LOCUS       NM_001404925            1366 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus autophagy related 10 (Atg10), transcript variant 9,
            mRNA.
ACCESSION   NM_001404925 XM_030247366
VERSION     NM_001404925.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1366)
  AUTHORS   Li,H., Li,C., Zhai,W., Zhang,X., Li,L., Wu,B., Yu,B., Zhang,P.,
            Li,J., Cui,C.P. and Zhang,L.
  TITLE     Destabilization of TP53 by USP10 is essential for neonatal
            autophagy and survival
  JOURNAL   Cell Rep 41 (1), 111435 (2022)
   PUBMED   36198274
REFERENCE   2  (bases 1 to 1366)
  AUTHORS   Radoshevich,L., Murrow,L., Chen,N., Fernandez,E., Roy,S., Fung,C.
            and Debnath,J.
  TITLE     ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and
            cell death
  JOURNAL   Cell 142 (4), 590-600 (2010)
   PUBMED   20723759
REFERENCE   3  (bases 1 to 1366)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   4  (bases 1 to 1366)
  AUTHORS   Nemoto,T., Tanida,I., Tanida-Miyake,E., Minematsu-Ikeguchi,N.,
            Yokota,M., Ohsumi,M., Ueno,T. and Kominami,E.
  TITLE     The mouse APG10 homologue, an E2-like enzyme for Apg12p
            conjugation, facilitates MAP-LC3 modification
  JOURNAL   J Biol Chem 278 (41), 39517-39526 (2003)
   PUBMED   12890687
  REMARK    GeneRIF: The isolated mouse APG10 gene product interacts with
            mammalian Apg12p dependent on mammalian Apg7p (E1-like enzyme), and
            facilitates Apg12p conjugation.
REFERENCE   5  (bases 1 to 1366)
  AUTHORS   Mizushima,N., Yoshimori,T. and Ohsumi,Y.
  TITLE     Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the
            conjugation-mediated yeast two-hybrid method
  JOURNAL   FEBS Lett 532 (3), 450-454 (2002)
   PUBMED   12482611
  REMARK    GeneRIF: APG10 has a role in mediating the conjugation of APG12
            with APG5
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160980.5, AC134461.4 and AC108947.5.
            
            On Apr 15, 2022 this sequence version replaced XM_030247366.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.227303.1,
                                           SRR12282455.34656745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC160980.5         94502-94550
            50-165              AC160980.5         110056-110171
            166-261             AC134461.4         5432-5527
            262-359             AC108947.5         138513-138610       c
            360-475             AC108947.5         137807-137922       c
            476-1366            AC108947.5         136575-137465       c
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 46.46 cM"
     gene            1..1366
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="autophagy related 10"
                     /db_xref="GeneID:66795"
                     /db_xref="MGI:MGI:1914045"
     exon            1..49
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            50..165
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..459
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="isoform 4 is encoded by transcript variant 9;
                     ubiquitin-like-conjugating enzyme ATG10; autophagy-related
                     protein 10"
                     /codon_start=1
                     /product="ubiquitin-like-conjugating enzyme ATG10 isoform
                     4"
                     /protein_id="NP_001391854.1"
                     /db_xref="GeneID:66795"
                     /db_xref="MGI:MGI:1914045"
                     /translation="MEDEFFGEKSFQHYCAEFIRHSQQIGDGWEWRTAKECSDGYMCK
                     TQFRIKNETLTPHASVLTCLPTEEHPILGQPFFVLHPCKTNEFMTAVLKNSQKINRNV
                     NYITSWLSLVGPVVGLNLPLSYAKATSQSE"
     exon            166..261
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            262..359
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            360..475
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1366
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      850..855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="hexamer: AATAAA"
     polyA_site      890
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="major polyA site"
     regulatory      1346..1351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="hexamer: ATTAAA"
     polyA_site      1366
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="major polyA site"
ORIGIN      
        1 gctccgcccc gtgcgcgccg ccggctccag gtcagggcga gcgagcgggt tctcattaac
       61 atggaggatg agttctttgg agaaaaaagc ttccagcatt attgtgcaga attcatcaga
      121 cattcacagc agataggcga tggctgggaa tggagaacag ccaaggaatg ttctgatggc
      181 tacatgtgca aaacacagtt tcgaataaag aatgagacct tgacaccaca tgccagtgtg
      241 ctcacatgtc tccctacaga ggaacatcca atacttgggc aaccattttt tgttctacat
      301 ccctgcaaga caaatgaatt catgactgct gtgctaaaga attcacagaa aatcaataga
      361 aatgtcaact atatcacatc atggctgagc ctcgtggggc cagtggttgg tctgaattta
      421 cctctgagct atgctaaagc aacatcacaa tcggagtgac ttgttaacaa gcaagatccg
      481 ctgatcttag aaactgcagc atgaagaatg ccaagagctg tacatggaaa tgggactgca
      541 atatctcaca tcaccaagat ttgatacaga tttctttcct cagaaagaag acatctgcag
      601 aagcctgttt ggaatagaac atgtgtggaa gaaacatgtc acagattccg atcactataa
      661 ataacaagaa tgaacctagt ttggtgatga tgtcatttct gacgtcatca gggcgtgcac
      721 aggtcgtttt tgcctaggca cagttctcct gctgtggaga ttgatgggga agtgtatttg
      781 tgtgctcgct ttagtgaacg atgaatgaaa attaaaatgt agaacttgcc tgtttctgaa
      841 aattaatgta ataaatatga cacatcttaa attattctcc cacagtcaaa ttcaggagca
      901 atggattatt tctctatcac tcaccaaaaa aaaaaaaaag tgtgtgtgtg tgtgtgtgtg
      961 tgtgtgtgtg tgtgtgtgcg cgtgtctgtg gtgtgtatgt taacacacac ataaaaaatt
     1021 agatgcagaa taaagaatag ctgatcattt taatataata atttgtttta caagctaagt
     1081 atggaatggt aactacaggt tttttaaata gctatagaaa acatttaagc attgcaaatg
     1141 cctttttttt ttttataaaa ataacacaat cattttcctt cttcctggga gacccacgac
     1201 tgctctgttg aattactgca ggcctctctt catagcccta caatgttctg tgtaatatga
     1261 gaataacaaa ctgtctcata acgttgctgt gagaactata tgaaatcatt aacacacaat
     1321 tattgaaaag tgtatacaaa tactaattaa atactcacct gctgca
//
