LOCUS       NM_178662               3693 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus ataxia, cerebellar, Cayman type (Atcay), mRNA.
ACCESSION   NM_178662
VERSION     NM_178662.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3693)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3693)
  AUTHORS   Guo,Y., Li,H., Ke,X., Deng,M., Wu,Z., Cai,Y., Afewerky,H.K.,
            Zhang,X., Pei,L. and Lu,Y.
  TITLE     Degradation of Caytaxin Causes Learning and Memory Deficits via
            Activation of DAPK1 in Aging
  JOURNAL   Mol Neurobiol 56 (5), 3368-3379 (2019)
   PUBMED   30120735
  REMARK    GeneRIF: activation of DAPK1 impairs learning and memory by
            degrading Caytaxin during aging.
REFERENCE   3  (bases 1 to 3693)
  AUTHORS   Luna-Cancalon,K., Sikora,K.M., Pappas,S.S., Singh,V., Wulff,H.,
            Paulson,H.L., Burmeister,M. and Shakkottai,V.G.
  TITLE     Alterations in cerebellar physiology are associated with a
            stiff-legged gait in Atcay(ji-hes) mice
  JOURNAL   Neurobiol Dis 67, 140-148 (2014)
   PUBMED   24727095
REFERENCE   4  (bases 1 to 3693)
  AUTHORS   Sikora,K.M., Nosavanh,L.M., Kantheti,P., Burmeister,M. and
            Hortsch,M.
  TITLE     Expression of Caytaxin protein in Cayman Ataxia mouse models
            correlates with phenotype severity
  JOURNAL   PLoS One 7 (11), e50570 (2012)
   PUBMED   23226316
  REMARK    GeneRIF: Caytaxin's role in maintaining normal neuronal function
REFERENCE   5  (bases 1 to 3693)
  AUTHORS   Castro,D.S., Martynoga,B., Parras,C., Ramesh,V., Pacary,E.,
            Johnston,C., Drechsel,D., Lebel-Potter,M., Garcia,L.G., Hunt,C.,
            Dolle,D., Bithell,A., Ettwiller,L., Buckley,N. and Guillemot,F.
  TITLE     A novel function of the proneural factor Ascl1 in progenitor
            proliferation identified by genome-wide characterization of its
            targets
  JOURNAL   Genes Dev 25 (9), 930-945 (2011)
   PUBMED   21536733
REFERENCE   6  (bases 1 to 3693)
  AUTHORS   Aoyama,T., Hata,S., Nakao,T., Tanigawa,Y., Oka,C. and Kawaichi,M.
  TITLE     Cayman ataxia protein caytaxin is transported by kinesin along
            neurites through binding to kinesin light chains
  JOURNAL   J Cell Sci 122 (Pt 22), 4177-4185 (2009)
   PUBMED   19861499
REFERENCE   7  (bases 1 to 3693)
  AUTHORS   Concepcion,D., Flores-Garcia,L. and Hamilton,B.A.
  TITLE     Multipotent genetic suppression of retrotransposon-induced
            mutations by Nxf1 through fine-tuning of alternative splicing
  JOURNAL   PLoS Genet 5 (5), e1000484 (2009)
   PUBMED   19436707
  REMARK    GeneRIF: The classical hesitant allele of Atcay is partially
            suppressed by CAST/Ei alleles of the nuclear export factor Nxf1.
REFERENCE   8  (bases 1 to 3693)
  AUTHORS   Buschdorf,J.P., Li Chew,L., Zhang,B., Cao,Q., Liang,F.Y.,
            Liou,Y.C., Zhou,Y.T. and Low,B.C.
  TITLE     Brain-specific BNIP-2-homology protein Caytaxin relocalises
            glutaminase to neurite terminals and reduces glutamate levels
  JOURNAL   J Cell Sci 119 (Pt 16), 3337-3350 (2006)
   PUBMED   16899818
REFERENCE   9  (bases 1 to 3693)
  AUTHORS   Bomar,J.M., Benke,P.J., Slattery,E.L., Puttagunta,R., Taylor,L.P.,
            Seong,E., Nystuen,A., Chen,W., Albin,R.L., Patel,P.D.,
            Kittles,R.A., Sheffield,V.C. and Burmeister,M.
  TITLE     Mutations in a novel gene encoding a CRAL-TRIO domain cause human
            Cayman ataxia and ataxia/dystonia in the jittery mouse
  JOURNAL   Nat Genet 35 (3), 264-269 (2003)
   PUBMED   14556008
  REMARK    GeneRIF: Mutations of mouse Atcay are an orthologous gene model for
            human Cayman ataxia.
