LOCUS       NM_001002897            3902 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus autophagy related 9B (Atg9b), mRNA.
ACCESSION   NM_001002897 XM_149596
VERSION     NM_001002897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3902)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3902)
  AUTHORS   Zhao,J., Chen,J., Zhu,W., Qi,X.M. and Wu,Y.G.
  TITLE     Exosomal miR-7002-5p derived from highglucose-induced macrophages
            suppresses autophagy in tubular epithelial cells by targeting Atg9b
  JOURNAL   FASEB J 36 (9), e22501 (2022)
   PUBMED   35971776
  REMARK    GeneRIF: Exosomal miR-7002-5p derived from highglucose-induced
            macrophages suppresses autophagy in tubular epithelial cells by
            targeting Atg9b.
REFERENCE   3  (bases 1 to 3902)
  AUTHORS   Zhong,Y., Long,T., Gu,C.S., Tang,J.Y., Gao,L.F., Zhu,J.X., Hu,Z.Y.,
            Wang,X., Ma,Y.D., Ding,Y.Q., Li,Z.G. and Wang,X.Y.
  TITLE     MYH9-dependent polarization of ATG9B promotes colorectal cancer
            metastasis by accelerating focal adhesion assembly
  JOURNAL   Cell Death Differ 28 (12), 3251-3269 (2021)
   PUBMED   34131310
  REMARK    GeneRIF: MYH9-dependent polarization of ATG9B promotes colorectal
            cancer metastasis by accelerating focal adhesion assembly.
REFERENCE   4  (bases 1 to 3902)
  AUTHORS   Liang,W., Moyzis,A.G., Lampert,M.A., Diao,R.Y., Najor,R.H. and
            Gustafsson,A.B.
  TITLE     Aging is associated with a decline in Atg9b-mediated autophagosome
            formation and appearance of enlarged mitochondria in the heart
  JOURNAL   Aging Cell 19 (8), e13187 (2020)
   PUBMED   32627317
  REMARK    GeneRIF: Aging is associated with a decline in Atg9b-mediated
            autophagosome formation and appearance of enlarged mitochondria in
            the heart.
REFERENCE   5  (bases 1 to 3902)
  AUTHORS   Chavez,G.G., Taylor,G., Garaliene,J., Richardson,G.P. and
            Korneev,S.A.
  TITLE     The temporal expression profile of a Nos3-related natural antisense
            RNA in the brain suggests a possible role in neurogenesis
  JOURNAL   Nitric Oxide 71, 27-31 (2017)
   PUBMED   29031735
  REMARK    GeneRIF: Nos3as undergoes differential expression during embryonic
            and post-embryonic stages of development of the brain. Low levels
            of Nos3as NAT coincide with active neurogenesis.
REFERENCE   6  (bases 1 to 3902)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   7  (bases 1 to 3902)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3902)
  AUTHORS   Nicola,A.M., Albuquerque,P., Martinez,L.R., Dal-Rosso,R.A.,
            Saylor,C., De Jesus,M., Nosanchuk,J.D. and Casadevall,A.
  TITLE     Macrophage autophagy in immunity to Cryptococcus neoformans and
            Candida albicans
  JOURNAL   Infect Immun 80 (9), 3065-3076 (2012)
   PUBMED   22710871
REFERENCE   9  (bases 1 to 3902)
  AUTHORS   Yamada,T., Carson,A.R., Caniggia,I., Umebayashi,K., Yoshimori,T.,
            Nakabayashi,K. and Scherer,S.W.
  TITLE     Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes
            an autophagy-related protein (APG9-like2) highly expressed in
            trophoblast
  JOURNAL   J Biol Chem 280 (18), 18283-18290 (2005)
   PUBMED   15755735
REFERENCE   10 (bases 1 to 3902)
  AUTHORS   Robb,G.B., Carson,A.R., Tai,S.C., Fish,J.E., Singh,S., Yamada,T.,
            Scherer,S.W., Nakabayashi,K. and Marsden,P.A.
  TITLE     Post-transcriptional regulation of endothelial nitric-oxide
            synthase by an overlapping antisense mRNA transcript
  JOURNAL   J Biol Chem 279 (36), 37982-37996 (2004)
   PUBMED   15234981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BK004021.1 and AC113055.9.
