LOCUS       NM_017406               2586 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus activating transcription factor 6 beta (Atf6b), mRNA.
ACCESSION   NM_017406 XM_001001528 XM_001001538 XM_001001551
VERSION     NM_017406.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Akai,R., Hamashima,H., Saito,M., Kohno,K. and Iwawaki,T.
  TITLE     Partial limitation of cellular functions and compensatory
            modulation of unfolded protein response pathways caused by
            double-knockout of ATF6alpha and ATF6beta
  JOURNAL   Cell Stress Chaperones 29 (1), 34-48 (2024)
   PUBMED   38320450
  REMARK    GeneRIF: Partial limitation of cellular functions and compensatory
            modulation of unfolded protein response pathways caused by
            double-knockout of ATF6alpha and ATF6beta.
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Tanaka,T., Nguyen,D.T., Kwankaew,N., Sumizono,M., Shinoda,R.,
            Ishii,H., Takarada-Iemata,M., Hattori,T., Oyadomari,S., Kato,N.,
            Mori,K. and Hori,O.
  TITLE     ATF6beta Deficiency Elicits Anxiety-like Behavior and Hyperactivity
            Under Stress Conditions
  JOURNAL   Neurochem Res 48 (7), 2175-2186 (2023)
   PUBMED   36853481
  REMARK    GeneRIF: ATF6beta Deficiency Elicits Anxiety-like Behavior and
            Hyperactivity Under Stress Conditions.
REFERENCE   4  (bases 1 to 2586)
  AUTHORS   Nguyen,D.T., Le,T.M., Hattori,T., Takarada-Iemata,M., Ishii,H.,
            Roboon,J., Tamatani,T., Kannon,T., Hosomichi,K., Tajima,A.,
            Taniuchi,S., Miyake,M., Oyadomari,S., Tanaka,T., Kato,N., Saito,S.,
            Mori,K. and Hori,O.
  TITLE     The ATF6beta-calreticulin axis promotes neuronal survival under
            endoplasmic reticulum stress and excitotoxicity
  JOURNAL   Sci Rep 11 (1), 13086 (2021)
   PUBMED   34158584
  REMARK    GeneRIF: The ATF6beta-calreticulin axis promotes neuronal survival
            under endoplasmic reticulum stress and excitotoxicity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2586)
  AUTHORS   Danilova,T., Galli,E., Pakarinen,E., Palm,E., Lindholm,P.,
            Saarma,M. and Lindahl,M.
  TITLE     Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is
            Highly Expressed in Mouse Tissues With Metabolic Function
  JOURNAL   Front Endocrinol (Lausanne) 10, 765 (2019)
   PUBMED   31781038
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2586)
  AUTHORS   Lee,A.H., Iwakoshi,N.N. and Glimcher,L.H.
  TITLE     XBP-1 regulates a subset of endoplasmic reticulum resident
            chaperone genes in the unfolded protein response
  JOURNAL   Mol Cell Biol 23 (21), 7448-7459 (2003)
   PUBMED   14559994
REFERENCE   7  (bases 1 to 2586)
  AUTHORS   Yung Yu,C., Yang,Z., Blanchong,C.A. and Miller,W.
  TITLE     The human and mouse MHC class III region: a parade of 21 genes at
            the centromeric segment
  JOURNAL   Immunol Today 21 (7), 320-328 (2000)
   PUBMED   10871871
  REMARK    Review article
REFERENCE   8  (bases 1 to 2586)
  AUTHORS   Ikuta,T., Sogawa,N., Ariga,H., Ikemura,T. and Matsumoto,K.
  TITLE     Structural analysis of mouse tenascin-X: evolutionary aspects of
            reduplication of FNIII repeats in the tenascin gene family
  JOURNAL   Gene 217 (1-2), 1-13 (1998)
   PUBMED   9795100
REFERENCE   9  (bases 1 to 2586)
  AUTHORS   Min,J., Shukla,H., Kozono,H., Bronson,S.K., Weissman,S.M. and
            Chaplin,D.D.
  TITLE     A novel Creb family gene telomeric of HLA-DRA in the HLA complex
  JOURNAL   Genomics 30 (2), 149-156 (1995)
   PUBMED   8586413
REFERENCE   10 (bases 1 to 2586)
  AUTHORS   Matsumoto,K., Saga,Y., Ikemura,T., Sakakura,T. and
            Chiquet-Ehrismann,R.
  TITLE     The distribution of tenascin-X is distinct and often reciprocal to
            that of tenascin-C
  JOURNAL   J Cell Biol 125 (2), 483-493 (1994)
   PUBMED   7512972
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009767.6, AK146671.1 and BP766726.1.
            
            On Nov 6, 2012 this sequence version replaced NM_017406.3.
