LOCUS       NM_030693               1753 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus activating transcription factor 5 (Atf5), transcript
            variant 1, mRNA.
ACCESSION   NM_030693 NM_033369
VERSION     NM_030693.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1753)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1753)
  AUTHORS   An,H., Zhou,B., Hayakawa,K., Duran Laforet,V., Park,J.H.,
            Nakamura,Y., Mandeville,E.T., Liu,N., Guo,S., Yu,Z., Shi,J., Wu,D.,
            Li,W., Lo,E.H. and Ji,X.
  TITLE     ATF5-Mediated Mitochondrial Unfolded Protein Response (UPRmt)
            Protects Neurons Against Oxygen-Glucose Deprivation and Cerebral
            Ischemia
  JOURNAL   Stroke 55 (7), 1904-1913 (2024)
   PUBMED   38913800
  REMARK    GeneRIF: ATF5-Mediated Mitochondrial Unfolded Protein Response
            (UPR[mt]) Protects Neurons Against Oxygen-Glucose Deprivation and
            Cerebral Ischemia.
REFERENCE   3  (bases 1 to 1753)
  AUTHORS   Ishii,C., Nakano,H., Higashiseto,R., Ooki,Y., Umemura,M.,
            Takahashi,S. and Takahashi,Y.
  TITLE     Nescient helix-loop-helix 1 (Nhlh1) is a novel activating
            transcription factor 5 (ATF5) target gene in olfactory and
            vomeronasal sensory neurons in mice
  JOURNAL   Cell Tissue Res 396 (1), 85-94 (2024)
   PUBMED   38388750
  REMARK    GeneRIF: Nescient helix-loop-helix 1 (Nhlh1) is a novel activating
            transcription factor 5 (ATF5) target gene in olfactory and
            vomeronasal sensory neurons in mice.
            Erratum:[Cell Tissue Res. 2024 May;396(2):291-292. doi:
            10.1007/s00441-024-03891-w.. PMID: 38530437]
REFERENCE   4  (bases 1 to 1753)
  AUTHORS   Xu,W.N., Zheng,H.L., Yang,R.Z., Sun,Y.F., Peng,B.R., Liu,C.,
            Song,J., Jiang,S.D. and Zhu,L.X.
  TITLE     The mitochondrial UPR induced by ATF5 attenuates intervertebral
            disc degeneration via cooperating with mitophagy
  JOURNAL   Cell Biol Toxicol 40 (1), 16 (2024)
   PUBMED   38472656
  REMARK    GeneRIF: The mitochondrial UPR induced by ATF5 attenuates
            intervertebral disc degeneration via cooperating with mitophagy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1753)
  AUTHORS   Chen,X.Z., Li,X.M., Xu,S.J., Hu,S., Wang,T., Li,R.F., Liu,C.Y.,
            Xue,J.Q., Zhou,L.Y., Wang,Y.H., Li,P.F. and Wang,K.
  TITLE     TMEM11 regulates cardiomyocyte proliferation and cardiac repair via
            METTL1-mediated m7G methylation of ATF5 mRNA
  JOURNAL   Cell Death Differ 30 (7), 1786-1798 (2023)
   PUBMED   37286744
  REMARK    GeneRIF: TMEM11 regulates cardiomyocyte proliferation and cardiac
            repair via METTL1-mediated m[7]G methylation of ATF5 mRNA.
REFERENCE   6  (bases 1 to 1753)
  AUTHORS   Persengiev,S.P., Devireddy,L.R. and Green,M.R.
  TITLE     Inhibition of apoptosis by ATFx: a novel role for a member of the
            ATF/CREB family of mammalian bZIP transcription factors
  JOURNAL   Genes Dev 16 (14), 1806-1814 (2002)
   PUBMED   12130540
  REMARK    GeneRIF: Inhibition of apoptosis by ATFx
REFERENCE   7  (bases 1 to 1753)
  AUTHORS   Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and
            Varki,A.
  TITLE     Cloning and characterization of human Siglec-11. A recently evolved
            signaling molecule that can interact with SHP-1 and SHP-2 and is
            expressed by tissue macrophages, including brain microglia
  JOURNAL   J Biol Chem 277 (27), 24466-24474 (2002)
   PUBMED   11986327
REFERENCE   8  (bases 1 to 1753)
  AUTHORS   Peters,C.S., Liang,X., Li,S., Kannan,S., Peng,Y., Taub,R. and
            Diamond,R.H.
  TITLE     ATF-7, a novel bZIP protein, interacts with the PRL-1
            protein-tyrosine phosphatase
  JOURNAL   J Biol Chem 276 (17), 13718-13726 (2001)
   PUBMED   11278933
REFERENCE   9  (bases 1 to 1753)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
REFERENCE   10 (bases 1 to 1753)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF375476.1 and AI851042.1.
