LOCUS       NM_026195               2611 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus 5-aminoimidazole-4-carboxamide ribonucleotide
            formyltransferase/IMP cyclohydrolase (Atic), mRNA.
ACCESSION   NM_026195 XM_912296 XM_922307 XM_922317 XM_922320
VERSION     NM_026195.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2611)
  AUTHORS   Shi,X., Ma,Q., Huo,Y. and Su,Y.
  TITLE     5-Aminoimidazole-4-carboxamide ribonucleotide
            formyltransferase/inosine monophosphate cyclohydrolase promotes
            pulmonary arterial smooth muscle cell proliferation via the Ras
            signaling pathway
  JOURNAL   Am J Physiol Cell Physiol 327 (4), C901-C912 (2024)
   PUBMED   39129491
REFERENCE   2  (bases 1 to 2611)
  AUTHORS   Ma,Q., Yang,Q., Xu,J., Sellers,H.G., Brown,Z.L., Liu,Z., Bordan,Z.,
            Shi,X., Zhao,D., Cai,Y., Pareek,V., Zhang,C., Wu,G., Dong,Z.,
            Verin,A.D., Gan,L., Du,Q., Benkovic,S.J., Xu,S., Asara,J.M.,
            Ben-Sahra,I., Barman,S., Su,Y., Fulton,D.J.R. and Huo,Y.
  TITLE     Purine synthesis suppression reduces the development and
            progression of pulmonary hypertension in rodent models
  JOURNAL   Eur Heart J 44 (14), 1265-1279 (2023)
   PUBMED   36721994
REFERENCE   3  (bases 1 to 2611)
  AUTHORS   Ma,Q., Yang,Q., Xu,J., Zhang,X., Kim,D., Liu,Z., Da,Q., Mao,X.,
            Zhou,Y., Cai,Y., Pareek,V., Kim,H.W., Wu,G., Dong,Z., Song,W.L.,
            Gan,L., Zhang,C., Hong,M., Benkovic,S.J., Weintraub,N.L., Fulton,D.
            Jr., Asara,J.M., Ben-Sahra,I. and Huo,Y.
  TITLE     ATIC-Associated De Novo Purine Synthesis Is Critically Involved in
            Proliferative Arterial Disease
  JOURNAL   Circulation 146 (19), 1444-1460 (2022)
   PUBMED   36073366
REFERENCE   4  (bases 1 to 2611)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   5  (bases 1 to 2611)
  AUTHORS   Davis,B.W., Aumiller,W.M. Jr., Hashemian,N., An,S., Armaou,A. and
            Keating,C.D.
  TITLE     Colocalization and Sequential Enzyme Activity in Aqueous Biphasic
            Systems: Experiments and Modeling
  JOURNAL   Biophys J 109 (10), 2182-2194 (2015)
   PUBMED   26588576
REFERENCE   6  (bases 1 to 2611)
  AUTHORS   Asby,D.J., Cuda,F., Beyaert,M., Houghton,F.D., Cagampang,F.R. and
            Tavassoli,A.
  TITLE     AMPK Activation via Modulation of De Novo Purine Biosynthesis with
            an Inhibitor of ATIC Homodimerization
  JOURNAL   Chem Biol 22 (7), 838-848 (2015)
   PUBMED   26144885
REFERENCE   7  (bases 1 to 2611)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   8  (bases 1 to 2611)
  AUTHORS   Liu,S.P., Li,Y.S., Chen,Y.J., Chiang,E.P., Li,A.F., Lee,Y.H.,
            Tsai,T.F., Hsiao,M., Huang,S.F. and Chen,Y.M.
