LOCUS       NP_001390444            2076 aa            linear   ROD 02-MAY-2024
DEFINITION  autophagy-related protein 2 homolog B isoform 2 [Mus musculus].
ACCESSION   NP_001390444 XP_006516423
VERSION     NP_001390444.1
DBSOURCE    REFSEQ: accession NM_001403515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2076)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 2076)
  AUTHORS   Sakai,S.S., Hasegawa,A., Ishimura,R., Tamura,N., Kageyama,S.,
            Komatsu-Hirota,S., Abe,M., Ling,Y., Okuda,S., Funayama,M.,
            Kikkawa,M., Miura,Y., Sakimura,K., Narita,I., Waguri,S., Shimizu,R.
            and Komatsu,M.
  TITLE     Loss of Atg2b and Gskip Impairs the Maintenance of the
            Hematopoietic Stem Cell Pool Size
  JOURNAL   Mol Cell Biol 42 (1), e0002421 (2022)
   PUBMED   34748402
REFERENCE   3  (residues 1 to 2076)
  AUTHORS   Yang,F., Lei,Y., Zhou,M., Yao,Q., Han,Y., Wu,X., Zhong,W., Zhu,C.,
            Xu,W., Tao,R., Chen,X., Lin,D., Rahman,K., Tyagi,R., Habib,Z.,
            Xiao,S., Wang,D., Yu,Y., Chen,H., Fu,Z. and Cao,G.
  TITLE     Development and application of a recombination-based library versus
            library high- throughput yeast two-hybrid (RLL-Y2H) screening
            system
  JOURNAL   Nucleic Acids Res 46 (3), e17 (2018)
   PUBMED   29165646
REFERENCE   4  (residues 1 to 2076)
  AUTHORS   Nicola,A.M., Albuquerque,P., Martinez,L.R., Dal-Rosso,R.A.,
            Saylor,C., De Jesus,M., Nosanchuk,J.D. and Casadevall,A.
  TITLE     Macrophage autophagy in immunity to Cryptococcus neoformans and
            Candida albicans
  JOURNAL   Infect Immun 80 (9), 3065-3076 (2012)
   PUBMED   22710871
REFERENCE   5  (residues 1 to 2076)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (residues 1 to 2076)
  AUTHORS   Gaubatz,J.W. and Cutler,R.G.
  TITLE     Mouse satellite DNA is transcribed in senescent cardiac muscle
  JOURNAL   J Biol Chem 265 (29), 17753-17758 (1990)
   PUBMED   1698780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158526.3 and AC068459.9.
            
            On Mar 31, 2022 this sequence version replaced XP_006516423.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.15655.1,
                                           SRR10223969.12197.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.82 cM"
     Protein         1..2076
                     /product="autophagy-related protein 2 homolog B isoform 2"
                     /note="autophagy-related protein 2 homolog B; ATG2
                     autophagy related 2 homolog B"
                     /calculated_mol_wt=231356
     Region          11..>105
                     /region_name="Chorein_N"
                     /note="N-terminal region of Chorein or VPS13; pfam12624"
                     /db_xref="CDD:463646"
     Region          17..>234
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Site            255
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BY7; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            496
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BY7; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            839
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            885
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BY7; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            898
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BY7; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            1007
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            1011
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            1015
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            1017
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            1021
