LOCUS       NM_001357752            4169 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus atlastin GTPase 2 (Atl2), transcript variant 4, mRNA.
ACCESSION   NM_001357752 XM_006524654
VERSION     NM_001357752.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4169)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4169)
  AUTHORS   Le Guillou,S., Laubier,J., Pechoux,C., Aujean,E., Castille,J.,
            Leroux,C. and Le Provost,F.
  TITLE     Defects of the endoplasmic reticulum and changes to lipid droplet
            size in mammary epithelial cells due to miR-30b-5p overexpression
            are correlated to a reduction in Atlastin 2 expression
  JOURNAL   Biochem Biophys Res Commun 512 (2), 283-288 (2019)
   PUBMED   30879769
  REMARK    GeneRIF: the increase in lipid droplet size observed in the mammary
            epithelial cells of transgenic mice might result from changes to
            lipid droplet formation and secretion because of direct
            modifications to Atl2 expression and indirect changes to
            endoplasmic reticulum morphology resulting from the overexpression
            of miR-30b-5p
REFERENCE   3  (bases 1 to 4169)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 4169)
  AUTHORS   Zhao,G., Zhu,P.P., Renvoise,B., Maldonado-Baez,L., Park,S.H. and
            Blackstone,C.
  TITLE     Mammalian knock out cells reveal prominent roles for atlastin
            GTPases in ER network morphology
  JOURNAL   Exp Cell Res 349 (1), 32-44 (2016)
   PUBMED   27669642
  REMARK    GeneRIF: Endoplasmic reticulum morphology is markedly disrupted in
            ATL1, ATL2, and ATL3 knockout cells.
REFERENCE   5  (bases 1 to 4169)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4169)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   7  (bases 1 to 4169)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4169)
  AUTHORS   Liu,Y. and Hogan,B.L.
  TITLE     Differential gene expression in the distal tip endoderm of the
            embryonic mouse lung
  JOURNAL   Gene Expr Patterns 2 (3-4), 229-233 (2002)
   PUBMED   12617806
REFERENCE   9  (bases 1 to 4169)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117261.4 and BM938279.1.
            
            On Nov 4, 2017 this sequence version replaced XM_006524654.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.15200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC117261.4         27638-27852
            216-460             AC117261.4         47715-47959
            461-595             AC117261.4         58585-58719
            596-700             AC117261.4         58954-59058
            701-751             AC117261.4         62282-62332
            752-808             AC117261.4         62602-62658
            809-901             AC117261.4         63882-63974
            902-1040            AC117261.4         66515-66653
            1041-1168           AC117261.4         67498-67625
            1169-1225           AC117261.4         69151-69207
            1226-1297           AC117261.4         69856-69927
            1298-1729           AC117261.4         70805-71236
            1730-1744           AC117261.4         72860-72874
            1745-3798           AC117261.4         72968-75021
            3799-4169           BM938279.1         19-389
FEATURES             Location/Qualifiers
     source          1..4169
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.3 cM"
     gene            1..4169
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="atlastin GTPase 2"
                     /db_xref="GeneID:56298"
                     /db_xref="MGI:MGI:1929492"
     exon            1..215
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1852
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ADP-ribosylation factor-like 6 interacting protein 2;
                     ARL-6 interacting protein-2; atlastin-2; ADP-ribosylation
