LOCUS       NM_019717               3639 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus atlastin GTPase 2 (Atl2), transcript variant 1, mRNA.
ACCESSION   NM_019717
VERSION     NM_019717.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3639)
  AUTHORS   Le Guillou,S., Laubier,J., Pechoux,C., Aujean,E., Castille,J.,
            Leroux,C. and Le Provost,F.
  TITLE     Defects of the endoplasmic reticulum and changes to lipid droplet
            size in mammary epithelial cells due to miR-30b-5p overexpression
            are correlated to a reduction in Atlastin 2 expression
  JOURNAL   Biochem Biophys Res Commun 512 (2), 283-288 (2019)
   PUBMED   30879769
  REMARK    GeneRIF: the increase in lipid droplet size observed in the mammary
            epithelial cells of transgenic mice might result from changes to
            lipid droplet formation and secretion because of direct
            modifications to Atl2 expression and indirect changes to
            endoplasmic reticulum morphology resulting from the overexpression
            of miR-30b-5p
REFERENCE   3  (bases 1 to 3639)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 3639)
  AUTHORS   Zhao,G., Zhu,P.P., Renvoise,B., Maldonado-Baez,L., Park,S.H. and
            Blackstone,C.
  TITLE     Mammalian knock out cells reveal prominent roles for atlastin
            GTPases in ER network morphology
  JOURNAL   Exp Cell Res 349 (1), 32-44 (2016)
   PUBMED   27669642
  REMARK    GeneRIF: Endoplasmic reticulum morphology is markedly disrupted in
            ATL1, ATL2, and ATL3 knockout cells.
REFERENCE   5  (bases 1 to 3639)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3639)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   7  (bases 1 to 3639)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3639)
  AUTHORS   Liu,Y. and Hogan,B.L.
  TITLE     Differential gene expression in the distal tip endoderm of the
            embryonic mouse lung
  JOURNAL   Gene Expr Patterns 2 (3-4), 229-233 (2002)
   PUBMED   12617806
REFERENCE   9  (bases 1 to 3639)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008381.1, AK038697.1, BC060501.1, AK032050.1 and BM938279.1.
            
            On Nov 13, 2013 this sequence version replaced NM_019717.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060501.1, SRR1660825.193048.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AK008381.1         2-83
            83-95               AK038697.1         11-23
            96-2927             BC060501.1         1-2832
            2928-3330           AK032050.1         3279-3681
            3331-3639           BM938279.1         81-389
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.3 cM"
     gene            1..3639
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="atlastin GTPase 2"
                     /db_xref="GeneID:56298"
                     /db_xref="MGI:MGI:1929492"
     exon            1..215
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1849
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like 6 interacting protein 2;
                     ARL-6 interacting protein-2; atlastin-2; ADP-ribosylation
                     factor-like protein 6-interacting protein 2;
                     ADP-ribosylation-like factor 6 interacting protein 2"
                     /codon_start=1
                     /product="atlastin-2 isoform 1"
                     /protein_id="NP_062691.3"
                     /db_xref="CCDS:CCDS37700.1"
                     /db_xref="GeneID:56298"
                     /db_xref="MGI:MGI:1929492"
                     /translation="MAEGDEAARRQQPQQGLRRRRQTSDSSVGVNHVSSTTSLGEDYE
                     DDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGA
                     FRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVID
                     RPNGTKVAVLLMDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQ
                     LFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEE
                     LQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAP
                     ENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARD
                     VYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVALKQFRSVKKMGGDEFCRRYQDQLEA
                     EIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVM
                     GLALTSLCTWAYVKYSGEFREIGTMIDQIAETLWEQVLKPLGDNLMEENIRQSVTNSI
                     KAGLTDQVSHHARLKTD"
     exon            216..460
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..595
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..700
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..751
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..808
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..901
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1040
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1168
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1225
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1297
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1729
