LOCUS       NM_001310070            1848 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus activating transcription factor 7 (Atf7), transcript
            variant 3, mRNA.
ACCESSION   NM_001310070
VERSION     NM_001310070.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Wang,K., Li,F.H., Zhou,L.Y., Zhao,X.M., Gao,X.Q., Liu,C.Y.,
            Li,X.M., Chen,X.Z., Zhao,Y., Cheng,X.L., Wang,R.Q., Li,R.F.,
            Zhang,Y.H., Gao,F., Tian,J.W. and Wang,K.
  TITLE     HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5
            C Methylation of Atf7 mRNA
  JOURNAL   Adv Sci (Weinh) 10 (34), e2304329 (2023)
   PUBMED   37870216
  REMARK    GeneRIF: HNEAP Regulates Necroptosis of Cardiomyocytes by
            Suppressing the m[5] C Methylation of Atf7 mRNA.
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   Yoshida,K., Maekawa,T., Ly,N.H., Fujita,S.I., Muratani,M., Ando,M.,
            Katou,Y., Araki,H., Miura,F., Shirahige,K., Okada,M., Ito,T.,
            Chatton,B. and Ishii,S.
  TITLE     ATF7-Dependent Epigenetic Changes Are Required for the
            Intergenerational Effect of a Paternal Low-Protein Diet
  JOURNAL   Mol Cell 78 (3), 445-458 (2020)
   PUBMED   32197065
  REMARK    GeneRIF: ATF7-Dependent Epigenetic Changes Are Required for the
            Intergenerational Effect of a Paternal Low-Protein Diet.
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   Meijer,B.J., Giugliano,F.P., Baan,B., van der Meer,J.H.M.,
            Meisner,S., van Roest,M., Koelink,P.J., de Boer,R.J., Jones,N.,
            Breitwieser,W., van der Wel,N.N., Wildenberg,M.E., van den
            Brink,G.R., Heijmans,J. and Muncan,V.
  TITLE     ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial
            Repair
  JOURNAL   Cell Mol Gastroenterol Hepatol 10 (1), 23-42 (2020)
   PUBMED   31958521
  REMARK    GeneRIF: ATF2 and ATF7 Are Critical Mediators of Intestinal
            Epithelial Repair.
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Maekawa,T., Liu,B., Liu,Y., Yoshida,K., Muratani,M., Chatton,B. and
            Ishii,S.
  TITLE     Stress-induced and ATF7-dependent epigenetic change influences
            cellular senescence
  JOURNAL   Genes Cells 24 (9), 627-635 (2019)
   PUBMED   31294895
  REMARK    GeneRIF: ATF7 is involved in regulating lifespan and stress-induced
            senescence via p16Ink4a gene transcription.
REFERENCE   6  (bases 1 to 1848)
  AUTHORS   Maekawa,T., Kim,S., Nakai,D., Makino,C., Takagi,T., Ogura,H.,
            Yamada,K., Chatton,B. and Ishii,S.
  TITLE     Social isolation stress induces ATF-7 phosphorylation and impairs
            silencing of the 5-HT 5B receptor gene
  JOURNAL   EMBO J 29 (1), 196-208 (2010)
   PUBMED   19893493
  REMARK    GeneRIF: Atf-7-deficient mice exhibit abnormal behaviours and
            increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe
            nuclei.
REFERENCE   7  (bases 1 to 1848)
  AUTHORS   Breitwieser,W., Lyons,S., Flenniken,A.M., Ashton,G., Bruder,G.,
            Willington,M., Lacaud,G., Kouskoff,V. and Jones,N.
  TITLE     Feedback regulation of p38 activity via ATF2 is essential for
            survival of embryonic liver cells
  JOURNAL   Genes Dev 21 (16), 2069-2082 (2007)
   PUBMED   17699753
REFERENCE   8  (bases 1 to 1848)
  AUTHORS   Nystedt,J.M., Brandt,A., Vilim,F.S., Ziff,E.B. and Panula,P.
  TITLE     Identification of transcriptional regulators of neuropeptide FF
            gene expression
  JOURNAL   Peptides 27 (5), 1020-1035 (2006)
   PUBMED   16515822
REFERENCE   9  (bases 1 to 1848)
  AUTHORS   Miyamoto-Sato,E., Ishizaka,M., Horisawa,K., Tateyama,S.,
            Takashima,H., Fuse,S., Sue,K., Hirai,N., Masuoka,K. and Yanagawa,H.
  TITLE     Cell-free cotranslation and selection using in vitro virus for
            high-throughput analysis of protein-protein interactions and
            complexes
  JOURNAL   Genome Res 15 (5), 710-717 (2005)
   PUBMED   15867431
REFERENCE   10 (bases 1 to 1848)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164412.1, AC123870.3 and AK047901.1.