                     factor-like protein 6-interacting protein 2;
                     ADP-ribosylation-like factor 6 interacting protein 2"
                     /codon_start=1
                     /product="atlastin-2 isoform 4"
                     /protein_id="NP_001344681.1"
                     /db_xref="GeneID:56298"
                     /db_xref="MGI:MGI:1929492"
                     /translation="MAEGDEAARRQQPQQGLRRRRQTSDSSVGVNHVSSTTSLGEDYE
                     DDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGA
                     FRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVID
                     RPNGTKVAVLLMDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQ
                     LFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEE
                     LQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAP
                     ENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARD
                     VYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVALKQFRSVKKMGGDEFCRRYQDQLEA
                     EIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVM
                     GLALTSLCTWAYVKYSGEFREIGTMIDQIAETLWEQRSPRKVFAKLFEVSRRRRVHRA
                     LSSAQRQRLSSNNNKKRN"
     exon            216..460
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..595
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..700
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..751
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..808
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..901
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1040
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1168
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1225
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1297
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1729
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1744
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..4148
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3450..3455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="hexamer: ATTAAA"
     polyA_site      3475
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="major polyA site"
     regulatory      4126..4131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
                     /note="hexamer: AATAAA"
     polyA_site      4148
                     /gene="Atl2"
                     /gene_synonym="2010110I21Rik; Aip-2; Arl6ip2"
ORIGIN      
        1 gctaggaccc gcaggccgcc ccgccggctc ccgggaggtt gataaagcgg cggcggcgtt
       61 tgacgtcagt ggggagttaa ttttaaatcg gtacaagatg gcggaggggg acgaggcagc
      121 gcgaaggcag cagccgcagc aggggctgag gcgccggcga cagaccagcg actcgagcgt
      181 cggagttaac cacgtctcgt ctacgacctc cctaggtgag gattatgaag atgatgacct
      241 agtaaactca gatgaggtta tgaagaaacc atgcccagta cagattgttc tcgcccatga
      301 agatgaccat aactttgagc ttgatgaaga ggctttggag cagatcctgc tgcaggagca
      361 catacgggat cttaacatag tcgtggtgtc tgtggcagga gctttccgta aagggaaatc
      421 atttctcctg gacttcatgc ttagatatat gtataacaag gattctcaaa gctggattgg
      481 tggaaacaat gaacccttga ctggctttac gtggcgaggt ggttgcgaaa gagaaacaac
      541 aggcatacaa gtttggaatg aagtgtttgt gattgacaga cctaatggaa caaaagtggc
      601 tgtgctgcta atggataccc agggtgcctt tgatagccag tcaaccatta aagactgtgc
      661 gacagtgttt gctctgagca ctatgaccag ctctgtgcag gtatataatt tgtctcagaa
      721 tattcaagaa gatgatcttc aacatctaca gttatttaca gagtatggaa gacttgcaat
      781 ggaagagatc taccagaagc catttcagac gctaatgttt ttgattcgag attggagtta
      841 tccttatgag cactcatatg gcttggaagg tgggaagcag ttccttgaga agagattaca
      901 ggtgaagcag aaccagcacg aggagctgca gaacgtcagg aagcacatcc acaactgctt
      961 ctcaaacctg ggctgcttcc tcctcccgca ccccggcctc aaagtcgcca ccaaccctag
     1021 ctttgatgga cgactgaaag atatcgatga agactttaaa cgggagcttc gaaatctggt
     1081 tccattgctg cttgctcctg aaaatcttgt tgagaaagag ataagtggat cgaaagtcac
