LOCUS       NM_053069               2396 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus autophagy related 5 (Atg5), transcript variant 1,
            mRNA.
ACCESSION   NM_053069
VERSION     NM_053069.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Wang,F., Trosdal,E.S., Paddar,M.A., Duque,T.L.A., Allers,L.,
            Mudd,M., Akepati,P.R., Javed,R., Jia,J., Salemi,M., Phinney,B. and
            Deretic,V.
  TITLE     The role of ATG5 beyond Atg8ylation and autophagy
  JOURNAL   Autophagy 20 (2), 448-450 (2024)
   PUBMED   37876292
  REMARK    GeneRIF: The role of ATG5 beyond Atg8ylation and autophagy.
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Huang,X., Ye,C., Zhao,X., Tong,Y., Lin,W., Huang,Q., Zheng,Y.,
            Wang,J., Zhang,A. and Mo,Y.
  TITLE     TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in
            septic encephalopathy
  JOURNAL   J Neuroinflammation 20 (1), 284 (2023)
   PUBMED   38037161
  REMARK    GeneRIF: TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis
            in septic encephalopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Cheng,J., Wang,Y., Yin,L., Liang,W., Zhang,J., Ma,C., Zhang,Y.,
            Liu,B., Wang,J., Zhao,W., Li,M. and Wei,L.
  TITLE     The nonstructural protein 1 of respiratory syncytial virus hijacks
            host mitophagy as a novel mitophagy receptor to evade the type I
            IFN response in HEp-2 cells
  JOURNAL   mBio 14 (6), e0148023 (2023)
   PUBMED   37909764
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Ma,X., Manley,S., Qian,H., Li,Y., Zhang,C., Li,K., Ding,B., Guo,F.,
            Chen,A., Zhang,X., Liu,M., Hao,M., Kugler,B., Morris,E.M.,
            Thyfault,J., Yang,L., Sesaki,H., Ni,H.M., McBride,H. and Ding,W.X.
  TITLE     Mitochondria-lysosome-related organelles mediate mitochondrial
            clearance during cellular dedifferentiation
  JOURNAL   Cell Rep 42 (10), 113291 (2023)
   PUBMED   37862166
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (bases 1 to 2396)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (bases 1 to 2396)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (bases 1 to 2396)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (bases 1 to 2396)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY126779.1, AK028315.1,
            AC155642.6 and CD776008.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_053069.7.
            
            On Sep 24, 2015 this sequence version replaced NM_053069.5.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028315.1, BC002166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY126779.1         2-20
            20-1394             AK028315.1         3-1377
            1395-2371           AC155642.6         187953-188929
            2372-2396           CD776008.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     gene            1..2396
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /note="autophagy related 5"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
     exon            1..246
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
     exon            247..412
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1132
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /note="isoform 1 is encoded by transcript variant 1;
                     autophagy protein 5"
                     /codon_start=1
                     /product="autophagy protein 5 isoform 1"
                     /protein_id="NP_444299.1"
                     /db_xref="CCDS:CCDS23824.1"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
                     /translation="MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSY
                     LTLVTDKVKKHFQKVMRQEDVSEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITV
