcag gagtgaggcc ataagcaagc ctcatttagc
     5281 aaagtgaaaa gtattcttgt ctcatgtggc ctgccgtagt gtctacggtt attttcatca
     5341 ggagttgtac tgtggctcca tcttggacac tggttcttat ctaccttttc atgctttaga
     5401 ttaatgtaca gggtgtacta aaagaaaatg ggactctgct ttgtagctag ggattgctga
     5461 agtggctttg tgctgtggcc ctgggatcat catttataaa catcagtagg tgaaaggtgg
     5521 gtgggtgggg gtggggtgaa tgatggagac tgagctgacc catggactgg aagtacccag
     5581 acaggagggc tcttcagcat ttctagcagc tttacctgag ctctgcctcc aggtctgctc
     5641 cccctagagt ttgctatgtt tagaaccatc agggtatcct aattcagatg attgtccaag
     5701 ctttttaaag ctgtcatagt gccttctctt aatgcctgcc tcacacacaa acaggtaatt
     5761 gggaaaacat tttaaaattt ttgagagtgt cctctttctc actctaaaaa agccccattg
     5821 ggcactgtga cttgaattcc tacatctttt gctgttttgt tttgagaaag ggtctcagtg
     5881 taaccttgtc tgttctggaa ctcaccatat atatagacca cgctggcctt aagctcacag
     5941 agatcaactt gtctctgcga atcccgaaac ctttaacaca cagaaaaccc taatgtatta
     6001 aatacctaat gaataaaaag gatgagatca taactatgaa agtcgttacc tatgtactcc
     6061 acagcaggaa ccagaacgct ttcttacagg aaagaatttc atgtgccaga gctggtgtaa
     6121 tgctcttaca aagtgaaggt cacattaatg cccaaacctt atagtcaggt gatcaaaatt
     6181 gttatgaatg taaaccttac aagaggtaaa tcttgaatat acacagttgt tctcaatttt
     6241 attttaaaaa tggtttgtta tgctttctgc taggtcattt gcctttgaat ggctttaaga
     6301 ctatagtttt ctttaaagca caatgggaat caatgatgct gtacatttaa tggattaaag
     6361 atcacaccac cgtgtcaaaa aaaaaaa
//