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..3618
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="hexamer: ATTAAA"
     polyA_site      2945
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="major polyA site"
     regulatory      3596..3601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="hexamer: AATAAA"
     polyA_site      3618
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
ORIGIN      
        1 gctaggaccc gcaggccgcc ccgccggctc ccgggaggtt gataaagcgg cggcggcgtt
       61 tgacgtcagt ggggagttaa ttttaaatcg gtacaagatg gcggaggggg acgaggcagc
      121 gcgaaggcag cagccgcagc aggggctgag gcgccggcga cagaccagcg actcgagcgt
      181 cggagttaac cacgtctcgt ctacgacctc cctaggtgag gattatgaag atgatgacct
      241 agtaaactca gatgaggtta tgaagaaacc atgcccagta cagattgttc tcgcccatga
      301 agatgaccat aactttgagc ttgatgaaga ggctttggag cagatcctgc tgcaggagca
      361 catacgggat cttaacatag tcgtggtgtc tgtggcagga gctttccgta aagggaaatc
      421 atttctcctg gacttcatgc ttagatatat gtataacaag gattctcaaa gctggattgg
      481 tggaaacaat gaacccttga ctggctttac gtggcgaggt ggttgcgaaa gagaaacaac
      541 aggcatacaa gtttggaatg aagtgtttgt gattgacaga cctaatggaa caaaagtggc
      601 tgtgctgcta atggataccc agggtgcctt tgatagccag tcaaccatta aagactgtgc
      661 gacagtgttt gctctgagca ctatgaccag ctctgtgcag gtatataatt tgtctcagaa
      721 tattcaagaa gatgatcttc aacatctaca gttatttaca gagtatggaa gacttgcaat
      781 ggaagagatc taccagaagc catttcagac gctaatgttt ttgattcgag attggagtta
      841 tccttatgag cactcatatg gcttggaagg tgggaagcag ttccttgaga agagattaca
      901 ggtgaagcag aaccagcacg aggagctgca gaacgtcagg aagcacatcc acaactgctt
      961 ctcaaacctg ggctgcttcc tcctcccgca ccccggcctc aaagtcgcca ccaaccctag
     1021 ctttgatgga cgactgaaag atatcgatga agactttaaa cgggagcttc gaaatctggt
     1081 tccattgctg cttgctcctg aaaatcttgt tgagaaagag ataagtggat cgaaagtcac
     1141 ttgtagagat cttgtagagt attttaaggc atacattaaa atatatcaag gagaggaact
     1201 accacaccca aagtctatgc ttcaggcaac agctgaggct aataacctgg cagcagtagc
     1261 aggagcaaga gatgtctatt gtaaaagtat ggagcaggta tgcggtggtg ataagccgta
     1321 cattgcacct tcagatttgg agcgaaaaca cctggatctc aaggaagtgg cgctcaaaca
     1381 gtttcgttct gtgaaaaaaa tgggtggaga tgaattctgc cgccgttatc aggaccagct
     1441 tgaagctgaa atcgaagaaa cctatgcaaa ttttataaag cacaatgatg gcaaaaatat
     1501 cttctatgct gctcgcaccc ctgccacact gtttgcagtc atgtttgcta tgtatatcat
     1561 ctcaggactg actggcttca ttggcctaaa ctctatagct gtcttatgca acctcgtcat
     1621 ggggctagca ctgacgtccc tttgtacttg ggcatatgtt aagtactctg gggagttcag
     1681 agaaatcgga acaatgattg atcagattgc tgaaacactg tgggaacagg tattgaagcc
     1741 cctgggtgat aatttgatgg aggaaaacat aaggcagtct gtaacaaact ctatcaaagc
     1801 aggcctgact gaccaggtgt ctcatcatgc ccgattaaag acagactgac agttcatctg
     1861 ctcatggact ccactctccc ttgttcatgc ttgctgtaca atgagaactc agataaaata
     1921 aaccaaagtt tacaatcaac tgtagaagta gtttagtgta actggcttca cagatggccg
     1981 ccacagagtg tgaacgttgt ttgttggttt gcagccttct ttgctgtctc cttagactcg
     2041 gtgactgcct gaggagcatc aggttatcat gcacacttgt gccatggtta attcttttct
     2101 ttctttttac cgaattcaat gttagtgaaa tttgtcttat gtaaaaggat atttcaggga
     2161 aatattttaa gaaatctatt tagagtctct ttaatatagt gtcccattga aattttaatt
     2221 tttagagaat ttatgaatca ctgtatcaag aatcagatgg gaatgacaat gaagccttta
     2281 ccgagccact acattaaaag tgtatattgc tttactgcct tcaattgcca gtattacata
     2341 aatgcatgtt tcagaaactt cacacaaatc acatgagaac tcttgtagct gagaaggtaa
     2401 ttctgaggtg tacatttgtc ttgccttttt aaatttgtaa acctgccctg aaaggagatg
     2461 cattatctgg gaaactgaac tgtctttttg cagtttagcc ttcatgtaca taaaatatgc
     2521 cattaatttt attgggggaa aaattccatc caaaaatgtt gcctacagct atgagttaag
     2581 agtgtctaca gcgtgtagct ttcattttct aaagattaca ggtagggcat gtatatgaat
     2641 tataaatata taaatacaat tttgtattaa aagttttgta gtttatggca aaacctggtt
     2701 ctgtggtagg ctactgagtc cagtcctgtg acaggagtgt ttgtggctcg tgtcactgtg
     2761 tgaacgcata gacagtgtga agttttgata tatttgtgat atttatcttc cctgagcact
     2821 gcagtctcac ccccaagaga attcaatggg aatgttttat tgtgacttgt cctctgttgc
     2881 attttaaagt tatttcctgt aatttatttt cagtacataa ttaaaaattt gttgtatata
     2941 taaaacgaaa gttgtgattc ttttttaagg aattctttca agtgtgtatc tcaccatata
     3001 acattgttca tgctgaaaga gggtgggtca gggtgcaccg agttagagct caaggtattg
     3061 tactttaaag ctgagcgtgt aaaaagttat ttttcgtgtc tttttatgta agggatattt
     3121 tttgtgataa tctatctggg gatttaataa ttttaatctt ttctccatct cttcccccac
     3181 tcccatcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg agagagagag agagagagag
     3241 agagagagag agagagaatg aatatgtgtg tgtttgcgtg tgggctatat atgtaaagct
     3301 accatttttc cagtacttat aacctccttt acagagacct attaaatcgc tcctatttgg
     3361 tttttaagag aattcagatg ttgagttgca tgcatgaagg tctgagtttg ctttgattgg
     3421 cacacttccc tcccactctg acccagtcct actttatatg gattgtattt gtttccgtct
     3481 gtggtaagca gctgccttct catctgttcc tacacagaac gaatccatcc gaacagtctc
     3541 tctttctctg accactttgt tttatgaatg ctgtaaattg tttttatgaa tgaaaaataa
     3601 aaagtttgtt gtatactaaa aaaaaaaaaa aaaaaaaaa
//
