LOCUS       NP_001342348             516 aa            linear   ROD 02-MAY-2024
DEFINITION  autophagy-related protein 13 isoform 4 [Mus musculus].
ACCESSION   NP_001342348 XP_006499953
VERSION     NP_001342348.1
DBSOURCE    REFSEQ: accession NM_001355419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 516)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 516)
  AUTHORS   Li,H., Li,C., Zhai,W., Zhang,X., Li,L., Wu,B., Yu,B., Zhang,P.,
            Li,J., Cui,C.P. and Zhang,L.
  TITLE     Destabilization of TP53 by USP10 is essential for neonatal
            autophagy and survival
  JOURNAL   Cell Rep 41 (1), 111435 (2022)
   PUBMED   36198274
REFERENCE   3  (residues 1 to 516)
  AUTHORS   Li,X., Zhu,Y., Lin,X., Chen,C., Liu,H. and Shi,Y.
  TITLE     Beclin1- and Atg13-dependent autophagy activation and morroniside
            have synergistic effect on osteoblastogenesis
  JOURNAL   Exp Biol Med (Maywood) 247 (19), 1764-1775 (2022)
   PUBMED   35957534
  REMARK    GeneRIF: Beclin1- and Atg13-dependent autophagy activation and
            morroniside have synergistic effect on osteoblastogenesis.
REFERENCE   4  (residues 1 to 516)
  AUTHORS   Ding,S., Abudupataer,M., Zhou,Z., Chen,J., Li,H., Xu,L., Zhang,W.,
            Zhang,S., Zou,Y., Hong,T., Wang,T.C., Yang,X. and Ge,J.
  TITLE     Histamine deficiency aggravates cardiac injury through
            miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis
  JOURNAL   Cell Death Dis 9 (6), 694 (2018)
   PUBMED   29880830
  REMARK    GeneRIF: acting through histamine 1 receptor, histamine increased
            miR-206 and miR-216b, which worked in concert to target to Atg13,
            resulting in the reduction of autophagy activation under hypoxia
            and acute myocardial infarction condition.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 516)
  AUTHORS   Wallot-Hieke,N., Verma,N., Schlutermann,D., Berleth,N.,
            Deitersen,J., Bohler,P., Stuhldreier,F., Wu,W., Seggewiss,S.,
            Peter,C., Gohlke,H., Mizushima,N. and Stork,B.
  TITLE     Systematic analysis of ATG13 domain requirements for autophagy
            induction
  JOURNAL   Autophagy 14 (5), 743-763 (2018)
   PUBMED   29173006
  REMARK    GeneRIF: these data establish the interaction between ATG13 and
            ATG101 as a promising target in disease-settings where the
            inhibition of autophagy is desired.
REFERENCE   6  (residues 1 to 516)
  AUTHORS   Jung,C.H., Jun,C.B., Ro,S.H., Kim,Y.M., Otto,N.M., Cao,J., Kundu,M.
            and Kim,D.H.
  TITLE     ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy
            machinery
  JOURNAL   Mol Biol Cell 20 (7), 1992-2003 (2009)
   PUBMED   19225151
REFERENCE   7  (residues 1 to 516)
  AUTHORS   Hosokawa,N., Hara,T., Kaizuka,T., Kishi,C., Takamura,A., Miura,Y.,
            Iemura,S., Natsume,T., Takehana,K., Yamada,N., Guan,J.L., Oshiro,N.
            and Mizushima,N.
  TITLE     Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200
            complex required for autophagy
  JOURNAL   Mol Biol Cell 20 (7), 1981-1991 (2009)
   PUBMED   19211835
REFERENCE   8  (residues 1 to 516)
  AUTHORS   Chan,E.Y., Longatti,A., McKnight,N.C. and Tooze,S.A.
  TITLE     Kinase-inactivated ULK proteins inhibit autophagy via their
            conserved C-terminal domains using an Atg13-independent mechanism
  JOURNAL   Mol Cell Biol 29 (1), 157-171 (2009)
   PUBMED   18936157
REFERENCE   9  (residues 1 to 516)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   10 (residues 1 to 516)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL714023.12.
            
            On Sep 20, 2017 this sequence version replaced XP_006499953.1.
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (4) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.141902.1,
                                           SRR1660819.190820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.63 cM"
     Protein         1..516
                     /product="autophagy-related protein 13 isoform 4"
                     /note="autophagy-related protein 13; ATG13 autophagy
                     related 13 homolog"
                     /calculated_mol_wt=56310
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O75143; propagated from
                     UniProtKB/Swiss-Prot (Q91YI1.2)"
     Region          19..192
                     /region_name="ATG13"
                     /note="Autophagy-related protein 13; pfam10033"
                     /db_xref="CDD:431003"
     Region          127..134
                     /region_name="Important for interaction with ATG101.
                     /evidence=ECO:0000250|UniProtKB:O75143"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YI1.2)"
     Region          336..359
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YI1.2)"
     Site            354
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ULK1.
                     /evidence=ECO:0000250|UniProtKB:O75143; propagated from
                     UniProtKB/Swiss-Prot (Q91YI1.2)"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75143; propagated from
                     UniProtKB/Swiss-Prot (Q91YI1.2)"
     Site            360
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75143; propagated from
                     UniProtKB/Swiss-Prot (Q91YI1.2)"
     Region          405..438
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YI1.2)"
     Region          443..446
                     /region_name="LIR"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YI1.2)"
     CDS             1..516
                     /gene="Atg13"
                     /gene_synonym="1110053A20Rik; D2Ertd391e; Harbi1"
                     /coded_by="NM_001355419.1:360..1910"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS89517.1"
                     /db_xref="GeneID:51897"
                     /db_xref="MGI:MGI:1196429"
ORIGIN      
        1 metelssqdr kdldkfikff alktvqvivq arlgekictr ssssptgsdw fnlaikdipe
       61 vtheakkals gqlpavgrsm cveislktse gdsmeleiwc lemnekcdke ikvsytvynr
      121 lslllkslla itrvtpayrl srkqgheyvi lyriyfgevq lnglgegfqt vrvgtvgtpv
      181 gtltlscayr inlafmstrq fertppimgi iidhfvdrpy pssspmhpcn yrtaedagva
      241 ypsvedsqev cttsfstspp sqlsssrlsy qpavlglgsa dlaypvvfta glntthahql
      301 mvpgkeggvt lapshpthga qadperlvmh mpsdgthcaa tpsssedtet vsnssegras
      361 phdiletifv rkvgafvnkp inqvtvtsld ipfamfapkn leledadpmv nppespetts
      421 plhgslhsdg ssggsggsth ddfvmidfkp afskddilpm dlgtfyrefq nppqlsslsi
      481 dfgaqsmaed ldslpeklav heknvrefda fvetlq
//