            
            On May 3, 2007 this sequence version replaced NM_001002897.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by orthologous human data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY515313.1, AY495541.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               BK004021.1         1-312
            313-313             AC113055.9         34221-34221
            314-3721            BK004021.1         314-3721
            3722-3902           AC113055.9         41691-41871
FEATURES             Location/Qualifiers
     source          1..3902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.49 cM"
     gene            1..3902
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /note="autophagy related 9B"
                     /db_xref="GeneID:213948"
                     /db_xref="MGI:MGI:2685420"
     exon            1..774
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            775..818
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            819..883
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1045
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1187
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1942
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2099
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2279
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2516
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2650
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2747
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2871
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3011
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3902
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /note="hexamer: ATTAAA"
     regulatory      3717..3722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /note="hexamer: AACAAG"
     polyA_site      3723
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /note="major polyA site"
     polyA_site      3734
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
     regulatory      3795..3800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
                     /note="hexamer: AATAAA"
     polyA_site      3824
                     /gene="Atg9b"
                     /gene_synonym="Apg912; Apg9l2; Apgdc2; eONE; Gm574;
                     Nos3as; sONE"
ORIGIN      
        1 actggtgtcc gtcccaggca tggggcttgg gccccaggtt gccttgcaag gagtgtgagt
       61 gatcacacag gtggctgagg gttggcatgc ctgaggcctg cccagcctga gtcacctagt
      121 gctgttgttg tcctgctcct tgttgaagtc tccgctcagc ttcactgacc tctgtggaaa
      181 caacagcagt ccagtccctt caacctctca agagaagctg cggcctgatg gtgagacgaa
      241 cggggtgggg ggggagcagg aggcaacggg ggcggtgggg agacttgggg cccagctcag
      301 tgcctctgct ccctatggca ctgccactgc ctgcttctcc atgccgggga actgggggaa
      361 ggaggatctc tgtcttctct ctgtcccctg cccctcgcac aagaagctgc tcctcttcag
      421 tgttccctcc ggcctcaggg tctccctgcc tggtgattca ggaggcaggg gcttctcaga
      481 ctccacacaa tgtcttaccc accccgacca caccctcaac gcaggcccat cccacaatga
      541 tacacacctc tgcttccccc tcgtgggggt cccactccac cccacccctg gcctcggcca
      601 ctccccctcc ctcctgcccg cgcccccagg accatcctgg gctgcggatg ggccctctga
      661 tccctgagca ggactatgaa cggctagagg actgtgaccc tgaggggtct caagactccc
      721 ctatccatgg ggaggaccac caacccttgc ttcatgtacc cgaaggactc cgcggttcct
      781 ggcatcacat ccagaacctg gacagttttt tcaccaagat ctacagctat catcagcgga
      841 atggctttgc ctgtatcctg ctggaggatg tcttccagct ggggcagttc attttcattg
      901 tcacctttac aaccttcctc cttcgctgcg tggattacaa tgttctcttc aacaaccaac
      961 caaagaacca tacaagacgt ggaccattac acagcaaagt gaccttgtca gatgccattc
