LOCUS       NM_172599               3466 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus autophagy related 14 (Atg14), mRNA.
ACCESSION   NM_172599 XM_003085045 XM_003085046
VERSION     NM_172599.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3466)
  AUTHORS   Feng,S., McNehlan,M.E., Kinsella,R.L., Sur Chowdhury,C.,
            Chavez,S.M., Naik,S.K., McKee,S.R., Van Winkle,J.A., Dubey,N.,
            Samuels,A., Swain,A., Cui,X., Hendrix,S.V., Woodson,R.,
            Kreamalmeyer,D., Smirnov,A., Artyomov,M.N., Virgin,H.W., Wang,Y.T.
            and Stallings,C.L.
  TITLE     Autophagy promotes efficient T cell responses to restrict high-dose
            Mycobacterium tuberculosis infection in mice
  JOURNAL   Nat Microbiol 9 (3), 684-697 (2024)
   PUBMED   38413834
REFERENCE   2  (bases 1 to 3466)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3466)
  AUTHORS   Huang,M., Zhang,Y., Park,J., Chowdhury,K., Xu,J., Lu,A., Wang,L.,
            Zhang,W., Ekser,B., Yu,L. and Dong,X.C.
  TITLE     ATG14 plays a critical role in hepatic lipid droplet homeostasis
  JOURNAL   Metabolism 148, 155693 (2023)
   PUBMED   37741434
REFERENCE   4  (bases 1 to 3466)
  AUTHORS   Choi,I., Wang,M., Yoo,S., Xu,P., Seegobin,S.P., Li,X., Han,X.,
            Wang,Q., Peng,J., Zhang,B. and Yue,Z.
  TITLE     Autophagy enables microglia to engage amyloid plaques and prevents
            microglial senescence
  JOURNAL   Nat Cell Biol 25 (7), 963-974 (2023)
   PUBMED   37231161
REFERENCE   5  (bases 1 to 3466)
  AUTHORS   Li,H., Li,C., Zhai,W., Zhang,X., Li,L., Wu,B., Yu,B., Zhang,P.,
            Li,J., Cui,C.P. and Zhang,L.
  TITLE     Destabilization of TP53 by USP10 is essential for neonatal
            autophagy and survival
  JOURNAL   Cell Rep 41 (1), 111435 (2022)
   PUBMED   36198274
REFERENCE   6  (bases 1 to 3466)
  AUTHORS   Itakura,E. and Mizushima,N.
  TITLE     p62 Targeting to the autophagosome formation site requires
            self-oligomerization but not LC3 binding
  JOURNAL   J Cell Biol 192 (1), 17-27 (2011)
   PUBMED   21220506
REFERENCE   7  (bases 1 to 3466)
  AUTHORS   Matsunaga,K., Saitoh,T., Tabata,K., Omori,H., Satoh,T.,
            Kurotori,N., Maejima,I., Shirahama-Noda,K., Ichimura,T., Isobe,T.,
            Akira,S., Noda,T. and Yoshimori,T.
  TITLE     Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally
            regulate autophagy at different stages
  JOURNAL   Nat Cell Biol 11 (4), 385-396 (2009)
   PUBMED   19270696
  REMARK    GeneRIF: Two Beclin 1 associated proteins, Atg14L and Rubicon, were
            identified.
REFERENCE   8  (bases 1 to 3466)
  AUTHORS   Zhong,Y., Wang,Q.J., Li,X., Yan,Y., Backer,J.M., Chait,B.T.,
            Heintz,N. and Yue,Z.
  TITLE     Distinct regulation of autophagic activity by Atg14L and Rubicon
            associated with Beclin 1-phosphatidylinositol-3-kinase complex
  JOURNAL   Nat Cell Biol 11 (4), 468-476 (2009)
   PUBMED   19270693
  REMARK    GeneRIF: Beclin 1 and its binding proteins orchestrate the precise
            function of the class III PI(3)K in regulating autophagy at
            multiple steps.
REFERENCE   9  (bases 1 to 3466)
  AUTHORS   Itakura,E., Kishi,C., Inoue,K. and Mizushima,N.
  TITLE     Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes
            with mammalian Atg14 and UVRAG
  JOURNAL   Mol Biol Cell 19 (12), 5360-5372 (2008)
   PUBMED   18843052
  REMARK    GeneRIF: These results suggest that mammalian cells have at least
            two distinct class III PI3-kinase complexes, and that beclin 1
            interacts distinctly with mammalian Atg14 and UVRAG in two of these
            complexes.
REFERENCE   10 (bases 1 to 3466)
  AUTHORS   Lindmo,K. and Stenmark,H.