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Region          1373..1403
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XK6.3)"
     Site            1525
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BY7; propagated from
                     UniProtKB/Swiss-Prot (Q80XK6.3)"
     Region          1760..1793
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XK6.3)"
     Region          1978..2072
                     /region_name="ATG_C"
                     /note="Autophagy-related protein C terminal domain;
                     pfam09333"
                     /db_xref="CDD:462761"
     Region          2056..2076
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XK6.3)"
     CDS             1..2076
                     /gene="Atg2b"
                     /gene_synonym="2410024A21Rik; C030004M05Rik;
                     C630028L02Rik; mKIAA4067"
                     /coded_by="NM_001403515.1:466..6696"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:76559"
                     /db_xref="MGI:MGI:1923809"
ORIGIN      
        1 mpwpfsesik kracryllqr ylghflqekl sleqlsldly qgtgslaqvp ldkwclneil
       61 esadaplevt egfiqsisls vpwgsllqdn calevrglem vfrprprvat gsepmywssf
      121 mtssmqlake clsqkltdeq geasqpfegl ekfaetietv lrrvkvtfid tvlriehvpe
      181 nsktgaalei rvdrtvycde tadessgvnv hqptafahkl lqlsgvslfw defsasakss
      241 pvcstapvet epklspswnp kivyephpql trtlpeiaps dpvqigrllg rlelsltlkq
      301 nevlpgakld vdgqidsfhl flsprqvhll ldmlaaiagp ensskiglan kdrknrpmqq
      361 edeyriqmel nryylrkdsl smgvsseksf yetetartps sreeevffsm admdmshsls
      421 slpplgdpph mdlelsltst ytntpagspl satvlqptwg efadhkeqpv rgpafqsdvv
      481 hpaslqkaal ssrsasvdes rpeficrlal gifsvsvlhi dplspaetsl nvnpltrmat
      541 dffscvekmd paifstgdfk sfravfaeac shdhlrfigt gikvsyeqrq rsasrhfstd
      601 msvgqmefle clfptdchsv pshytelltf hskegtdahl pvclqlhykh setrgpqgnq
      661 arlssvpqka elqiklnpvc celdisivdr lnsllqpqkl ttvemmashm yasynkhisl
      721 hkaftevfld dshspanrrv svqvatpalh lsvrfpipdl rsdqergpwf kkslqketlh
      781 leftdleskt efvggstpeq tkleltfrel sgsfqeekgg psvkffhvsg gvdgdtassd
      841 dfdwprmvlk inppamhsil eriaaeeeee ndghyqeeed ggahslkdvc dlrrpapspf
      901 ssrrvmfene qmvmpgdpve mtefqdkais nshyvlelll pnihltlpnk gfyeklynri
      961 fndlllwept apspvetlen vsygiglsva sqlintfskd sfspfksavh ydedsgseee
     1021 tlqyfsavdp nyrsrrkkkl dsqnknsqsf lsvllsinhg lmavftdvkq engdpmeskh
     1081 gefwlefnsg sffcvtkyeg fedkhyiclh ssslrlyhkg ivdgailpte trlpcstrph
     1141 wleptiysse edglsrtasd gvggdnlnml svavkilsdk sesntkeflv avglkgatlq
     1201 hrvlpaglsw heqilnflni adepvlgynp ptsfttfhvh lwscaldyrp lhlplrsllt
     1261 vetfsisssv aldkssstlr iimdeaalhl sdkcntvtvn lnrdyvrvmd mglleltita
     1321 vksdsdgeqt aprfelhcss dvvhirtcsd scaalmnliq yvasygdlhg phkaemkpgv
     1381 pqrkpkvdss arssshgpvl peadqqilrd lmsdameeid lqqasapvgp qangvldeks
     1441 htqepccsdl flfpdesgnv sqesspayps lthhlisdav tgvtaenddf cilfapktvv
     1501 qekeeepvik imvddaivik ddyfslpitr tdsskaplhf pipavryvvk evslvwhlyg
     1561 gkdfatappt spaksyisph sspsqtptrh grhtvcggkg rnhdflmeiq lskvkfqhev
     1621 yppckpeces sllehpvsrq vfivqdleir drlatsqmnk flylycskdm prkahsnmlt
     1681 ikalhvrpes grspqecclr vslmplrlni dqdalfflkd fftslsteve llltpdpevt
     1741 kspgadvtcs lprhlstske pnlvvsfpgp kqaspnhran saeggnglee dvsaeetsfs
     1801 dqpvffrefr ftaevpirld yhgkhvsmdq gtlagiligl aqlncselkl krlfyrhgll
     1861 gidklfsyai sewlsdikkn qlpgilggvg pmhslvqlvq glkdlvwlpi eqyrkdgriv
     1921 rgfqrgaasf gtstamaale ltnrmvqtiq aaaetaydmv spstlsiepk kakrfphhrl
     1981 ahqpvdlreg vakaysvvke gitdtaqtiy etaarehesr gvtgavgevl rqippavvrp
     2041 livateatsn vlggmrnqir pdvrqdesqk wrhged
//
