LOCUS       NM_001111111            2183 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Mus musculus autophagy related 16 like 2 (Atg16l2), transcript
            variant 1, mRNA.
ACCESSION   NM_001111111 XM_001474185 XM_001476186 XM_001476205 XM_905729
VERSION     NM_001111111.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2183)
  AUTHORS   Wen,Z., Yuan,T., Liu,J., Wang,D., Ni,J., Yan,X., Tang,J., Tang,J.,
            Wu,X. and Wang,Z.
  TITLE     Atg16l2 augments Nlrc4 inflammasome activation by facilitating
            NAIPs-NLRC4 association
  JOURNAL   Eur J Immunol 54 (11), e2451078 (2024)
   PUBMED   39175123
  REMARK    GeneRIF: Atg16l2 augments Nlrc4 inflammasome activation by
            facilitating NAIPs-NLRC4 association.
REFERENCE   2  (bases 1 to 2183)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2183)
  AUTHORS   Wang,D., Yuan,T., Liu,J., Wen,Z., Shen,Y., Tang,J., Wang,Z. and
            Wu,X.
  TITLE     ATG16L2 inhibits NLRP3 inflammasome activation through promoting
            ATG5-12-16L1 complex assembly and autophagy
  JOURNAL   Eur J Immunol 52 (8), 1321-1334 (2022)
   PUBMED   35426127
  REMARK    GeneRIF: ATG16L2 inhibits NLRP3 inflammasome activation through
            promoting ATG5-12-16L1 complex assembly and autophagy.
REFERENCE   4  (bases 1 to 2183)
  AUTHORS   Khor,B., Conway,K.L., Omar,A.S., Biton,M., Haber,A.L., Rogel,N.,
            Baxt,L.A., Begun,J., Kuballa,P., Gagnon,J.D., Lassen,K.G., Regev,A.
            and Xavier,R.J.
  TITLE     Distinct Tissue-Specific Roles for the Disease-Associated Autophagy
            Genes ATG16L2 and ATG16L1
  JOURNAL   J Immunol 203 (7), 1820-1829 (2019)
   PUBMED   31451676
  REMARK    GeneRIF: results show that ATG16L1 and ATG16L2 contribute very
            distinctly to autophagy and cellular ontogeny in myeloid, lymphoid,
            and epithelial lineages. Dysregulation of any of these lineages
            could contribute to complex diseases like Crohn disease and
            systemic lupus erythematosus.
REFERENCE   5  (bases 1 to 2183)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2183)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   7  (bases 1 to 2183)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 2183)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   9  (bases 1 to 2183)
  AUTHORS   Mizushima,N., Kuma,A., Kobayashi,Y., Yamamoto,A., Matsubae,M.,
            Takao,T., Natsume,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic
            isolation membrane with the Apg12-Apg5 conjugate
  JOURNAL   J Cell Sci 116 (Pt 9), 1679-1688 (2003)
   PUBMED   12665549
REFERENCE   10 (bases 1 to 2183)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060054.1, AK010773.1 and BP767155.1.
            
            On or before Dec 8, 2007 this sequence version replaced
            XM_905729.2, XM_001474185.1, XM_001476186.1, XM_001476205.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155125.1, AK157410.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1175              BC060054.1         164-1338
            1176-2163           AK010773.1         1097-2084
            2164-2183           BP767155.1         28-47               c
FEATURES             Location/Qualifiers
     source          1..2183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.54 cM"
     gene            1..2183
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /note="autophagy related 16 like 2"
                     /db_xref="GeneID:73683"
                     /db_xref="MGI:MGI:1920933"
     exon            1..188
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1933
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /note="autophagy-related protein 16-2; mFLJ00012 protein;
                     APG16-like 2; Atg16L2 beta; autophagy-related 16-like 2
                     beta; Atg16L2 alpha; autophagy-related 16-like 2 alpha"
                     /codon_start=1
                     /product="protein Atg16l2"
                     /protein_id="NP_001104581.1"
                     /db_xref="CCDS:CCDS52329.1"
                     /db_xref="GeneID:73683"
                     /db_xref="MGI:MGI:1920933"
                     /translation="MAGPGAPCDPCAPAAVWKRHIVRQLRHRDRTQKALFLELVPAYN
                     HLLEKAELLAKFSEKLKSEPKDAISTRHEDWREEVSGTGPDQVSSPASLRVKWQQEKK
                     GLQLVCGEMAYQVVKKSAALDTLQSQLEERQDRLEALQACVVQLQEARAQQSRQLEER
                     QAENAAQREAYETLLQQAVHQEAALRRLQEEARDLLEQLVQRKARAAAERNLRNERRE
