LOCUS       NM_001025093            4300 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus activating transcription factor 2 (Atf2), transcript
            variant 1, mRNA.
ACCESSION   NM_001025093 XM_001479504
VERSION     NM_001025093.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4300)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4300)
  AUTHORS   Zhu,M., Long,S., Tao,Y., Zhang,Z., Zhou,Z., Wang,X. and Chen,W.
  TITLE     The P38MAPK/ATF2 signaling pathway is involved in PND in mice
  JOURNAL   Exp Brain Res 242 (1), 109-121 (2024)
   PUBMED   37973625
  REMARK    GeneRIF: The P38MAPK/ATF2 signaling pathway is involved in PND in
            mice.
REFERENCE   3  (bases 1 to 4300)
  AUTHORS   Zuo,H., Xiao,Y., Han,J., Lin,Y., Tian,C., Zhang,S., Yuan,G., Liu,H.
            and Chen,Z.
  TITLE     Phosphorylation of ATF2 promotes odontoblastic differentiation via
            intrinsic HAT activity
  JOURNAL   J Genet Genomics 50 (7), 497-510 (2023)
   PUBMED   36809837
  REMARK    GeneRIF: Phosphorylation of ATF2 promotes odontoblastic
            differentiation via intrinsic HAT activity.
REFERENCE   4  (bases 1 to 4300)
  AUTHORS   Yang,Z.B., Xiang,Y., Zuo,M.L., Mao,L., Hu,G.H., Song,G.L.,
            Sheikh,M.S.A. and Tan,L.M.
  TITLE     lncRNA PINK1-AS Aggravates Cerebral Ischemia/Reperfusion Oxidative
            Stress Injury through Regulating ATF2 by Sponging miR-203
  JOURNAL   Oxid Med Cell Longev 2022, 1296816 (2022)
   PUBMED   35855866
  REMARK    GeneRIF: lncRNA PINK1-AS Aggravates Cerebral Ischemia/Reperfusion
            Oxidative Stress Injury through Regulating ATF2 by Sponging
            miR-203.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4300)
  AUTHORS   Xu,J., Xu,L., Sui,P., Chen,J., Moya,E.A., Hume,P., Janssen,W.J.,
            Duran,J.M., Thistlethwaite,P., Carlin,A., Gulleman,P.,
            Banaschewski,B., Goldy,M.K., Yuan,J.X., Malhotra,A., Pryhuber,G.,
            Crotty-Alexander,L., Deutsch,G., Young,L.R. and Sun,X.
  TITLE     Excess neuropeptides in lung signal through endothelial cells to
            impair gas exchange
  JOURNAL   Dev Cell 57 (7), 839-853 (2022)
   PUBMED   35303432
REFERENCE   6  (bases 1 to 4300)
  AUTHORS   Giese,K., Kingsley,C., Kirshner,J.R. and Grosschedl,R.
  TITLE     Assembly and function of a TCR alpha enhancer complex is dependent
            on LEF-1-induced DNA bending and multiple protein-protein
            interactions
  JOURNAL   Genes Dev 9 (8), 995-1008 (1995)
   PUBMED   7774816
REFERENCE   7  (bases 1 to 4300)
  AUTHORS   Lee,M.R., Chung,C.S., Liou,M.L., Wu,M., Li,W.F., Hsueh,Y.P. and
            Lai,M.Z.
  TITLE     Isolation and characterization of nuclear proteins that bind to T
            cell receptor V beta decamer motif
  JOURNAL   J Immunol 148 (6), 1906-1912 (1992)
   PUBMED   1531847
REFERENCE   8  (bases 1 to 4300)
  AUTHORS   Georgopoulos,K., Morgan,B.A. and Moore,D.D.
  TITLE     Functionally distinct isoforms of the CRE-BP DNA-binding protein
            mediate activity of a T-cell-specific enhancer
  JOURNAL   Mol Cell Biol 12 (2), 747-757 (1992)
   PUBMED   1531087
REFERENCE   9  (bases 1 to 4300)
  AUTHORS   Ivashkiv,L.B., Liou,H.C., Kara,C.J., Lamph,W.W., Verma,I.M. and
            Glimcher,L.H.
  TITLE     mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic
            AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response
            element
  JOURNAL   Mol Cell Biol 10 (4), 1609-1621 (1990)
   PUBMED   2138707
REFERENCE   10 (bases 1 to 4300)
  AUTHORS   Hai,T.W., Liu,F., Coukos,W.J. and Green,M.R.
  TITLE     Transcription factor ATF cDNA clones: an extensive family of
            leucine zipper proteins able to selectively form DNA-binding
            heterodimers
  JOURNAL   Genes Dev 3 (12B), 2083-2090 (1989)
   PUBMED   2516827
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):682]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844581.7, AK051591.1, BC082596.1, BC079883.1 and AL845523.6.
