LOCUS       NM_007498               1981 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus activating transcription factor 3 (Atf3), mRNA.
ACCESSION   NM_007498
VERSION     NM_007498.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1981)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1981)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1981)
  AUTHORS   Hou,Y., Sun,L., LaFleur,M.W., Huang,L., Lambden,C., Thakore,P.I.,
            Geiger-Schuller,K., Kimura,K., Yan,L., Zang,Y., Tang,R., Shi,J.,
            Barilla,R., Deng,L., Subramanian,A., Wallrapp,A., Choi,H.S.,
            Kye,Y.C., Ashenberg,O., Schiebinger,G., Doench,J.G., Chiu,I.M.,
            Regev,A., Sharpe,A.H. and Kuchroo,V.K.
  TITLE     Neuropeptide signalling orchestrates T cell differentiation
  JOURNAL   Nature 635 (8038), 444-452 (2024)
   PUBMED   39415015
REFERENCE   4  (bases 1 to 1981)
  AUTHORS   Hu,S., Cassim Bawa,F.N., Zhu,Y., Pan,X., Wang,H., Gopoju,R., Xu,Y.
            and Zhang,Y.
  TITLE     Loss of adipose ATF3 promotes adipose tissue lipolysis and the
            development of MASH
  JOURNAL   Commun Biol 7 (1), 1300 (2024)
   PUBMED   39390075
  REMARK    GeneRIF: Loss of adipose ATF3 promotes adipose tissue lipolysis and
            the development of MASH.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1981)
  AUTHORS   Shao,Y., Li,Y., Liu,Y., Zhu,S., Wu,J., Ma,K., Li,G., Huang,S.,
            Wen,H., Zhang,C., Ma,X.L., Li,P., Du,J. and Li,Y.
  TITLE     ATF3 coordinates the survival and proliferation of cardiac
            macrophages and protects against ischemia-reperfusion injury
  JOURNAL   Nat Cardiovasc Res 3 (1), 28-45 (2024)
   PUBMED   39195894
  REMARK    GeneRIF: ATF3 coordinates the survival and proliferation of cardiac
            macrophages and protects against ischemia-reperfusion injury.
REFERENCE   6  (bases 1 to 1981)
  AUTHORS   Allen-Jennings,A.E., Hartman,M.G., Kociba,G.J. and Hai,T.
  TITLE     The roles of ATF3 in glucose homeostasis. A transgenic mouse model
            with liver dysfunction and defects in endocrine pancreas
  JOURNAL   J Biol Chem 276 (31), 29507-29514 (2001)
   PUBMED   11371557
REFERENCE   7  (bases 1 to 1981)
  AUTHORS   Okamoto,Y., Chaves,A., Chen,J., Kelley,R., Jones,K., Weed,H.G.,
            Gardner,K.L., Gangi,L., Yamaguchi,M., Klomkleaw,W., Nakayama,T.,
            Hamlin,R.L., Carnes,C., Altschuld,R., Bauer,J. and Hai,T.
  TITLE     Transgenic mice with cardiac-specific expression of activating
            transcription factor 3, a stress-inducible gene, have conduction
            abnormalities and contractile dysfunction
  JOURNAL   Am J Pathol 159 (2), 639-650 (2001)
   PUBMED   11485922
REFERENCE   8  (bases 1 to 1981)
  AUTHORS   Drysdale,B.E., Howard,D.L. and Johnson,R.J.
  TITLE     Identification of a lipopolysaccharide inducible transcription
            factor in murine macrophages
  JOURNAL   Mol Immunol 33 (11-12), 989-998 (1996)
   PUBMED   8960123
REFERENCE   9  (bases 1 to 1981)
  AUTHORS   Ishiguro,T., Nakajima,M., Naito,M., Muto,T. and Tsuruo,T.
  TITLE     Identification of genes differentially expressed in B16 murine
            melanoma sublines with different metastatic potentials
  JOURNAL   Cancer Res 56 (4), 875-879 (1996)
   PUBMED   8631027
REFERENCE   10 (bases 1 to 1981)
  AUTHORS   Hai,T.W., Liu,F., Coukos,W.J. and Green,M.R.
  TITLE     Transcription factor ATF cDNA clones: an extensive family of
            leucine zipper proteins able to selectively form DNA-binding
            heterodimers
  JOURNAL   Genes Dev 3 (12B), 2083-2090 (1989)
   PUBMED   2516827
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):682]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133965.1 and BE199676.1.