                     RANQALVSQELKKAAKRTVSISEIPNTLEDGTKEETVALAPAALPEFSESETCEKWKR
                     PFRSASATSLTLSRCVDVVKGLLDFKKRRGHSVGGAPEQRYQSIPVCVSAQIPSQAQD
                     VLDAHLSEVNAVCFGPNSSLLATGGADRLIHLWNVVGGRLEANQTLEGAGGSITSVDF
                     DPSGSQVLAATYNQAAQLWKVGETQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTV
                     KEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCIQVIPVQGR
                     VTSLHLSYDQLHLLSCSRDNTLKVIDLRISNIRQVFRADGFKCSSDWTKAVFSPDRSY
                     ALAGSSNGDLYIWDVNTGKLETSLQGPHCTAVNAVAWCFSGNHVVSVDQGRKVVLWH"
     exon            189..288
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..391
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            392..465
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            466..717
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            718..783
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..897
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            898..960
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1069
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1175
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1246
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1318
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1439
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1545
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1695
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1743
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1845
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2164
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2164
                     /gene="Atg16l2"
                     /gene_synonym="2410118P20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaggctcc gcccccctgc tcgggctgga gctttgcgcg gccgctaggg actcggcggc
       61 catggcagga cctggcgccc cctgcgatcc ctgcgcgccc gccgctgtct ggaagcgcca
      121 catcgtgcgg cagctgcggc atcgggaccg cacgcaaaag gcgctcttcc tggagctagt
      181 gccggcttat aaccatctcc tagagaaggc tgaactgcta gccaagttct cagaaaagtt
      241 gaagtccgaa ccaaaggatg ccatctccac ccgacatgag gactggaggg aggaggtctc
      301 agggacaggc cctgaccaag tctcatcacc agcctctctg agggtgaagt ggcagcagga
      361 gaagaagggg ctgcagctgg tctgtggtga gatggcctac caggtggtga agaagagcgc
      421 agccctagac accctgcagt cacagctgga ggagcggcag gacaggttgg aagccctgca
      481 ggcctgcgtg gtgcagctac aggaggcgcg ggctcagcag tcccggcagc tggaggaacg
      541 gcaagcggag aacgcagcac agagagaagc ctatgagacg ctgctccagc aagctgtgca
      601 ccaggaggcg gcactgcgca ggctccagga agaggcacgc gacttgctgg agcagcttgt
      661 gcagcgtaag gcgcgcgccg ccgctgagcg caatctacgt aatgagcgta gagagagggc
      721 caaccaggct ctggtgtccc aggagctgaa gaaagcggct aagcggactg tgagcatcag
      781 cgagatccca aacactctag aagatgggac gaaagaagag actgtggctc tagctcctgc
      841 cgctctgcct gagttctcag agagtgagac ttgtgaaaaa tggaagaggc ctttcaggtc
      901 tgcctcggcc acctccctga cactgtcccg ctgtgtggat gtggtgaagg ggctgttgga
      961 cttcaagaaa agaagaggtc actcggttgg gggcgcacct gagcagcggt accaaagcat
     1021 ccctgtgtgt gtgtctgccc aaattccctc ccaggctcag gatgtcttgg atgcccatct
     1081 ctctgaggtc aatgctgttt gttttggccc caacagcagc ctcctggcca ctggaggggc
     1141 tgaccggctg atccacctct ggaatgttgt aggaggtcgc ctggaggcca accagaccct
     1201 ggaaggagct ggcggcagca tcaccagtgt ggattttgac ccctcaggct cccaggtttt
     1261 ggcagctact tacaaccagg ctgcccagct ctggaaggtg ggagagactc agtccaagga
     1321 aacattgtcc ggacacaagg acaaagtgac tgctgccaaa ttcaagctaa caaggcacca
     1381 ggcagtgact gggagccgag accggacagt gaaggagtgg gacctgggcc gcgcctactg
     1441 ttccaggact atcaatgtac tttcctactg caatgacgtg gtgtgcgggg accacatcat
     1501 catcagtggc cacaatgacc aaaagatccg gttctgggac agcaggggcc ctcactgcat
     1561 ccaggtcatc cccgtgcagg gccgggttac ctccctgcac ctcagctatg accagctgca
     1621 tctgcttagc tgttcccgag acaacacact caaggttatc gacctgcgaa tcagcaatat
     1681 ccgacaggtg ttcagggcag atggcttcaa gtgcagttct gactggacca aagctgtgtt
     1741 cagccctgac agaagctatg cactggcagg ctcttcaaac ggcgacctgt acatctggga
     1801 tgtgaacacc gggaaactgg agaccagcct acagggaccc cactgcactg ctgttaatgc
     1861 cgtggcttgg tgcttctccg ggaaccacgt tgtgagtgtg gaccaaggca ggaaggtggt
     1921 gctctggcac tgagtggcac aagttccctg tatgggttgg actctgaagc cagaagccag
     1981 agaacagctt ccctgtgctc aggactccag agctggggtt ggggtctact acagaattca
     2041 tgtgagggcc aggcaggacc tggcctgttt gttaaaaatc aaagtgtggg ttaggaacta
     2101 cagttttgtt ttttaaaatc tatttgttta ctctcttcag tgttaaaaac tgtatctaag
     2161 ccgtaaaaaa aaaaaaaaaa aaa
//
