LOCUS       NP_001395209            1916 aa            linear   ROD 01-MAY-2025
DEFINITION  autophagy-related protein 2 homolog A isoform 1 [Mus musculus].
ACCESSION   NP_001395209 XP_006531835
VERSION     NP_001395209.1
DBSOURCE    REFSEQ: accession NM_001408280.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1916)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1916)
  AUTHORS   Nicola,A.M., Albuquerque,P., Martinez,L.R., Dal-Rosso,R.A.,
            Saylor,C., De Jesus,M., Nosanchuk,J.D. and Casadevall,A.
  TITLE     Macrophage autophagy in immunity to Cryptococcus neoformans and
            Candida albicans
  JOURNAL   Infect Immun 80 (9), 3065-3076 (2012)
   PUBMED   22710871
REFERENCE   3  (residues 1 to 1916)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127556.4.
            
            On Jun 14, 2022 this sequence version replaced XP_006531835.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.20334.1,
                                           SRR9219379.1313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.37 cM"
     Protein         1..1916
                     /product="autophagy-related protein 2 homolog A isoform 1"
                     /note="autophagy-related protein 2 homolog A; ATG2
                     autophagy related 2 homolog A"
                     /calculated_mol_wt=211037
     Region          14..111
                     /region_name="Chorein_N"
                     /note="N-terminal region of Chorein or VPS13; pfam12624"
                     /db_xref="CDD:463646"
     Region          43..>240
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Site            764
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2TAZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Site            869
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Site            875
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Site            877
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Site            1248
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Site            1284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2TAZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Site            1292
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2TAZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Region          1301..1339
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Region          1339..1385
                     /region_name="WIPI-interacting.
                     /evidence=ECO:0000250|UniProtKB:Q2TAZ0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Site            1383
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2TAZ0; propagated from
                     UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Region          1429..1454
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Region          1591..1636
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Region          1805..1824
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T0.2)"
     Region          1817..1910
                     /region_name="ATG_C"
                     /note="Autophagy-related protein C terminal domain;
                     pfam09333"
                     /db_xref="CDD:462761"
     CDS             1..1916
                     /gene="Atg2a"
                     /gene_synonym="1810013C15Rik; A830054M12; mKIAA0404"
                     /coded_by="NM_001408280.1:75..5825"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:329015"
                     /db_xref="MGI:MGI:1916291"
ORIGIN      
        1 msrwlwpwsn cvkervcryl lqhylghffq ehlsldqlsl dlykgsvalr dihletwsvn
       61 eflrsmespl elvegfvssi evavpwaall tdhctvcvsg lqltlqprqg sgpgaadsqs
      121 wascmttslq laqeclregl pepseppqpl eglemfaqti etvlrrikvt flntvvrveh
      181 slgdedrsva vevrvqrley cdeavrdpsq appvdvhqpp aflhkllqls gvclyfeelp
      241 sqadppqppl qigsctgyve lmvrlkqnea fpgpklevsg qlgslhlllt prqlqqlqrl
      301 lsavnladpa gladklnksr plgaedlwli eqdlnqqlqa gavaeslsly pitnplnlds
      361 tdlffsmagl tssvtsavse lsvysvdlgs svhsnmafhr pstpphsggk maptplldtt
      421 rpdslvkmtl ggvsltllqt aspssgpsdl pthffaefda akdgpfgsrd fshlrprfqr
      481 acpcshvrlt gtavqlswel rtgshsrrts stevhfgqle vleclwpraa tepeyteils
      541 fpshsgseas arpcahlrht qtirrvlksr srrstachch selsldladf qsdvelgsld
      601 rlaalfrqvt tpseppagll teppqatelq tvfrlsapra tlrlrfpipd lrpdrdpwag
      661 qavraeqlrl elsepqfrse lnsgpgppap trleltcsdl qgiyedgekp pvpclrvska
      721 lnprsteaky flpqvvvtln pqssgtqwet ayekgrdlel stespcelqq pepspfsskr
      781 tmyeteemvi pgdpeemrtf qsrtlalsrc tldvimpsah iflpskevye siynrinndl
      841 lmwepadllp tssaaarppg ssgfkmcksa fkldsdsdee daqffsmasg vpqtpapeps
      901 rrqsqstfst lvtvlkgrit alceakdetg krldvthgel vldveqgtif svaqyrgqpg
      961 lgyfcleaek aklyhraaie dyllpthlev psfappaqla ptiypseegv tergtlgrkg
     1021 qgppmlsaav rihldphknv keflvtvrlh katlrhymap peqswhsqll dfldvlddpv
     1081 lgylpptvit vlhthlfsca vdyrplylpv rvlvtaetft lssnivmdts tfllrfildd
     1141 salylsdkce vesldlrrdy vcvldidlle lviktwkgst egrlsqplfe lrcsnnvvhv
     1201 hscadscall vnllqyltss gdlhppprpp spteiagqkv qlsespaslp sclpvetali
     1261 nqrdltdall dterrglqel aqssggplpq aspvsvylfp gersgaqapl pppgasshtl
     1321 gskakehene eegdgdtlds defcildapg lgiaprdgep ivtqlhpgpi ivhdghfsqp
     1381 lgstdllrap ahfpvpssrv vlrevsfiwh lyggrdfglh ptyrarvglt gprvspsrss
     1441 gpnrpqnswr tqggigrqhq vlmeiqlskv sfqhevypee saiagglgqe lderplsrqv
     1501 livqeleird rlatskinkf lhlhtserlp rrthsnmlti kalhvaptss vggpecclrv
     1561 smmplrlnvd qdalfflkdf ftslaasinp mvpgdtseap rethsrpgsp qegqsedtet
     1621 asnppeapgs shsssdqqpi yfrefrftse vpicldyhgk hvtvdqvgtf mglliglaql
     1681 ncselklkrl ccrhgllgvd kvlcyalnew lqdirknqlp gllggvgpmh svvqlfqgfr
     1741 dllwlpieqy rkdgrlirgl qrgaasfgss tasaalelsn rlvqaiqata etvydilspa
     1801 spvsrslqdk rssrklrrgq qpadlregma kaydavregi ldtaqticdv asrgheqkgl
     1861 tgavggvirq lpptvvkpii vateatsnvl ggmrnqilpd ahkdhalkwr leeaqd
//
