LOCUS       NM_001029856            7272 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase family, AAA domain containing 5 (Atad5), mRNA.
ACCESSION   NM_001029856 XM_111221
VERSION     NM_001029856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7272)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7272)
  AUTHORS   Zanotti,K.J., Maul,R.W., Castiblanco,D.P., Yang,W., Choi,Y.J.,
            Fox,J.T., Myung,K., Saribasak,H. and Gearhart,P.J.
  TITLE     ATAD5 deficiency decreases B cell division and Igh recombination
  JOURNAL   J Immunol 194 (1), 35-42 (2015)
   PUBMED   25404367
  REMARK    GeneRIF: Atad5+/m cells accumulate in the S phase, have decreased
            proliferation, and have reduced double-strand breaks, class switch
            recombination, and translocations
REFERENCE   3  (bases 1 to 7272)
  AUTHORS   Gazy,I., Liefshitz,B., Parnas,O. and Kupiec,M.
  TITLE     Elg1, a central player in genome stability
  JOURNAL   Mutat Res Rev Mutat Res 763, 267-279 (2015)
   PUBMED   25795125
  REMARK    GeneRIF: Authors discuss many functions of Elg1 protein as
            embryonic lethal when lost in mice, as a tumor suppressor in mice
            and humans, interacts with human Fanconi Anemia pathway and may
            contribute to some of the phenotypes associated with
            neurofibromatosis. [Review]
            Review article
REFERENCE   4  (bases 1 to 7272)
  AUTHORS   Bell,D.W., Sikdar,N., Lee,K.Y., Price,J.C., Chatterjee,R.,
            Park,H.D., Fox,J., Ishiai,M., Rudd,M.L., Pollock,L.M.,
            Fogoros,S.K., Mohamed,H., Hanigan,C.L., Zhang,S., Cruz,P.,
            Renaud,G., Hansen,N.F., Cherukuri,P.F., Borate,B., McManus,K.J.,
            Stoepel,J., Sipahimalani,P., Godwin,A.K., Sgroi,D.C., Merino,M.J.,
            Elliot,G., Elkahloun,A., Vinson,C., Takata,M., Mullikin,J.C.,
            Wolfsberg,T.G., Hieter,P., Lim,D.S. and Myung,K.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Predisposition to cancer caused by genetic and functional defects
            of mammalian Atad5
  JOURNAL   PLoS Genet 7 (8), e1002245 (2011)
   PUBMED   21901109
  REMARK    GeneRIF: loss-of-function mutations in mammalian Atad5 are
            sufficient to cause genomic instability and tumorigenesis.
REFERENCE   5  (bases 1 to 7272)
  AUTHORS   Ishii,H., Inageta,T., Mimori,K., Saito,T., Sasaki,H., Isobe,M.,
            Mori,M., Croce,C.M., Huebner,K., Ozawa,K. and Furukawa,Y.
  TITLE     Frag1, a homolog of alternative replication factor C subunits,
            links replication stress surveillance with apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 102 (27), 9655-9660 (2005)
   PUBMED   15983387
REFERENCE   6  (bases 1 to 7272)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591113.14, AL672178.8 and AL663057.7.
