LOCUS       NM_001402641            4833 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus arginyltransferase 1 (Ate1), transcript variant 5,
            mRNA.
ACCESSION   NM_001402641 XM_006507264
VERSION     NM_001402641.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4833)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4833)
  AUTHORS   Jung,E.J., Sung,K.W., Bae,T.H., Kim,H.Y., Choi,H.R., Kim,S.H.,
            Jung,C.H., Mun,S.R., Son,Y.S., Kim,S., Suh,Y.H., Kashina,A.,
            Park,J.W. and Kwon,Y.T.
  TITLE     The N-degron pathway mediates lipophagy: The chemical modulation of
            lipophagy in obesity and NAFLD
  JOURNAL   Metabolism 146, 155644 (2023)
   PUBMED   37385404
REFERENCE   3  (bases 1 to 4833)
  AUTHORS   Shim,S.M., Choi,H.R., Kwon,S.C., Kim,H.Y., Sung,K.W., Jung,E.J.,
            Mun,S.R., Bae,T.H., Kim,D.H., Son,Y.S., Jung,C.H., Lee,J.,
            Lee,M.J., Park,J.W. and Kwon,Y.T.
  TITLE     The Cys-N-degron pathway modulates pexophagy through the N-terminal
            oxidation and arginylation of ACAD10
  JOURNAL   Autophagy 19 (6), 1642-1661 (2023)
   PUBMED   36184612
REFERENCE   4  (bases 1 to 4833)
  AUTHORS   Drazic,A., Timmerman,E., Kajan,U., Marie,M., Varland,S., Impens,F.,
            Gevaert,K. and Arnesen,T.
  TITLE     The Final Maturation State of beta-actin Involves N-terminal
            Acetylation by NAA80, not N-terminal Arginylation by ATE1
  JOURNAL   J Mol Biol 434 (2), 167397 (2022)
   PUBMED   34896361
  REMARK    GeneRIF: The Final Maturation State of beta-actin Involves
            N-terminal Acetylation by NAA80, not N-terminal Arginylation by
            ATE1.
REFERENCE   5  (bases 1 to 4833)
  AUTHORS   Heo,A.J., Kim,S.B., Ji,C.H., Han,D., Lee,S.J., Lee,S.H., Lee,M.J.,
            Lee,J.S., Ciechanover,A., Kim,B.Y. and Kwon,Y.T.
  TITLE     The N-terminal cysteine is a dual sensor of oxygen and oxidative
            stress
  JOURNAL   Proc Natl Acad Sci U S A 118 (50) (2021)
   PUBMED   34893540
REFERENCE   6  (bases 1 to 4833)
  AUTHORS   Lee,M.J., Tasaki,T., Moroi,K., An,J.Y., Kimura,S., Davydov,I.V. and
            Kwon,Y.T.
  TITLE     RGS4 and RGS5 are in vivo substrates of the N-end rule pathway
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15030-15035 (2005)
   PUBMED   16217033
REFERENCE   7  (bases 1 to 4833)
  AUTHORS   Rai,R. and Kashina,A.
  TITLE     Identification of mammalian arginyltransferases that modify a
            specific subset of protein substrates
  JOURNAL   Proc Natl Acad Sci U S A 102 (29), 10123-10128 (2005)
   PUBMED   16002466
REFERENCE   8  (bases 1 to 4833)
  AUTHORS   Kwon,Y.T., Kashina,A.S., Davydov,I.V., Hu,R.G., An,J.Y., Seo,J.W.,
            Du,F. and Varshavsky,A.
  TITLE     An essential role of N-terminal arginylation in cardiovascular
            development
  JOURNAL   Science 297 (5578), 96-99 (2002)
   PUBMED   12098698
  REMARK    GeneRIF: role in cardiovascular development
REFERENCE   9  (bases 1 to 4833)
  AUTHORS   Kwon,Y.T., Balogh,S.A., Davydov,I.V., Kashina,A.S., Yoon,J.K.,
            Xie,Y., Gaur,A., Hyde,L., Denenberg,V.H. and Varshavsky,A.
  TITLE     Altered activity, social behavior, and spatial memory in mice
            lacking the NTAN1p amidase and the asparagine branch of the N-end
            rule pathway
  JOURNAL   Mol Cell Biol 20 (11), 4135-4148 (2000)
   PUBMED   10805755
REFERENCE   10 (bases 1 to 4833)
  AUTHORS   Kwon,Y.T., Kashina,A.S. and Varshavsky,A.
