LOCUS       NM_026217               2492 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus autophagy related 12 (Atg12), mRNA.
ACCESSION   NM_026217
VERSION     NM_026217.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2492)
  AUTHORS   Dellorusso,P.V., Proven,M.A., Calero-Nieto,F.J., Wang,X.,
            Mitchell,C.A., Hartmann,F., Amouzgar,M., Favaro,P., DeVilbiss,A.,
            Swann,J.W., Ho,T.T., Zhao,Z., Bendall,S.C., Morrison,S.,
            Gottgens,B. and Passegue,E.
  TITLE     Autophagy counters inflammation-driven glycolytic impairment in
            aging hematopoietic stem cells
  JOURNAL   Cell Stem Cell 31 (7), 1020-1037 (2024)
   PUBMED   38754428
REFERENCE   2  (bases 1 to 2492)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2492)
  AUTHORS   Li,H., Li,C., Zhai,W., Zhang,X., Li,L., Wu,B., Yu,B., Zhang,P.,
            Li,J., Cui,C.P. and Zhang,L.
  TITLE     Destabilization of TP53 by USP10 is essential for neonatal
            autophagy and survival
  JOURNAL   Cell Rep 41 (1), 111435 (2022)
   PUBMED   36198274
REFERENCE   4  (bases 1 to 2492)
  AUTHORS   Huang,C., Xue,X., Gong,N. and Jiang,J.
  TITLE     Ginsenoside Rg1 suppresses paraquat-induced epithelial cell
            senescence by enhancing autophagy in an ATG12-dependent manner
  JOURNAL   Environ Toxicol 37 (9), 2302-2313 (2022)
   PUBMED   35657166
  REMARK    GeneRIF: Ginsenoside Rg1 suppresses paraquat-induced epithelial
            cell senescence by enhancing autophagy in an ATG12-dependent
            manner.
REFERENCE   5  (bases 1 to 2492)
  AUTHORS   Yang,Y., Gomez,M., Marsh,T., Poillet-Perez,L., Sawant,A., Chen,L.,
            Park,N.R., Jackson,S.R., Hu,Z., Alon,N., Liu,C., Debnath,J.,
            Guan,J.L., Davidson,S., Verzi,M. and White,E.
  TITLE     Autophagy in PDGFRalpha+ mesenchymal cells is essential for
            intestinal stem cell survival
  JOURNAL   Proc Natl Acad Sci U S A 119 (21), e2202016119 (2022)
   PUBMED   35537042
REFERENCE   6  (bases 1 to 2492)
  AUTHORS   Jounai,N., Takeshita,F., Kobiyama,K., Sawano,A., Miyawaki,A.,
            Xin,K.Q., Ishii,K.J., Kawai,T., Akira,S., Suzuki,K. and Okuda,K.
  TITLE     The Atg5 Atg12 conjugate associates with innate antiviral immune
            responses
  JOURNAL   Proc Natl Acad Sci U S A 104 (35), 14050-14055 (2007)
   PUBMED   17709747
  REMARK    GeneRIF: Overexpression of Atg5 or Atg12 resulted in Atg5-Atg12
            conjugate formation and suppression of RNA-mediated signaling.
REFERENCE   7  (bases 1 to 2492)
  AUTHORS   Mizushima,N., Kuma,A., Kobayashi,Y., Yamamoto,A., Matsubae,M.,
            Takao,T., Natsume,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic
            isolation membrane with the Apg12-Apg5 conjugate
  JOURNAL   J Cell Sci 116 (Pt 9), 1679-1688 (2003)
   PUBMED   12665549
REFERENCE   8  (bases 1 to 2492)
  AUTHORS   Mizushima,N., Yoshimori,T. and Ohsumi,Y.
  TITLE     Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the
            conjugation-mediated yeast two-hybrid method
  JOURNAL   FEBS Lett 532 (3), 450-454 (2002)
   PUBMED   12482611
REFERENCE   9  (bases 1 to 2492)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   10 (bases 1 to 2492)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB853539.1, BC070470.1 and AV295996.1.