     1021 taccctcggc ccagtgtgca gagaagatcc acgacagtcc cctgttggtc ttcctcctag
     1081 tcctggctgc tggcttctgg ctgttccagc tgcttcgctc ggtctgcaac ctcttcagct
     1141 actgggacat ccaggtgttt tacagggagg ccctgcacat tcccccagag gagctcagct
     1201 cggtaccctg ggccgaggtg cagtctcgcc tcctggaact gcagaggagc ggtgggctgt
     1261 gtgtgcagcc gcggccgctg acggaactgg acgtccacca ccgcatcctg cgctacacca
     1321 actaccaggt agcgttagcc aacaagggtc tgctgcctgc ccgctgcccg ctgccctggg
     1381 ggagcagcgc cgccttcctc agccgcggcc tggcgctcaa cgtggacttg ctgctcttcc
     1441 gcggtccctt ctcactcttc cgcgggggct gggagcttcc cgaagcctac aagcgcagcg
     1501 acctccgggg cgtcctggct aaccgctggc ggcgcacggt gctgctgctg gccgccgtga
     1561 acttggccct gagcccgctg gtgctggcct ggcaggtatt gcacgccttc tacagccacg
     1621 tggagctgct gcggcgcgag cccggagcct tcggggcgcg ccgctggtcc cgcctggccc
     1681 gcctgcagct tcgccacttt aacgagctgc cgcacgagct gcgtgcgcgc ctgggccgcg
     1741 cctaccggcc cgccgccgcc ttcctgcgtg cagcggagcc cccagctccc ctgcgcgcgc
     1801 tgctggcccg ccagctggtc ttcttctcgg gagctctctt tgccgcgctg ctagtgctca
     1861 ccatctacga tgaggacgtg ttggccgtgg agcatgtgct cactaccatg acggcgctcg
     1921 gggtcacagc cactgtggcc aggtccttca ttccagaaga gcaatgccag gggcgttcct
     1981 cccagcttct gctgcaggca gccctggcgc acatgcatta cctcccagag gagcctggtg
     2041 caacgggtgc tcgagccagc tcttactggc agatggcgca gctgcttcag taccgagcag
     2101 tctccctcct ggaagagctc ctgtctccac tcctgacccc attgtttctg ctcttctggt
     2161 tccgcccccg tgctctggag attattgact tttttcatca cttcactgtg gatgtggctg
     2221 gtgtagggga catctgttct tttgcattaa tggatgtgaa gcgccacggg catcctcagt
     2281 ggctttcaga gggacagaca gaggcctcac tctctcagcg tgcagaggat ggaaagaccg
     2341 aactctcctt aatgcggttc tccctggcac acccacaatg gcagccacca gggcacagct
     2401 ctaagttcct tggacacctt cggggccggg tacaacaaga tgcagctgcc tggggtgctc
     2461 cctcgactcg gagtcccccc accccaggag tgctcagtga ctgtacatcc cctctgccag
     2521 aagccttcct tgccaacctc ttggtaaatc cccgcccacc ccagagggac ctgagtccca
     2581 cagccccctg ccctgctgca gccacagcca gcctccttgc ctctatttca cgaatggtcc
     2641 aggaccccag ctgtgtgtcc ccaggaggca cagggggcca gaagctgacc cagctcccag
     2701 agcttgtctc tgctgagatg agcctccacg ctatttacct acatcagctt catcaacagc
     2761 agcagcaaga actatgggga gaggcttcag cttcctcccc atccaggccc tggtccagcc
     2821 cttcacagcc aggctcacct gatgaggaga agccatcttg gtcaagtgat ggctccagtc
     2881 ctgcttctag cccaagacaa cagtggggca cccagagggc ccagaatctg ttcccaaagg
     2941 ggtttcagga gaacacagac acccagaagg agcccctaac aggccccttg cactgactga
     3001 ggatatctca ggttctggct tttccagctg caggaaattt gatgggtggc atggaaggac
     3061 acttgaagcc atcttctgag ctccattcct atttccgatg acaggcccag gatattttag
     3121 ttggccatat ctgggagtca aagaggggct tgcccggaga acagtgaaaa agtaggagat
     3181 gattgtgagc tgaggtagcc tacagatggg ccccacaagt gaggataaga gaacactagc
     3241 ctggctggtt gtggagcagt tgcctgggaa ggaccccagt ggcctcaagg tggggccagg
     3301 gcccaggcat ggttcaactc agtgttaggg aagttgttcc tgtcgacctc ccctttgagt
     3361 tcctgtggga ctaggggtgg ggaatatgga gacgggtgag tggaaaaacc agagagggct
     3421 gctggttttg gacgtcagca ctgctgtgat agcaggagga agtgggtggg actcctcatc
     3481 ctgtacgaaa caagcagcag aaattgctca tggttgagct gcacatcttt gccatgggaa
     3541 tgtctggcac gccccactct tggaagctga ggactgcacc tgttcactca agcgcaaaac
     3601 tgtctgtccc tggttagaaa cttttttttt tttgcagagt actgggttac agagaggtgt
     3661 ctgggactca ctgtcaaaga attattatcc caacatcttt acacattaaa gcattgaaca
     3721 agtctcattt tcaatcattg taactcacaa ggtttgggtt gggcatctgg catggtcttt
     3781 tatgataatt tttcaataaa taccgggatg acttagactt taaacgtaag atactccaga
     3841 gagagagtta aagggagtct acagtccatc aaagcatatg aagagggcag caggatgccc
     3901 ta
//