            
            On Oct 1, 2013 this sequence version replaced NM_001025093.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.53226.1,
                                           SRR1660815.144336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL844581.7         71093-71103         c
            12-423              AK051591.1         2-413
            424-568             BC082596.1         307-451
            569-2213            AK051591.1         462-2106
            2214-4288           BC079883.1         2039-4113
            4289-4300           AL845523.6         44386-44397         c
FEATURES             Location/Qualifiers
     source          1..4300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.86 cM"
     gene            1..4300
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /note="activating transcription factor 2"
                     /db_xref="GeneID:11909"
                     /db_xref="MGI:MGI:109349"
     exon            1..165
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            166..262
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            263..338
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            339..401
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            402..471
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..1887
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic AMP-dependent transcription factor ATF-2;
                     cAMP-dependent transcription factor ATF-2; cAMP response
                     element-binding protein CRE-BP1"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-2
                     isoform 1"
                     /protein_id="NP_001020264.1"
                     /db_xref="CCDS:CCDS16134.1"
                     /db_xref="GeneID:11909"
                     /db_xref="MGI:MGI:109349"
                     /translation="MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDS
                     VIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIR
                     SKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTS
                     SDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASIT
                     SSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDT
                     VKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTSGRRRRAANEDPD
                     EKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQ
                     LLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSK
                     AEAVATSVLTQMADQSTEPALSQIVMAPPSQAQPSGS"
     exon            472..568
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            569..687
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            688..816
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            817..995
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1110
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1197
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1347
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1554
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1660
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..4300
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2194..2199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /note="hexamer: AATAAA"
     polyA_site      2215
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /note="major polyA site"
     regulatory      4270..4275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /note="hexamer: AATAAA"
     polyA_site      4291
                     /gene="Atf2"
                     /gene_synonym="Atf-2; CRE-BP; Creb2; D130078H02Rik; mXBP;
                     Tg(Gzma-Klra1)7Wum"
                     /note="major polyA site"
ORIGIN      
        1 ggagaaggtt tgtcagtcgg atctcgcgag agaggacgga agcctgtggg agcccgtggc
       61 ctttaaagtg cgattcagcc ctctcctccg gggctagttt gtaaacacgg ccggcctccg
      121 ggctcgcggg tggctggcag gaccatgaat tagtgacctg gaaagagata ctagatggca
      181 acttgggaag tattgcttgc ttagcaagag cttagggata attcctgtta acagtaaaac
      241 tcatggccca ccagctacaa agtgtctttg ccatgaaaca gaggacatga taaactgttt
      301 accttaatga aattcaagtt gcatgtgaat tctgccagat actggattta tgacttaaaa
      361 ccttcccaca gagaaaatcc caggctcata tagcttcact gataaaacac ggacctgtgg
      421 aatatgagtg atgacaaacc ctttctatgc actgcccctg ggtgtggcca gcgttttacc
      481 aacgaggatc atttggctgt ccataaacat aaacatgaga tgacactgaa atttggtcca
      541 gcacgtaatg acagtgtcat tgtggctgat cagactccaa cgccaacaag attcctaaaa
      601 aactgtgaag aagtgggttt gttcaatgag ttggcaagtc catttgaaaa tgaattcaag