  TITLE     Glycine N-methyltransferase-/- mice develop chronic hepatitis and
            glycogen storage disease in the liver
  JOURNAL   Hepatology 46 (5), 1413-1425 (2007)
   PUBMED   17937387
  REMARK    Erratum:[Hepatology. 2008 Feb;47(2):769. Hwang, Shiu-Feng
            [corrected to Huang, Shiu-Feng]]
REFERENCE   9  (bases 1 to 2611)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   10 (bases 1 to 2611)
  AUTHORS   Swain,J.L., Hines,J.J., Sabina,R.L., Harbury,O.L. and Holmes,E.W.
  TITLE     Disruption of the purine nucleotide cycle by inhibition of
            adenylosuccinate lyase produces skeletal muscle dysfunction
  JOURNAL   J Clin Invest 74 (4), 1422-1427 (1984)
   PUBMED   6480832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ178786.1, AK010611.2 and AK012074.1.
            
            On Apr 28, 2009 this sequence version replaced NM_026195.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012074.1, BC039925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CJ178786.1         1-18
            19-1211             AK010611.2         2-1194
            1212-1769           AK012074.1         1149-1706
            1770-2360           AK010611.2         1753-2343
            2361-2611           AK012074.1         2297-2547
FEATURES             Location/Qualifiers
     source          1..2611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.03 cM"
     gene            1..2611
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /note="5-aminoimidazole-4-carboxamide ribonucleotide
                     formyltransferase/IMP cyclohydrolase"
                     /db_xref="GeneID:108147"
                     /db_xref="MGI:MGI:1351352"
     exon            1..119
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1879
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /note="bifunctional purine biosynthesis protein PURH;
                     AICAR transformylase/inosine monophosphate cyclohydrolase"
                     /codon_start=1
                     /product="bifunctional purine biosynthesis protein ATIC"
                     /protein_id="NP_080471.2"
                     /db_xref="CCDS:CCDS15030.1"
                     /db_xref="GeneID:108147"
                     /db_xref="MGI:MGI:1351352"
                     /translation="MAPSQLALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDA
                     GLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCN
                     LYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHG
                     SDSKDTSLETRRHLALKAFTHTAQYDEAISDYFRKQYSKGISQMPLRYGMNPHQTPAQ
                     LYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVG
                     VPLSEDEARVCMVYDLYPTLTPLAVAYARARGADRMSSFGDFVALSDICDVPTAKIIS
                     REVSDGIVAPGYEEEALKILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLRLSQKRNN
                     GVVDKSLFSNIVTKNKDLPESALRDLIVATVAVKYTQSNSVCYAKDGQVIGIGAGQQS
                     RIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEISNAIDQYVTGTIGEGEDLVKW
                     EALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGST
                     ADKVVIEACDELGIVLAHTDLRLFHH"
     exon            120..246
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..323
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            324..390
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            391..479
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            480..631
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            632..788
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..914
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1022
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1108
