LOCUS       NM_009716               1746 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus activating transcription factor 4 (Atf4), transcript
            variant 1, mRNA.
ACCESSION   NM_009716
VERSION     NM_009716.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Lu,W.H., Chen,H.F., King,P.C., Peng,C. and Huang,Y.S.
  TITLE     CPEB2-activated Prdm16 translation promotes brown adipocyte
            function and prevents obesity
  JOURNAL   Mol Metab 89, 102034 (2024)
   PUBMED   39305947
  REMARK    GeneRIF: CPEB2-activated Prdm16 translation promotes brown
            adipocyte function and prevents obesity.
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Xiong,X., Hou,J., Zheng,Y., Jiang,T., Zhao,X., Cai,J., Huang,J.,
            He,H., Xu,J., Qian,S., Lu,Y., Wang,X., Wang,W., Ye,Q., Zhou,S.,
            Lian,M., Xiao,J., Song,W. and Xie,C.
  TITLE     NAD+-boosting agent nicotinamide mononucleotide potently improves
            mitochondria stress response in Alzheimer's disease via
            ATF4-dependent mitochondrial UPR
  JOURNAL   Cell Death Dis 15 (10), 744 (2024)
   PUBMED   39394148
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Vattem,K.M. and Wek,R.C.
  TITLE     Reinitiation involving upstream ORFs regulates ATF4 mRNA
            translation in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (31), 11269-11274 (2004)
   PUBMED   15277680
  REMARK    GeneRIF: delayed reinitiation allows for ribosomes to scan through
            the inhibitory uORF2 and instead reinitiate at the ATF4-coding
            region.
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Lee,F.S., Lane,T.F., Kuo,A., Shackleford,G.M. and Leder,P.
  TITLE     Insertional mutagenesis identifies a member of the Wnt gene family
            as a candidate oncogene in the mammary epithelium of int-2/Fgf-3
            transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2268-2272 (1995)
   PUBMED   7892260
REFERENCE   8  (bases 1 to 1746)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   9  (bases 1 to 1746)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   10 (bases 1 to 1746)
  AUTHORS   Mielnicki,L.M. and Pruitt,S.C.
  TITLE     Isolation and nucleotide sequence of a murine cDNA homologous to
            human activating transcription factor 4
  JOURNAL   Nucleic Acids Res 19 (22), 6332 (1991)
   PUBMED   1956797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003001.1, BC085169.1 and BE992821.1.
            
            On Dec 4, 2013 this sequence version replaced NM_009716.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003001.1, BC085169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 15277680
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AK003001.1         1-109
            110-1725            BC085169.1         1-1616
            1726-1746           BE992821.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..1746
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /note="activating transcription factor 4"
                     /db_xref="GeneID:11911"
                     /db_xref="MGI:MGI:88096"
     exon            1..502
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      399..410
                     /regulatory_class="uORF"
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15277680]"
                     /note="this uORF is predicted to encode a 3 aa peptide
                     (PMID:15277680)"
     regulatory      498..677
                     /regulatory_class="uORF"
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15277680]"
                     /note="this uORF is predicted to encode a 59 aa peptide
                     (PMID:15277680)"
     exon            503..817