            
            On Dec 2, 2008 this sequence version replaced NM_001029856.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY557610.1, SRR10223969.11193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               AL591113.14        196137-196573
            438-2305            AL591113.14        200892-202759
            2306-2402           AL672178.8         2584-2680
            2403-2564           AL672178.8         4945-5106
            2565-2691           AL672178.8         6413-6539
            2692-2773           AL672178.8         7891-7972
            2774-2958           AL672178.8         10885-11069
            2959-3113           AL672178.8         13114-13268
            3114-3273           AL672178.8         13995-14154
            3274-3462           AL672178.8         14578-14766
            3463-3559           AL672178.8         16106-16202
            3560-3648           AL672178.8         17380-17468
            3649-3788           AL672178.8         17706-17845
            3789-3939           AL672178.8         18787-18937
            3940-4116           AL663057.7         6492-6668
            4117-4253           AL663057.7         6994-7130
            4254-4347           AL663057.7         8209-8302
            4348-4412           AL663057.7         11594-11658
            4413-4593           AL663057.7         14784-14964
            4594-4772           AL663057.7         18731-18909
            4773-5614           AL663057.7         19992-20833
            5615-5773           AL663057.7         21556-21714
            5774-7272           AL663057.7         21820-23318
FEATURES             Location/Qualifiers
     source          1..7272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.48 cM"
     gene            1..7272
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /note="ATPase family, AAA domain containing 5"
                     /db_xref="GeneID:237877"
                     /db_xref="MGI:MGI:2442925"
     exon            1..437
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..5852
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /note="chromosome fragility-associated gene 1 protein;
                     chromosome fragility associated gene 1"
                     /codon_start=1
                     /product="ATPase family AAA domain-containing protein 5"
                     /protein_id="NP_001025027.1"
                     /db_xref="CCDS:CCDS25127.1"
                     /db_xref="GeneID:237877"
                     /db_xref="MGI:MGI:2442925"
                     /translation="MVGVLSMAAAAAPLPVKDYEIEPCKKRRKDDDNSSCETITKYLS
                     PIGKTGDKVFSPPKPSNILHYFRKTSLTTEKPQSTKAYKIKPSPPLLVGNSKDCKTPL
                     EVFSNREFKRKRKRVSLSSQLNDIKIQDECPVEISNNDSKEDGGLSDCVESSASVSLY
                     KEHVEVLAESIEDSRNQPNTKSSKKKVNPKQCTTKSDDRILRKRKRSKVTGQSESVPL
                     ADELSLPEDGGKDSKLTKPSLAEENDSRTHATKRADLKESTITVSYEEFVKSHKAAKV
                     EEIPDPAVPACVPSGPGEAVKSGSEGELSGSCEPSPQLHLKTVTVLAQVHPTPPKKKG
                     KIPPIFLKQKQPELENSLSDPENEQPVQKRKSNVVIQEGQLELAVLEAWNSEASVPKC
                     SMEERQQFMRAFRQPPPDTLKNGFKKPLEKQKDPSEKSVHEGDSSSEKIIENPNIQRV