  TITLE     Alternative splicing results in differential expression, activity,
            and localization of the two forms of arginyl-tRNA-protein
            transferase, a component of the N-end rule pathway
  JOURNAL   Mol Cell Biol 19 (1), 182-193 (1999)
   PUBMED   9858543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122258.4 and AC157606.5.
            
            On Mar 21, 2022 this sequence version replaced XM_006507264.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.85072.1,
                                           SRR10662773.2374521.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC122258.4         181147-181340       c
            195-258             AC122258.4         177896-177959       c
            259-321             AC122258.4         175553-175615       c
            322-425             AC122258.4         172602-172705       c
            426-677             AC122258.4         170798-171049       c
            678-895             AC122258.4         169273-169490       c
            896-1024            AC122258.4         166485-166613       c
            1025-1153           AC122258.4         165513-165641       c
            1154-1186           AC122258.4         143474-143506       c
            1187-1368           AC122258.4         129047-129228       c
            1369-1468           AC122258.4         125922-126021       c
            1469-1589           AC122258.4         80239-80359         c
            1590-4833           AC157606.5         169223-172466       c
FEATURES             Location/Qualifiers
     source          1..4833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.19 cM"
     gene            1..4833
                     /gene="Ate1"
                     /note="arginyltransferase 1"
                     /db_xref="GeneID:11907"
                     /db_xref="MGI:MGI:1333870"
     exon            1..194
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1768
                     /gene="Ate1"
                     /EC_number="2.3.2.8"
                     /note="isoform 5 is encoded by transcript variant 5;
                     arginyl-tRNA--protein transferase 1; R-transferase 1;
                     arginine-tRNA--protein transferase 1"
                     /codon_start=1
                     /product="arginyl-tRNA--protein transferase 1 isoform 5"
                     /protein_id="NP_001389570.1"
                     /db_xref="GeneID:11907"
                     /db_xref="MGI:MGI:1333870"
                     /translation="MASWSAPSPSLVEYFEGQTSFQCGYCKNKLGSRSYGMWAHSMTV
                     QDYQDLIDRGWRRSGKYVYKPVMDQTCCPQYTIRCHPLQFQPSKSHKKVLKKMLKFLA
                     KGEISKGNCEDEPMDSTVEDAVDGDFALINKLDIKCDLKTLSDLKGSIESEEKEKEKS
                     IKKEGSKEFIHPQSIEEKLGSGEPSHPIKVHIGPKPGKGADLSKPPCRKAREMRKERQ
                     RLKRMQQASAAASEAQGQPVCLLPKAKSNQPKSLEDLIFQSLPENASHKLEVRVVRSS
                     PPSPQFRATFQESYQVYKRYQMVVHKDPPDKPTVSQVRLVPASFEDPEFNSSFNQSFS
                     LYTKYQVAIHQEAPEICEKSEFTRFLCSSPLEAEHPADGPECGYGSFHQQYWLDGKII
                     AVGVLDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFY
                     IHSCPKMRYKGQYRPSDLLCPETYVWVPIEQCLPSLDNSKYCRFNQDPEAEDEGRSKE
                     LDRLRVFHRRSAMPYGVYKNHQEDPSEEAGVLEYANLVGQKCSERMLLFRH"
     exon            195..258
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..321
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..425