            
            On Nov 15, 2007 this sequence version replaced NM_007498.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019946.1, AK133965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN02415122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1964              AK133965.1         5-1968
            1965-1981           BE199676.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..1981
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /note="activating transcription factor 3"
                     /db_xref="GeneID:11910"
                     /db_xref="MGI:MGI:109384"
     exon            1..241
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /inference="alignment:Splign:2.1.0"
     exon            242..485
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..791
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /note="transcription factor LRG-21; cAMP-dependent
                     transcription factor ATF-3"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-3"
                     /protein_id="NP_031524.2"
                     /db_xref="CCDS:CCDS15616.1"
                     /db_xref="GeneID:11910"
                     /db_xref="MGI:MGI:109384"
                     /translation="MMLQHPGQVSASEVSATAIVPCLSPPGSLVFEDFANLTPFVKEE
                     LRFAIQNKHLCHRMSSALESVTVNNRPLEMSVTKSEAAPEEDERKRRRRERNKIAAAK
                     CRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNG
                     RTPEDERNLFIQQIKEGTLQS"
     exon            486..593
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /inference="alignment:Splign:2.1.0"
     exon            594..1977
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /note="hexamer: AATAAA"
     polyA_site      1977
                     /gene="Atf3"
                     /gene_synonym="LRG-21"
                     /note="major polyA site"
ORIGIN      
        1 ctgggattgg taacctggag ttaagcgggc tccctgccaa cgcgagggct ttaaaagggg
       61 tgatgcaacg cgctcccagc cacagtctca ctcagcgaga cgccgcgcac ggtgcttccc
      121 cagtggagcc aatcggctaa cccgcgctcc ggcagagtcc ttggcgctcg cccgccggcg
      181 ggacagacca cccgcctctg gccgctctct ggaccctggc cgccccgagc gaagactgga
      241 gcaaaatgat gcttcaacat ccaggccagg tctctgcctc agaagtcagt gcgaccgcca
      301 ttgtcccctg cctctcacct cctgggtcac tggtatttga ggattttgct aacctgacac
      361 cctttgtcaa ggaagagctg agattcgcca tccagaataa acacctctgc catcggatgt
      421 cctctgcgct ggagtcagtt accgtcaaca acagacccct ggagatgtca gtcaccaagt
      481 ctgaggcggc ccctgaagaa gatgagagga aaaggaggcg gcgagaaaga aataaaattg
      541 ctgctgccaa gtgtcgaaac aagaaaaagg agaagacaga gtgcctgcag aaagagtcag
      601 agaaactgga gagtgtgaat gctgagctga aggcccagat tgaggagctg aagaatgaga
      661 aacagcattt gatatacatg ctcaacctgc accggcccac ctgcatcgtc cgggctcaga
      721 atggacggac accggaagac gagaggaacc tctttatcca acagataaaa gaaggaacat
      781 tgcagagcta agcagaggtg gcacggaggc aattggggag ttcttactga atcctccttt
      841 tccaccccac accctgaagc cattggaaaa ctggcttcct gtgcacttct agaatcccag
      901 cagccaagag ccgttggggc aggagggcct gtggtgacct actgcattga cccactctgc
      961 ccccgagtga accgtggagc aggcaggagc atcctttgtc tcaccaattc caggatttag
     1021 gccttatcat cccggccagt ctcagatgac ctagctggcc ccaggctggg gtcctatgca
     1081 aagcaggatc ccactaatgg gattcaggca gaagtgtcta ccttgatagg tggggtggga
     1141 ccacatcctc cactgtggct gacaacgccc ttccaaggga atatggaatg agaacattca
     1201 ttattgaggt tgtccaatgg ccagggtatg ctttctagaa aatatgctgt tctgtcccag
     1261 aatgactgtg catagggtat ccgtttcaga gcctggtgtt gtgctattta gatgtttgtc
     1321 ttgcacaaca ttggcatgat ttttccggga gtttcatcag atctgatttc tgagagtctg
     1381 gggatctgcc atggtggaaa gtgcccctca aaagcatttg tgtggccaca tgaactggct
     1441 ggcaccaggg gagtgaaact ggctgatgac cagctgagcc actttgtgcc aacagaggat
     1501 ggacgacacc tttccctgta cccactgcag aggaagaacc ctgggcacag cagctttgtc
     1561 cttggctaca aactgttaca acgtcacaca atgaaggcac aaagtccaac tttcaaaggg
     1621 tgtaggactc catactcagt gacagggcag gaagagccaa agataaccac agccacagcc
     1681 tgtggagacc agggttggaa gccaggtgca gggccaggca tctgcattgt gggatgttaa
     1741 tggcactttt gtcttgtagc tattttgaga tgtggtccag agcatttcag ctgggagatc
     1801 tccctctggc caccaggact ctggctactg ttaaaatcct gatgtttctg tggaatcctc
     1861 agtgtttaat cccactcaat agtatcatta cagttttctg taagagaaaa tattacttat
     1921 ttatcccagt attcctagcc tgtcaacata ataaatatcg gaacaaaacc tggtaaaaaa
     1981 a
//
