LOCUS       NM_175029               3236 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus autophagy related 4C, cysteine peptidase (Atg4c),
            transcript variant 1, mRNA.
ACCESSION   NM_175029
VERSION     NM_175029.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3236)
  AUTHORS   Tamargo-Gomez,I., Martinez-Garcia,G.G., Suarez,M.F., Mayoral,P.,
            Bretones,G., Astudillo,A., Prieto-Lloret,J., Sveen,C., Fueyo,A.,
            Engedal,N., Lopez-Otin,C. and Marino,G.
  TITLE     Analysis of ATG4C function in vivo
  JOURNAL   Autophagy 19 (11), 2912-2933 (2023)
   PUBMED   37459465
  REMARK    GeneRIF: Analysis of ATG4C function in vivo.
REFERENCE   2  (bases 1 to 3236)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3236)
  AUTHORS   Farfariello,V., Amantini,C. and Santoni,G.
  TITLE     Transient receptor potential vanilloid 1 activation induces
            autophagy in thymocytes through ROS-regulated AMPK and Atg4C
            pathways
  JOURNAL   J Leukoc Biol 92 (3), 421-431 (2012)
   PUBMED   22753949
  REMARK    GeneRIF: we demonstrated for the first time that triggering of
            TRPV1 induces autophagy in mouse thymocytes resulting in AMPK
            activation and increased Atg4C mRNA expression
REFERENCE   4  (bases 1 to 3236)
  AUTHORS   Maiuri,M.C., Tasdemir,E., Criollo,A., Morselli,E., Vicencio,J.M.,
            Carnuccio,R. and Kroemer,G.
  TITLE     Control of autophagy by oncogenes and tumor suppressor genes
  JOURNAL   Cell Death Differ 16 (1), 87-93 (2009)
   PUBMED   18806760
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058981.1 and AK134838.1.
            
            On Mar 21, 2009 this sequence version replaced NM_175029.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058981.1, AK134838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-836               BC058981.1         1-836
            837-1193            AK134838.1         604-960
            1194-2634           BC058981.1         1194-2634
            2635-2638           AK134838.1         2402-2405
            2639-3236           BC058981.1         2635-3232
FEATURES             Location/Qualifiers
     source          1..3236
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.61 cM"
     gene            1..3236
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /note="autophagy related 4C, cysteine peptidase"
                     /db_xref="GeneID:242557"
                     /db_xref="MGI:MGI:2651854"
     exon            1..519
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..654
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             579..1955
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /note="AUT-like 3 cysteine endopeptidase;
                     autophagy-related protein 4 homolog C; autophagy-related
                     cysteine endopeptidase 3; AUT-like 1, cysteine
                     endopeptidase; APG4 (ATG4) autophagy-related homolog C;
                     cysteine protease involved in autophagy; autophagin 3;
                     autophagy-related 4C"
                     /codon_start=1
                     /product="cysteine protease ATG4C"
                     /protein_id="NP_778194.3"
                     /db_xref="CCDS:CCDS18382.1"
                     /db_xref="GeneID:242557"
                     /db_xref="MGI:MGI:2651854"
                     /translation="MEASGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLL
                     GKCYHFKYEDESKMLPARSGCAIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEASA
                     LTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALHIENADSDSWTSNTVKKFTAS
                     FEASLSGDRELRTPAVSLKETSGKCPDDHAVRNEAYHRKIISWFGDSPVAVFGLHRLI
                     EFGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGLTIYVAQDCTVYNSDVIDKQT
                     DSVTAGDARDKAVIILVPVRLGGERTNTDYLEFVKGVLSLEYCVGIIGGKPKQSYYFA
                     GFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQ
                     DFERASEEITKMLKISSKEKYPLFTFVNGHSKDFDFTSTAASEEDLFSEDERKNFKRF
                     STEEFVLL"
     exon            655..738
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..972
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1303
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1374
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1511
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1590
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1667