            
            Transcript Variant: This variant (3) contains an alternate 3'
            terminal exon resulting in a novel 3' coding region and 3' UTR,
            compared to variant 1. It encodes isoform 2 which is shorter and
            has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047901.1, SRR17253011.3510438.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AK164412.1         2-72
            72-72               AC123870.3         94645-94645
            73-391              AK164412.1         74-392
            392-1848            AK047901.1         2-1458
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.66 cM"
     gene            1..1848
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /note="activating transcription factor 7"
                     /db_xref="GeneID:223922"
                     /db_xref="MGI:MGI:2443472"
     exon            1..426
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..495
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..1722
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /note="isoform 2 is encoded by transcript variant 3;
                     cyclic AMP-dependent transcription factor ATF-7;
                     transcription factor ATF-A; cAMP-dependent transcription
                     factor ATF-7"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-7
                     isoform 2"
                     /protein_id="NP_001296999.1"
                     /db_xref="CCDS:CCDS84197.1"
                     /db_xref="GeneID:223922"
                     /db_xref="MGI:MGI:2443472"
                     /translation="MGDDRPFVCSAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDS
                     VIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKASDDDEKKGAAGPLDMSLPSTP
                     DIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTTKPVVISTPTPTIVRPGSLPLHL
                     GYDPLHPTLPSPTSVITQAPPSNRQIGSPTGSLPLVMHLANGQTMPMLPGPPVQMPSV
                     ISLARPVSMVPNIPGIPGPPVNNSGSISPSGHPMPSEAKMRLKATLTHQVSSINGGCG
                     MVVGTASTMVTARPEQNQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDER
                     RQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLL
                     LAHKDCPVTALQKKTQGYLEHQKPDLEGLPLQ"
     exon            496..592
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            593..711
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..849
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1007
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1107
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1221
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1374
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1572
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1681
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1848
                     /gene="Atf7"
                     /gene_synonym="1110012F10Rik; 9430065F09Rik;
                     C130020M04Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgggagga aagtatctgc tccgctgagg ggggaaagga ggagcaggag acagattgtg
       61 ggaccgagcg cgggcgggcg ggaggcgccg gagctaccag cgggtgagtc ctgttaacat
      121 tagctagtcc gtggcctgac aggagtctct ccttctactc tggccagtcc cagcgtcccg
      181 ggccggggtc tcccctccca gtctgttgga cgggggcgct gaggcggtgg ccaggcctgt
      241 ctgaggaaga gggtggggcg taggctaaag acaaccaata ggagagaagg aagccacaat
      301 tggcggccat gagcgctaat gggagatcgc ctttaccttg cggagtgccg ccctcttctc
      361 ttctcccgcc tccttccttt tggaggaagg cggggccaga ggactgaagt gtggggagaa
      421 cttgggctct gctctgcttt atgaaatatg ggagacgaca gaccgtttgt gtgcagtgcc
      481 ccgggctgtg gacagagatt tacaaatgag gaccacctgg cagttcataa acataagcat
      541 gagatgacac tgaaatttgg cccagcccga acggactcag tcatcattgc agatcaaacg
      601 cctactccaa ctagattcct gaagaactgt gaggaagtgg ggctcttcaa tgaactagct
      661 agctcctttg aacatgaatt taagaaagct tctgatgacg atgagaaaaa gggtgctgct
      721 gggcctcttg acatgtctct gccttctaca ccagacatca aaatcaagga agaagagcca
      781 gtggaagtag actcatcgcc ccctgacagt cctgcttcta gcccctgttc cccaccactg
      841 aaggagaagg aagttaccac aaaaccggtt gtgatctcta cccctacacc taccattgta
      901 cgtcctggct ccctgcctct ccacttaggt tatgatccac ttcatccaac tcttccttcc
      961 ccaacctctg tcatcacaca ggctccacca tccaacaggc aaataggatc tcctactggc
     1021 tccctccctc tcgtcatgca tcttgctaat ggacagacca tgcctatgtt gccagggcct
     1081 ccagtacaga tgccttctgt tatttcgctg gccagacctg tgtccatggt gcccaacatt
     1141 cctggtatac ctggcccacc ggttaacaac agtggctcca tttctccctc tggccaccct
     1201 atgccgtcag aagccaaaat gagactaaaa gccacgctga cccatcaagt ttcttcaatc
     1261 aatggaggtt gtggaatggt ggtgggtact gcaagcacca tggtgactgc ccgtccagag
     1321 caaaaccaga tcctcatcca gcacccagat gccccatccc ctgcccagcc acaggtctct
     1381 ccagctcagc ccacccctag cactggggga cggcgacggc gtacagtgga tgaagatcca
     1441 gatgagcggc ggcagcggtt tttagagcga aacagagctg cagcctctcg atgccggcaa
     1501 aagcggaaac tgtgggtgtc ctccctggaa aagaaggcag aagaacttac ttctcagaac
     1561 attcagctga gtaatgaagt cacattacta cgcaatgagg tggctcagct gaagcagcta
     1621 ctgttagctc ataaagattg cccagtcact gcactacaga aaaagactca aggctaccta
     1681 gaacatcaga aacctgatct agaaggtctc cctctgcagt agagcacctg cctaccatac
     1741 acaaggctct tcatttggac ttgattccca agaaagaaat tttaaaatgc cacttatccg
     1801 caaacctaaa atgtaagttg gttccaataa agtacttccc tgttgagc
//
