LOCUS       NP_666203                541 aa            linear   ROD 27-APR-2025
DEFINITION  atlastin-3 isoform 2 [Mus musculus].
ACCESSION   NP_666203 NP_081842
VERSION     NP_666203.3
DBSOURCE    REFSEQ: accession NM_146091.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 541)
  AUTHORS   Behrendt,L., Hoischen,C. and Kaether,C.
  TITLE     Disease-causing mutated ATLASTIN 3 is excluded from distal axons
            and reduces axonal autophagy
  JOURNAL   Neurobiol Dis 155, 105400 (2021)
   PUBMED   34019998
  REMARK    GeneRIF: Disease-causing mutated ATLASTIN 3 is excluded from distal
            axons and reduces axonal autophagy.
REFERENCE   3  (residues 1 to 541)
  AUTHORS   Lee,S.H., Hadipour-Lakmehsari,S., Murthy,H.R., Gibb,N., Miyake,T.,
            Teng,A.C.T., Cosme,J., Yu,J.C., Moon,M., Lim,S., Wong,V., Liu,P.,
            Billia,F., Fernandez-Gonzalez,R., Stagljar,I., Sharma,P.,
            Kislinger,T., Scott,I.C. and Gramolini,A.O.
  TITLE     REEP5 depletion causes sarco-endoplasmic reticulum vacuolization
            and cardiac functional defects
  JOURNAL   Nat Commun 11 (1), 965 (2020)
   PUBMED   32075961
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 541)
  AUTHORS   Zhao,G., Zhu,P.P., Renvoise,B., Maldonado-Baez,L., Park,S.H. and
            Blackstone,C.
  TITLE     Mammalian knock out cells reveal prominent roles for atlastin
            GTPases in ER network morphology
  JOURNAL   Exp Cell Res 349 (1), 32-44 (2016)
   PUBMED   27669642
  REMARK    GeneRIF: Endoplasmic reticulum morphology is markedly disrupted in
            ATL1, ATL2, and ATL3 knockout cells.
REFERENCE   5  (residues 1 to 541)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   6  (residues 1 to 541)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA318221.1, BY108453.1, AK077752.1, AK147720.1, AK085735.1,
            AC163276.4 and BP759756.1.
            
            On Jul 29, 2009 this sequence version replaced NP_666203.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147720.1, AK028842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.32 cM"
     Protein         1..541
                     /product="atlastin-3 isoform 2"
                     /note="atlastin-3"
                     /calculated_mol_wt=60444
     Region          1..22
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YH5.1)"
     Region          37..305
                     /region_name="GBP"
                     /note="Guanylate-binding protein, N-terminal domain;
                     pfam02263"
                     /db_xref="CDD:460516"
     Site            391
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6DD88; propagated from
                     UniProtKB/Swiss-Prot (Q91YH5.1)"
     Site            446..466
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YH5.1)"
     Site            468..488
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YH5.1)"
     CDS             1..541
                     /gene="Atl3"
                     /gene_synonym="4633402C03Rik; 5730596K20Rik"
                     /coded_by="NM_146091.4:179..1804"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS29527.1"
                     /db_xref="GeneID:109168"
                     /db_xref="MGI:MGI:1924270"
ORIGIN      
        1 mlspqrtaav asrgagdame ngkpgpvqvv lvhkeqhsfe leeralasvl lqdhirdldv
       61 vvvsvagafr kgksfildfm lrylysqkeg ghsdwlgdpe epltgfswrg gsdpettgiq
      121 iwsevftvkk pcgkkvavvl mdtqgafdsq stvkdcatif alstmtssvq iynlsqniqe
      181 ddlqqlqlft eygrlamdei fqkpfqtlmf lirdwsfpye ynyglqggma fldkrlhvke
      241 hqheeiqnvr nhihscfsdv tcfllphpgl qvatspnfdg klkdiasefk eqlqalipyv
      301 lnpsklmeke ingskvtcrg lleyfkayik iyqgedlphp ksmlqataea nnlaaaasak
      361 diyynnmeei cggekpylsp dileekhlef kqlaldhfkk ikkmggkdfs fryqqeleee
      421 ikelyenfck hngsknvfst frtpavlftg iaalyiasgf tgfiglevva qlfncmvgll
      481 lialltwgyi rysgqyrelg gaidsgaayv leqasshign stqaavrdav vgrppadkks
      541 q
//