            Erratum:[Nat Genet. 2005 May;37(5):555]
REFERENCE   10 (bases 1 to 3693)
  AUTHORS   Kapfhamer,D., Sweet,H.O., Sufalko,D., Warren,S., Johnson,K.R. and
            Burmeister,M.
  TITLE     The neurological mouse mutations jittery and hesitant are allelic
            and map to the region of mouse chromosome 10 homologous to 19p13.3
  JOURNAL   Genomics 35 (3), 533-538 (1996)
   PUBMED   8812488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028298.1, AK038990.1 and AC155932.6.
            
            [WARNING] On Mar 15, 2024 this sequence was replaced by
            NM_178662.5.
            
            On Jun 22, 2018 this sequence version replaced NM_178662.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028298.1, BC048903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AK028298.1         1-7
            8-3684              AK038990.1         2-3678
            3685-3693           AC155932.6         164110-164118       c
FEATURES             Location/Qualifiers
     source          1..3693
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3693
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /note="ataxia, cerebellar, Cayman type"
                     /db_xref="GeneID:16467"
                     /db_xref="MGI:MGI:2448730"
     exon            1..295
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            296..423
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1465
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /note="hesitant; jittery; ataxia, cerebellar, Cayman type
                     homolog"
                     /codon_start=1
                     /product="caytaxin"
                     /protein_id="NP_848777.1"
                     /db_xref="CCDS:CCDS24047.1"
                     /db_xref="GeneID:16467"
                     /db_xref="MGI:MGI:2448730"
                     /translation="MGTTEATLRMENVDVRDEWQDEDLPRPLPEDTGVERLGGAVEDS
                     SSPPSTLNLSGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPD
                     ETDSLEFLGNGNELEWEDDTPVATAKNMPGDSADLFGDGSAEDGSAANGRLWRTVIIG
                     EQEHRIDLHMIRPYMKVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYV
                     ISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWF
                     IRTVLAISRPFISVKFISKIQYVHSLEELERLIPMEHVQLPDCVLQYEEQRLRAKRES
                     TRPPQPEFLLPRSEEKPETVEEEDRAAEATEDQETSMS"
     exon            424..482
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            483..704
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            705..890
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            891..993
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1125
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1212
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1311
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1347
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1422
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1455
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..3693
                     /gene="Atcay"
                     /gene_synonym="3322401A10Rik; BNIP-H; CLAC; hes; ji"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagacaga gcctcagcca tcagaaaggg aaaagccaga gccgcggcag gcctgggctg
       61 cgatggcagg ggaaacagtg actaaagggg gacaggggtg ctgctactaa cccacggcgc
      121 cgccttctac agttgggccg gacaggtgtg ctgtggccac gtcgccctgg gtgaccttcc
      181 tcagatgtgg acttggccct gagcatcctt ccaccaggcc cctcgcctgg gtaccatcga
      241 gaaatgcccg cctttgtgtc caagtgacag cgcagaggca gcttccgcta ccgagatcat
      301 cttctgggtc acccgagttt ccagaccact tctctttcca gctctcatgg gaaccacaga
      361 agctacacta aggatggaaa atgtggacgt gagggatgaa tggcaggatg aggatctgcc
      421 cagaccgctc ccagaagaca ccggggtgga gcggctgggt ggcgcagtgg aagactcctc
      481 ctcacctccc tccaccctga acttgagcgg agcacatcga aagagaaaga cgctggtggc
      541 tccagagatc aacatctccc tggaccaaag cgagggctct ctgctgtccg acgacttcct