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..677
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..895
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1024
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1153
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1186
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1368
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1468
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1589
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..4833
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4813..4818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ate1"
                     /note="hexamer: AATAAA"
     polyA_site      4833
                     /gene="Ate1"
                     /note="major polyA site"
ORIGIN      
        1 gcgttgcatt gtggggtggt ggaggcgaag gcggcggtag cggcggctgc gtaggactgg
       61 gtggcgcagc ggcggcgggg tcgcggacat ggcttcttgg agcgcgcctt cacctagcct
      121 tgtagagtat tttgagggcc agacctcctt ccagtgtggc tactgcaaga acaagttggg
      181 cagtcgctcc tatggcatgt gggcacattc catgacagtg caggattatc aggatcttat
      241 agaccgagga tggagaagaa gtgggaaata tgtgtacaaa cctgtcatgg atcaaacatg
      301 ctgtcctcag tatacaataa ggtgtcatcc tttacagttt cagccatcaa aatctcacaa
      361 gaaagttttg aaaaaaatgc tgaaatttct ggctaaagga gagatctcga aaggcaattg
      421 tgaggatgag cccatggatt ctacagtgga ggatgctgtt gacggtgact ttgcattaat
      481 taacaagctg gatataaagt gtgatctcaa aacactcagt gacctcaaag gaagcataga
      541 gagtgaagag aaggagaaag aaaagagtat aaagaaagaa gggtctaaag aattcattca
      601 tccacaatct atagaggaga agttgggctc tggtgaacca tcacatccaa tcaaagttca
      661 tattggtcct aagccaggca aaggggctga cttgagtaag cctccatgtc ggaaagcaag
      721 ggaaatgagg aaagaaaggc aaagattaaa acggatgcag caggcctcag ctgcagcctc
      781 ggaggctcaa ggtcagccag tctgtttgtt accaaaggct aaatccaacc agcccaagtc
      841 actggaagat ttgatttttc aatctttacc agaaaatgca tcgcacaagt tagaggtgag
      901 ggtggtaaga tcttctccac caagtcctca gttcagagcc acatttcagg agtcttacca
      961 ggtctataaa cgctaccaga tggttgttca caaggacccg cctgataagc caaccgtgag
     1021 ccaggtgagg ctagtacctg cctcctttga ggacccagag ttcaactcat ccttcaacca
     1081 gtccttttct ttatatacca agtatcaagt ggctatacac caggaagcac ctgaaatatg
     1141 tgaaaagtct gagtttacaa gattcctttg cagctcacca ttggaggcag agcaccctgc
     1201 tgatggacca gaatgtggtt atggctcctt tcaccagcag tactggctcg atgggaagat
     1261 cattgctgtg ggggtgttag acattctccc gtactgtgtg tcttctgtgt atctctacta
     1321 cgatcctgat tattcatttc tgtctttggg tgtctattca gcattaagag aaattgcttt
     1381 tactagacaa ctgcatgaga aaacatcgca actcagctat tattatatgg gtttctacat
     1441 tcattcctgt cccaagatga gatacaaggg tcaatataga ccttctgatt tgctgtgtcc
     1501 tgagacgtat gtctgggtgc ccattgagca gtgcctgcct tctctggaca actccaagta
     1561 ctgccgtttc aaccaggacc ccgaagcaga ggatgaagga cgcagtaagg aacttgaccg
     1621 actaagggtg tttcacagac gatctgccat gccttacggt gtttataaga atcaccaaga
     1681 agacccaagt gaggaggctg gtgtgctgga gtatgcaaac ctcgtaggac agaagtgctc
     1741 ggagaggatg ctgctgttca gacactgaag gcctgcacct cagcccagcg ccagcctggc
     1801 atctcttgcc acagtcccac ctgcttctcg gctcctgcag ccattcacca agtacattcg
     1861 tagagctttt taaaaatatt ttgtggaatt gtatttatga gaatcttgtg gttaatataa
     1921 agattttaaa atattctatg acctagccct ttaattggga cttgtccttt gcagcttgct
     1981 tctggagcaa ggtgtgcttc atgtctccag tgaatattta gggaaggaaa atgaagaagt
     2041 caatataagt cattttgtca cagttactgt tctgtgctgg agaaattctg acacagagac
