LOCUS       NM_026402               2013 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus autophagy related 3 (Atg3), transcript variant 1,
            mRNA.
ACCESSION   NM_026402
VERSION     NM_026402.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Zhang,Q., Li,Z., Li,Q., Trammell,S.A., Schmidt,M.S., Pires,K.M.,
            Cai,J., Zhang,Y., Kenny,H., Boudina,S., Brenner,C. and Abel,E.D.
  TITLE     Control of NAD+ homeostasis by autophagic flux modulates
            mitochondrial and cardiac function
  JOURNAL   EMBO J 43 (3), 362-390 (2024)
   PUBMED   38212381
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Iwaya,C., Suzuki,A., Shim,J., Ambrose,C.G. and Iwata,J.
  TITLE     Autophagy Plays a Crucial Role in Ameloblast Differentiation
  JOURNAL   J Dent Res 102 (9), 1047-1057 (2023)
   PUBMED   37249312
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Quarato,G., Mari,L., Barrows,N.J., Yang,M., Ruehl,S., Chen,M.J.,
            Guy,C.S., Low,J., Chen,T. and Green,D.R.
  TITLE     Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis
  JOURNAL   Sci Adv 9 (21), eadg8156 (2023)
   PUBMED   37224250
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Li,H., Li,C., Zhai,W., Zhang,X., Li,L., Wu,B., Yu,B., Zhang,P.,
            Li,J., Cui,C.P. and Zhang,L.
  TITLE     Destabilization of TP53 by USP10 is essential for neonatal
            autophagy and survival
  JOURNAL   Cell Rep 41 (1), 111435 (2022)
   PUBMED   36198274
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Radoshevich,L., Murrow,L., Chen,N., Fernandez,E., Roy,S., Fung,C.
            and Debnath,J.
  TITLE     ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and
            cell death
  JOURNAL   Cell 142 (4), 590-600 (2010)
   PUBMED   20723759
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Mizushima,N., Yoshimori,T. and Levine,B.
  TITLE     Methods in mammalian autophagy research
  JOURNAL   Cell 140 (3), 313-326 (2010)
   PUBMED   20144757
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Sou,Y.S., Waguri,S., Iwata,J., Ueno,T., Fujimura,T., Hara,T.,
            Sawada,N., Yamada,A., Mizushima,N., Uchiyama,Y., Kominami,E.,
            Tanaka,K. and Komatsu,M.
  TITLE     The Atg8 conjugation system is indispensable for proper development
            of autophagic isolation membranes in mice
  JOURNAL   Mol Biol Cell 19 (11), 4762-4775 (2008)
   PUBMED   18768753
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Fujita,N., Itoh,T., Omori,H., Fukuda,M., Noda,T. and Yoshimori,T.
  TITLE     The Atg16L complex specifies the site of LC3 lipidation for
            membrane biogenesis in autophagy
  JOURNAL   Mol Biol Cell 19 (5), 2092-2100 (2008)
   PUBMED   18321988
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Komatsu,M., Waguri,S., Koike,M., Sou,Y.S., Ueno,T., Hara,T.,
            Mizushima,N., Iwata,J., Ezaki,J., Murata,S., Hamazaki,J.,
            Nishito,Y., Iemura,S., Natsume,T., Yanagawa,T., Uwayama,J.,
            Warabi,E., Yoshida,H., Ishii,T., Kobayashi,A., Yamamoto,M., Yue,Z.,
            Uchiyama,Y., Kominami,E. and Tanaka,K.
  TITLE     Homeostatic levels of p62 control cytoplasmic inclusion body
            formation in autophagy-deficient mice
  JOURNAL   Cell 131 (6), 1149-1163 (2007)
   PUBMED   18083104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129601.4.
