LOCUS       NM_179203               2426 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus ATPase family, AAA domain containing 3A (Atad3a),
            mRNA.
ACCESSION   NM_179203 NM_133233
VERSION     NM_179203.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2426)
  AUTHORS   Li,S., Xu,R., Yao,Y. and Rousseau,D.
  TITLE     ATAD3 is a limiting factor in mitochondrial biogenesis and
            adipogenesis of white adipocyte-like 3T3-L1 cells
  JOURNAL   Cell Biol Int 48 (10), 1473-1489 (2024)
   PUBMED   38923254
  REMARK    GeneRIF: ATAD3 is a limiting factor in mitochondrial biogenesis and
            adipogenesis of white adipocyte-like 3T3-L1 cells.
REFERENCE   2  (bases 1 to 2426)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2426)
  AUTHORS   Li,Z., Hu,O., Xu,S., Lin,C., Yu,W., Ma,D., Lu,J. and Liu,P.
  TITLE     The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial
            calcium homeostasis in cardiac hypertrophy
  JOURNAL   Int J Biol Sci 20 (3), 831-847 (2024)
   PUBMED   38250153
  REMARK    GeneRIF: The SIRT3-ATAD3A axis regulates MAM dynamics and
            mitochondrial calcium homeostasis in cardiac hypertrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2426)
  AUTHORS   Watanabe,S., Horiuchi,M., Murata,Y., Komine,O., Kawade,N., Sobue,A.
            and Yamanaka,K.
  TITLE     Sigma-1 receptor maintains ATAD3A as a monomer to inhibit
            mitochondrial fragmentation at the mitochondria-associated membrane
            in amyotrophic lateral sclerosis
  JOURNAL   Neurobiol Dis 179, 106031 (2023)
   PUBMED   36736924
  REMARK    GeneRIF: Sigma-1 receptor maintains ATAD3A as a monomer to inhibit
            mitochondrial fragmentation at the mitochondria-associated membrane
            in amyotrophic lateral sclerosis.
REFERENCE   5  (bases 1 to 2426)
  AUTHORS   Lee,H. and Kim,D.W.
  TITLE     Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria
            structure and function in pre-osteoblast
  JOURNAL   Dev Dyn 251 (12), 1982-2000 (2022)
   PUBMED   36000457
  REMARK    GeneRIF: Deletion of ATAD3A inhibits osteogenesis by impairing
            mitochondria structure and function in pre-osteoblast.
REFERENCE   6  (bases 1 to 2426)
  AUTHORS   Goller,T., Seibold,U.K., Kremmer,E., Voos,W. and Kolanus,W.
  TITLE     Atad3 function is essential for early post-implantation development
            in the mouse
  JOURNAL   PLoS One 8 (1), e54799 (2013)
   PUBMED   23372768
  REMARK    GeneRIF: ATAD3 is present in five native mitochondrial protein
            complexes of different sizes, indicating complex roles of the
            protein in mitochondrial architecture and function.
REFERENCE   7  (bases 1 to 2426)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 2426)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 2426)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 2426)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB839884.1, AK149702.1 and BF318525.1.
            
            On Jun 17, 2009 this sequence version replaced NM_179203.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172350.1, BC058373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BB839884.1         2-3
            3-2190              AK149702.1         2-2189
            2191-2426           BF318525.1         1-236               c
FEATURES             Location/Qualifiers
     source          1..2426
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.2 cM"
     gene            1..2426
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /note="ATPase family, AAA domain containing 3A"
                     /db_xref="GeneID:108888"
                     /db_xref="MGI:MGI:1919214"
     exon            1..297
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1871
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /note="ATPase family AAA domain-containing protein 3;
                     AAA-ATPase TOB3"
                     /codon_start=1
                     /product="ATPase family AAA domain-containing protein 3A"
                     /protein_id="NP_849534.2"
                     /db_xref="CCDS:CCDS19037.1"
                     /db_xref="GeneID:108888"
                     /db_xref="MGI:MGI:1919214"
                     /translation="MSWLFGIKGPKGEGTGPPLPLPPAQPGAEGGGDRGAGDRPSPKD
                     KWSNFDPTGLERAAKAARELEHSRHAKEALSLAQMQEQTLQLEQQSKLKEYEAAVEQL
                     KSEQIRVQAEERRKTLTEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEE
                     SVQKQEAIRRATVEREMELRHKNEMLRVEAEARARAKADRENADIIREQIRLKAAEHR
                     QTILESIRTAGTLLGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATSVAGRYIEA
