LOCUS       NP_001025027            1826 aa            linear   ROD 27-APR-2025
DEFINITION  ATPase family AAA domain-containing protein 5 [Mus musculus].
ACCESSION   NP_001025027 XP_111221
VERSION     NP_001025027.1
DBSOURCE    REFSEQ: accession NM_001029856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1826)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1826)
  AUTHORS   Zanotti,K.J., Maul,R.W., Castiblanco,D.P., Yang,W., Choi,Y.J.,
            Fox,J.T., Myung,K., Saribasak,H. and Gearhart,P.J.
  TITLE     ATAD5 deficiency decreases B cell division and Igh recombination
  JOURNAL   J Immunol 194 (1), 35-42 (2015)
   PUBMED   25404367
  REMARK    GeneRIF: Atad5+/m cells accumulate in the S phase, have decreased
            proliferation, and have reduced double-strand breaks, class switch
            recombination, and translocations
REFERENCE   3  (residues 1 to 1826)
  AUTHORS   Gazy,I., Liefshitz,B., Parnas,O. and Kupiec,M.
  TITLE     Elg1, a central player in genome stability
  JOURNAL   Mutat Res Rev Mutat Res 763, 267-279 (2015)
   PUBMED   25795125
  REMARK    GeneRIF: Authors discuss many functions of Elg1 protein as
            embryonic lethal when lost in mice, as a tumor suppressor in mice
            and humans, interacts with human Fanconi Anemia pathway and may
            contribute to some of the phenotypes associated with
            neurofibromatosis. [Review]
            Review article
REFERENCE   4  (residues 1 to 1826)
  AUTHORS   Bell,D.W., Sikdar,N., Lee,K.Y., Price,J.C., Chatterjee,R.,
            Park,H.D., Fox,J., Ishiai,M., Rudd,M.L., Pollock,L.M.,
            Fogoros,S.K., Mohamed,H., Hanigan,C.L., Zhang,S., Cruz,P.,
            Renaud,G., Hansen,N.F., Cherukuri,P.F., Borate,B., McManus,K.J.,
            Stoepel,J., Sipahimalani,P., Godwin,A.K., Sgroi,D.C., Merino,M.J.,
            Elliot,G., Elkahloun,A., Vinson,C., Takata,M., Mullikin,J.C.,
            Wolfsberg,T.G., Hieter,P., Lim,D.S. and Myung,K.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Predisposition to cancer caused by genetic and functional defects
            of mammalian Atad5
  JOURNAL   PLoS Genet 7 (8), e1002245 (2011)
   PUBMED   21901109
  REMARK    GeneRIF: loss-of-function mutations in mammalian Atad5 are
            sufficient to cause genomic instability and tumorigenesis.
REFERENCE   5  (residues 1 to 1826)
  AUTHORS   Ishii,H., Inageta,T., Mimori,K., Saito,T., Sasaki,H., Isobe,M.,
            Mori,M., Croce,C.M., Huebner,K., Ozawa,K. and Furukawa,Y.
  TITLE     Frag1, a homolog of alternative replication factor C subunits,
            links replication stress surveillance with apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 102 (27), 9655-9660 (2005)
   PUBMED   15983387
REFERENCE   6  (residues 1 to 1826)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591113.14, AL672178.8 and AL663057.7.
            
            On Jul 27, 2005 this sequence version replaced XP_111221.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY557610.1, SRR10223969.11193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1826
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.48 cM"
     Protein         1..1826
                     /product="ATPase family AAA domain-containing protein 5"
                     /note="chromosome fragility-associated gene 1 protein;
                     chromosome fragility associated gene 1"
                     /calculated_mol_wt=203779
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          170..254
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          282..311
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          323..367
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Site            351
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          365..381
                     /region_name="Interaction with WDR48.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Site            366
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          398..572
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          588..623
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Site            591
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Site            603
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          647..684
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          709..729
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Site            727
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Site            801
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          965..1034
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          1036..>1154
                     /region_name="PRK04195"
                     /note="replication factor C large subunit; Provisional"
                     /db_xref="CDD:235250"
     Site            1104
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3; propagated from
                     UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          1183..1216
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          1415..1419
                     /region_name="LXCXE motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          1527..1552
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          1592..1611
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     Region          1612..1701
                     /region_name="Interaction with RAD51 and RFC5.