                     SSQGCLQSHADRGSFPKEKSKKPNKKGKKTRTTAGGNREENIQKEKTAFSLKDEQDQN
                     SLRRSVRQKSEVLKSNALLNSENLVCEDTAHDSVQMSLCNRNKSRSSSTPTRDMVTHH
                     RAEPGSSLEYVSTRQPIRRSLRSCSTPATNALGGTESEDAQDTIPVKASTPKSARTSE
                     KHNLYTAELIIVSSDSESPIRMKFTRISTPKKSKKSSKKSETTEEELTSQKKKANSTS
                     KNISKAKELIEEAKAFQIGGSKTEETVVPLRRSSRHQARSAKEKSPEIDDSVIVIDSS
                     PTSIREPEKSQKKLQNLNDVLGKKLNKSSKNVPGKMKIAPLFLAKRTKRAAIPVFDLD
                     ESSQDSSEQTQDCDVQFKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVH
                     VQQKDDEYWLWHLKPPSCPLLTEFKELNTKVTDLSEYVVAFGEFSTLNPNPRSNPAAV
                     MMRTRKDFTKEVRNLLLEEIKCSNPEFSLEKYFPLLLKKRIEHQVLCEGHGKQASPQL
                     QPDVSQKETKRKQVATGNQKSKRKRQNEYSVSPEEMKGRSKDLDERISSSCTNLDPSR
                     DSGTEDMLWTEKYQPQNSNELIGNELAVKKLHSWLKDWKRRAELEERHNLKGKRDEKE
                     EGILDLSDSTDFKGSSDDEENRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNAS
                     SQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNNYNIGKSPKKLNSPGKVVTSPRK
                     LPPSSPKTSGQKRALLPKTLANYFKVSSKSKSNDDVGALMGDDKGVKNSSLEQRQLIQ
                     TKSTNANNSHIKDVGAEESNRKKATSLILFEEVDVIFDEDAGFLNAVKTFMATTKRPV
                     ILTTSDPTFSLVFDGCFEEINFSIPSLLNVASYLQVICLVENFRTDFKDFVTLLTANA
                     CDIRKSILYLQFWIRSGGGILEERPLSHCRENSRNTLVCSEDGSDANINSKKPKRNRV
                     ALPRCDTGCAEALFGLKNIASPSQDLLSLLKHKITTKEEWQKLIQVLTEFHVQNIDLL
                     HSNLEVILPLPVHVVPDVRGAYGFPVTTQASAPASMGHLTRKQSKDQPLRKSQKRKQK
                     KMVILDDSDLFDTGLDFSGELPSLSPAPSLSVEDNIRRDSNPEIKTQNSGFKPHSVPQ
                     PPKTLAEKKCCMLVSHCLNSLSEFMENMSFIDALLTDPGEQNELGRSAFHWTNGRVKS
                     GLCDEFSLENRDRWAPQSAGELKATAEALSFTECSSTISKALESLNSCKQLERDPTNE
                     LTVCVSQRRHDACFRQSAANLDNADKRMAVIKSVFSSRSFLTLGNKQASIIDYLPTLR
                     NICRTEKLKEQEKNKRRFLHYFEGIHLEIPEETITTLAADFP"
     exon            438..2305
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2402
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2564
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2691
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2773
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2958
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3113
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3273
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3462
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3559
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3648
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3788
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3939
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4116
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            4117..4253
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4347
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4412
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4593
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4772
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..5614
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            5615..5773