                     RLGKPSLVRETSRISVLEALRHPIQVSRRLVSRPQDALEGVILSPSLEARVRDIAIAT
                     RNTKKNKSLYRNVLMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMH
                     KVFDWASTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLHRTGQHSSKFMLVL
                     ASNQPEQFDWAINDRIDEMVCFALPQREERERLVRMYFDKYVLKPATEGKQRLKVAQF
                     DYGKKCSEVAQLTEGMSGREIAQLAVAWQAMAYSSEDGVLTEAMMDARVQDAVQQHQQ
                     KMQWLKVERPDSQTNKPPHPSLLSC"
     exon            298..374
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..476
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..536
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            537..606
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..772
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..842
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..998
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1055
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1181
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1306
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1358
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1429
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1597
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1706
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..2419
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /note="hexamer: AATAAA"
     polyA_site      2412
                     /gene="Atad3a"
                     /gene_synonym="2400004H09Rik; Atad3; mKIAA1273; Tob3"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgagtc gcgcccgcgg cgcgtggtga ctgcgaggag cctcgcgagt cacgctccgg
       61 tacggtccgc cgagggcgcg cggagcttgc agaccatgtc gtggctcttc ggcatcaagg
      121 gccccaaggg cgaaggcaca gggcctccgc tgcccttgcc gcccgctcaa cccggggcgg
      181 agggcggcgg tgaccgcggg gcgggagacc ggccatcgcc caaggacaaa tggagcaact
      241 tcgacccgac gggcctggaa cgtgcggcca aagcggctcg cgagttggag cactcgcgcc
      301 atgccaagga ggcactgagt ctcgcacaga tgcaggagca gacgctgcag ctggaacagc
      361 agtccaagct caaggagtac gaagctgccg tagagcagct gaagagcgaa cagatccgtg
      421 tgcaagccga ggaaagaagg aaaaccctga ctgaagagac acgacagcac caggctaggg
      481 cccagtacca ggataagctc gctcgacagc gctatgagga ccagctgaaa caacagcaac
      541 ttctgaatga agagaattta aggaaacaag aggagtctgt gcagaagcag gaggccatac
      601 ggcgagccac tgtggagcgc gagatggagc tgaggcataa aaacgagatg ttgcgggtgg
      661 aagctgaagc ccgagcacgg gccaaggctg atcgagagaa tgcagatatc atccgggaac
      721 agattcgact caaggctgct gagcaccgcc agaccatctt ggagtctatc aggacagctg
      781 gcaccttgct tggtgaagga ttccgtgcat ttgtgacaga ctgggacaaa gtgacagcta
      841 cggtggctgg gttgacacta ttagctgttg gagtctattc tgcaaagaat gctacttctg
      901 ttgctggtcg gtatattgag gcccgattgg gaaagccgtc cttggtgaga gagacctccc
      961 gaatctcagt gctagaggca ttgaggcatc ccatccaggt cagcaggcga ctggtcagca
     1021 gaccccagga tgcattggag ggcgtcatcc tcagtcctag cctggaggca cgggtccgag
     1081 atattgccat cgcaacaaga aataccaaga agaacaaaag cctgtatagg aacgttctga
     1141 tgtatgggcc cccggggact ggcaagacac tatttgccaa gaaacttgca ctgcattcag
     1201 gcatggacta cgccatcatg acaggcgggg acgtggcccc aatggggcgg gagggtgtga
     1261 ctgccatgca caaggtcttc gactgggcaa gcaccagccg acgaggcctc ctgctctttg
     1321 tggatgaagc agacgccttc ctcaggaaac gagcgactga aaagataagt gaagacctca
     1381 gggctactct gaatgccttc ctacacagga caggacagca cagtagtaag ttcatgctgg
     1441 tcctggccag taaccagcct gagcagtttg attgggctat caatgaccgc attgacgaga
     1501 tggtctgctt tgccctgcca cagcgggagg agcgagagcg cctggtgaga atgtattttg
     1561 acaagtatgt ccttaagccg gccacagaag gaaagcagcg cttgaaggtg gcccagtttg
     1621 actatggaaa gaaatgctca gaggttgccc agctaacgga ggggatgtca ggccgggaga
     1681 ttgctcagct tgctgtggcg tggcaggcca tggcatattc atctgaggat ggagtcctca
     1741 cggaagctat gatggatgcc cgtgtgcagg atgctgtgca gcagcaccag cagaagatgc
     1801 agtggcttaa agtagagaga cccgattccc agaccaacaa gccgccacat ccttcactcc
     1861 tcagctgctg agctggacct ggacaccttg tacacctgac tggggcagcc agtctctatg
     1921 accacactgc tccctccttt cctgtcttct ttgacctctg taagaggtca acattgctcc
     1981 aaatgcctct gcggagttgt gggatactgg aggtgtcagc ttctctgcct cccacacctc
     2041 ctcgtctctg actctgagtg ctggcagagg gaggcatact gccttccttt acctcagtac
     2101 actggtgaga catgtctaca agcccagagc agagcagaga gtgtgcagag tgccgtacca
     2161 caagccagtg gctatgccag cgggactggg gcctacaggg accaggctaa aggcacaggg
     2221 ggccctcagc ttcctggaca ttactcctac catatacaca tctgtgccaa gaattggccc
     2281 agtctttact cggtagagtg gatctggtgc tagacagcgc ttggcccgtg gcatccaagc
     2341 gtcagaacta ccgccttccc tctactgagt ccgggccttt taaatccaga atcgaataaa
     2401 actgtgactg attttctgaa aaaaaa
//