                     /evidence=ECO:0000250|UniProtKB:Q96QE3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QY64.1)"
     CDS             1..1826
                     /gene="Atad5"
                     /gene_synonym="C130052G03Rik; FRAG1; Gm17"
                     /coded_by="NM_001029856.2:372..5852"
                     /db_xref="CCDS:CCDS25127.1"
                     /db_xref="GeneID:237877"
                     /db_xref="MGI:MGI:2442925"
ORIGIN      
        1 mvgvlsmaaa aaplpvkdye iepckkrrkd ddnsscetit kylspigktg dkvfsppkps
       61 nilhyfrkts lttekpqstk aykikpsppl lvgnskdckt plevfsnref krkrkrvsls
      121 sqlndikiqd ecpveisnnd skedgglsdc vessasvsly kehvevlaes iedsrnqpnt
      181 ksskkkvnpk qcttksddri lrkrkrskvt gqsesvplad elslpedggk dskltkpsla
      241 eendsrthat kradlkesti tvsyeefvks hkaakveeip dpavpacvps gpgeavksgs
      301 egelsgscep spqlhlktvt vlaqvhptpp kkkgkippif lkqkqpelen slsdpeneqp
      361 vqkrksnvvi qegqlelavl eawnseasvp kcsmeerqqf mrafrqpppd tlkngfkkpl
      421 ekqkdpseks vhegdsssek iienpniqrv ssqgclqsha drgsfpkeks kkpnkkgkkt
      481 rttaggnree niqkektafs lkdeqdqnsl rrsvrqksev lksnallnse nlvcedtahd
      541 svqmslcnrn ksrssstptr dmvthhraep gssleyvstr qpirrslrsc stpatnalgg
      601 tesedaqdti pvkastpksa rtsekhnlyt aeliivssds espirmkftr istpkkskks
      661 skksetteee ltsqkkkans tskniskake lieeakafqi ggskteetvv plrrssrhqa
      721 rsakekspei ddsvividss ptsirepeks qkklqnlndv lgkklnkssk nvpgkmkiap
      781 lflakrtkra aipvfdldes sqdsseqtqd cdvqfkakrd flmsglpdll krqiakkaaa
      841 ldvynavsts fqrvvhvqqk ddeywlwhlk ppscplltef kelntkvtdl seyvvafgef
      901 stlnpnprsn paavmmrtrk dftkevrnll leeikcsnpe fslekyfpll lkkriehqvl
      961 ceghgkqasp qlqpdvsqke tkrkqvatgn qkskrkrqne ysvspeemkg rskdlderis
     1021 ssctnldpsr dsgtedmlwt ekyqpqnsne lignelavkk lhswlkdwkr raeleerhnl
     1081 kgkrdekeeg ildlsdstdf kgssddeenr lcntvlitgp tgvgktaavy acaqelgfki
     1141 fevnassqrs grqilsqlke atqshqvdkq gvnsqkpcff nnynigkspk klnspgkvvt
     1201 sprklppssp ktsgqkrall pktlanyfkv ssksksnddv galmgddkgv knssleqrql
     1261 iqtkstnann shikdvgaee snrkkatsli lfeevdvifd edagflnavk tfmattkrpv
     1321 ilttsdptfs lvfdgcfeei nfsipsllnv asylqviclv enfrtdfkdf vtlltanacd
     1381 irksilylqf wirsgggile erplshcren srntlvcsed gsdaninskk pkrnrvalpr
     1441 cdtgcaealf glkniaspsq dllsllkhki ttkeewqkli qvltefhvqn idllhsnlev
     1501 ilplpvhvvp dvrgaygfpv ttqasapasm ghltrkqskd qplrksqkrk qkkmvildds
     1561 dlfdtgldfs gelpslspap slsvednirr dsnpeiktqn sgfkphsvpq ppktlaekkc
     1621 cmlvshclns lsefmenmsf idalltdpge qnelgrsafh wtngrvksgl cdefslenrd
     1681 rwapqsagel kataealsft ecsstiskal eslnsckqle rdptneltvc vsqrrhdacf
     1741 rqsaanldna dkrmaviksv fssrsfltlg nkqasiidyl ptlrnicrte klkeqeknkr
     1801 rflhyfegih leipeetitt laadfp
//