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     exon            5774..7272
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7248..7253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /note="hexamer: ATTAAA"
     polyA_site      7259
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /note="major polyA site"
ORIGIN      
        1 tccgccccct gcgctccgga cggcgggaaa acccaattga cagaactccc gccgaagccc
       61 cactagtccg atctgcgttc tgtggggctc gagcgcttat tctggagaat ctgccccggg
      121 ggcaccttgt attgtcccgc cgccacctcg gggcctgagc ccgggcttcc cgtacatctc
      181 tgtctgagtc tgactcggcg gccctgggcc cagcctctca ctcgcgtccg gccggtggtc
      241 tctacgagac ccgagacggg ctccccggct cgcagctcgc tcccactgga cctgccgccc
      301 ctatggcctc cagccaggct gggccggacc tctgaagggc ctaggagccc gggttctagg
      361 aggcagagat catggtgggg gtcctgagca tggcggcggc tgcagcaccc cttcctgtga
      421 aggactacga gattgagcca tgcaaaaagc ggagaaaaga tgatgacaac tcttcctgcg
      481 aaacaatcac caaatattta tcaccaatag ggaagactgg agacaaggtt ttctctccac
      541 caaaacccag taatattcta cattatttta gaaagacctc actcacaacc gagaagccac
      601 aatcgacaaa ggcgtacaaa ataaagccat ctcccccatt gcttgttggc aacagcaaag
      661 actgtaagac gccattggaa gtattctcaa atagagaatt taagaggaaa agaaagagag
      721 ttagtttatc ctctcaactg aatgatatta aaattcagga tgagtgtcca gttgaaatta
      781 gtaacaatga tagtaaggag gacggtggtt taagtgattg tgtggaaagc agtgcttctg
      841 tttcccttta caaggaacat gtggaggttc tcgcagaaag tattgaagac agcagaaacc
      901 agccaaatac taagtcctcc aaaaagaaag taaatcctaa acaatgcacc acaaaaagtg
      961 atgacaggat actgaggaag aggaagcgta gcaaggtaac gggtcagtct gaaagtgtgc
     1021 ccttagcaga tgaacttagt ctgcctgagg atggtggcaa agacagcaag ctgactaaac
     1081 cttccctagc tgaggaaaac gactccagga ctcatgcaac caaaagagct gatttaaagg
     1141 agagtacaat tactgtctcc tatgaggaat ttgtaaaaag tcacaaggca gctaaagtgg
     1201 aagagatacc tgaccctgca gttccagcct gtgttccttc tgggccaggt gaagcagtca
     1261 aaagtggttc tgaaggcgaa ttgtcgggaa gctgcgaacc atcgccacag ctgcacctca
     1321 agacagttac tgttcttgca caagttcacc ccactccccc taagaagaaa gggaaaatac
     1381 ccccaatttt cttgaaacag aagcagcctg agctggagaa tagtctctct gacccagaaa
     1441 atgagcagcc agttcagaag aggaaatcta atgttgtgat ccaggagggc caattagagc
     1501 tggcggtgct ggaagcctgg aactctgagg cttcagtacc aaagtgcagc atggaggaaa
     1561 gacagcagtt catgagagca tttaggcagc caccgccaga cacgctcaaa aatggattca
     1621 agaaacctct ggagaagcag aaagacccaa gtgaaaaatc tgtccatgaa ggagatagca
     1681 gttctgaaaa aattatagaa aatcctaata ttcaaagagt ttcaagccaa ggctgtctac
     1741 agtcacatgc cgatagagga agttttccta aggagaaaag taaaaagcca aataaaaagg
     1801 gtaagaaaac taggactact gcaggtggaa acagagaaga aaacatacaa aaggaaaaaa
     1861 cagccttttc cttaaaagat gaacaggatc aaaatagcct acgaaggagt gtaagacaga
     1921 aatcagaagt tctcaaaagc aatgcattac ttaacagtga aaatcttgtt tgtgaggata
     1981 cggcacatga ctctgtacaa atgtctctgt gtaatagaaa taagtcaaga agcagcagca
     2041 caccaaccag ggatatggtt acacatcaca gagctgagcc tggaagtagc ctggagtatg
     2101 tctctacacg ccaaccaatc aggagatctc tgagaagttg cagcacgcct gcaacaaatg
     2161 ctctgggagg tactgagtct gaggatgctc aggacactat tccagtgaag gcttccaccc