            
            Sequence Note: An in-frame AUG is located 15 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is in a weak Kozak sequence context and very
            near the 5' end of the transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013534.1, AK146671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CT009767.6         204573-204606
            35-2564             AK146671.1         2-2531
            2565-2586           BP766726.1         28-49               c
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.22 cM"
     gene            1..2586
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /note="activating transcription factor 6 beta"
                     /db_xref="GeneID:12915"
                     /db_xref="MGI:MGI:105121"
     exon            1..171
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..251
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..330
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..422
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..558
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..644
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..780
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..912
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1046
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1232
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1324
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1504
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1612
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1694
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1765
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1877
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1962
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2566
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2538..2543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /note="hexamer: AATAAA"
     polyA_site      2566
                     /gene="Atf6b"
                     /gene_synonym="ATF6beta; Creb-rp; Crebl1"
                     /note="major polyA site"
ORIGIN      
        1 cgccggtttt cctcagcgag ctcatggatt tgccgcggcc gggaggaggc gggccgggga
       61 gccggctcat ggtggggggt ggggggaaga tggcggagct gatgctcctc agtgagatcg
      121 ccgacccgac gcgcttcttc accgacaacc tgctgagtcc ggaggactgg gacagcacct
      181 tgtacagtgg cctggatgaa gtggccgagg agcaggcaca gttgttccgt tgcgtggagc
      241 aggatgtccc gtttgacagc agctctctgg atgtggggat ggatgtcagc ccccctgagc
      301 ccccttggga ccctctaccc atcttcccag atcttcaggt gaagtccgag ccatcctctc
      361 cctgctcgtc ctcctccctc agctcagagt cctcacatct ttccacagag ccccccagcc
      421 aggtccctgg tgtaggcgag gtgctgcatg tgaagatgga gtccctggca cccccactct
      481 gcctgctggg ggatgatcca gcatccccct ttgaaacggt ccagatcact gtgggctctg
      541 cctctgatga tctttcagat atccagacca agctggaacc tgcctctccg tcttcttctg
      601 tccactctga ggcctccttg ctgtcagcag actctcccag tcagcctttt ataggagagg
      661 aggttctgga agtgaagaca gagtctccgt cccctccagg gtgcctcctg tgggatgtcc
      721 cagcctcttc gctcggagct gtccagatca gcatgggtcc atcccctgat agttcctcag
      781 ggaaagctcc ggccactcgg aagcctccac tgcagcccaa gcctgtggta ctaaccacag
      841 ttccggtgcc acctagagct gggcctacca gcgctgccgt cctcctgcaa cccctggtcc
      901 agcagcctgc ggtgtcccca gtggtcctca tccaaggtgc tatccgagtc cagcctgaag
      961 ggccagctcc cgcagctccc cggcctgaga ggaagagcat tgttccagcc cctatgccgg
     1021 ggaactcctg cccgcctgaa gtggatgcaa agctgttgaa gcggcagcag cggatgatca
     1081 agaatcgaga gtcggcctgc cagtcccgcc gcaagaagaa agagtacctg caaggcctgg
     1141 aggcccggct gcaggctgtg ctggccgaca accagcagct gcgcagggag aacgctgccc
     1201 tccggcggcg gctggaggcc ctgctggcag agaacagcgg gctcaagctg gggtctggaa
     1261 acaggaaggt tgtctgcatc atggtcttcc ttctcttcat tgccttcaac tttgggcctg
     1321 tgagcatcag cgagccgcct ccagctccca tgtctcctcg gatgagcagg gaggaacctc
     1381 gaccccagag gcacctgctg ggcttctcag aaccagggcc agctcatggc atggaacccc
     1441 ttcgggaagc cgcccagagc cccggggagc agcagcccag ctctgcaggc aggcccagct
     1501 tcagaaacct gacggccttc cccgggggag ccaaggagct gctgctgaga gacctggacc
     1561 agctcttcct ctcctcagac tgtcgccatt tcaaccgaac tgagtctctg aggcttgctg
     1621 atgagctgag tggctgggtc caacgtcacc agagaggtcg acggaagata cctcacaggg
     1681 cccaggagag acagaagtct cagctacgga agaagtctcc tccagtgaaa cctgtcccca
     1741 cccaacctcc aggaccccct gaaagggacc ccgtgggcca gctgcagctc taccgccacc
     1801 ccggccgctc gcagccggag tttctagacg caattgaccg gagggaggat accttctatg
     1861 ttgtctcctt ccgaagggac cacctgctgc tcccagccat cagccacaac aagacatcca
     1921 ggcccaagat gtcgctggtg atgccagcca tggcccccaa tgagaccgtg tcaggccggg
     1981 gccccccagg ggactatgag gagatgatgc agatcgagtg tgaggtcatg gacaccaggg
     2041 tgattcacat caagacctct acggtgcccc cctcgctccg gaagcagccg tccccatccc
     2101 cgggcaatac cacaggtggc cccttgccag gctccgcagc tagtcctgcc catcaggcct
     2161 cccagcccct ctacctcaat cacccctgac atcctcacct cacagtgact tagaaccggg
     2221 ttagggaacc tgatcctggg gctcgggggc aattgtaaag gaagacgggg tgtgggggtt
     2281 aagcacttag tgggactagg gtgggtggtt cacctctctt ctcactcttt ccagaaatat
     2341 agggctcctc tcattcctgc actcccagtc ctctttcccc gagggtacct cgtgagggtt
     2401 tcccccatat cctcttcatt ctctccttta tctgtttggg agtcaaggtg ggactaggtc
     2461 cccaggtggg acaagggatg gttgtgggtg gcagaagtca gtttatgtgt gtgcgtatct
     2521 tttttttatt attattaaat aaacaacgtg gaggggtgta aaggaaaaaa aaaaaaaaaa
     2581 aaaaaa
//