     2101 tgttctttta gaccaatggt tcttaacctg tgggctcacc acactcacag gccgaatgtt
     2161 agatagcctg tgtgagatca actcataata actcataatc gtagcaaaat tacagttatg
     2221 aagtagcaac aaaataattt tatggtttgg ggtgggatca ccacaacgtg aggaaatgta
     2281 ttaaaggatg gcagtattag gaaggtagag aaagaaccac tggctaagac ccatgcaaga
     2341 cattagctta tgctgggaaa ttcagatggg cttaaaggtg aagagcacat tccatcccag
     2401 gaaatgtgcc tttcccacaa accagaaccc tgttactctg cttgatagta aacctgccag
     2461 tgttgtagtg tataatagac aacaggaact gtaaacattg caaacatcag gtgttcactt
     2521 tgggtgtctg tccaggactg tcctgcctat gtctgttgtc ttggcataat tgttttcctt
     2581 gtcactagtg ttcccttgtg ccccagagtt atctctgttt ggatgataaa atatgcagtg
     2641 atcttagtgg tgtttgttct atttctacaa atataagaaa caactttcta aagaaacgtc
     2701 gtaactcctg cttgatctga ggcttatcca aagaaaatag cttcctactt tccattctct
     2761 ggaactcaga cgcttttttg tggttagtga tagaagtgat tattatctag tcccgtagct
     2821 atgcacagcc gtagtggagt tggtggggcc tctagcctct gcattcctct tctagttgtg
     2881 ggtcagagag taggcgctgc catggtactt cagaatggag accagccatt cactttcatt
     2941 cttgtgctgt tgggccttct gcttgttcac caaatgcctg ctgtcaagga ggcaggcagc
     3001 cagctacttc gtgaggcaca tcagacctgg tgaggagagg cttccctcag gtgctcggga
     3061 agctggatgc acaggttagc cctttgtttg aacttgttct cagctagccc cttctagaag
     3121 tgcttccaag cctggccttg gagctgctga gagcacctat cccacagtga gggtagggtt
     3181 gttactttat ttcttttcat aaaaatcact ccaatgggaa gcacctggaa cgctaagaaa
     3241 ttaaaagtcg tttgaaatcc tcccaggcat agagaaagga gcattatgga aacccacaaa
     3301 tctcttgtcc accccaaata aaactgtgca ttccttgcta tgtagttgcc ctcggtgaat
     3361 gtgtgtgaga ttgaagattg cagaagatgt gataggtaat ctcagtattc ttcagtagga
     3421 tgggatcaca tatatgacct tggcattggg cagccaggca tatcctggta ggtggtatag
     3481 ccatgctacc agaggggttt gtttttggga gggggcgggg ggtcagccca acatcttacc
     3541 ctagctctga gtttctcctg cagagaatag aggaaaatgg ctcactgtcc ctgtttctag
     3601 actgatgcgc ctaacctagg gtggccctac tgaggcttca gagcgtcttg ggcatgaaaa
     3661 ctctctcttc agctcagttg ctttgtattc attctttcct ccctcctccc tctatcctct
     3721 cctcaataca gtttttttcg actagtatga aaccttaggg ttctagatgt tgtcgaagat
     3781 gtgtccttgg gtgggactga ggagatagcc cagttagtac agtgcctgag ttcagttctc
     3841 tagagcccat gtaaaatgtt gggtctggta gtgtgtgttt gaaatgcagg cactggggat
     3901 tcagtagagg agtacctctt gggcccactg gccactggcc tagccactgg gcatcgagcc
     3961 actgagagac cctgtctaaa tggagttgga cagcatttat gagaacatta ggggcttgct
     4021 aatattttga gctcttgagt gagtgtccat cacagctcgg ttaggacagt caagaaagta
     4081 tcccaacttg gcatttttgt aaagtctcgc tgaggcggct gattctgtca gtgattttca
     4141 tgtaaataaa gatgcgtgca agcctttcag ggacagtgtc tgacttctcc aggtaggaag
     4201 gtctgtgtgt tccatctcct tcttagtgtc cccttctgag ttcaggtaga gtcacacctt
     4261 cctccatgcc tacagcgtag ggctcatttt gattctcagt gtaccatctt tatttaaatt
     4321 attttcagtt ctctgagact tttgttactt ttattacagg taatctgagc acttttatat
     4381 tctaagatag aaactatatt atcagatgaa tatagtcact caattaaaat tatttagata
     4441 aaattattgt ttatgttttc tttcaagcaa tctatcctat ttttatccat ttgcaaatgc
     4501 cagttttgtg tggtttctta gcatatcaaa attattatgt agaagaatgt ttctagcttt
     4561 ctgaacagca aatagtttgg tgtgtaaata ttgtattatt tcagtgtgaa taaaggtgag
     4621 agagaatatg aacatttaac caaagtgatt ctactgtggc tgacttaaaa gaacggaagg
     4681 aagtgagtgg ggatttgaca cgtttgaatt acgagttatt cagtgtgcgt tcctctccta
     4741 cgggaaccac tggccagaag gcaaagtaag tctgactgca ttggagattt tcgttcttgt
     4801 aaaaaagccc aaaataaaaa tactaacaat aaa
//