     2221 caaaatcagc cagaacatca gaaaagcaca acctgtatac agcagaatta ataatagtat
     2281 cttctgattc cgagagcccc attagaatga aattcactag aattagtact cccaaaaaat
     2341 ccaagaaaag ttctaagaaa tctgaaacaa ctgaggaaga gctcacttct cagaagaaaa
     2401 aggcaaatag tacttcaaaa aatatatcaa aagcaaaaga actgattgag gaagcaaaag
     2461 cattccaaat tggcggatca aagactgaag aaacagtggt acccttgagg cggtcctcta
     2521 ggcaccaggc acgttctgca aaggagaagt cgccagagat agatgactct gtaatagtaa
     2581 tagactcaag tccaacttct ataagagaac cagagaaaag tcagaagaaa cttcagaatc
     2641 tgaatgatgt actaggaaaa aaacttaaca agtcttctaa aaatgtccct ggaaaaatga
     2701 aaattgctcc tttatttctt gccaaaagga ccaaaagagc agccattcct gtctttgatt
     2761 tggatgaaag cagtcaagat tcatcagaac aaactcagga ttgtgatgta cagtttaaag
     2821 caaagcgtga ttttctaatg agtggtttgc cagatttact gaaacgtcag attgcaaaga
     2881 aagctgctgc attagatgtg tacaatgcag tgagtacaag tttccagagg gttgttcatg
     2941 tacaacagaa ggatgatgaa tattggttat ggcatttgaa gccaccttct tgtcctctgt
     3001 taactgaatt taaggaatta aatactaaag taacagatct ctcagaatat gttgttgctt
     3061 ttggtgaatt ttccaccttg aatccaaatc caagaagtaa tcctgctgct gtgatgatga
     3121 ggacaaggaa ggactttact aaagaagtaa gaaacctttt gctggaggaa ataaagtgct
     3181 caaatccaga attttctttg gaaaaatatt ttcccttgct tcttaaaaaa cgaattgaac
     3241 accaggtact ttgtgagggt catggtaaac aagcaagtcc acaactacag cctgatgtca
     3301 gtcaaaaaga aaccaaaagg aaacaagtgg caacgggaaa tcagaagtca aaaagaaaga
     3361 gacaaaatga atattcagtg agcccggaag agatgaaggg gagatcaaaa gaccttgacg
     3421 aaagaatcag ctcttcttgt acaaatctag atccttccag agattctgga actgaagaca
     3481 tgctttggac agaaaagtac caacctcaga attcgaatga actcataggc aatgagttag
     3541 ctgtcaaaaa gttacatagt tggttgaagg actggaaaag aagagctgaa ctggaagaaa
     3601 gacataattt gaaaggaaag agagatgaaa aagaggaagg tattttggat ttatcggata
     3661 gcacggactt taaaggcagt tcagatgatg aagagaatcg tctttgcaac actgttctta
     3721 taacaggacc aacgggagtg ggaaaaactg ctgccgtgta tgcttgtgct caggagcttg
     3781 ggtttaagat atttgaagtg aatgcctctt cacagcgaag tggtaggcaa atcctgtctc
     3841 agctgaagga agctacccag tcccatcaag tagataagca aggtgtaaac tcacaaaaac
     3901 cctgtttctt taacaactac aacattggca agtcaccaaa aaagttaaac tccccgggga
     3961 aagttgttac atcaccaagg aagcttcctc catcgtcacc aaagacaagt gggcagaagc
     4021 gagcacttct tcctaaaact ttggcaaatt actttaaagt gtcctccaaa tccaaaagta
     4081 atgacgacgt aggagcactc atgggagatg acaaaggagt caaaaattcg tctttggaac
     4141 agaggcaact tattcagact aaatcaacca atgcaaataa ttcacatatt aaagatgttg
     4201 gagctgaaga atccaacagg aagaaggcga catcactcat tctctttgag gaggttgatg
     4261 tcatttttga tgaagatgct gggtttttga atgcagtcaa aaccttcatg gcaacaacta
     4321 aacgaccagt aattctcacg acaagtgatc ccacatttag tctagtgttt gatggctgct
     4381 ttgaagaaat caatttcagt attccttccc tgctaaatgt tgccagctat ctacaagtga
     4441 tttgtctagt tgagaatttc agaactgact ttaaagactt tgtaaccttg ttgactgcaa
     4501 atgcttgtga catcagaaaa agtatccttt acttacagtt ttggattaga agtggaggtg
     4561 gaattttaga agaaaggcca ttatcacact gtcgagaaaa tagcagaaat acactggttt
     4621 gttcagaaga tggctctgat gcaaacatca actctaaaaa acccaaaagg aaccgtgtgg
     4681 ccctccccag gtgtgacact ggctgtgcag aggctttgtt tggactcaag aacattgcct