  TITLE     Regulation of membrane traffic by phosphoinositide 3-kinases
  JOURNAL   J Cell Sci 119 (Pt 4), 605-614 (2006)
   PUBMED   16467569
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054196.1, BC090995.1, AK029967.1 and AW123154.1.
            
            On or before Jan 14, 2011 this sequence version replaced
            XM_003085046.1, XM_003085045.1, NM_172599.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090995.1, AK029967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               AK054196.1         2-504
            504-3126            BC090995.1         484-3106
            3127-3437           AK029967.1         3108-3418
            3438-3466           AW123154.1         300-328
FEATURES             Location/Qualifiers
     source          1..3466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..3466
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /note="autophagy related 14"
                     /db_xref="GeneID:100504663"
                     /db_xref="MGI:MGI:1261775"
     exon            1..249
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1507
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /note="Atg14-like protein; autophagy-related protein
                     14-like protein; barkor; VATG14 autophagy related 14
                     homolog"
                     /codon_start=1
                     /product="beclin 1-associated autophagy-related key
                     regulator"
                     /protein_id="NP_766187.1"
                     /db_xref="CCDS:CCDS26989.1"
                     /db_xref="GeneID:100504663"
                     /db_xref="MGI:MGI:1261775"
                     /translation="MASPSGKGSWTPEAPGFGPRALARDLVDSVDDAEGLYVAVERCP
                     LCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSQLKNKQEEFQKEVLKAMEG
                     KRLTDQLRWKIMSCKMRIEQLKQTICKGNEEMKKNSEGLLKNKEKNQKLYSRAQRHQE
                     KKEKIQRHNRKLGDLVEKKTIDLKSHYERLARLRRSHILELTSIIFPIDEVKTSGRDP
                     ADVSSETDSAMTSSMVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDY
                     SAYYNWVEEKKTTQGPDMEHNNPAYTISAALGYATQLVNIVSHILDINLPKKLCNSEF
                     CGENLSKQKLTRAVRKLNANILYLCSSQHVNLDQLQPLHTLRNLMHLVSPRSEHLGRS
                     GPFEVRADLEESMEFVDPGVAGESDASGDERVSDEETDLGTDWENLPSPRFCDIPSQP
                     VEVSQSQSTQVSPPIASSSAGGMISSAAASVTSWFKAYTGHR"
     exon            250..312
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            313..355
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            356..437
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            438..675
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            676..905
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1023
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1114
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1200
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..3451
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3433..3438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /note="hexamer: AATAAA"
     polyA_site      3451
                     /gene="Atg14"
                     /gene_synonym="4832427M01; Atg14L; D14Ertd114e;
                     D14Ertd436e"
                     /note="major polyA site"
ORIGIN      
        1 acgtgactgg ccctgagctc agatcatcat ggcgtctccc agtgggaagg gatcttggac
       61 gcccgaggct cctggttttg ggccgcgggc gctagcacgg gacctggtgg actcggtgga
      121 cgacgccgag ggcctttacg tggctgttga gcggtgtcct ctgtgcaaca ccactcgccg
      181 gcggttgact tgcgccaagt gcgtccagag cggtgatttc gtctatttcg acggccgcga
      241 ccgggagagg tttattgaca agaaggaaag actaagccaa cttaagaaca agcaagaaga
      301 atttcagaaa gaagtactaa aagctatgga aggaaagcgg cttacagatc agttgagatg
      361 gaaaataatg tcatgcaaga tgaggattga acagctgaag caaacaatat gtaaaggaaa