      661 aaggcttccg aagatgacat taaaaaaatg cctctagatt tgtcccctct tgcaacaccc
      721 atcataagaa gcaaaattga ggagccttct gttgtagaaa caactcacca ggacagccct
      781 ttacctcacc ccgagtcgac taccagtgat gaaaaggaag taccattggc acaaactgca
      841 cagcccacat cagctatcgt tcgtccagca tcattacagg ttcccaatgt gctgctcaca
      901 agttctgact caagtgtaat tattcaacaa gcagtacctt caccaacctc aagtactgta
      961 atcacccagg caccatcctc taacaggcca attgttcctg taccaggccc atttcctctt
     1021 ctcttacatc ttcctaatgg acaaaccatg cccgttgcta ttcctgcatc aattacaagt
     1081 tctaatgtgc atgttccagc tgcagtccca cttgttcggc cagtcaccat ggtgcctagt
     1141 gttccaggaa tcccaggccc ttcctctcct caaccagtcc agtcagaagc aaaaatgaga
     1201 ttaaaagctg ctttgaccca gcaacaccct ccagttacca atggtgatac tgtaaaaggc
     1261 catggcagtg gattggttag gactcagtca gaagagtctc gcccacagtc cttgcagcag
     1321 ccagccacct ccactacaga aactccggct tctccagctc acacaactcc tcagacccaa
     1381 aatacaagtg gccgtcgaag aagagcagct aatgaagatc ctgatgagaa aaggaggaag
     1441 tttctagaac gaaatagagc agcagcttca agatgccgac aaaaaaggaa agtgtgggtt
     1501 cagtccttag agaagaaagc agaagacttg agttcactaa atggccagct gcagagcgaa
     1561 gtcaccctgc tgagaaatga agtggcccag ctgaaacagc ttcttctggc tcataaagat
     1621 tgccctgtaa ctgccatgca gaagaagtct ggctatcata ctgctgataa agatgacagt
     1681 tcagaagacc tttctgtgcc aagcagtcca catacagaag cgatccagca cagctctgtc
     1741 agcacatcca atggagtcag ttcaacatca aaagcagaag ctgtagccac ttcagtcctc
     1801 acccagatgg cggaccagag cacggagcct gcactttcac agattgtcat ggctcctccc
     1861 tcccaggcac agccctcagg aagttgatta aaacctgcag tgcaacagtt ttagatactg
     1921 attagtgact tcaaagggaa atcaaggaaa gaccagtttg catttatgcg aaatctgtgg
     1981 ttgtaaattt tttttttttt acttgaagtt aaatttgtct ctggagttgg tatagcagca
     2041 gttgatgatc agactgaata tgtttttagt ctctggaaga ctgattttcc ttttttatac
     2101 atattgttaa gatttattaa ttttcctgtg ctcaatgtgt aaattgtatc ataactcatt
     2161 gtggttgatt tcactttgat ttagtggcat cttaataaat gggggtgtta ctgaatcact
     2221 cttcccactt ccatttcttt gcccacccct tcaccctgag atgtgatggt agtcttgtta
     2281 tcatttatac caaagttctg cagagtccct attgtctgtg taagatggac aaagttgtaa
     2341 gacactaggg aagagaaaga aagacggaaa gttcctttta atctttttgc cttttatttt
     2401 gcacattatg caaaaggaag aatattagaa acactttttt ttaagtgagt gaaagtatgg
     2461 taagacggtt agtgctttgt gcacttctta gactaatcaa ggtcatccat cgccctgcaa
     2521 tgtttttaag attaagtaaa caaaaatttt ggaatcttga gcatttcaaa aaatgacttg
     2581 attttttaag tcttaaattc agtattttaa acctgtgttc ttgaggctga aaactatgaa
     2641 attatataat gtatgataca gggttatcag atagtaattt ttaaaatttg ctcttgtcat
     2701 ttgggatttg ttttgtttgg gattttgttg tgtgtgattt gttttgtttt gttttgcaga
     2761 tttcaggtaa caaagtgaga cgcttatgca taaagaagtg tgatgtggtt gccagaaaag
     2821 cctaaaatta tgacttagaa acgttaagac tgtttccccc attgtcgtac ttgtacttgc
     2881 gagctaactt gtacttattc ttgtgaaagc actgtcatct tttagtagcc aattttgata
     2941 atgtttctcg tggaaaaaaa tcagtatcta tctttagaac aatgtaatta taacgtggga
     3001 atgtgagtga gagaatgagt atgtgtatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3061 gtgtgtgtgt gtgcgcgcgc gcgcgtgtgt gtgcatcttc cactagttta tgccagcgat
     3121 attgcttgaa tgtttaacga tgccttcagt gtgatgctgg caatagatga ctgcagtttc
     3181 agatgccatt actgtgcagg cttggataac taacattcca tgatgtagct tgttctgatg
     3241 aaatgattgt agttacactt tgctcattct ccagtcatct gtggaatact gagttttcta
     3301 atgtgccatt atctattttt attctgcagt tacgttaaaa atacagtaca atattttaaa
     3361 tagactaaat tgttaaacat aaaaattaaa aaaaaagtag tagatgtgtg taagaaaact
     3421 ttgtaaaata gttatgagtc ctacccagta gcaacttctg gcgttcaagc aggattccat
     3481 tctgtaaata cctgtaatgt gtttataata agttgtgtag tctgttctgc atccatacta
     3541 cattattgct atggtctcag tgtcatctct taaagagatt gacgtttcca aagccgtatg
     3601 gaatgccctt gagagttcag gggaacaccc accccacctg cctcctaagt tccaatctgg
     3661 gaaacatgca aattatataa atgacatttc acgacttttg agtatgaaga taataggaat
     3721 tttattacat ggcttattaa aaatgagagc attttggttg ctgattctac tttgtatcta
     3781 ttactttcac ctgatctcat atttaatcag tttaaatcac aattttgtca tagttatgct
     3841 aaggagttga tctcaaaggc acaaaacatg aattccccat gcaagctttt tgttgtagat
     3901 ggataaggtt ggtcagagcc tccatgtgtc accctctgca ccctctcaac atttttcttt
     3961 catcttctga tttgtgcaag cttcagttct ttggtaacag atccttgcaa ttgtaaagta
     4021 gaagtgcata gatgtgagaa gtcatgtgac ggggaatgac cttccacggt ggacagcgct
     4081 cgttttaaat cagtctgtac tcagcaaata aaaatcaata ttagttgtat aaacacacaa
     4141 aaattacatt ttgaattcca ggatgtcaca ctacttctgt acctagcatt ttgagtcctt
     4201 atatttgcaa tgttacacaa actgtactat tttcttttat gtacagtttg catgactaaa
     4261 ccatcagaga ataaattcta tctttaaatt atgtttataa
//