            
            On Dec 9, 2009 this sequence version replaced NM_030693.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF375476.1, CX236169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1734              AF375476.1         1-1734
            1735-1753           AI851042.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.92 cM"
     gene            1..1753
                     /gene="Atf5"
                     /gene_synonym="AFTA; Atf7; Atfx; ODA-10"
                     /note="activating transcription factor 5"
                     /db_xref="GeneID:107503"
                     /db_xref="MGI:MGI:2141857"
     exon            1..177
                     /gene="Atf5"
                     /gene_synonym="AFTA; Atf7; Atfx; ODA-10"
                     /inference="alignment:Splign:2.1.0"
     exon            178..471
                     /gene="Atf5"
                     /gene_synonym="AFTA; Atf7; Atfx; ODA-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1145
                     /gene="Atf5"
                     /gene_synonym="AFTA; Atf7; Atfx; ODA-10"
                     /note="transcription factor-like protein ODA-10;
                     activating transcription factor 7; NAP1; BZIP protein
                     ATF7; NRIF3-associated protein; transcription factor ATFx;
                     cAMP-dependent transcription factor ATF-5; activating
                     transcription factor 5-alpha/beta; activating
                     transcription factor X"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-5"
                     /protein_id="NP_109618.1"
                     /db_xref="CCDS:CCDS21215.1"
                     /db_xref="GeneID:107503"
                     /db_xref="MGI:MGI:2141857"
                     /translation="MSLLATLGLELDRALLPASGLGWLVDYGKLPLAPAPLGPYEVLG
                     GALEGGLPGGGEPLAGDGFSDWMTERVDFTALLPLEAPLPPGTLPPPSPAPPDLEAMA
                     SLLKKELEQMEDFFLDAPLLPPPSPPPPPPPAAAPSLPLPLPLPTFDLPQPPTLDTLD
                     LLAVYCRSEAGPGDSGLSTLPVPQQPPPLAPLPSPARPAPYPSPASTRGDRKQKKRDQ
                     NKSAALRYRQRKRAEGEALEGECQGLEARNRELRERAESVEREIQYVKDLLIEVYKAR
                     SQRTRST"
     exon            472..1736
                     /gene="Atf5"
                     /gene_synonym="AFTA; Atf7; Atfx; ODA-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1713..1718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atf5"
                     /gene_synonym="AFTA; Atf7; Atfx; ODA-10"
                     /note="hexamer: AATAAA"
     polyA_site      1735
                     /gene="Atf5"
                     /gene_synonym="AFTA; Atf7; Atfx; ODA-10"
                     /note="major polyA site"
ORIGIN      
        1 aatttttaag ggaagagcgg gatctgtgtg tgtgacactg atgaagggcc caggcatgca
       61 gaattattct gggaacccct gtggattaaa gggggtatag tctaatgatg cggaaggggc
      121 acggctagaa ggaaattccc ttgggattga aatttttatg aagaggaata agatgaggtc
      181 ctccaccttc gccttggtgc ctgtcttcac ccagctgaac aatcttccac gctgcctccc
      241 aattgttggt gcagcctcca ttgccgtcgc tgccctgtgc ctgtgtcaca gccatgtcac
      301 tcctggcgac cctgggactg gagctggaca gggccctgct cccagctagc gggctgggct
      361 ggctcgtaga ctatgggaaa ctccccctgg cccctgcccc cctgggcccc tatgaggtcc
      421 ttgggggtgc cctggagggc gggcttccag gggggggaga gcccctggca ggtgacggct
      481 tctctgattg gatgactgag cgggtggact tcacagctct ccttcctctg gaggcccctc
      541 tgcccccagg cactctcccc ccaccctccc cggccccccc tgacctggaa gccatggcat
      601 ccctactcaa gaaggagctg gaacagatgg aagacttctt ccttgatgcc ccacttctcc
      661 caccgccctc cccaccacca cctccaccac cagcagcagc accctctctg cccctgccct
      721 tgcccttgcc cacctttgac ctccctcagc ctcctaccct ggataccttg gacctgctgg
      781 ctgtttactg ccgcagtgag gccgggccgg gggattcagg cttgtcaacc ctgcctgtcc
      841 cacagcagcc tcctcctctg gcccctctgc cttcacccgc ccgcccagcc ccttatccta
      901 gtcctgccag cacacgaggg gaccgcaagc aaaagaagag agaccagaat aagtcagctg
      961 ctctcaggta ccgccagagg aagcgggcag agggcgaggc cctggagggc gagtgccagg
     1021 ggctggaggc ccggaaccgg gagctgaggg agagggctga gtcagtggag cgggagatcc
     1081 agtacgtgaa ggacctgcta attgaggtgt ataaggcccg aagccagagg acccgcagca
     1141 cctagggtac aggtccaggc tggagaggga ggtctcgtgt acgtctgtct ccagcgtcac
     1201 actacccctc cattccactt tcctatccag tccatctcta ggcttcccct ctgcctaacc
     1261 cactgtgggc tatttggcag agtcagtttc tgtacccctt cagtgcaact gagaaagcaa
     1321 ggccctcagg gaactggagg aggagccagc ctgatccctg gcctctggag tcttaaagca
     1381 agtgtgtttt tgcaggtagt cctagttggg tgtaggggga ggctgccagg cctggcatga
     1441 acataaagca ggaagccact ctgggtgatg gcagatgaga acctagtcag ggagggaggg
     1501 ttttaaggag gggacttgga acacaagtga gaagccagtc aagaaaaggg agccaggacc
     1561 tcagaattta tactggccta ggggacagga aggggtgatt gtagttggta actaggggtc
     1621 attttagctc tgtgagagaa tcagtgtttt gtgagggtgt gggggaaggg ttgcatctag
     1681 tggaggctga tcctctaggg gttatgggca caaataaaat gcagattttc ctgtggaaaa
     1741 aaaaaaaaaa aaa
//