      421 tgaggaaatg aagaaaaatt ctgaaggtct cctcaagaac aaggaaaaga accagaagct
      481 ttacagccga gcacagcggc accaagagaa aaaggagaag attcagcggc acaaccgcaa
      541 gcttggggac ctggtggaga agaagaccat tgacttgaag agtcactatg agcggttggc
      601 gcggcttcga aggtcacaca tcctagagct cacctccatc atattcccaa tcgacgaagt
      661 gaagacttct gggagagacc ctgcagacgt gtcttcagag actgacagtg ccatgacctc
      721 aagcatggtg agcaagcttg ctgaggcccg gaggacaact tacctctctg gaagatgggt
      781 ctgtgatgac cacaatggtg acaccagcat tagcatcaca ggcccgtgga ttagcctacc
      841 aaacaacggg gactactctg cttactacaa ttgggtagaa gagaagaaaa caacccaagg
      901 acctgacatg gagcataaca accccgccta cactatcagc gccgcgctgg gctacgccac
      961 gcagctcgtc aacattgtgt ctcacatact tgacatcaat cttcccaaaa agctgtgcaa
     1021 cagcgagttc tgtggcgaaa acctcagcaa gcagaaactg acacgcgcag tgaggaaact
     1081 gaacgcaaac atcctttacc tttgttcttc tcagcatgta aatctggatc agttgcaacc
     1141 actgcacaca ctcaggaacc tgatgcactt ggtcagcccg cgctctgagc acctaggcag
     1201 gtcaggaccc tttgaagttc gagcagacct cgaggagtcc atggaatttg tggaccctgg
     1261 agttgctgga gaatcagacg cgagtggaga tgagcgtgta agcgatgagg agactgacct
     1321 gggcacagac tgggagaacc tgccaagccc ccgattctgt gacatccctt cccagccggt
     1381 ggaagtgtcc cagagccaga gcacccaggt gtccccaccc attgccagca gcagcgctgg
     1441 tgggatgatc tcctccgctg cggcctcggt gacctcttgg ttcaaagctt acactggaca
     1501 ccgctaacga gttgggacca aaaatgctga ttttgtgtct cagagtcttt cccactgcac
     1561 tctcataacc ttgtctgtgt agttgcgata gagcttggaa gctatcgcca ggacaagatt
     1621 agtgtcaggg cctgagctcg gggctcctgg gcccaggtcc tcagtatgct ggttcctggg
     1681 tgcagagtct ccctgacact aagtcctagg ctttgatcag atcacaaaga agtgtttctt
     1741 ggtaatgagg aatgaaagac aaaggctgag tttgtttttc tgtcatcctc ttgagagacc
     1801 agccagcagg ccagcagcag tttggcctca tccgggagag gtggttgtct ggggaaggag
     1861 gaaatgaaag cttattgctt attgcttatt gtcagtcatt gtgcgtcaca ttcctgattt
     1921 cctactacac accaaagaaa ccaaattctt tatttctgta gacccatatc tgcgaatggg
     1981 gagtctgctg ggatggttag atgtctaaac agttctcttg tattctgaag ggagataagt
     2041 cattgggatt gtctgtacta cactcacttc ctccatcatt ccctggatgg gctaaatgct
     2101 acccgagcgt tggctgaaca cttacgtggt cactcgcttg ctgtccggtt tcttccttgg
     2161 tggtggtggt ggggttaact agtagcaggt gtttccaggg aactcttcct tcttgttcct
     2221 gaggtcttct tgtccctggg gtctctgaga ctgaagacag caccttatgc agagtgtagc
     2281 gcggagcagc tgtcccagga aatgctcagc tatcaaggga tttcctcaga ggtcattcta
     2341 atgacaatct tatagaaagc tataaaaaga gaggcattat gttcaagtca taaggagttc
     2401 tttttttatt tttagtaact tcaaaaagga agttctgtgt aacagactcc tgcagtcctg
     2461 tgagaaagca cccccctccc ctggccttgt caccatatcc tcctgttgtg actggtgtga
     2521 tggtacctca gccaggtcct tcagcagtct gccacgccct ggcttctgtt gactcacact
     2581 gtggttggta ctttgcctgc agattgaggt gctgtggcgc tttggcagtt attagaagtg
     2641 taggaaggac ttcatcctgc ccaggttccc cacgttccca agctctagat acccagctgt
     2701 ggagcaggcg gctggagtct gttctgtgct cagctctgcg actgctgggc tcgtgtttta
     2761 ccacctactt ctaggactta cagactgagt gcgctgggag gaagctacag aaagtgcaga
     2821 ggccaccaac taccgcctac agcaatttaa ccacagttgc agaaagcaca gggctgggtg
     2881 gccttgtttt atttcatatc aatcagaggc acttttgtca tcgtccctca cagtaagtga
     2941 ccagcacgga ctgcctaggc tgctcaagtc cttggggttt tgttattttg cactggatcc
     3001 acctgttgta aatagtctta aatacacatt tcaaccactg tttggttcct acactctttg
     3061 ctgctcatta aaactttttg tgtaggtgtc agaaccgtac acaaacagct ttctagaaaa
     3121 aaaaaaatga agctggtgtt ttgttttttt tttttaaacc gaaagccata gaagttgatc
     3181 atgttttcca tttaaaaatg atttcttgga acaaggtaat actaatagac actcagaggc
     3241 accacatggg ctgctttaca tggtcttacg tagaaccaag aaatgtaact taccatggta
     3301 tgggggtcag cattgggtgg ggttcaggtg tgcattggga aagctgcaac gtcagaaccc
     3361 ccttgctgcg actgaaactt ccaggtcagg ttgatcacac agatgttttc taaacctttg
     3421 ttgtattact gcaataaatc ctttaacagt aaaaaaaaaa aaaaaa
//