                     HFKSFPEKDLLHCPSKDAVEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQND
                     RFDQFWAINRKLMEYPPEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDL
                     LREVCPSAVAPEDGEKRSQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIVPQPTD"
     exon            413..540
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
     exon            541..619
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
     exon            620..782
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
     exon            783..877
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
     exon            878..995
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
     exon            996..2379
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgtcatct ccgggcgccg agggtgactg gacctacggt gggcgcccgg cgctgcggtt
       61 cactctggtt ccgagggcgg aagtgcccgt cgggctgttt tctgacccgg gcggcagcac
      121 tgtgcggctg cgcgcgcact gggacttctg ctcctgcgcc tctgcaggac agtgtgatcc
      181 cggcagacag aacccgaccg agcggctttc gcgctgcggg aagccggagc agagccggca
      241 cctcggtttg gctttggttg aaggaagaac ttagcctata tgtactgctt catccactgg
      301 aagaatgaca gatgacaaag atgtgcttcg agatgtgtgg tttggacgaa ttccaacttg
      361 ctttactctc tatcaggatg agataactga aagagaagca gaaccatact atttgctttt
      421 gccaagagtc agctatttga cgttggtaac tgacaaagtg aaaaagcact ttcagaaggt
      481 tatgagacaa gaagatgtta gtgagatatg gtttgaatat gaaggcacac ccctgaaatg
      541 gcattatcca attggtttac tatttgatct tcttgcatca agttcagctc ttccttggaa
      601 catcacagta catttcaaga gttttccaga aaaggacctt ctacactgtc catccaagga
      661 tgcggttgag gctcacttta tgtcgtgtat gaaagaagct gatgctttaa agcataaaag
      721 tcaagtgatc aacgaaatgc agaaaaaaga ccacaagcag ctctggatgg gactgcagaa
      781 tgacagattt gaccagtttt gggccatcaa ccggaaactc atggaatatc ctccagaaga
      841 aaatggattt cgttatatcc cctttagaat atatcagacc acgacggagc ggcctttcat
      901 ccagaagctg ttccggcctg tggccgcaga tggacagctg cacacacttg gagatctcct
      961 cagagaagtc tgtccttccg cagtcgcccc tgaagatgga gagaagagga gccaggtgat
     1021 gattcacggg atagagccaa tgctggaaac ccctctgcag tggctgagcg agcatctgag
     1081 ctacccagat aactttcttc atattagcat tgtcccccag ccaacagatt gaaagagtgt
     1141 gtcctcctcg ctagatggaa ccaccttgag tcaggacaac gaggcgtgac acccttgctt
     1201 cagtcaagtt cagtggaggc aacagaaacc cgggctgctg caagccaagg aggagaagat
     1261 tccatgagag atagggcgcc cgggcagggc tgagtgtgca ccactgcttc gctgagacac
     1321 acaggaccac tgcagcctcc tcttctcgtg aaatgcaatg cagccgaagc ctttgctcaa
     1381 tgaaaaaaaa aaaaatggaa atgtgccaca gtttgtattt ctgattaaca aataagtggg
     1441 gtatttccta aggtgaccat ggtggaacct taggcaggag aatggaaaca ttggttgaat
     1501 tttcaataga attagactta agaaagtaaa agagaaattc tgttattaat aacttgcagt
     1561 aatttttttg taaaagatca aattacagta aacccatctt tccttaatga gactttcctg
     1621 tttacagtca gtctattggt atgcaaacaa tcttgtaact ttgataatga acagtgagag
     1681 atttttaaat aaagcctcta actatgtttt gtcatttaat aacatacagt ttgtcacttt
     1741 tcaaagacct cctgaatctc atagagtaag ccactttttc ttctgtgttc ccatttctca
     1801 ctggcatagc aagggtgcgg ggcataaggc gacttgtctc aggagctgtc acaggattta
     1861 ttactgtgac ttgaaaaatc tgtcttctat atactaaagg tataaataat cctatctgtc
     1921 tttgctgtta cgttggtcac tgtaaacctg tcaaatcata gtatgccaag tatctgtcta
     1981 tgataatttt tgaatatttt gaatctcccg ttcctttcca gtgtttttgt ttggtttggt
     2041 tttggttttt tgttttacgt ttttgttttt tggctcctgg attatgtcat tgtggcccct
     2101 ggcagccagt ctttaaagcc tgcaggtgac ctgtctctag actgcagtag cttttcctta
     2161 tcattaccaa aaacatccag aggttactgg aactcctacc acagtaagga aagtttgctg
     2221 cactctctcg atggctgctt ggagactcct gctgttgatt tgtgagctag cttgctgtcc
     2281 acattgaatg tcaacccatc tgagtatgct aaaagatgat atcataaaat aatggttcta
     2341 gattcaataa taaagatgaa tgttttctta taaaaattaa aaaaaaaaaa aaaaaa
//