            
            On Apr 29, 2007 this sequence version replaced NM_026402.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011409.1, AK150914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AC129601.4         109335-109677
            344-385             AC129601.4         112912-112953
            386-435             AC129601.4         117486-117535
            436-506             AC129601.4         120372-120442
            507-614             AC129601.4         122152-122259
            615-664             AC129601.4         125755-125804
            665-746             AC129601.4         128736-128817
            747-781             AC129601.4         133162-133196
            782-937             AC129601.4         133327-133482
            938-1065            AC129601.4         134188-134315
            1066-1134           AC129601.4         136672-136740
            1135-2013           AC129601.4         138166-139044
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.45 cM"
     gene            1..2013
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /note="autophagy related 3"
                     /db_xref="GeneID:67841"
                     /db_xref="MGI:MGI:1915091"
     exon            1..343
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1216
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-like-conjugating enzyme ATG3; autophagy-related
                     protein 3"
                     /codon_start=1
                     /product="ubiquitin-like-conjugating enzyme ATG3 isoform
                     1"
                     /protein_id="NP_080678.1"
                     /db_xref="CCDS:CCDS28194.1"
                     /db_xref="GeneID:67841"
                     /db_xref="MGI:MGI:1915091"
                     /translation="MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGD
                     HLVHHCPTWQWATGEELKVKAYLPTDKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDD
                     GDGGWVDTYHNTGITGITEAVKEITLESKDSIKLQDCSALCDEEDEEDEGEAADMEEY
                     EESGLLETDEATLDTRKIVEACKAKADAGGEDAILQTRTYDLYITYDKYYQTPRLWLF
                     GYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIET
                     VAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM"
     exon            344..385
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            386..435
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            436..506
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            507..614
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            615..664
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            665..746
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            747..781
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            782..937
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1065
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1134
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..2013
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /note="hexamer: AATAAA"
     polyA_site      1369
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /note="major polyA site"
     regulatory      1383..1388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
                     /note="hexamer: AATAAA"
     polyA_site      1402
                     /gene="Atg3"
                     /gene_synonym="2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96"
ORIGIN      
        1 gttcagtgga gctccgggga agagagacag cttggagaag gccgggggct gcgcgcgcac
       61 ccgcctctcg ctcagccggc ttgggccctc tgcggtggcg gccaggtgac agctgggccg
      121 ggcctccgcg tgtcgccgcc cctccccccc ggccgggccg gtgccgctgc gaggttcgat
      181 gccagtcggg cacgtccggg gcagtttttg actcccctgt ggcccggatt gcgacagtcc
      241 ctccgtgccc tatcgctgct ccagccccag gatgcagaat gtgatcaaca cggtgaaggg
      301 aaaggctctg gaagtggccg agtacctgac cccggtcctc aaggaatcaa aatttaagga
      361 aacgggtgta atcaccccag aagagtttgt ggcagctgga gatcacttag tccaccactg
      421 tccaacatgg caatgggcta caggggaaga attgaaagtg aaggcatatc ttccgacaga
      481 caaacaattt ttggtaacca aaaatgttcc atgctacaag cggtgtaaac agatggagta
      541 ttcggatgaa ttggaagcta tcattgaaga agatgatggt gatgggggat gggtagatac
      601 atatcacaac acaggtatta caggaattac tgaagcagtt aaggagatta cactggaaag
      661 caaggacagt ataaaactcc aagattgctc agcactgtgt gatgaagaag acgaggaaga
      721 tgaaggggaa gctgcagaca tggaagaata tgaagagagt ggattgttgg aaacagatga
      781 ggctacccta gacacaagga aaatagtgga agcctgcaaa gctaaggctg acgctggagg
      841 tgaagatgct attttacaaa caagaacata cgacctgtac atcacttacg acaaatatta
      901 ccagacacca cggctatggt tgtttggcta tgatgagcaa cggcagcctt taacagttga
      961 gcacatgtat gaagacatca gtcaagatca tgtgaagaaa acagtgacca ttgaaaacca
     1021 tcctcatctc ccaccacctc ctatgtgttc agttcaccca tgcaggcatg ctgaagtgat
     1081 gaagaaaatt attgagacag ttgcagaagg cgggggagag cttggtgttc atatgtatct
     1141 tttaattttt ttgaaatttg ttcaagctgt cattccaaca atagaatatg actacacaag
     1201 acacttcaca atgtagtgga gaggctatag agtctatcct aattactgct tctgattttt
     1261 aaagaattaa tacatagctg tgaccattga ccatatttac caataagaat aatttctcta
     1321 ataatgggat tatatgttta tgcattaaat aaaaactgtt ctactaccag ccttatttgt
     1381 ttaataaaaa tgtttgtgaa gagatgtttt catttcctgt cagaaggttc tagtagggtt
     1441 tcccctgtca gacgatgatt gcagagtcag ggtgctattg aacatctacc agtgtcagaa
     1501 ctagctctag aaagtgttcc atgccagcct gtgtgtctct ccctactcca ttcccagcct
     1561 tgtcctctcc ctacatctgc tctgtgcttg tagttcatgt ttctgaagtg ctaactgtat
     1621 gccaagaaac atgctcagaa acattacctg tttcatgatt tattgccatc acccagatta
     1681 cttcttatta acgatatggg gatgtttttc ttaacatgat tgtcagtaga atagtgggac
     1741 ttgaagggga atctttgctt gtattgtgtc agttcataga tctgaaaatg ggagtttaaa
     1801 aagcagattt ttctgaaaca tactttaagc tgtggaggag aatcctgatc tttggttttg
     1861 tttttttatt tgtttttaac ctttgcctaa aatccctgtt atgcctctca gtctccatat
     1921 tagtctgtgt caagtgtgat atcttccctt gtcttccatt ttgtttacat catctaagaa
     1981 tatccctctt aattaaaaac ttttgaaaat gtc
//