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1198
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1327
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1420
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1603
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1759
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2611
                     /gene="Atic"
                     /gene_synonym="2610509C24Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgacacg ccctgcccac tgcttcctga accgcggggt ccggcctgcc tgcctacgca
       61 cgtggcctgt ccgtcccttg actccgcgac ccaacgcagc atggctccgt ctcagcttgc
      121 cctgttcagt gtgtctgaca aaactggcct cgtggaattt gccagaagtc tcgcgtctct
      181 tggtttgagt ctggtcgctt ccggaggcac ggcaaaagcg atcagggatg ctggcctggc
      241 agtcagagat gtgtctgagc taacagggtt ccctgaaatg ttagggggac gcgtgaaaac
      301 cttgcaccct gcggtccatg ctgggatctt ggcacgcaac attccagaag acgctgcaga
      361 catggccagg cttgatttca accttgtaag ggttgtggtc tgtaacctgt accccttcgt
      421 gaagactgtg gcttctccag atgtaactgt tgaggcagct gttgaacaaa ttgatattgg
      481 tggcgtgaca ttactgagag ctgcagccaa aaaccacgct cgagtgacag tcgtctgtga
      541 accagaggac tatgcggggg tagctgcaga gatgcacggc tctgatagta aggacacctc
      601 cctagagacc aggcgccact tggccttgaa ggcattcact cataccgctc aatacgatga
      661 agcaatttca gattacttca ggaaacagta cagtaaggga atttctcaga tgcccttgcg
      721 gtatgggatg aacccccatc agactcctgc ccagttgtat acgctgaagc ccaaacttcc
      781 catcacagtt ctcaatggag ccccaggatt cataaacttg tgtgacgctt tgaacgcctg
      841 gcagctggtg acagagctga gaggagcagt agacatccca gcggctgctt ctttcaagca
      901 cgtcagcccg gcaggtgctg ctgttggggt tccactcagt gaggacgagg ccagagtctg
      961 catggtctat gacctctacc cgaccctcac gcccctggcc gttgcatatg caagagcaag
     1021 aggagctgat aggatgtctt catttggtga ttttgttgca ttgtctgaca tttgtgatgt
     1081 cccaactgca aaaattatct ccagagaagt gtcggatggt attgttgccc cgggatatga
     1141 agaagaagcc ttgaaaatac tttctaaaaa gaaaaatgga aactactgtg ttcttcagat
     1201 ggaccagtcc tacaaaccag atgaaaatga agttcgaaca ctctttggtc ttcgtttaag
     1261 ccagaagaga aataatggtg tcgttgacaa gtcattattt agcaatattg tcaccaagaa
     1321 taaagatctg ccggagtctg cactcagaga cctcattgtc gccaccgtcg ctgtcaagta
     1381 tactcagtct aattcggtgt gctatgccaa ggatgggcag gttattggca tcggagcagg
     1441 acagcagtct cggatacact gcactcgcct tgcaggtgat aaggcaaact cttggtggct
     1501 tcggcaccac ccacgagtgc tgtccatgaa gtttaaagcc ggggtgaaga gagcagagat
     1561 ctccaatgcg attgatcagt atgtgaccgg cactatcggt gagggcgaag acctggtgaa
     1621 atgggaagca ctgttcgaag aggttcctga gttactcacg gaggcggaga agaaggaatg
     1681 ggtggacaag ctgagcggcg tgtctgtcag ctccgacgcc ttctttcctt tcagggataa
     1741 tgtggaccga gctaaaagga gtggtgtggc ctacattgtc gctccatctg gatctactgc
     1801 tgacaaggtt gtgattgagg cgtgcgacga gctggggatt gtcttggctc atacggatct
     1861 ccggctcttc caccactgac cttagctgac attgtttcct ggtcgtagat aatcatgtgt
     1921 ggggtcttgg aagtacctct agaagagtca tttgtatctt aatatctggg tgtgtggttt
     1981 agtaggtggg tcttacttat ctgaaaggta gagctttcta gcctaagaca ccttatgtga
     2041 ggcttgtttc tgcaaaacct gaaagcatct ctccctcctg gagccagctt tcaggaaaag
     2101 tccctgtgag acacctaagt gcaggtaacc aggagaagcc acgctgcctt atgatgacat
     2161 gccaccccca ccccacccca ccaccaccac cctgcccagc gctctcccca gggctccttt
     2221 cttcctgcct ctcggaagct taactgtttg cttcccatta tcccctggga actgggtcct
     2281 taactagatc taaatgctgg gactgctctt tctttctcca gaattgctta aaacctctgt
     2341 tggctactta gtattcctgt ttggtataaa cttataaatg gactggcgtt ctgcatagag
     2401 cttttcaccc aaagtgagca gatattaact tgtgggggtc agggggaagt gggggtgggg
     2461 gtggagtgcc tccctgtacc aggcaggaca taactggatc tatgtccctg tggttatagt
     2521 cctcactgtt cacccagagg atccctgtgg tcacttagcc ttaggttagt tttgccttct
     2581 ttccaatcct ctaaataaat tttaaaactt t
//
