LOCUS       NM_001142744            1463 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus alpha tubulin acetyltransferase 1 (Atat1), transcript
            variant 1, mRNA.
ACCESSION   NM_001142744
VERSION     NM_001142744.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1463)
  AUTHORS   Sun,S., Xu,Z., He,L., Shen,Y., Yan,Y., Lv,X., Zhu,X., Li,W.,
            Tian,W.Y., Zheng,Y., Lin,S., Sun,Y. and Li,L.
  TITLE     Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed
            alpha-tubulin lactylation
  JOURNAL   Nat Commun 15 (1), 8377 (2024)
   PUBMED   39333081
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1463)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   3  (bases 1 to 1463)
  AUTHORS   Genova,M., Grycova,L., Puttrich,V., Magiera,M.M., Lansky,Z.,
            Janke,C. and Braun,M.
  TITLE     Tubulin polyglutamylation differentially regulates
            microtubule-interacting proteins
  JOURNAL   EMBO J 42 (5), e112101 (2023)
   PUBMED   36636822
REFERENCE   4  (bases 1 to 1463)
  AUTHORS   Yang,Y., Chen,X., Feng,Z., Cai,X., Zhu,X., Cao,M., Yang,L.,
            Chen,Y., Wang,Y. and Feng,H.
  TITLE     MEC17-induced alpha-tubulin acetylation restores mitochondrial
            transport function and alleviates axonal injury after intracerebral
            hemorrhage in mice
  JOURNAL   J Neurochem 160 (1), 51-63 (2022)
   PUBMED   34407220
REFERENCE   5  (bases 1 to 1463)
  AUTHORS   Even,A., Morelli,G., Turchetto,S., Shilian,M., Bail,R.L.,
            Laguesse,S., Krusy,N., Brisker,A., Brandis,A., Inbar,S.,
            Chariot,A., Saudou,F., Dietrich,P., Dragatsis,I., Brone,B.,
            Broix,L., Rigo,J.M., Weil,M. and Nguyen,L.
  TITLE     ATP-citrate lyase promotes axonal transport across species
  JOURNAL   Nat Commun 12 (1), 5878 (2021)
   PUBMED   34620845
  REMARK    Erratum:[Nat Commun. 2021 Nov 12;12(1):6678. doi:
            10.1038/s41467-021-26998-y.. PMID: 34772940]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1463)
  AUTHORS   Yang,W., Guo,X., Thein,S., Xu,F., Sugii,S., Baas,P.W., Radda,G.K.
            and Han,W.
  TITLE     Regulation of adipogenesis by cytoskeleton remodelling is
            facilitated by acetyltransferase MEC-17-dependent acetylation of
            alpha-tubulin
  JOURNAL   Biochem J 449 (3), 605-612 (2013)
   PUBMED   23126280
  REMARK    GeneRIF: Acetylation of alpha-tubulin is under the control of the
            acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and
            HDAC6 (histone deacetylase 6). Adipocyte development is inhibited
            in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing
            cells.
REFERENCE   7  (bases 1 to 1463)
  AUTHORS   Friedmann,D.R., Aguilar,A., Fan,J., Nachury,M.V. and Marmorstein,R.
  TITLE     Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and
            implications for tubulin-specific acetylation
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19655-19660 (2012)
   PUBMED   23071314
REFERENCE   8  (bases 1 to 1463)
  AUTHORS   Akella,J.S., Wloga,D., Kim,J., Starostina,N.G., Lyons-Abbott,S.,
            Morrissette,N.S., Dougan,S.T., Kipreos,E.T. and Gaertig,J.
  TITLE     MEC-17 is an alpha-tubulin acetyltransferase
  JOURNAL   Nature 467 (7312), 218-222 (2010)
   PUBMED   20829795
REFERENCE   9  (bases 1 to 1463)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1463)
  AUTHORS   Zhang,Y., Ma,C., Delohery,T., Nasipak,B., Foat,B.C., Bounoutas,A.,
            Bussemaker,H.J., Kim,S.K. and Chalfie,M.