            
            On Apr 27, 2007 this sequence version replaced NM_026217.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.53835.1, AK008698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BB853539.1         2-31
            31-2482             BC070470.1         1-2452
            2483-2492           AV295996.1         276-285
FEATURES             Location/Qualifiers
     source          1..2492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.76 cM"
     gene            1..2492
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /note="autophagy related 12"
                     /db_xref="GeneID:67526"
                     /db_xref="MGI:MGI:1914776"
     exon            1..199
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..459
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /note="autophagy-related protein 12"
                     /codon_start=1
                     /product="ubiquitin-like protein ATG12"
                     /protein_id="NP_080493.2"
                     /db_xref="CCDS:CCDS37811.1"
                     /db_xref="GeneID:67526"
                     /db_xref="MGI:MGI:1914776"
                     /translation="MSEDSEVVLQLPSAPVGAGGESLPELSPETATPEPPSSAAVSPG
                     TEEPPGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLF
                     IYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG"
     exon            200..336
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /inference="alignment:Splign:2.1.0"
     exon            337..399
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /inference="alignment:Splign:2.1.0"
     exon            400..2492
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="Atg12"
                     /gene_synonym="4931423H11Rik; A330058M13Rik; Apg12l;
                     Atg12l"
                     /note="major polyA site"
ORIGIN      
        1 gtcacttccg ccgccgcctc tcagcaagca aagatgtcgg aagattcaga ggttgtgctg
       61 cagctcccct cggctcctgt aggagccggc ggcgagagcc ttccagagct ctccccggaa
      121 acagccaccc cagagccccc gtcctcggct gcagtttcgc ccggaacgga ggaacctccc
      181 ggagacacca agaaaaaaat tgacatcctg ctgaaggctg taggagacac tcctataatg
      241 aaaacaaaga aatgggctgt ggagcgaacc cggaccatcc aaggactcat tgacttcatc
      301 aaaaagttcc ttaaactggt ggcctcggaa cagttgttta tttatgtgaa tcagtccttt
      361 gccccttccc cagaccaaga agttggaact ctatatgagt gttttggcag tgatggtaaa
      421 ctggtcctgc attactgcaa atcccaggca tggggatgag ccagaaatga acaacttgat
      481 attttcacag aagaaaaaaa atcagagaca tttcggtgct gtgggaagag acttactatc
      541 aaatattcag catgaatctg ttaggacctg tgtttatgta taagaaaaca tcatagagta
      601 tatagactaa tgaatgagat ttgtgtcacc ataaaatcat catgagagat tgacgttaga
      661 gtgtgccatt actcccacac actcctgttc caggtcacgt tagaaaggag actgaagttg
      721 tatgtggatt gcaggtctca ggatgactga aggcatttac ttggttggca ctatgttaat
      781 tccgtgataa gaactaattt actgaagggt ttgtgttttg aggtaattta gtttttttgc
      841 ttattcaggg gacctctatt tgggatatag aatgtttaca tttatctgta ttgctctgta
      901 aaaaatagtg cactgatcta agttgtccgg tagagggcag ccagttggca aaaaggcttg
      961 acagttttca tggctttgcc aggtgattgg gggcaagact gttgaaccta atttctagtt
     1021 aatgtgtaat ccggaaagca gctgtgttga cacactggag gatgtgcata gtttaaaatt
     1081 aatcatgcag ggacacagtt ttacaaattg tgagcagatg agtctcagct cttcagtcct
     1141 gtcatttctg gttcttgcgc ctcatcctgg gcattgtgat ccatacctgc tgtctcagcg
     1201 ctcaggacac ctgagcagga agagtgaacc aggagtccac aactagactg cactgcaaaa
     1261 gaacttatcc caaaaagatt ctagagccct acccagtgtg gggaccacgc agcaccaact
     1321 tacccatctc ccaaccctca cttctcgtct ctatgtgctt ttagtttggg ttttgttttg
     1381 gtttttttgt tttgttttgt tttttttcca ggcctgggga tcattcccct tgcttgtgca
     1441 ctcaaggcat gggctttgct gagctgcatc tctccagcat tcattgagtg ttcataatgt
     1501 atttcccaaa ttgaaagtat tcagagctaa tggttgaaaa ctagtatcca attttatgtg
     1561 tattccgtgc catcacatac acacaaaaag agtgcagctg tcactggtga tgttagcctg
     1621 gctattgctt gagctaacat ttgacctttt tcttacatat tttatctcaa actttttttt
     1681 gaagctgggt ctcactatgt agatctgcct agcctggaac ttgcagagat cagtgtgtct
     1741 gtctatgcct ccaaagtgct gagatgaagg gatagcccac ctcactcagc cccacagcag
     1801 tcttaaattc caaccagaag cacacatggc agcactccta gcattgagga agtggaaaca
     1861 agcagactga aagtttaaga ctgtgtgggc tacagagtga gattgtctca cctctggggg
     1921 aaaaattaca gtaaaatgct actctgttgt tgtcctgctt ttgagattga ctgtgtcact
     1981 caggctgacc tgcctcaggc tccggggctt gcagctgtgc accactgcat ctggctcctt
     2041 tttaactctt tagctagagt gtgctctaga ggagcctcag ccatgtgagc catggaagaa
     2101 gctgtggaac aacacggtgc agtgctgacc acttgtcttc tgcgcaagag tgtgaattgt
     2161 ggacatgccc ttcctcagca tgccttgcag tgaggtcatg cagggaatag tcacagagca
     2221 ctgtggacag tggcttatgc acagtacagc cttaggaaaa caccttatat cttgaaaact
     2281 gggccgtatt atttatgaac aatgtcagtg ggaaagaaaa aagatgtgtt ctagctttgc
     2341 ctggtaattg gtgactgaaa gaacatagta gtagatattt acaggagaag tatgttgaat
     2401 ttattgttgg ctggtattca ttcgagatga cagaatgctt attacttcta tgaaatcaaa
     2461 aataaacttg aatttgaaac atttttacca ga
//