      601 cgacacacct gatgacctgg acatcaatgt ggacgacatt gagacgccag atgaaactga
      661 ctctctggag ttcttgggaa atggcaatga acttgagtgg gaagatgaca ccccagtggc
      721 caccgccaaa aacatgcctg gtgacagtgc ggacctgttt ggggacggct ctgcggaaga
      781 cggcagtgcg gccaacggtc gtctgtggcg aactgtcatc ataggggagc aagagcatcg
      841 catcgacctg catatgatcc ggccctacat gaaggtggtc acccatggag gatactacgg
      901 ggaaggtctc aacgccatca tcgtgtttgc agcctgcttc ctgccagata gcagctcccc
      961 agactatcac tacatcatgg agaatctctt cctgtacgtc atcagcagcc tagaactgct
     1021 cgtggctgag gactacatga tcgtgtatct gaacggcgcc acgccccgga ggaggatgcc
     1081 tggcattggt tggctgaaga agtgttacca catgattgac aggagactga ggaagaatct
     1141 aaagtccctg atcatcgtcc acccctcctg gttcattcgc actgtgttgg ccatctcccg
     1201 gccattcatc agtgtcaagt tcatcagtaa aattcagtac gtgcacagcc tggaagagct
     1261 ggagcgactg attcccatgg aacacgtgca gctgccagac tgtgtcctgc aatatgaaga
     1321 gcagagactc cgagccaaga gggagagcac acggccaccg cagccggagt tcctccttcc
     1381 caggtcagaa gaaaagccag agactgtgga agaagaggac agggcagcag aggcaacaga
     1441 ggaccaggaa actagcatgt cctgatctac ccagaaccta gacatggaca gagattattc
     1501 ccaacatcat gtaaccctca tccgaagccc tgggagcccc gccttcatcg agcctccacc
     1561 gcctgaggat gcctggctcc accatgtccc ctgcacccgg gtcctctcac tgcttgagtc
     1621 catttcactg ttttattttg aagaaggcgg tatgagcaca tctcggaatg gagcaggttc
     1681 ttgacccttt cacagtctgg gcttgtggat gccaaaggtg gatgtgggca gtgccaccca
     1741 cggttactct tccaggcctt ggcatcccca agatgccctt ctctgtccca gctaggataa
     1801 cacagatatg cattttgggc tgacccaatg agagaccctt tgctcggttg ccacctgtcc
     1861 ctagctggag cctcagatgt ctggtggccc tggctgcagc tgcatctgct tctctgtgga
     1921 atgtgaccca ctgtcccctc tccctgccac cccaggcagg gttgtgactg ctgacctcac
     1981 atctccacct gacatgcact attctgccat ttgactgtct ttgggggcct tcaagcccat
     2041 tgcacatgta ctgatcagcc tggtggtcaa caaacccaac attttgagct cctttaaagt
     2101 agatgtgact ccagatgtta actgacacct cattccaagg gaagaagttg tatccacttt
     2161 cctatcctct gcccagacca gactcagcct ctgtgtcatc aagtaggaga catttggtgt
     2221 ctgagaagaa agatgaagat ccagggctgt gggtgctaga ggatctgggg gaccccctag
     2281 gacagtatat cctggtgggt gggatgctgc gaccacctga tctccaagct gggctcaaag
     2341 cacatgtctg cccgagatga ctacatagtc taagctaatg agtgtgctga gcctcctgtc
     2401 cccagggaca cataaggcca gatgacattt gcagggagga gtctccctgt ggttccctaa
     2461 agacttgagt atctctatgt taagaaatct tagcactgcg cagtggtggc atatgccttt
     2521 aatttcagca ctcaggaata ggaggcaggg ggatttctgt gagttccaag atagcaaggg
     2581 ctacatagtg agaccctgtc cagaaaaaaa aagaggaaga gagagagaca gacagagaga
     2641 gagagctctg tgcctctccc ccaaaggtag gttctatcca ccccactgtg aggtgtcccc
     2701 tctgacatgt ttcttgcttc tcggcctctg atggccgcag gacagcagct tccacctaga
     2761 gagaatcaga gtgtcctgcc aataacaccc atggatctga gctctgcagg aaacacacca
     2821 caaccagagc tactctgtgg caccgggagg ggacccgaga gagtagagca aagcagtgct
     2881 ttttgttttg ttttgagaga agatcttgct atgaagacca gcctggcctc aaactcctga
     2941 tcctcctgcc tcagcctcct gagagctgag atggcaggtg tgtgaccccc caggctgggc
     3001 tggtggtttg taagttgtct ttatccagca tcagaagatg agaaccaaga tggtgcctgg
     3061 ggccaggtcc acagacagcc cctcttggct ttttgaaaac agaatcctgg aggctttttc
     3121 tgactaggcg gctgctggtg acagccaagg cctatgaggt gagaggatct ctgtgtctgg
     3181 gatggatgga tggatgaatg gacacaaccc tgctgtcccc aaaggtctaa ggtcctgcct
     3241 ccaagcccag gaactccagt gggggccacc tgctccatcc acctccttgc tgccatggca
     3301 tgctcaccgc ccctttggaa tcaccagcac ccactgatac aggcaagcag aacccaccag
     3361 ggccactgaa gaccccccaa acaggagacc ccgaggggct taatattcta gcccacacct
     3421 gggaccacca ccccaggtac ctgggggaca gtgaggcaag acacagaggt ccagcagcct
     3481 catggggaag ggctgttcca tttctttact gagacaccca ggatccattt ggcaagtgac
     3541 ccagagcaac agtgtccacc gcccaccagc aaattgtgca gttataaaca cagagacggt
     3601 ggggacagtc cccaaagtaa cacaaagtcc ggggaggctg gggtggggat ttttatgtga
     3661 aataaataaa ttataatgca gagggaagat ata
//