     4741 ccccatccca ggacttactt tcattattga agcacaagat cacaacaaag gaagaatggc
     4801 agaaactcat tcaggttctc accgaattcc acgtgcaaaa tatcgatctg ctacatagta
     4861 accttgaggt catcctgcca ctgccagttc atgtggttcc agatgtaagg ggtgcttatg
     4921 gcttcccagt gactacacag gccagtgcac cagcaagcat ggggcatctt accaggaagc
     4981 agtcaaaaga ccagccattg agaaagtcac agaaaaggaa acagaaaaag atggtgatcc
     5041 tagatgacag tgacctgttt gacactggcc tagacttttc tggtgaactg cctagcctat
     5101 ctcctgcacc ctccttgtct gtagaagaca acataagaag agacagcaat ccagagatta
     5161 agacacagaa cagtggtttc aagccccact ctgtacctca gccccctaag acactagcag
     5221 agaagaagtg ttgcatgctc gtttcccact gtttaaattc tctcagtgag ttcatggaga
     5281 acatgtcctt catagatgct cttttaacag atccagggga acagaatgaa ttgggtagaa
     5341 gtgcctttca ctggacaaat ggaagggtta aaagtggact ttgtgatgag tttagtcttg
     5401 agaatagaga caggtgggct cctcagagcg ctggagaatt aaaagcaact gcagaagcac
     5461 tgagctttac tgagtgttct tctaccattt caaaagcact ggagtccttg aattcatgca
     5521 agcaattaga aagagaccca accaatgaac tcacagtctg tgtttcacaa aggcgccatg
     5581 atgcatgctt ccgccaatca gcagctaatc tagacaatgc tgacaagagg atggcagtta
     5641 ttaaaagtgt gttttctagt cgttcttttc tgaccctggg taataaacaa gctagtataa
     5701 ttgactacct gccaactctt cggaacattt gtcggacaga aaagctaaaa gaacaagaga
     5761 aaaataaaag aaggtttctg cactattttg aaggaattca tctagagatt cctgaagaaa
     5821 ccataactac tttggcagct gacttccctt gatgctcccc gtcgtcagcc ttgtagagac
     5881 tgtgtggtcc tgatgactct agagtatggt gactttaaag aagagcttat ttctcttaat
     5941 gtaaattttg aaagactttt gtatttttgt ggttcaagtt taaaatgaaa aatttgagtt
     6001 acaaattgta tatatgactg tgacattttt tctgaatgtt tggattatct atttttgctt
     6061 tattgtatac tttctgtatg tgtgaactgt ttgtagaata attttcactt atagatttct
     6121 agagctgttt cagttctaag cttacctgtc atttttccct tttcctgtaa ttgtcctctc
     6181 ctgccaagca gcagagctgt gccactgtaa ataggcagtc tctaaagtta cacaatggaa
     6241 aacagttatg tacagggtat tttaaaatgt cctaggaagt aaattatgcc tcggttgtga
     6301 aaagcattgc ctttgtttct tgtgccttct tccaccacgt tttacatgta atcattgagt
     6361 cattagcact ggcagagtaa agccttctga attctagcat ttgcctagat aagaccatct
     6421 gtcactcact ccctgtagtt acacagtcca gtgaatcttg ccaactcaag tcgtttgtac
     6481 attttctggt acttttatat cattgtttta tttcataaag taatgacact gtttatctgt
     6541 tgtggacaac ttgttgatgg ttcaagaagt aatgacggat tctaccatgg ggcttctacc
     6601 tgactgctgt tcccatttga gtatggcgtt tgttgttggt ttttgttttt ggtgctgagg
     6661 attaaattta agggtttttg tattataggc aaatgtcttg tatcctagta tatacacagg
     6721 cgttgtgttt tactaattat ttgcagtggt acgtatcaaa tccaagatct cgtgcattct
     6781 atgaacatgc taaaccacag agcgagaacc cccatcctgt ttttgaggca gggtctggta
     6841 tattgcttag gctactccta atctccttcc agaattttgt aatccccgtc tcaagctcct
     6901 tcagtactta caggtatttg ctaccacact gagcaaggtc atcttttaat attttttgag
     6961 tacctatttt taactttagt agcaagtttt taaaatgcac attttactta atgttatttt
     7021 gcagattatg aggtttgttt aaaattcctt cataatgtaa atatttgtat aataatatat
     7081 tattcaggta cattttctga tgaattgtat ttttaattca gaaggtaagg atcctagttt
     7141 tgtacttttt aaaaatatag ttgcatacct gtttacaaat gtgtataaag atgtgttttt
     7201 acctcttgtt caacctacct tcttgaatta gttagtaaat tgatctaatt aaagctaaat
     7261 gcttggtgtg tt
//
