LOCUS       NM_026566               1270 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus autophagy related 101 (Atg101), transcript variant 1,
            mRNA.
ACCESSION   NM_026566
VERSION     NM_026566.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1270)
  AUTHORS   Morishita,H., Kanda,Y., Kaizuka,T., Chino,H., Nakao,K., Miki,Y.,
            Taketomi,Y., Guan,J.L., Murakami,M., Aiba,A. and Mizushima,N.
  TITLE     Autophagy Is Required for Maturation of Surfactant-Containing
            Lamellar Bodies in the Lung and Swim Bladder
  JOURNAL   Cell Rep 33 (10), 108477 (2020)
   PUBMED   33296658
REFERENCE   2  (bases 1 to 1270)
  AUTHORS   Jung,C.H., Seo,M., Otto,N.M. and Kim,D.H.
  TITLE     ULK1 inhibits the kinase activity of mTORC1 and cell proliferation
  JOURNAL   Autophagy 7 (10), 1212-1221 (2011)
   PUBMED   21795849
REFERENCE   3  (bases 1 to 1270)
  AUTHORS   Kim,J., Kundu,M., Viollet,B. and Guan,K.L.
  TITLE     AMPK and mTOR regulate autophagy through direct phosphorylation of
            Ulk1
  JOURNAL   Nat Cell Biol 13 (2), 132-141 (2011)
   PUBMED   21258367
REFERENCE   4  (bases 1 to 1270)
  AUTHORS   Jung,C.H., Jun,C.B., Ro,S.H., Kim,Y.M., Otto,N.M., Cao,J., Kundu,M.
            and Kim,D.H.
  TITLE     ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy
            machinery
  JOURNAL   Mol Biol Cell 20 (7), 1992-2003 (2009)
   PUBMED   19225151
REFERENCE   5  (bases 1 to 1270)
  AUTHORS   Chan,E.Y., Longatti,A., McKnight,N.C. and Tooze,S.A.
  TITLE     Kinase-inactivated ULK proteins inhibit autophagy via their
            conserved C-terminal domains using an Atg13-independent mechanism
  JOURNAL   Mol Cell Biol 29 (1), 157-171 (2009)
   PUBMED   18936157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163018.3.
            
            On Mar 18, 2023 this sequence version replaced NM_026566.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150298.1, AK151381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC163018.3         81744-81988
            246-563             AC163018.3         84376-84693
            564-1270            AC163018.3         87711-88417
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.67 cM"
     gene            1..1270
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
                     /note="autophagy related 101"
                     /db_xref="GeneID:68118"
                     /db_xref="MGI:MGI:1915368"
     exon            1..245
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            246..563
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..968
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
                     /codon_start=1
                     /product="autophagy-related protein 101"
                     /protein_id="NP_080842.1"
                     /db_xref="CCDS:CCDS27849.1"
                     /db_xref="GeneID:68118"
                     /db_xref="MGI:MGI:1915368"
                     /translation="MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGT
                     YSIGTVGIQDVDCDFIDFTYVRVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEF
                     YQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMS
                     RHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITEALGTSVTTTMRRLIKDTLAL
                     "
     exon            564..1270
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1241
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
                     /note="major polyA site"
     polyA_site      1270
                     /gene="Atg101"
                     /gene_synonym="9430023L20Rik"
ORIGIN      
        1 agaggaagcg gaggcctgga ccggcgtctg tagggtctgg actcggtcct cgtcgtctgc
       61 actgctgtcc cgagacggcg cgaggtcgcg ggcagcgatc ctgacgtccg gtccggtcag
      121 aattctcggt gcgggtccaa atagcctgtt tttgcttttg gtctgtcccc gaatactgcg
      181 tgttcgcgtt agggaagaag gggacccgag gctgagtggc tcctgctcgg atttctacca
      241 gcaaggttgg cccctaggtg gggtgaagta tcctgtgtct tgcctttgct ccggctccag
      301 ctgcctgcag gatgaactgt cgatcagaag tgctggaggt gtcggtggag gggcggcagg
      361 tggaggaggc catgctggcg gtgctgcaca cggtgctcct gcaccgcagc acgggcaagt
      421 ttcactacaa gaaggagggc acgtactcca taggcaccgt gggcatccag gatgtagact
      481 gtgacttcat cgacttcacc tatgtgcgcg tctcctcaga ggagctggac cgtgccttgc
      541 gcaaggttgt tggggaattc aaggatgcac tgaggaactc aggtggtgat ggcctgggcc
      601 agatgtcctt ggaattctat cagaagaaaa agtctcgatg gcctttttcg gatgagtgca
      661 tcccctggga ggtgtggact gtcaaggtgc acgtggtagc cttggccaca gagcaggagc
      721 ggcagatatg cagggagaag gtgggcgaga agctgtgcga gaagatcatt aacatcgtgg
      781 aggtgatgag ccggcatgag tacctgccca agatgcccac gcagtcagag gtggacaacg
      841 tgtttgacac gggcctgcgg gacgtgcagc cctacctcta caagatctcc tttcagatca
      901 ccgaggccct gggcacctca gtcaccacca ccatgcgcag gctcatcaaa gacacccttg
      961 ccctgtaggt cttgctggag ccttaatggc agctccttaa tggttctggg agcgtgttgc
     1021 tgggatctcg gggctctgga acctgcacta gatccttggt gagacttgaa gagaagctcg
     1081 tggtgtcctt gttttgtggt tgccagcctc tggtgaccct gtcacctttg cagtggtctg
     1141 gtcctggatg cagcctttcc acctgctctg gtggggttca agttctacac tgtactgtac
     1201 tgtaggggtg ctgaataaag ttgaggtgtg agtttgtctc agctctcttg gcctgtgtcc
     1261 tgccctgaaa
//