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /inference="alignment:Splign:2.1.0"
     CDS             595..1644
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /note="taxREB67 homolog; c/EBP-related ATF; cAMP-dependent
                     transcription factor ATF-4; tax-responsive enhancer
                     element-binding protein 67 homolog; cAMP-responsive
                     element-binding protein 2; cyclic AMP-responsive
                     element-binding protein 2"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-4"
                     /protein_id="NP_033846.2"
                     /db_xref="CCDS:CCDS37145.1"
                     /db_xref="GeneID:11911"
                     /db_xref="MGI:MGI:88096"
                     /translation="MTEMSFLNSEVLAGDLMSPFDQSGLGAEESLGLLDDYLEVAKHL
                     KPHGFSSDKAGSSEWPAMDDGLASASDTGKEDAFSGTDWMLEKMDLKEFDFDALFRMD
                     DLETMPDELLTTLDDTCDLFAPLVQETNKEPPQTVNPIGHLPESLIKVDQVAPFTFLQ
                     PFPCSPGVLSSTPEHSFSLELGSEVDISEGDRKPDSAAYITLIPPCVKEEDTPSDNDS
                     GICMSPESYLGSPQHSPSTSRAPPDNLPSPGGSRGSPRPKPYDPPGVSLTAKVKTEKL
                     DKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKEKADSLAKEIQYLKD
                     LIEEVRKARGKKRVP"
     exon            818..1729
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1701..1706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /note="hexamer: AATAAA"
     polyA_site      1725
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /note="major polyA site"
ORIGIN      
        1 ggctaggtgt cccaccccgc cttgtaagac accggaaatt cgtcaacgag cgatccctcc
       61 gcgctccgga accagaccgc ggctggtcgt caacctataa agtagtgcac ttttctctca
      121 tggggccttt aggacgatct ctaacgccac agttaccccc cgagcacagc ggagaagggt
      181 tggggcgggc gagggcgtca gtgagaggcg gtttggtggc gctgcggtag gatcacgtga
      241 ccacagtggg aggatacgcg gtgtgctgcg tccctggccg aggctataaa gggcgggttt
      301 agggcgtgcc gccgccattt ctgcttgctg tctgccggtt taagttgtgt gctcgggtgt
      361 ccctttcctc ttcccctccc gcagggcttg cggccaccat ggcgtattag aggcagcagt
      421 gcctgcggca gcgttggcct ttgcagcggc ggcagcagca ccaggctctg cagcggcaac
      481 ccccaccggc ctaagccatg gcgctcttca cgaaatccag cagcagtgtt gctgtaacgg
      541 acaaagatac cttcgagtta agcacattcc tcgaatccag caaagcccca caacatgacc
      601 gagatgagct tcctgaacag cgaagtgttg gcgggggact tgatgtcccc cttcgaccag
      661 tcgggtttgg gggctgaaga aagcctaggt ctcttagatg actatctgga ggtggccaag
      721 cacttgaaac ctcatgggtt ctccagcgac aaggcgggct cctcggaatg gccggctatg
      781 gatgatggct tggccagtgc ctcagacacc ggcaaggagg atgccttttc cgggacagat
      841 tggatgttgg agaaaatgga tctgaaagag tttgacttcg atgctctgtt tcgaatggat
      901 gacctggaaa ccatgccaga tgagctcttg accacgttgg atgacacatg tgatcttttt
      961 gcccctctag tccaagagac taataaggag ccccctcaga cagtgaaccc aattggccat
     1021 ctcccagaaa gtttaataaa agtcgaccag gttgccccct ttacattctt gcagcctttc
     1081 ccctgttccc caggggttct gtcttccact ccagagcatt cctttagttt agagctaggc
     1141 agtgaagttg atatctctga aggagacagg aagcctgact ctgctgctta cattactcta
     1201 atccctccat gtgtaaagga ggaagacact ccctctgaca atgacagtgg catctgtatg
     1261 agcccagagt cctacctggg ctctccccag catagcccct ccacctccag ggccccacca
     1321 gacaatctgc cttctccagg tggttcccgt gggtctcctc ggcccaaacc ttatgaccca
     1381 cctggagtta gtttgacagc taaagtgaag actgagaaat tggataagaa gctgaaaaag
     1441 atggagcaaa acaagacagc agccactagg taccgccaga agaagcgggc tgagcaggag
     1501 gccctcactg gcgagtgtaa ggagctagaa aaaaagaatg aggctctgaa agagaaggca
     1561 gattctctgg ccaaggagat ccagtatctg aaagacctga tagaagaggt ccgtaaggca
     1621 agggggaaga agagagttcc gtaatagggt agtcaggtgc tttgtgcttg tacatagtct
     1681 tgtgttgctg tgtttgctgt aataaattat tttgtagtga aagtacctaa aaaaaaaaaa
     1741 aaaaaa
//