     1141 ttgtagagat cttgtagagt attttaaggc atacattaaa atatatcaag gagaggaact
     1201 accacaccca aagtctatgc ttcaggcaac agctgaggct aataacctgg cagcagtagc
     1261 aggagcaaga gatgtctatt gtaaaagtat ggagcaggta tgcggtggtg ataagccgta
     1321 cattgcacct tcagatttgg agcgaaaaca cctggatctc aaggaagtgg cgctcaaaca
     1381 gtttcgttct gtgaaaaaaa tgggtggaga tgaattctgc cgccgttatc aggaccagct
     1441 tgaagctgaa atcgaagaaa cctatgcaaa ttttataaag cacaatgatg gcaaaaatat
     1501 cttctatgct gctcgcaccc ctgccacact gtttgcagtc atgtttgcta tgtatatcat
     1561 ctcaggactg actggcttca ttggcctaaa ctctatagct gtcttatgca acctcgtcat
     1621 ggggctagca ctgacgtccc tttgtacttg ggcatatgtt aagtactctg gggagttcag
     1681 agaaatcgga acaatgattg atcagattgc tgaaacactg tgggaacaga ggagtcccag
     1741 gaaggtgttt gccaaactgt ttgaagtcag tagacgtcga agggtccacc gtgctctctc
     1801 gtcagcacag cgacagagac tgtcatccaa caataacaag aagagaaatt agacaggatt
     1861 tttaactttt ttctctatct gaagtgttca cacttacaca tgtaggacaa taagcaggac
     1921 cgtctgggcc ggtctgcata atgctgtata cataccagat ttgatgctgc acatagggta
     1981 tggattgcac atccgtctca taggatttgt aaatggtttg agtaagagga aagtaacttt
     2041 cgttgcatta taaaatgtct taactgcatt gtttgtagca tcataacttt ttctttcttt
     2101 ttcttttttc tttgttcttt tgggagaagc atctttttat ttctcacatt cctgattatt
     2161 tttgtcatta atttaaattg aattttttat atctgttttt atatgtactc tttttttacc
     2221 tcatgctttt gtttgttttg cacatttctc ataccacagg tattgaagcc cctgggtgat
     2281 aatttgatgg aggaaaacat aaggcagtct gtaacaaact ctatcaaagc aggcctgact
     2341 gaccaggtgt ctcatcatgc ccgattaaag acagactgac agttcatctg ctcatggact
     2401 ccactctccc ttgttcatgc ttgctgtaca atgagaactc agataaaata aaccaaagtt
     2461 tacaatcaac tgtagaagta gtttagtgta actggcttca cagatggccg ccacagagtg
     2521 tgaacgttgt ttgttggttt gcagccttct ttgctgtctc cttagactcg gtgactgcct
     2581 gaggagcatc aggttatcat gcacacttgt gccatggtta attcttttct ttctttttac
     2641 cgaattcaat gttagtgaaa tttgtcttat gtaaaaggat atttcaggga aatattttaa
     2701 gaaatctatt tagagtctct ttaatatagt gtcccattga aattttaatt tttagagaat
     2761 ttatgaatca ctgtatcaag aatcagatgg gaatgacaat gaagccttta ccgagccact
     2821 acattaaaag tgtatattgc tttactgcct tcaattgcca gtattacata aatgcatgtt
     2881 tcagaaactt cacacaaatc acatgagaac tcttgtagct gagaaggtaa ttctgaggtg
     2941 tacatttgtc ttgccttttt aaatttgtaa acctgccctg aaaggagatg cattatctgg
     3001 gaaactgaac tgtctttttg cagtttagcc ttcatgtaca taaaatatgc cattaatttt
     3061 attgggggaa aaattccatc caaaaatgtt gcctacagct atgagttaag agtgtctaca
     3121 gcgtgtagct ttcattttct aaagattaca ggtagggcat gtatatgaat tataaatata
     3181 taaatacaat tttgtattaa aagttttgta gtttatggca aaacctggtt ctgtggtagg
     3241 ctactgagtc cagtcctgtg acaggagtgt ttgtggctcg tgtcactgtg tgaacgcata
     3301 gacagtgtga agttttgata tatttgtgat atttatcttc cctgagcact gcagtctcac
     3361 ccccaagaga attcaatggg aatgttttat tgtgacttgt cctctgttgc attttaaagt
     3421 tatttcctgt aatttatttt cagtacataa ttaaaaattt gttgtatata taaaacgaaa
     3481 gttgtgattc ttttttaagg aattctttca agtgtgtatc tcaccatata acattgttca
     3541 tgctgaaaga gggtgggtca gggtgcaccg agttagagct caaggtattg tactttaaag
     3601 ctgagcgtgt aaaaagttat ttttcgtgtc tttttatgta agggatattt tttgtgataa
     3661 tctatctggg gatttaataa ttttaatctt ttctccatct cttcccccac tcccatcgtg
     3721 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg agagagagag agagagagag agagagagag
     3781 agagagaatg aatatgtgtg tgtttgcgtg tgggctatat atgtaaagct accatttttc
     3841 cagtacttat aacctccttt acagagacct attaaatcgc tcctatttgg tttttaagag
     3901 aattcagatg ttgagttgca tgcatgaagg tctgagtttg ctttgattgg cacacttccc
     3961 tcccactctg acccagtcct actttatatg gattgtattt gtttccgtct gtggtaagca
     4021 gctgccttct catctgttcc tacacagaac gaatccatcc gaacagtctc tctttctctg
     4081 accactttgt tttatgaatg ctgtaaattg tttttatgaa tgaaaaataa aaagtttgtt
     4141 gtatactaaa aaaaaaaaaa aaaaaaaaa
//