  TITLE     Identification of genes expressed in C. elegans touch receptor
            neurons
  JOURNAL   Nature 418 (6895), 331-335 (2002)
   PUBMED   12124626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB857404.1, AK133694.1, AK011750.2 and BQ748472.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). It should be noted that this variant contains an overlapping
            upstream ORF that may interfere with the translation of the
            annotated CDS.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028847.1, AK011750.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB857404.1         12-34
            24-1001             AK133694.1         1-978
            1002-1427           AK011750.2         978-1403
            1428-1463           BQ748472.1         464-499
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.75 cM"
     gene            1..1463
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /note="alpha tubulin acetyltransferase 1"
                     /db_xref="GeneID:73242"
                     /db_xref="MGI:MGI:1913869"
     exon            1..140
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1299
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /EC_number="2.3.1.108"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-TAT; acetyltransferase mec-17 homolog; alpha-TAT1;
                     alpha-tubulin N-acetyltransferase 1"
                     /codon_start=1
                     /product="alpha-tubulin N-acetyltransferase 1 isoform 1"
                     /protein_id="NP_001136216.1"
                     /db_xref="CCDS:CCDS50096.1"
                     /db_xref="GeneID:73242"
                     /db_xref="MGI:MGI:1913869"
                     /translation="MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIM
                     TIVDELGKASAKAQHLPAPITSALRMQSNRHVIYILKDTSARPAGKGAIIGFLKVGYK
                     KLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQHMLQKERVEPHQLAIDRPS
                     PKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRPPTSSLRATRHSRAAVADPIPAA
                     PARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNS
                     PDRGPLRPFVPEQELLRSLRLCPPHPTARLLLATDPGGSPAQRRRTRGTPWGLVAQSC
                     HYSRHGGFNTSFLGTGNQERKQGEQEAEDRSASEDRVLLLDGSGEEPTQTGAPRAQAP
                     PPQSWTVGGDIMNARVIRNLQERRSTRPW"
     exon            141..201
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            202..293
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            294..354
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            355..468
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            469..570
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            571..616
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            617..685
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            686..757
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1001
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1081
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1124
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1445
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /note="hexamer: AATAAA"
     polyA_site      1431
                     /gene="Atat1"
                     /gene_synonym="0610011P08Rik; 2610008K08Rik;
                     2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT"
                     /note="major polyA site"
ORIGIN      
        1 gtgtggggcg tgtctggtcc cgcacaatgg gccatggagt tcccgttcga tgtggatgcg
       61 ctgttcccgg agcggatcac cgtgctggac cagcacctgc ggcctccggc ccgccgaccc
      121 ggaaccacaa cgccggcccg tgtggatctg cagcagcaaa tcatgactat tgtagatgag
      181 ctgggcaagg cttctgccaa ggcgcagcac ctccctgcac ccatcaccag cgctttgagg
      241 atgcaaagca accggcacgt tatttacata ctgaaggaca cctcagcccg accggcaggg
      301 aaaggagcca ttattggttt cctcaaagtt ggatacaaga agctctttgt actggatgac
      361 cgggaggctc acaatgaggt agaacccctt tgcattctgg acttttacat ccacgagtcg
      421 gtgcaacggc atggccacgg gcgagaactt tttcagcata tgttacagaa agagcgagtg
      481 gagccccacc aactggccat tgaccgacca tcgccgaagc tgctcaagtt cctgaataag
      541 cactacaacc tggagaccac agtcccacag gtgaacaact ttgtcatctt tgaaggcttc
      601 tttgcccatc agcaccggcc ccccacttcc tctctgagag caactcgaca ctctcgtgct
      661 gctgtggccg atcccatacc tgctgctcca gcacggaagc tgccaccaaa aagagcagag
      721 ggagacatta agccatactc ttccagtgac agagaattcc tgaaggtagc tgtggagcct
      781 ccttggcccc tgaacagggc ccctcggcgt gccacacctc cagcccaccc acctccacgt
      841 tctagcagcc tgggcaactc accggatcgg ggtccccttc ggccctttgt tccagagcag
      901 gagctgcttc gctccctgcg tctctgtccc ccacacccta ctgcacgcct tctgctggcc
      961 actgaccctg gaggcagccc agcccagcgc agacgcacca gggggactcc ctgggggctg
     1021 gtagcccaaa gctgccacta cagccgccat gggggattca atacctcatt cctgggtaca
     1081 ggcaaccaag aacggaagca gggggaacag gaagcggagg ataggtcggc cagtgaggat
     1141 cgggtcttgt tactggatgg gtctggggag gagcctacac agacaggtgc tccaagggcc
     1201 caggcgccac ccccccagtc ctggacggtg ggtggggaca taatgaacgc cagggtcatt
     1261 cgaaacctgc aggaacgccg cagcaccagg ccttggtaac catggccaaa gcttagtcct
     1321 cagtatggat gcattcattc actcattcat tcaacaggcc tgtcagcctc agatcctttg
     1381 tatcgttatt tttaaccaga gcaataaaag tatttatttg ttatcactat agctaccgac
     1441 aaaaaaaaaa aaaaaaaaaa aaa
//