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1787
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..3178
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3158..3163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /note="hexamer: ATTAAA"
     polyA_site      3178
                     /gene="Atg4c"
                     /gene_synonym="Apg4-C; Apg4c; Atg4cl; Autl1"
                     /note="major polyA site"
ORIGIN      
        1 tgcgtggcgg gtagtagctg aagtccagta gttacagtta cgagggacag ctgtaaatct
       61 aacttgggcc tgcccctcac aaatgaactg ctctaggctc tgagcttgca gcccgggagc
      121 ttagggtctc cgacagggct tcctgcagga ccgcggcctg cggaggcttc ggtgtgctgt
      181 gctacggtgg ccgcgcgggg ccgcgggccg cacgtcctgc ggtgcgtacg cgctgttcgg
      241 agcggctgct ggagccgacg cgcgtctggt gtggggactc ctgcgcggct gtacagttat
      301 ccagtcccgt gtcgccgagg ggtcggctcg aggctggcgg agtggagaag gttggagctt
      361 ggtgtttgta gtctacgaat ggccggttct gggggcggcc ctgcccttgg tgcagacccg
      421 tggccaaccg tctgggttcc tggagggttt tggagcctct ctcgattctg cttcctcctg
      481 agggttatct tctgacgact cctcctcgcc ctttgaactt atattggatt ttctaaaaga
      541 atggaatcaa gtgatggctt tttctccaga atttgaatat ggaggcttca ggaacagatg
      601 aagttgacaa gctaaaaact aaatttatat ctgcttggaa caatatgaaa tatagttggg
      661 tgttgaaaac aaagacatat tttagtagaa attcacctgt tttattgctt ggaaaatgtt
      721 atcattttaa atatgaagat gaaagcaaga tgttgcctgc aagatcagga tgtgccattg
      781 aagatcatgt aattgcaggg aatgtggaag agttccgtaa ggatttcatt tctagaatat
      841 ggctgaccta cagggaagaa tttcctcaaa tcgaagcttc agccttgacg acagactgtg
      901 gctggggctg cacgctgcgg accggccaga tgctgctggc tcagggactc atactccatt
      961 ttctcggtag agcttggacc tggcctgatg cgctgcacat tgagaacgca gactctgact
     1021 catggacttc caacactgtc aaaaagttta ctgcatcgtt tgaagcttca ctttcggggg
     1081 acagagaact cagaactcca gcagtttctc tgaaggaaac atctgggaag tgtcccgatg
     1141 accacgcagt gcggaatgag gcttatcaca ggaagatcat ctcttggttt ggagattccc
     1201 ccgtggccgt ctttggctta catcgtctga tagagtttgg gaagaagtct gggaaaaaag
     1261 ctggcgattg gtatggacca gcggtggttg ctcacatttt aagaaaagca gttgaagaag
     1321 caaggcatcc ggatttgcaa gggctaacta tttatgttgc ccaggactgt acagtttaca
     1381 attctgacgt gattgataag cagactgact ccgtgacagc tggagatgca cgtgacaagg
     1441 ctgtcattat tttagttcct gttagactcg gtggagaaag gaccaatacc gactatctgg
     1501 agtttgtgaa gggtgtttta agccttgaat actgtgtagg tatcattggc ggcaaaccta
     1561 aacagtcata ttactttgct ggatttcaag atgacagttt gatttacatg gatcctcatt
     1621 actgccagtc ttttgtagat gtcagcataa aggatttccc tctcgagaca ttccactgtc
     1681 catctcctaa aaagatgtca tttcgaaaaa tggatcctag ttgtacgata ggattttact
     1741 gtcgaaatgt ccaggacttt gaacgagcgt ctgaagaaat cactaagatg ttgaaaattt
     1801 cctctaagga gaaatatcca ctatttactt ttgtaaatgg ccattccaaa gactttgatt
     1861 ttacatctac cgcagccagt gaagaagacc ttttctcaga agatgaaagg aagaatttca
     1921 aaagatttag cacagaagag tttgtcctcc tttaaagggg aagacatttg tgacatttgt
     1981 gcttctgaga ggcgctcgaa cacagcagag tcaaggagcg caacagtgag ctggagactc
     2041 taacggagcg cgttcctcta acagcacaca tttgaaaaca cctagactat aaaggtattt
     2101 ttctgaatac cttttctaaa tgacttgatg gctcttgctt tccagtgata aataacaagc
     2161 gattctggtt gcattcctgt ttcccaaaga tgtgctaatg gaacactaca tcaactgcaa
     2221 gcctttcggt ccccagcatt ttctccctga gcccattggt cccctgaagg ctttatgata
     2281 catgtttcct caaagagtca gatcaccaag ttacttttaa aagcctccct ttgtattaat
     2341 gacaggagac tggatcttca gagctaccca acctcctgct cttaatgtaa ccagaggact
     2401 ttcgggtttg agtaactgga tagtgaaatg gacacatata attatgtaag caggatttta
     2461 aggcaatact tacccatatg attttatagc agctactctt tatgcatttt gcggagtctt
     2521 ctatgaggaa tgaatacaaa acacttgttt ccctccccct ccctccctcc cttcctcctt
     2581 cctttctttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttcct
     2641 tccttccttc cttccttcct tccttccttc cttccttcct tccttccttc cttccttctt
     2701 ttccttcttt atttcctttc ttcttcctgt caggactggg tctgggggtt gaacccaggg
     2761 ccttgtatat gataggtatg tgttctacct ctgagctgtc ctaaagtatt gattttctct
     2821 acatatttaa aagttaaatt ttcagtagta tctatattta ttttaattag gtaaaggaaa
     2881 ttacagactt attgtagctt ttgttttcaa tcttaaaagt gaaattttat ggaaatccaa
     2941 tgtattactt aatttttaac tcaaatgatg aatacaagga atatatggat gctttctgct
     3001 tttactgttt gtgtaaaatg gtgtcatgac atttaggagc tgagacatgt acaggttaaa
     3061 tctgccttaa gtgtgctgtg agtttactta aagacaaact tgtgatataa gagtgtaaga
     3121 gctattacca agccaggatt ataaaacaaa tactttaatt aaaaacatga aaacataaaa
     3181 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
