LOCUS       NM_001404919            1796 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus autophagy related 10 (Atg10), transcript variant 4,
            mRNA.
ACCESSION   NM_001404919
VERSION     NM_001404919.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Li,H., Li,C., Zhai,W., Zhang,X., Li,L., Wu,B., Yu,B., Zhang,P.,
            Li,J., Cui,C.P. and Zhang,L.
  TITLE     Destabilization of TP53 by USP10 is essential for neonatal
            autophagy and survival
  JOURNAL   Cell Rep 41 (1), 111435 (2022)
   PUBMED   36198274
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Radoshevich,L., Murrow,L., Chen,N., Fernandez,E., Roy,S., Fung,C.
            and Debnath,J.
  TITLE     ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and
            cell death
  JOURNAL   Cell 142 (4), 590-600 (2010)
   PUBMED   20723759
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Nemoto,T., Tanida,I., Tanida-Miyake,E., Minematsu-Ikeguchi,N.,
            Yokota,M., Ohsumi,M., Ueno,T. and Kominami,E.
  TITLE     The mouse APG10 homologue, an E2-like enzyme for Apg12p
            conjugation, facilitates MAP-LC3 modification
  JOURNAL   J Biol Chem 278 (41), 39517-39526 (2003)
   PUBMED   12890687
  REMARK    GeneRIF: The isolated mouse APG10 gene product interacts with
            mammalian Apg12p dependent on mammalian Apg7p (E1-like enzyme), and
            facilitates Apg12p conjugation.
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Mizushima,N., Yoshimori,T. and Ohsumi,Y.
  TITLE     Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the
            conjugation-mediated yeast two-hybrid method
  JOURNAL   FEBS Lett 532 (3), 450-454 (2002)
   PUBMED   12482611
  REMARK    GeneRIF: APG10 has a role in mediating the conjugation of APG12
            with APG5
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160980.5, AC134461.4 and AC108947.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.186938.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC160980.5         94502-94550
            50-242              AC160980.5         101967-102159
            243-358             AC160980.5         110056-110171
            359-454             AC134461.4         5432-5527
            455-593             AC134461.4         118756-118894
            594-691             AC134461.4         137077-137174
            692-789             AC108947.5         138513-138610       c
            790-905             AC108947.5         137807-137922       c
            906-1796            AC108947.5         136575-137465       c
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 46.46 cM"
     gene            1..1796
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="autophagy related 10"
                     /db_xref="GeneID:66795"
                     /db_xref="MGI:MGI:1914045"
     exon            1..49
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            50..242
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            243..358
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..889
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="isoform 1 is encoded by transcript variant 4;
                     ubiquitin-like-conjugating enzyme ATG10; autophagy-related
                     protein 10"
                     /codon_start=1
                     /product="ubiquitin-like-conjugating enzyme ATG10 isoform
                     1"
                     /protein_id="NP_001391848.1"
                     /db_xref="GeneID:66795"
                     /db_xref="MGI:MGI:1914045"
                     /translation="MEDEFFGEKSFQHYCAEFIRHSQQIGDGWEWRTAKECSDGYMCK
                     TQFRIKNETLTPHASVLTCLPTEENLELPMDDSEVTRPAAVAEVIKHEYHVLYSCSYQ
                     VPVLYFRASFLDGRPLALEDIWEGVHECYKPRLLQGPWDTITQQEHPILGQPFFVLHP
                     CKTNEFMTAVLKNSQKINRNVNYITSWLSLVGPVVGLNLPLSYAKATSQSE"
     exon            359..454
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            455..593
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            594..691
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            692..789
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            790..905
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1796
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1280..1285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="major polyA site"
     regulatory      1776..1781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="hexamer: ATTAAA"
     polyA_site      1796
                     /gene="Atg10"
                     /gene_synonym="5330424L23Rik; 5430428K15Rik; Agp10; APG10;
                     Apg10l; Apg10p; Atg10l; mAPG10"
                     /note="major polyA site"
ORIGIN      
        1 gctccgcccc gtgcgcgccg ccggctccag gtcagggcga gcgagcgggt acacggtagc
       61 tgtcttcaga cacagcagaa ggcagcattg gatcccatta cagatggctg tgagccgcca
      121 tgtggctgct gaggattgaa ctcaggacct ctggaagagc aatcagtgct cttaaccgct
      181 gagccgtctc tccagccccg aaatctacat tttcgagctt tgtctgtcag ggacccttcg
      241 agttctcatt aacatggagg atgagttctt tggagaaaaa agcttccagc attattgtgc
      301 agaattcatc agacattcac agcagatagg cgatggctgg gaatggagaa cagccaagga
      361 atgttctgat ggctacatgt gcaaaacaca gtttcgaata aagaatgaga ccttgacacc
      421 acatgccagt gtgctcacat gtctccctac agaggagaat ttagagctac caatggatga
      481 ttctgaagtg acgagacctg cagcggtggc agaagtgatt aaacatgagt atcatgtctt
      541 atactcttgt agttaccaag tgccggttct ttactttagg gcaagctttt tagatgggag
      601 accgttagct ctggaggata tatgggaagg tgttcatgag tgctataagc cgaggctgct
      661 ccagggaccg tgggatacca tcacccagca ggaacatcca atacttgggc aaccattttt
      721 tgttctacat ccctgcaaga caaatgaatt catgactgct gtgctaaaga attcacagaa
      781 aatcaataga aatgtcaact atatcacatc atggctgagc ctcgtggggc cagtggttgg
      841 tctgaattta cctctgagct atgctaaagc aacatcacaa tcggagtgac ttgttaacaa
      901 gcaagatccg ctgatcttag aaactgcagc atgaagaatg ccaagagctg tacatggaaa
      961 tgggactgca atatctcaca tcaccaagat ttgatacaga tttctttcct cagaaagaag
     1021 acatctgcag aagcctgttt ggaatagaac atgtgtggaa gaaacatgtc acagattccg
     1081 atcactataa ataacaagaa tgaacctagt ttggtgatga tgtcatttct gacgtcatca
     1141 gggcgtgcac aggtcgtttt tgcctaggca cagttctcct gctgtggaga ttgatgggga
     1201 agtgtatttg tgtgctcgct ttagtgaacg atgaatgaaa attaaaatgt agaacttgcc
     1261 tgtttctgaa aattaatgta ataaatatga cacatcttaa attattctcc cacagtcaaa
     1321 ttcaggagca atggattatt tctctatcac tcaccaaaaa aaaaaaaaag tgtgtgtgtg
     1381 tgtgtgtgtg tgtgtgtgtg tgtgtgtgcg cgtgtctgtg gtgtgtatgt taacacacac
     1441 ataaaaaatt agatgcagaa taaagaatag ctgatcattt taatataata atttgtttta
     1501 caagctaagt atggaatggt aactacaggt tttttaaata gctatagaaa acatttaagc
     1561 attgcaaatg cctttttttt ttttataaaa ataacacaat cattttcctt cttcctggga
     1621 gacccacgac tgctctgttg aattactgca ggcctctctt catagcccta caatgttctg
     1681 tgtaatatga gaataacaaa ctgtctcata acgttgctgt gagaactata tgaaatcatt
     1741 aacacacaat tattgaaaag tgtatacaaa tactaattaa atactcacct gctgca
//
